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Protein

p53-induced death domain-containing protein 1

Gene

Pidd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways.1 Publication

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • apoptotic process Source: UniProtKB-KW
  • cellular response to DNA damage stimulus Source: MGI
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • positive regulation of apoptotic signaling pathway Source: MGI
  • positive regulation of extrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-MMU-6803207. TP53 Regulates Transcription of Caspase Activators and Caspases.

Names & Taxonomyi

Protein namesi
Recommended name:
p53-induced death domain-containing protein 1
Alternative name(s):
Leucine-rich repeat and death domain-containing protein
Gene namesi
Name:Pidd1
Synonyms:Lrdd, Pidd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1889507. Pidd1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • Golgi apparatus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 915914p53-induced death domain-containing protein 1PRO_0000245244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei304 – 3041PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9ERV7.
PaxDbiQ9ERV7.
PRIDEiQ9ERV7.

PTM databases

PhosphoSiteiQ9ERV7.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Inductioni

Induced by TP53/tumor suppressor p53 AND gamma-irradiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000025507.
CleanExiMM_LRDD.
ExpressionAtlasiQ9ERV7. baseline and differential.
GenevisibleiQ9ERV7. MM.

Interactioni

Subunit structurei

Interacts with FADD and MAP-kinase activating death domain/MADD. Forms a complex with IKBKG and with receptor-interacting serine-threonine kinase 1/RIP1. Forms also a complex named PIDDosome with CASP2 and CRADD (By similarity). Interacts with CRADD.By similarity1 Publication

Protein-protein interaction databases

BioGridi208363. 2 interactions.
STRINGi10090.ENSMUSP00000026580.

Structurei

3D structure databases

ProteinModelPortaliQ9ERV7.
SMRiQ9ERV7. Positions 38-881.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati131 – 15222LRR 1Add
BLAST
Repeati154 – 17623LRR 2Add
BLAST
Repeati177 – 19923LRR 3Add
BLAST
Repeati200 – 22122LRR 4Add
BLAST
Repeati223 – 24523LRR 5Add
BLAST
Repeati246 – 26823LRR 6Add
BLAST
Repeati269 – 29022LRR 7Add
BLAST
Domaini320 – 427108ZU5 1PROSITE-ProRule annotationAdd
BLAST
Domaini428 – 45730Peptidase S68Add
BLAST
Domaini458 – 570113ZU5 2PROSITE-ProRule annotationAdd
BLAST
Domaini793 – 87886DeathPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni585 – 721137UPA domainBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 peptidase S68 domain.Curated
Contains 2 ZU5 domains.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000290659.
HOVERGENiHBG066762.
InParanoidiQ9ERV7.
KOiK10130.
OMAiVPHFSWF.
OrthoDBiEOG091G01ZE.
PhylomeDBiQ9ERV7.
TreeFamiTF331183.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR019502. Peptidase_S68_pidd.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF13855. LRR_8. 2 hits.
PF10461. Peptidase_S68. 1 hit.
PF00791. ZU5. 2 hits.
[Graphical view]
SMARTiSM00005. DEATH. 1 hit.
SM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS51450. LRR. 7 hits.
PS51145. ZU5. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ERV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVLEGQEP EETAAAAEDA ATSTLEAVDA GPGAPFLPAG NQLNLDLRPG
60 70 80 90 100
GCHRLQYLCS QQPPQLLQVE FLRLSTHEDP QLLDDTLAKV PWSLLRLRSL
110 120 130 140 150
VLKGGQSRGA LGACLHGTLT TLPAGLSDLA CLAHLDLSFN RLETLPTCVP
160 170 180 190 200
ELHGLDALLL SHNHLSELPE ALGALPALTF LTVTHNRLER LPLTLGSLST
210 220 230 240 250
LQRLDLSENL LDTIPSEIGN LRSLSELNLA SNRLQSLPAS LAGLRSLRLL
260 270 280 290 300
VLHSNLLTSV PTGLVHLPLI TRLDLRDNRL RDLPAELLDA PFVRLQGNPL
310 320 330 340 350
GEASPAPPSP PDISQVPEMP RLLLTSDLDS FLVTPHGCSV TLACGVRLQF
360 370 380 390 400
PAGATTTPVT IHYRLWLPEP GLVSLGPHDF LLSSVLELQP HGVAFQQDVS
410 420 430 440 450
LWLLFVPPRV RRCREVVVRT RSNNTWNDLE TQLEEEAPKR LWARCQVPHF
460 470 480 490 500
SWFLVVLRPV SNTCLLPPEG ALLCSSGHPG VRVTFPPGVT EEPRQVSMQV
510 520 530 540 550
VHMAGLELRT LLEESEASVS PLLCLSQSGP PSFLQPVTVQ LPLPPGVTGF
560 570 580 590 600
SLDRSHLHLL YRTPLTTTWD DITTQVALEF THLYARFQVT HFSWYWLWYT
610 620 630 640 650
TKTCVGGLAR KAWERLRLHR VNLIALQRRR DPEQVLLQCL PRNKVDATLS
660 670 680 690 700
RLLVRYRGPE PSETVEMFEG EKFFAAFERG IDVDADRPDC VDGRICFVFY
710 720 730 740 750
SHLKNVKEVY ITTALDREAQ DVRGQVSFYR GSLPVEVPAE AEAARQRKGT
760 770 780 790 800
DALWMATLPI KLPRLRGAQG SGQGTDFSLM PLNLGDAETG FLTQSNLLSV
810 820 830 840 850
ASRLGPDWPA VALHLGMPYH KLQRIRHEFR DDLDGQVRHM LFSWAERQTG
860 870 880 890 900
QPGAVGHLVQ ALEQSDRRDV AEEVRAILEL GRHKYQDSIR RTGLAPEDST
910
LPGTSASQTP ESAQA
Length:915
Mass (Da):101,141
Last modified:March 1, 2001 - v1
Checksum:i49FAA7B91D08E135
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274973 mRNA. Translation: AAG13462.1.
BC145857 mRNA. Translation: AAI45858.1.
CCDSiCCDS22014.1.
RefSeqiNP_073145.1. NM_022654.1.
XP_006536281.1. XM_006536218.2.
XP_011248150.1. XM_011249848.1.
UniGeneiMm.334321.

