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Q9ERZ3

- ACM3_MOUSE

UniProt

Q9ERZ3 - ACM3_MOUSE

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Protein
Muscarinic acetylcholine receptor M3
Gene
Chrm3, Chrm-3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

GO - Molecular functioni

  1. G-protein coupled acetylcholine receptor activity Source: Ensembl
  2. acetylcholine binding Source: Ensembl
  3. acetylcholine receptor activity Source: MGI
  4. drug binding Source: Ensembl
  5. guanyl-nucleotide exchange factor activity Source: Reactome
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled acetylcholine receptor signaling pathway Source: MGI
  2. digestion Source: MGI
  3. phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway Source: MGI
  4. positive regulation of smooth muscle contraction Source: MGI
  5. regulation of GTPase activity Source: GOC
  6. regulation of vascular smooth muscle contraction Source: Ensembl
  7. saliva secretion Source: InterPro
  8. smooth muscle contraction Source: MGI
  9. synaptic transmission, cholinergic Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M3
Alternative name(s):
Mm3 mAChR
Gene namesi
Name:Chrm3
Synonyms:Chrm-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:88398. Chrm3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6666Extracellular By similarity
Add
BLAST
Transmembranei67 – 9024Helical; Name=1; By similarity
Add
BLAST
Topological domaini91 – 10313Cytoplasmic By similarity
Add
BLAST
Transmembranei104 – 12421Helical; Name=2; By similarity
Add
BLAST
Topological domaini125 – 14117Extracellular By similarity
Add
BLAST
Transmembranei142 – 16322Helical; Name=3; By similarity
Add
BLAST
Topological domaini164 – 18320Cytoplasmic By similarity
Add
BLAST
Transmembranei184 – 20623Helical; Name=4; By similarity
Add
BLAST
Topological domaini207 – 22822Extracellular By similarity
Add
BLAST
Transmembranei229 – 25123Helical; Name=5; By similarity
Add
BLAST
Topological domaini252 – 491240Cytoplasmic By similarity
Add
BLAST
Transmembranei492 – 51221Helical; Name=6; By similarity
Add
BLAST
Topological domaini513 – 52614Extracellular By similarity
Add
BLAST
Transmembranei527 – 54620Helical; Name=7; By similarity
Add
BLAST
Topological domaini547 – 58943Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. asymmetric synapse Source: Ensembl
  2. axon terminus Source: Ensembl
  3. basolateral plasma membrane Source: UniProtKB-SubCell
  4. cell junction Source: UniProtKB-KW
  5. dendrite Source: Ensembl
  6. integral component of plasma membrane Source: MGI
  7. plasma membrane Source: Reactome
  8. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Muscarinic acetylcholine receptor M3
PRO_0000069030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15 – 151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi48 – 481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi140 ↔ 220 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ERZ3.
PRIDEiQ9ERZ3.

PTM databases

PhosphoSiteiQ9ERZ3.

Expressioni

Gene expression databases

ArrayExpressiQ9ERZ3.
BgeeiQ9ERZ3.
CleanExiMM_CHRM3.
GenevestigatoriQ9ERZ3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055579.

Structurei

3D structure databases

ProteinModelPortaliQ9ERZ3.
SMRiQ9ERZ3. Positions 63-259, 399-559.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi274 – 2807Basolateral sorting signal By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250863.
GeneTreeiENSGT00690000101881.
HOGENOMiHOG000231484.
HOVERGENiHBG105720.
InParanoidiQ9ERZ3.
KOiK04131.
OMAiIWQVVFI.
OrthoDBiEOG7V49Z7.
PhylomeDBiQ9ERZ3.
TreeFamiTF320495.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001183. Musac_Ach_M3_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PANTHERiPTHR24249:SF61. PTHR24249:SF61. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00540. MUSCRINICM3R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERZ3-1 [UniParc]FASTAAdd to Basket

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MTLHSNSTTS PLFPNISSSW VHSPSEAGLP LGTVSQLDSY NISQTSGNFS    50
SNDTSSDPLG GHTIWQVVFI AFLTGFLALV TIIGNILVIV AFKVNKQLKT 100
VNNYFLLSLA CADLIIGVIS MNLFTTYIIM NRWALGNLAC DLWLSIDYVA 150
SNASVMNLLV ISFDRYFSIT RPLTYRAKRT TKRAGVMIGL AWVISFVLWA 200
PAILFWQYFV GKRTVPPGEC FIQFLSEPTI TFGTAIAAFY MPVTIMTILY 250
WRIYKETEKR TKELAGLQAS GTEAEAENFV HPTGSSRSCS SYELQQQGTK 300
RSSRRKYGGC HFWFTTKSWK PSAEQMDQDH SSSDSWNNND AAASLENSAS 350
SDEEDIGSET RAIYSIVLKL PGHSTILNST KLPSSDNLQV PDKDLGTMDV 400
ERNAHKLQAQ KSMDDRDNCQ KDFSKLPIQL ESAVDTAKTS DTNSSVDKTT 450
AALPLSFKEA TLAKRFALKT RSQITKRKRM SLIKEKKAAQ TLSAILLAFI 500
ITWTPYNIMV LVNTFCDSCI PKTYWNLGYW LCYINSTVNP VCYALCNKTF 550
RTTFKMLLLC QCDKRKRRKQ QYQQRQSVIF HKRVPEQAL 589
Length:589
Mass (Da):66,212
Last modified:March 1, 2001 - v1
Checksum:iAB782149EBEE7804
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF264050 Genomic DNA. Translation: AAG14344.1.
S74908 mRNA. Translation: AAB33576.2.
CCDSiCCDS26238.1.
RefSeqiNP_150372.1. NM_033269.4.
XP_006516531.1. XM_006516468.1.
UniGeneiMm.342315.

Genome annotation databases

EnsembliENSMUST00000063093; ENSMUSP00000055579; ENSMUSG00000046159.
GeneIDi12671.
KEGGimmu:12671.
UCSCiuc007plb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF264050 Genomic DNA. Translation: AAG14344.1 .
S74908 mRNA. Translation: AAB33576.2 .
CCDSi CCDS26238.1.
RefSeqi NP_150372.1. NM_033269.4.
XP_006516531.1. XM_006516468.1.
UniGenei Mm.342315.

3D structure databases

ProteinModelPortali Q9ERZ3.
SMRi Q9ERZ3. Positions 63-259, 399-559.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000055579.

Chemistry

BindingDBi Q9ERZ3.
ChEMBLi CHEMBL5105.
GuidetoPHARMACOLOGYi 15.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9ERZ3.

Proteomic databases

PaxDbi Q9ERZ3.
PRIDEi Q9ERZ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063093 ; ENSMUSP00000055579 ; ENSMUSG00000046159 .
GeneIDi 12671.
KEGGi mmu:12671.
UCSCi uc007plb.1. mouse.

Organism-specific databases

CTDi 1131.
MGIi MGI:88398. Chrm3.

Phylogenomic databases

eggNOGi NOG250863.
GeneTreei ENSGT00690000101881.
HOGENOMi HOG000231484.
HOVERGENi HBG105720.
InParanoidi Q9ERZ3.
KOi K04131.
OMAi IWQVVFI.
OrthoDBi EOG7V49Z7.
PhylomeDBi Q9ERZ3.
TreeFami TF320495.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 281910.
PROi Q9ERZ3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9ERZ3.
Bgeei Q9ERZ3.
CleanExi MM_CHRM3.
Genevestigatori Q9ERZ3.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001183. Musac_Ach_M3_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view ]
PANTHERi PTHR24249:SF61. PTHR24249:SF61. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00540. MUSCRINICM3R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation, sequence and functional expression of mouse muscarinic acetylcholine receptor genes."
    Gomeza J., Wess J.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cultured neurons from mouse brain reproduce the muscarinic receptor profile of their tissue of origin."
    Andre C., Dos Santos G., Koulakoff A.
    Eur. J. Neurosci. 6:1691-1701(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 314-439.
    Tissue: Brain.

Entry informationi

Entry nameiACM3_MOUSE
AccessioniPrimary (citable) accession number: Q9ERZ3
Secondary accession number(s): Q64055
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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