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Q9ERU3

- ZNF22_MOUSE

UniProt

Q9ERU3 - ZNF22_MOUSE

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Protein

Zinc finger protein 22

Gene
Znf22, Krox25, Krox26, Zfp422
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 7723C2H2-type 1Add
BLAST
Zinc fingeri83 – 10523C2H2-type 2Add
BLAST
Zinc fingeri111 – 13323C2H2-type 3Add
BLAST
Zinc fingeri139 – 16123C2H2-type 4Add
BLAST
Zinc fingeri167 – 18923C2H2-type 5Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. odontogenesis Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 22
Alternative name(s):
Zinc finger protein 422
Zinc finger protein Krox-25
Zinc finger protein Krox-26
Gene namesi
Name:Znf22
Synonyms:Krox25, Krox26, Zfp422
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1914505. Zfp422.

Subcellular locationi

Nucleus By similarity By similarity

GO - Cellular componenti

  1. nucleolus Source: Ensembl
  2. nucleus Source: UniProtKB
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Zinc finger protein 22PRO_0000047349Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181N6-acetyllysine1 Publication
Modified residuei23 – 231N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9ERU3.
PRIDEiQ9ERU3.

PTM databases

PhosphoSiteiQ9ERU3.

Expressioni

Tissue specificityi

Expressed predominantly in developing craniofacial bones and dental organs, and in molar tooth germs of postnatal animals. Also detected in embryonic heart, liver, thymus, kidney, brain, lung, muscle and calvaria. In the adult, highly expressed in lung, kidney, bone and incisors.3 Publications

Developmental stagei

In the embryo, expression is detected from day 7 with highest levels between days 11 and 15.2 Publications

Gene expression databases

BgeeiQ9ERU3.
CleanExiMM_ZFP422.
GenevestigatoriQ9ERU3.

Interactioni

Protein-protein interaction databases

IntActiQ9ERU3. 1 interaction.
MINTiMINT-4140652.

Structurei

3D structure databases

ProteinModelPortaliQ9ERU3.
SMRiQ9ERU3. Positions 24-192.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00740000115574.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9ERU3.
OMAiTHLVSSW.
OrthoDBiEOG7QG44V.
PhylomeDBiQ9ERU3.
TreeFamiTF350836.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERU3-1 [UniParc]FASTAAdd to Basket

« Hide

MRLGKPKGGI SRSASQGKAY ESKRKTARQR QKWGVAIRFD SGLSRRRRNV    50
DEKPYKCAKC SKSFSQSSTL FQHKKIHTGK KSHKCADCGK SFFQSSNLIQ 100
HRRIHTGEKP YKCDECGERF KQSSNLIQHQ RIHTGEKPYC CDECGRCFSQ 150
SSHLIQHQRT HTGEKPYQCE ECDKCFSQSS HLRQHMKVHK EKKPHKRGKN 200
ARVKTHPVSW KRGKGRKAVA GIRQVKGATS GLFKKKK 237
Length:237
Mass (Da):27,294
Last modified:March 15, 2004 - v2
Checksum:i1653220411F3C7DD
GO

Sequence cautioni

The sequence AAG12466.1 differs from that shown. Reason: Frameshift at position 224.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921K → N in AAG12466. 1 Publication
Sequence conflicti216 – 2161R → K1 Publication
Sequence conflicti216 – 2161R → K1 Publication
Sequence conflicti224 – 2241Q → R1 Publication
Sequence conflicti224 – 2241Q → R1 Publication
Sequence conflicti225 – 23713Missing1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF281634 mRNA. Translation: AAG12466.1. Frameshift.
AK082970 mRNA. Translation: BAC38716.1.
AK169251 mRNA. Translation: BAE41015.1.
BC018339 mRNA. Translation: AAH18339.1.
CCDSiCCDS20459.1.
RefSeqiNP_080333.1. NM_026057.2.
XP_006506566.1. XM_006506503.1.
XP_006506567.1. XM_006506504.1.
UniGeneiMm.18810.

Genome annotation databases

EnsembliENSMUST00000057540; ENSMUSP00000084926; ENSMUSG00000059878.
ENSMUST00000079749; ENSMUSP00000078685; ENSMUSG00000059878.
ENSMUST00000112880; ENSMUSP00000108501; ENSMUSG00000059878.
GeneIDi67255.
KEGGimmu:67255.
UCSCiuc009dkj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF281634 mRNA. Translation: AAG12466.1 . Frameshift.
AK082970 mRNA. Translation: BAC38716.1 .
AK169251 mRNA. Translation: BAE41015.1 .
BC018339 mRNA. Translation: AAH18339.1 .
CCDSi CCDS20459.1.
RefSeqi NP_080333.1. NM_026057.2.
XP_006506566.1. XM_006506503.1.
XP_006506567.1. XM_006506504.1.
UniGenei Mm.18810.

3D structure databases

ProteinModelPortali Q9ERU3.
SMRi Q9ERU3. Positions 24-192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9ERU3. 1 interaction.
MINTi MINT-4140652.

PTM databases

PhosphoSitei Q9ERU3.

Proteomic databases

PaxDbi Q9ERU3.
PRIDEi Q9ERU3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000057540 ; ENSMUSP00000084926 ; ENSMUSG00000059878 .
ENSMUST00000079749 ; ENSMUSP00000078685 ; ENSMUSG00000059878 .
ENSMUST00000112880 ; ENSMUSP00000108501 ; ENSMUSG00000059878 .
GeneIDi 67255.
KEGGi mmu:67255.
UCSCi uc009dkj.1. mouse.

Organism-specific databases

CTDi 67255.
MGIi MGI:1914505. Zfp422.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00740000115574.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9ERU3.
OMAi THLVSSW.
OrthoDBi EOG7QG44V.
PhylomeDBi Q9ERU3.
TreeFami TF350836.

Miscellaneous databases

NextBioi 324022.
PROi Q9ERU3.
SOURCEi Search...

Gene expression databases

Bgeei Q9ERU3.
CleanExi MM_ZFP422.
Genevestigatori Q9ERU3.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25."
    Lee S.K., Kim Y.S., Lee S.S., Lee Y.J., Song I.S., Park S.C., Kozak C., Yamada Y.
    Genomics 83:243-253(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Craniofacial.
  2. "Krox-26 is a novel C2H2 zinc finger transcription factor expressed in developing dental and osteogenic tissues."
    Ganss B., Teo W., Chen H., Poon T.
    Connect. Tissue Res. 43:161-166(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Spinal cord.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  5. "Developmental expression pattern and DNA-binding properties of the zinc finger transcription factor Krox-26."
    Teo W., Chen H., Poon T., Ganss B.
    Connect. Tissue Res. 44:161-166(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-18 AND LYS-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiZNF22_MOUSE
AccessioniPrimary (citable) accession number: Q9ERU3
Secondary accession number(s): Q3TF83, Q8VEK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi