Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 15 member 2

Gene

Slc15a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.1 Publication

GO - Molecular functioni

  • high-affinity oligopeptide transporter activity Source: MGI
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • oligopeptide transport Source: MGI
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Protein family/group databases

TCDBi2.A.17.4.4. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 2
Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2
Gene namesi
Name:Slc15a2
Synonyms:Pept2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1890457. Slc15a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei58 – 7821HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence analysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence analysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence analysisAdd
BLAST
Transmembranei568 – 58821HelicalSequence analysisAdd
BLAST
Transmembranei612 – 63221HelicalSequence analysisAdd
BLAST
Transmembranei644 – 66421HelicalSequence analysisAdd
BLAST
Transmembranei675 – 69521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: MGI
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2073678.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Solute carrier family 15 member 2PRO_0000064309Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Modified residuei9 – 91PhosphoserineCombined sources
Modified residuei12 – 121PhosphothreonineCombined sources
Modified residuei28 – 281PhosphoserineBy similarity
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence analysis
Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence analysis
Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence analysis
Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9ES07.
PaxDbiQ9ES07.
PRIDEiQ9ES07.

PTM databases

iPTMnetiQ9ES07.
PhosphoSiteiQ9ES07.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023616.

Structurei

3D structure databases

ProteinModelPortaliQ9ES07.
SMRiQ9ES07. Positions 42-601, 603-662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
HOVERGENiHBG052962.
InParanoidiQ9ES07.
PhylomeDBiQ9ES07.

Family and domain databases

InterProiIPR029028. Alpha/beta_knot_MTases.
IPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ES07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPFQKNESK ETLFSPVSTE EMLPGPPSPP KKSTPKLFGS SYPLSIAFIV
60 70 80 90 100
VNEFCERFSY YGMKAVLTLY FLYFLHWNED TSTSVYHAFS SLCYFTPILG
110 120 130 140 150
AAIADSWLGK FKTIIYLSLV YVLGHVFKSL GAIPILGGKM LHTILSLVGL
160 170 180 190 200
SLIALGTGGI KPCVAAFGGD QFEEEHAEAR TRYFSVFYLS INAGSLISTF
210 220 230 240 250
ITPMLRGDVK CFGEDCYALA FGIPGLLMVL ALVVFAMGSK MYRKPPPEGN
260 270 280 290 300
IVAQVTKCIW FAICNRFRNR SEDIPKRQHW LDWAAEKYPK HLIMDVKALT
310 320 330 340 350
RILFLYIPLP MFWALLDQQG SRWTLQANKM DGDLGFFVLQ PDQMQVLNPF
360 370 380 390 400
LVLVFIPLFD LVIYRLISKC GVNFSSLRKM AVGMILACLA FAVAALVEIK
410 420 430 440 450
INGMIHPQPA SQEIFLQVLN LADGEIEVTV QGNRNNPLLV ESISSFQNTT
460 470 480 490 500
HYSKLRLETK SQDLHFHLKY NNLSVHNEYS VEEKNCYQLV VHENGESLSS
510 520 530 540 550
MLVKDTGIKP ANGMTAIRFI NTLHKDMNIS LDANAPLSVG KDYGVSEYRT
560 570 580 590 600
VQRGKYPAVH CETEDNVFSL NLGQLDFGTT YLFVITNITN RGLQAWKAED
610 620 630 640 650
IPANKLSIAW QLPQYVLVTA AEVMFSVTGL EFSYSQAPSS MKSVLQAAWL
660 670 680 690 700
LTVAVGNIIV LIVAQFSGLV QWAEFVLFSC LLLVVCLIFS VMGYYYVPLK
710 720
SEGIHEATEK QIPHIQGNMI NLETKNTRL
Length:729
Mass (Da):81,632
Last modified:March 1, 2001 - v1
Checksum:iF3C9D3481B1F671C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257711 Genomic DNA. Translation: AAG25926.1.
PIRiJC7501.
UniGeneiMm.281804.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257711 Genomic DNA. Translation: AAG25926.1.
PIRiJC7501.
UniGeneiMm.281804.

3D structure databases

ProteinModelPortaliQ9ES07.
SMRiQ9ES07. Positions 42-601, 603-662.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023616.

Chemistry

ChEMBLiCHEMBL2073678.

Protein family/group databases

TCDBi2.A.17.4.4. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

iPTMnetiQ9ES07.
PhosphoSiteiQ9ES07.

Proteomic databases

MaxQBiQ9ES07.
PaxDbiQ9ES07.
PRIDEiQ9ES07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1890457. Slc15a2.

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
HOVERGENiHBG052962.
InParanoidiQ9ES07.
PhylomeDBiQ9ES07.

Miscellaneous databases

ChiTaRSiSlc15a2. mouse.
PROiQ9ES07.
SOURCEiSearch...

Family and domain databases

InterProiIPR029028. Alpha/beta_knot_MTases.
IPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the gene encoding the mouse peptide transporter PEPT2."
    Rubio-Aliaga I., Boll M., Daniel H.
    Biochem. Biophys. Res. Commun. 276:734-741(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: 129/SvEvTacfBr.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9 AND THR-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Kidney.

Entry informationi

Entry nameiS15A2_MOUSE
AccessioniPrimary (citable) accession number: Q9ES07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2001
Last modified: February 17, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.