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Protein
Submitted name:

2P domain K+ channel TWIK-2

Gene

Kcnk6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • potassium channel activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
2P domain K+ channel TWIK-2Imported
Gene namesi
Name:Kcnk6Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621450. Kcnk6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11220HelicalSequence analysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Transmembranei169 – 19426HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9ERU5.
PRIDEiQ9ERU5.

Expressioni

Gene expression databases

GenevisibleiQ9ERU5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061815.

Structurei

3D structure databases

ProteinModelPortaliQ9ERU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 14556Ion_trans_2InterPro annotationAdd
BLAST
Domaini180 – 25879Ion_trans_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
KOiK04917.
PhylomeDBiQ9ERU5.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR005409. 2pore_dom_K_chnl_TWIK2.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01587. TWIK2CHANNEL.
PR01586. TWIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9ERU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGALLASA LVAYAGYLAL GALLVARLER PHEARLRAEL GTLREQLLRH
60 70 80 90 100
SPCVAAHALD AFVERVLAAG RLGRAVLANA SGPANASDPA WDFASALFFA
110 120 130 140 150
STLVTTMGYG YTTPLTDAGK AFSIVFALLG VPITMLLLTA SAQRLSLLLT
160 170 180 190 200
HAPLSWLSLR WGWHPQRAAR WHLVALLMVI VAIFFLIPAA VFAYLEEAWS
210 220 230 240 250
FLDAFYFCFI SLSTIGLGDY VPGEAPGQPY RSLYKVLVTA YLFLGLVAMV
260 270 280 290 300
LVLQTFRRVS DLHGLTELIL LPDPDPARLH QDEDDQVDIL DARTDLHQHL
310
SAASHANYAS IPR
Length:313
Mass (Da):34,215
Last modified:March 1, 2001 - v1
Checksum:iA93629568785CD8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281304 mRNA. Translation: AAG10508.1.
RefSeqiNP_446258.2. NM_053806.2.
UniGeneiRn.43365.

Genome annotation databases

GeneIDi116491.
KEGGirno:116491.
UCSCiRGD:621450. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281304 mRNA. Translation: AAG10508.1.
RefSeqiNP_446258.2. NM_053806.2.
UniGeneiRn.43365.

3D structure databases

ProteinModelPortaliQ9ERU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061815.

Proteomic databases

PaxDbiQ9ERU5.
PRIDEiQ9ERU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116491.
KEGGirno:116491.
UCSCiRGD:621450. rat.

Organism-specific databases

CTDi9424.
RGDi621450. Kcnk6.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
KOiK04917.
PhylomeDBiQ9ERU5.

Gene expression databases

GenevisibleiQ9ERU5. RN.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR005409. 2pore_dom_K_chnl_TWIK2.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01587. TWIK2CHANNEL.
PR01586. TWIKCHANNEL.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ9ERU5_RAT
AccessioniPrimary (citable) accession number: Q9ERU5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.