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Protein

Solute carrier family 15 member 2

Gene

Slc15a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:11027540). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity).By similarity1 Publication

Kineticsi

  1. KM=56.6 µM for D-Phe-Ala (at pH 6.0)1 Publication

    pH dependencei

    Optimum pH is 6.0 or lower.1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • oligopeptide transport Source: MGI
    • protein transport Source: UniProtKB-KW

    Keywordsi

    Biological processPeptide transport, Protein transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.17.4.4 the proton-dependent oligopeptide transporter (pot/ptr) family

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 15 member 2
    Alternative name(s):
    Kidney H(+)/peptide cotransporter
    Oligopeptide transporter, kidney isoform
    Peptide transporter 2
    Gene namesi
    Name:Slc15a2
    Synonyms:Pept2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    Proteomesi
    • UP000000589 Componenti: Unplaced

    Organism-specific databases

    MGIiMGI:1890457 Slc15a2

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 57CytoplasmicCuratedAdd BLAST57
    Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
    Topological domaini79 – 87ExtracellularCurated9
    Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
    Topological domaini109 – 113CytoplasmicCurated5
    Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
    Topological domaini135 – 139ExtracellularCurated5
    Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
    Topological domaini161 – 183CytoplasmicCuratedAdd BLAST23
    Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
    Topological domaini205 – 217ExtracellularCuratedAdd BLAST13
    Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
    Topological domaini239 – 295CytoplasmicCuratedAdd BLAST57
    Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
    Topological domaini317 – 343ExtracellularCuratedAdd BLAST27
    Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
    Topological domaini365 – 380CytoplasmicCuratedAdd BLAST16
    Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
    Topological domaini402 – 611ExtracellularCuratedAdd BLAST210
    Transmembranei612 – 632HelicalSequence analysisAdd BLAST21
    Topological domaini633 – 643CytoplasmicCuratedAdd BLAST11
    Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
    Topological domaini665 – 674ExtracellularCurated10
    Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
    Topological domaini696 – 729CytoplasmicCuratedAdd BLAST34

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Chemistry databases

    ChEMBLiCHEMBL2073678

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000643091 – 729Solute carrier family 15 member 2Add BLAST729

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei9PhosphoserineCombined sources1
    Modified residuei12PhosphothreonineCombined sources1
    Modified residuei28PhosphoserineBy similarity1
    Glycosylationi448N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi472N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi528N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi587N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9ES07
    PaxDbiQ9ES07
    PRIDEiQ9ES07

    PTM databases

    iPTMnetiQ9ES07
    PhosphoSitePlusiQ9ES07

    Expressioni

    Tissue specificityi

    Expressed in kidney brush border cells (at protein level).1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000023616

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ES07
    SMRiQ9ES07
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG1237 Eukaryota
    COG3104 LUCA
    HOVERGENiHBG052962
    InParanoidiQ9ES07
    PhylomeDBiQ9ES07

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR029028 Alpha/beta_knot_MTases
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR004768 Oligopep_transport
    IPR000109 POT_fam
    IPR018456 PTR2_symporter_CS
    PANTHERiPTHR11654 PTHR11654, 1 hit
    PfamiView protein in Pfam
    PF00854 PTR2, 2 hits
    SUPFAMiSSF103473 SSF103473, 2 hits
    SSF75217 SSF75217, 1 hit
    TIGRFAMsiTIGR00926 2A1704, 1 hit
    PROSITEiView protein in PROSITE
    PS01022 PTR2_1, 1 hit
    PS01023 PTR2_2, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q9ES07-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MNPFQKNESK ETLFSPVSTE EMLPGPPSPP KKSTPKLFGS SYPLSIAFIV
    60 70 80 90 100
    VNEFCERFSY YGMKAVLTLY FLYFLHWNED TSTSVYHAFS SLCYFTPILG
    110 120 130 140 150
    AAIADSWLGK FKTIIYLSLV YVLGHVFKSL GAIPILGGKM LHTILSLVGL
    160 170 180 190 200
    SLIALGTGGI KPCVAAFGGD QFEEEHAEAR TRYFSVFYLS INAGSLISTF
    210 220 230 240 250
    ITPMLRGDVK CFGEDCYALA FGIPGLLMVL ALVVFAMGSK MYRKPPPEGN
    260 270 280 290 300
    IVAQVTKCIW FAICNRFRNR SEDIPKRQHW LDWAAEKYPK HLIMDVKALT
    310 320 330 340 350
    RILFLYIPLP MFWALLDQQG SRWTLQANKM DGDLGFFVLQ PDQMQVLNPF
    360 370 380 390 400
    LVLVFIPLFD LVIYRLISKC GVNFSSLRKM AVGMILACLA FAVAALVEIK
    410 420 430 440 450
    INGMIHPQPA SQEIFLQVLN LADGEIEVTV QGNRNNPLLV ESISSFQNTT
    460 470 480 490 500
    HYSKLRLETK SQDLHFHLKY NNLSVHNEYS VEEKNCYQLV VHENGESLSS
    510 520 530 540 550
    MLVKDTGIKP ANGMTAIRFI NTLHKDMNIS LDANAPLSVG KDYGVSEYRT
    560 570 580 590 600
    VQRGKYPAVH CETEDNVFSL NLGQLDFGTT YLFVITNITN RGLQAWKAED
    610 620 630 640 650
    IPANKLSIAW QLPQYVLVTA AEVMFSVTGL EFSYSQAPSS MKSVLQAAWL
    660 670 680 690 700
    LTVAVGNIIV LIVAQFSGLV QWAEFVLFSC LLLVVCLIFS VMGYYYVPLK
    710 720
    SEGIHEATEK QIPHIQGNMI NLETKNTRL
    Length:729
    Mass (Da):81,632
    Last modified:March 1, 2001 - v1
    Checksum:iF3C9D3481B1F671C
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF257711 Genomic DNA Translation: AAG25926.1
    PIRiJC7501
    UniGeneiMm.281804

    Similar proteinsi

    Entry informationi

    Entry nameiS15A2_MOUSE
    AccessioniPrimary (citable) accession number: Q9ES07
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: March 1, 2001
    Last modified: April 25, 2018
    This is version 101 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health