Sry

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	5 – 73	HMG boxPROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB-KW
DNA binding Source: UniProtKB-UniRule
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl
transcription factor binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
male sex determination Source: InterPro
positive regulation of male gonad development Source: Ensembl
positive regulation of transcription, DNA-templated Source: Ensembl
sex differentiation Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	ActivatorSAAS annotation, Calmodulin-bindingSAAS annotation, DNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological process	Differentiation, Sexual differentiationSAAS annotation, Transcription, Transcription regulationSAAS annotation

Enzyme and pathway databases

Reactomeⁱ	R-RNO-3769402. Deactivation of the beta-catenin transactivating complex.

Reactomeⁱ

R-RNO-3769402. Deactivation of the beta-catenin transactivating complex.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sex-determining region Y proteinSAAS annotation
Gene namesⁱ	Name:SryImported Synonyms:Sry1Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unassembled WGS sequence

Organism-specific databases

Rat genome database More...RGDⁱ	3759. Sry.

RGDⁱ

3759. Sry.

Subcellular locationⁱ

Nucleus speckle
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00548901

GO - Cellular componentⁱ

nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

Interactionⁱ

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB-KW
transcription factor binding Source: Ensembl

Complete GO annotation...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 73	HMG box DNA-bindingInterPro annotationAdd BLAST		69

Sequence similaritiesⁱ

Belongs to the SRY family.SAAS annotation

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118988.
HOVERGENⁱ	HBG008712.
KEGG Orthology (KO) More...KOⁱ	K09266.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JDD.

Family and domain databases

Gene3Dⁱ	1.10.30.10. 1 hit.
InterProⁱ	View protein in InterPro IPR009071. HMG_box_dom. IPR017253. SRY.
PANTHERⁱ	PTHR10270:SF251. PTHR10270:SF251. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505. HMG_box. 1 hit.
SMARTⁱ	View protein in SMART SM00398. HMG. 1 hit.
SUPFAMⁱ	SSF47095. SSF47095. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50118. HMG_BOX_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9ERV8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEGHVKRPMN AFMVWSRGER RKLAQQNPSM QNSEISKHLG YQWKSLTEAE 
        60         70         80         90        100
KRPFFQEAQR LKTLHREKYP NYKYQPHRRV KVPQRSYTLQ REVASTKLYN 
       110        120        130        140        150
LLQWDNNLHT IIYGQDWARA AHQSSKNQKS IYLQPVDIPT GYPLQQKQQH 
       160 
QQQQHVHLQQ QQQQQHQFH

Length:169

Mass (Da):20,465

Last modified:March 1, 2001 - v1

Checksum:ⁱD3A027A6735FE432

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC243442 Genomic DNA. No translation available. AF274872 Genomic DNA. Translation: AAG09809.1. AY157669 Genomic DNA. Translation: AAN37592.1. EU984075 Genomic DNA. Translation: ACI00058.1. FJ168060 Genomic DNA. Translation: ACI29003.1. FJ168067 Genomic DNA. Translation: ACI29010.1. KC215142 Genomic DNA. Translation: AGG39658.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_036904.1. NM_012772.1.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000092902; ENSRNOP00000076001; ENSRNOG00000062090.
GeneIDⁱ	25221.
KEGGⁱ	rno:25221.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC243442 Genomic DNA. No translation available. AF274872 Genomic DNA. Translation: AAG09809.1. AY157669 Genomic DNA. Translation: AAN37592.1. EU984075 Genomic DNA. Translation: ACI00058.1. FJ168060 Genomic DNA. Translation: ACI29003.1. FJ168067 Genomic DNA. Translation: ACI29010.1. KC215142 Genomic DNA. Translation: AGG39658.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_036904.1. NM_012772.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000092902; ENSRNOP00000076001; ENSRNOG00000062090.
GeneIDⁱ	25221.
KEGGⁱ	rno:25221.

Organism-specific databases

CTDⁱ	6736.
Rat genome database More...RGDⁱ	3759. Sry.

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118988.
HOVERGENⁱ	HBG008712.
KEGG Orthology (KO) More...KOⁱ	K09266.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JDD.

Enzyme and pathway databases

Reactomeⁱ	R-RNO-3769402. Deactivation of the beta-catenin transactivating complex.

Reactomeⁱ

R-RNO-3769402. Deactivation of the beta-catenin transactivating complex.

Family and domain databases

Gene3Dⁱ	1.10.30.10. 1 hit.
InterProⁱ	View protein in InterPro IPR009071. HMG_box_dom. IPR017253. SRY.
PANTHERⁱ	PTHR10270:SF251. PTHR10270:SF251. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505. HMG_box. 1 hit.
SMARTⁱ	View protein in SMART SM00398. HMG. 1 hit.
SUPFAMⁱ	SSF47095. SSF47095. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50118. HMG_BOX_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q9ERV8_RAT
Accessionⁱ	Q9ERV8Primary (citable) accession number: Q9ERV8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 1, 2001
	Last sequence update:	March 1, 2001
	Last modified:	June 7, 2017
	This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB - Q9ERV8 (Q9ERV8_RAT)

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Sex-determining region Y protein

Select a section on the left to see content.

Functionⁱ

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Similar proteinsⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9ERV8 (Q9ERV8_RAT)

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Sex-determining region Y protein

Sry

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