Genome annotation databases

EnsembliENSMUST00000026580; ENSMUSP00000026580; ENSMUSG00000025507.
ENSMUST00000106005; ENSMUSP00000101627; ENSMUSG00000025507.
GeneIDi57913.
KEGGimmu:57913.
UCSCiuc009klc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274973 mRNA. Translation: AAG13462.1.
BC145857 mRNA. Translation: AAI45858.1.
CCDSiCCDS22014.1.
RefSeqiNP_073145.1. NM_022654.1.
XP_006536281.1. XM_006536218.2.
XP_011248150.1. XM_011249848.1.
UniGeneiMm.334321.

3D structure databases

ProteinModelPortaliQ9ERV7.
SMRiQ9ERV7. Positions 38-881.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208363. 2 interactions.
STRINGi10090.ENSMUSP00000026580.

PTM databases

PhosphoSiteiQ9ERV7.

Proteomic databases

MaxQBiQ9ERV7.
PaxDbiQ9ERV7.
PRIDEiQ9ERV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026580; ENSMUSP00000026580; ENSMUSG00000025507.
ENSMUST00000106005; ENSMUSP00000101627; ENSMUSG00000025507.
GeneIDi57913.
KEGGimmu:57913.
UCSCiuc009klc.1. mouse.

Organism-specific databases

CTDi55367.
MGIiMGI:1889507. Pidd1.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000290659.
HOVERGENiHBG066762.
InParanoidiQ9ERV7.
KOiK10130.
OMAiVPHFSWF.
OrthoDBiEOG091G01ZE.
PhylomeDBiQ9ERV7.
TreeFamiTF331183.

Enzyme and pathway databases

ReactomeiR-MMU-6803207. TP53 Regulates Transcription of Caspase Activators and Caspases.

Miscellaneous databases

PROiQ9ERV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025507.
CleanExiMM_LRDD.
ExpressionAtlasiQ9ERV7. baseline and differential.
GenevisibleiQ9ERV7. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR019502. Peptidase_S68_pidd.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF13855. LRR_8. 2 hits.
PF10461. Peptidase_S68. 1 hit.
PF00791. ZU5. 2 hits.
[Graphical view]
SMARTiSM00005. DEATH. 1 hit.
SM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS51450. LRR. 7 hits.
PS51145. ZU5. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIDD1_MOUSE
AccessioniPrimary (citable) accession number: Q9ERV7
Secondary accession number(s): A6H6F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.