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Protein

Sex-determining region Y protein

Gene

Sry

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorSAAS annotation

Keywords - Biological processi

Differentiation, Sexual differentiationSAAS annotation, Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

Calmodulin-bindingSAAS annotation, DNA-bindingSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-3769402. Deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-determining region Y proteinSAAS annotation
Gene namesi
Name:SryImported
Synonyms:Sry1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unassembled WGS sequence

Organism-specific databases

RGDi3759. Sry.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 7369HMG box DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SRY family.SAAS annotation
Contains HMG box DNA-binding domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118988.
HOVERGENiHBG008712.
KOiK09266.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017253. SRY.
[Graphical view]
PANTHERiPTHR10270:SF199. PTHR10270:SF199. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGHVKRPMN AFMVWSRGER RKLAQQNPSM QNSEISKHLG YQWKSLTEAE
60 70 80 90 100
KRPFFQEAQR LKTLHREKYP NYKYQPHRRV KVPQRSYTLQ REVASTKLYN
110 120 130 140 150
LLQWDNNLHT IIYGQDWARA AHQSSKNQKS IYLQPVDIPT GYPLQQKQQH
160
QQQQHVHLQQ QQQQQHQFH
Length:169
Mass (Da):20,465
Last modified:March 1, 2001 - v1
Checksum:iD3A027A6735FE432
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC243442 Genomic DNA. No translation available.
AF274872 Genomic DNA. Translation: AAG09809.1.
AY157669 Genomic DNA. Translation: AAN37592.1.
EU984075 Genomic DNA. Translation: ACI00058.1.
FJ168060 Genomic DNA. Translation: ACI29003.1.
FJ168067 Genomic DNA. Translation: ACI29010.1.
KC215142 Genomic DNA. Translation: AGG39658.1.
RefSeqiNP_036904.1. NM_012772.1.

Genome annotation databases

EnsembliENSRNOT00000084732; ENSRNOP00000073240; ENSRNOG00000051574.
GeneIDi25221.
KEGGirno:25221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC243442 Genomic DNA. No translation available.
AF274872 Genomic DNA. Translation: AAG09809.1.
AY157669 Genomic DNA. Translation: AAN37592.1.
EU984075 Genomic DNA. Translation: ACI00058.1.
FJ168060 Genomic DNA. Translation: ACI29003.1.
FJ168067 Genomic DNA. Translation: ACI29010.1.
KC215142 Genomic DNA. Translation: AGG39658.1.
RefSeqiNP_036904.1. NM_012772.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084732; ENSRNOP00000073240; ENSRNOG00000051574.
GeneIDi25221.
KEGGirno:25221.

Organism-specific databases

CTDi6736.
RGDi3759. Sry.

Phylogenomic databases

GeneTreeiENSGT00760000118988.
HOVERGENiHBG008712.
KOiK09266.

Enzyme and pathway databases

ReactomeiR-RNO-3769402. Deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

NextBioi605765.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017253. SRY.
[Graphical view]
PANTHERiPTHR10270:SF199. PTHR10270:SF199. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence Comparison of Multiple Copies of Sry on the Rat Y Chromosome."
    Turner M.E., Martins A.S., Codispoti C., Francis M., Ely D.L., Milsted A.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SHR/akrImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. "Genomic and expression analysis of multiple Sry loci from a single Rattus norvegicus Y chromosome."
    Turner M.E., Martin C., Martins A.S., Dunmire J., Farkas J., Ely D.L., Milsted A.
    BMC Genet. 8:11-11(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SHR/AkrImported.
  4. "Which Sry locus is the hypertensive Y chromosome locus?"
    Turner M.E., Farkas J., Dunmire J., Ely D., Milsted A.
    Hypertension 53:430-435(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SHR/AkrImported, SHR/CrlImported and WKY/AkrImported.
  5. "Analysis of Sry duplications on the Rattus norvegicus Y-chromosome."
    Prokop J.W., Underwood A.C., Turner M.E., Miller N., Pietrzak D., Scott S., Smith C., Milsted A.
    BMC Genomics 14:792-792(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SHR/AkrImported.
  6. Ensembl
    Submitted (JUN-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ9ERV8_RAT
AccessioniPrimary (citable) accession number: Q9ERV8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.