Reviewed,
UniProtKB/Swiss-Prot Q9ERZ8 (TRPV4_RAT)
Last modified
February 9, 2010.
Version 60.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Transient receptor potential cation channel subfamily V member 4 Short name=TrpV4 Alternative name(s): Osm-9-like TRP channel 4 Short name=OTRPC4 Vanilloid receptor-related osmotically-activated channel Short name=VR-OAC | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 871 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism By similarity. Ref.1 |
| Subunit structure | Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES By similarity. |
| Subcellular location | Membrane; Multi-pass membrane protein Probable. |
| Tissue specificity | Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia. Ref.1 |
| Sequence similarities | Belongs to the transient receptor family. TrpV subfamily. Contains 3 ANK repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Calcium transport Ion transport Transport |
| Cellular component | Membrane |
| Domain | ANK repeat Repeat Transmembrane |
| Ligand | Calcium Calmodulin-binding |
| Molecular function | Calcium channel Ionic channel |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW hypotonic response Ref.1Inferred from direct assay. Source: RGD transmembrane transportInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | calcium channel activity Inferred from electronic annotation. Source: UniProtKB-KW calcium ion bindingInferred from electronic annotation. Source: UniProtKB-KW calmodulin bindingInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 871 | 871 | Transient receptor potential cation channel subfamily V member 4 | PRO_0000215349 | |||||
Regions | |||||||||
| Topological domain | 1 – 465 | 465 | Cytoplasmic Potential | ||||||
| Transmembrane | 466 – 486 | 21 | Potential | ||||||
| Topological domain | 487 – 508 | 22 | Extracellular Potential | ||||||
| Transmembrane | 509 – 529 | 21 | Potential | ||||||
| Topological domain | 530 – 550 | 21 | Cytoplasmic Potential | ||||||
| Transmembrane | 551 – 571 | 21 | Potential | ||||||
| Topological domain | 572 | 1 | Extracellular Potential | ||||||
| Transmembrane | 573 – 593 | 21 | Potential | ||||||
| Topological domain | 594 – 616 | 23 | Cytoplasmic Potential | ||||||
| Transmembrane | 617 – 637 | 21 | Potential | ||||||
| Topological domain | 638 – 690 | 53 | Pore forming Probable | ||||||
| Transmembrane | 691 – 711 | 21 | Potential | ||||||
| Topological domain | 712 – 871 | 160 | Cytoplasmic Potential | ||||||
| Repeat | 237 – 266 | 30 | ANK 1 | ||||||
| Repeat | 284 – 313 | 30 | ANK 2 | ||||||
| Repeat | 369 – 398 | 30 | ANK 3 | ||||||
| Region | 812 – 831 | 20 | Interaction with calmodulin By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 253 | 1 | Phosphotyrosine By similarity | ||||||
Sequences
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References
| [1] | "Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor." Liedtke W.B., Choe Y., Marti-Renom M.A., Bell A.M., Denis C.S., Sali A., Hudspeth A.J., Friedman J.M., Heller S. Cell 103:525-535(2000) [PubMed: 11081638] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Kidney. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF263521 mRNA. Translation: AAG28027.1. |
| IPI | IPI00191593. |
| RefSeq | NP_076460.1. |
| UniGene | Rn.64508 |
3D structure databases | |
| SMR | Q9ERZ8. Positions 149-393. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9ERZ8. |
Protein family/group databases | |
| TCDB | 1.A.4.2.5. transient receptor potential Ca2+ channel (TRP-CC) family. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000001586; ENSRNOP00000001586; ENSRNOG00000001195; Rattus norvegicus. [Genome view] |
| GeneID | 66026. |
| KEGG | rno:66026. |
| UCSC | NM_023970. rat. |
Organism-specific databases | |
| CTD | 66026. |
| RGD | 69337. Trpv4. |
Phylogenomic databases | |
| eggNOG | roNOG14417. |
| HOVERGEN | Q9ERZ8. |
| InParanoid | Q9ERZ8. |
| OMA | ESTLYES. |
| OrthoDB | EOG9SR0FX. |
| PhylomeDB | Q9ERZ8. |
Gene expression databases | |
| ArrayExpress | Q9ERZ8. |
| Genevestigator | Q9ERZ8. |
| GermOnline | ENSRNOG00000001195. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR005821. Ion_trans. IPR004729. TRP_channel. IPR008347. Vanilpoid_rcpt. IPR008348. Vanilpoid_rcpt_2. [Graphical view] |
| Gene3D | G3DSA:1.25.40.20. ANK. 1 hit. |
| Pfam | PF00023. Ank. 1 hit. PF00520. Ion_trans. 1 hit. [Graphical view] |
| PRINTS | PR01768. TRPVRECEPTOR. PR01769. VRL2RECEPTOR. |
| SMART | SM00248. ANK. 3 hits. [Graphical view] |
| TIGRFAMs | TIGR00870. trp. 1 hit. |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 614333. |
Entry information
| Entry name | TRPV4_RAT | ||||||||
| Accession | Primary (citable) accession number: Q9ERZ8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


