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Protein
Submitted name:

2P domain K+ channel TWIK-2

Gene

Kcnk6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • potassium channel activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
2P domain K+ channel TWIK-2Imported
Gene namesi
Name:Kcnk6Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621450. Kcnk6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei169 – 194HelicalSequence analysisAdd BLAST26
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineUniRule annotation1

Proteomic databases

PaxDbiQ9ERU5.
PRIDEiQ9ERU5.

Expressioni

Gene expression databases

GenevisibleiQ9ERU5. RN.

Structurei

3D structure databases

ProteinModelPortaliQ9ERU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 145Ion_trans_2InterPro annotationAdd BLAST56
Domaini180 – 258Ion_trans_2InterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
KOiK04917.
PhylomeDBiQ9ERU5.

Family and domain databases

InterProiView protein in InterPro
IPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR005409. 2pore_dom_K_chnl_TWIK2.
IPR013099. K_chnl_dom.
PANTHERiPTHR11003:SF28. PTHR11003:SF28. 1 hit.
PfamiView protein in Pfam
PF07885. Ion_trans_2. 2 hits.
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01587. TWIK2CHANNEL.
PR01586. TWIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9ERU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGALLASA LVAYAGYLAL GALLVARLER PHEARLRAEL GTLREQLLRH
60 70 80 90 100
SPCVAAHALD AFVERVLAAG RLGRAVLANA SGPANASDPA WDFASALFFA
110 120 130 140 150
STLVTTMGYG YTTPLTDAGK AFSIVFALLG VPITMLLLTA SAQRLSLLLT
160 170 180 190 200
HAPLSWLSLR WGWHPQRAAR WHLVALLMVI VAIFFLIPAA VFAYLEEAWS
210 220 230 240 250
FLDAFYFCFI SLSTIGLGDY VPGEAPGQPY RSLYKVLVTA YLFLGLVAMV
260 270 280 290 300
LVLQTFRRVS DLHGLTELIL LPDPDPARLH QDEDDQVDIL DARTDLHQHL
310
SAASHANYAS IPR
Length:313
Mass (Da):34,215
Last modified:March 1, 2001 - v1
Checksum:iA93629568785CD8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281304 mRNA. Translation: AAG10508.1.
RefSeqiNP_446258.2. NM_053806.2.
UniGeneiRn.43365.

Genome annotation databases

GeneIDi116491.
KEGGirno:116491.
UCSCiRGD:621450. rat.

Similar proteinsi

Entry informationi

Entry nameiQ9ERU5_RAT
AccessioniPrimary (citable) accession number: Q9ERU5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)