Reviewed, UniProtKB/Swiss-Prot Q9ERY9 (ERG28_MOUSE)

Names and origin

Protein names

Recommended name:
    Probable ergosterol biosynthetic protein 28

Gene names

Name:

ORF11

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ERG28 family.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Gene Ontology (GO)
Biological process	sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	Probable ergosterol biosynthetic protein 28		PRO_0000193904
Regions
	Transmembrane	4 – 24	21	Potential
	Transmembrane	52 – 72	21	Potential
	Transmembrane	79 – 99	21	Potential
	Transmembrane	105 – 125	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ERY9-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: BDD082A4916E9E50	FASTA	140	15,806
	10 20 30 40 50 60 MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA RTFGIWTLLS 70 80 90 100 110 120 SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVFGT AAPTVGVLAP LMVASFSILG 130 140 MLVGLRYLEA EPVSRQKKRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genomic structure of c14orf1 is conserved across eukarya." Ottolenghi C., Daizadeh I., Ju A., Kossida S., Renault G., Jacquet M., Fellous A., Gilbert W., Veitia R.A. Mamm. Genome 11:786-788(2000) [PubMed: 10967139] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Bone marrow and Embryo.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF270646 mRNA. Translation: AAG17664.1. AK004480 mRNA. Translation: BAB23325.1. AK152230 mRNA. Translation: BAE31057.1. BC004591 mRNA. Translation: AAH04591.1.
IPI	IPI00112901.
RefSeq	NP_067421.1.
UniGene	Mm.143795
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ERY9.
Proteomic databases
PRIDE	Q9ERY9.
Genome annotation databases
Ensembl	ENSMUST00000021676; ENSMUSP00000021676; ENSMUSG00000021252; Mus musculus. [Genome view]
GeneID	58520.
KEGG	mmu:58520.
UCSC	uc007ohf.1. mouse.
Organism-specific databases
MGI	MGI:1915571. 0610007P14Rik.
Phylogenomic databases
HOGENOM	Q9ERY9.
HOVERGEN	Q9ERY9.
OMA	RTLYHIT
OrthoDB	EOG9D2990
Gene expression databases
ArrayExpress	Q9ERY9.
Bgee	Q9ERY9.
CleanEx	MM_0610007P14RIK.
Genevestigator	Q9ERY9.
GermOnline	ENSMUSG00000021252. Mus musculus.
Family and domain databases
InterPro	IPR005352. Erg28. [Graphical view]
Pfam	PF03694. Erg28. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	314330.
SOURCE	Search...

Entry information

Entry name

ERG28_MOUSE

Accession

Primary (citable) accession number: Q9ERY9
Secondary accession number(s): Q3U8G1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	March 1, 2001
Last modified:	November 24, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)