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Q9ERU3

- ZNF22_MOUSE

UniProt

Q9ERU3 - ZNF22_MOUSE

Protein

Zinc finger protein 22

Gene

Znf22

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (15 Mar 2004)
      Previous versions | rss
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    Functioni

    Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation.1 Publication1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri55 – 7723C2H2-type 1CuratedPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri83 – 10523C2H2-type 2CuratedPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri111 – 13323C2H2-type 3CuratedPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 16123C2H2-type 4CuratedPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri167 – 18923C2H2-type 5CuratedPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. odontogenesis Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 22
    Alternative name(s):
    Zinc finger protein 422
    Zinc finger protein Krox-25
    Zinc finger protein Krox-26
    Gene namesi
    Name:Znf22
    Synonyms:Krox25, Krox26, Zfp422
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1914505. Zfp422.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleolus Source: Ensembl
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 237237Zinc finger protein 22PRO_0000047349Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei18 – 181N6-acetyllysine1 Publication
    Modified residuei23 – 231N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9ERU3.
    PRIDEiQ9ERU3.

    PTM databases

    PhosphoSiteiQ9ERU3.

    Expressioni

    Tissue specificityi

    Expressed predominantly in developing craniofacial bones and dental organs, and in molar tooth germs of postnatal animals. Also detected in embryonic heart, liver, thymus, kidney, brain, lung, muscle and calvaria. In the adult, highly expressed in lung, kidney, bone and incisors.3 Publications

    Developmental stagei

    In the embryo, expression is detected from day 7 with highest levels between days 11 and 15.2 Publications

    Gene expression databases

    BgeeiQ9ERU3.
    CleanExiMM_ZFP422.
    GenevestigatoriQ9ERU3.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9ERU3. 1 interaction.
    MINTiMINT-4140652.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ERU3.
    SMRiQ9ERU3. Positions 24-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.CuratedPROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri55 – 7723C2H2-type 1CuratedPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri83 – 10523C2H2-type 2CuratedPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri111 – 13323C2H2-type 3CuratedPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 16123C2H2-type 4CuratedPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri167 – 18923C2H2-type 5CuratedPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00740000115574.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9ERU3.
    OMAiTHLVSSW.
    OrthoDBiEOG7QG44V.
    PhylomeDBiQ9ERU3.
    TreeFamiTF350836.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ERU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLGKPKGGI SRSASQGKAY ESKRKTARQR QKWGVAIRFD SGLSRRRRNV    50
    DEKPYKCAKC SKSFSQSSTL FQHKKIHTGK KSHKCADCGK SFFQSSNLIQ 100
    HRRIHTGEKP YKCDECGERF KQSSNLIQHQ RIHTGEKPYC CDECGRCFSQ 150
    SSHLIQHQRT HTGEKPYQCE ECDKCFSQSS HLRQHMKVHK EKKPHKRGKN 200
    ARVKTHPVSW KRGKGRKAVA GIRQVKGATS GLFKKKK 237
    Length:237
    Mass (Da):27,294
    Last modified:March 15, 2004 - v2
    Checksum:i1653220411F3C7DD
    GO

    Sequence cautioni

    The sequence AAG12466.1 differs from that shown. Reason: Frameshift at position 224.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti192 – 1921K → N in AAG12466. (PubMed:14706453)Curated
    Sequence conflicti216 – 2161R → K(PubMed:14706453)Curated
    Sequence conflicti216 – 2161R → K(PubMed:12489153)Curated
    Sequence conflicti224 – 2241Q → R(PubMed:14706453)Curated
    Sequence conflicti224 – 2241Q → R(PubMed:12489153)Curated
    Sequence conflicti225 – 23713Missing(PubMed:12489153)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF281634 mRNA. Translation: AAG12466.1. Frameshift.
    AK082970 mRNA. Translation: BAC38716.1.
    AK169251 mRNA. Translation: BAE41015.1.
    BC018339 mRNA. Translation: AAH18339.1.
    CCDSiCCDS20459.1.
    RefSeqiNP_080333.1. NM_026057.2.
    XP_006506566.1. XM_006506503.1.
    XP_006506567.1. XM_006506504.1.
    UniGeneiMm.18810.

    Genome annotation databases

    EnsembliENSMUST00000057540; ENSMUSP00000084926; ENSMUSG00000059878.
    ENSMUST00000079749; ENSMUSP00000078685; ENSMUSG00000059878.
    ENSMUST00000112880; ENSMUSP00000108501; ENSMUSG00000059878.
    GeneIDi67255.
    KEGGimmu:67255.
    UCSCiuc009dkj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF281634 mRNA. Translation: AAG12466.1 . Frameshift.
    AK082970 mRNA. Translation: BAC38716.1 .
    AK169251 mRNA. Translation: BAE41015.1 .
    BC018339 mRNA. Translation: AAH18339.1 .
    CCDSi CCDS20459.1.
    RefSeqi NP_080333.1. NM_026057.2.
    XP_006506566.1. XM_006506503.1.
    XP_006506567.1. XM_006506504.1.
    UniGenei Mm.18810.

    3D structure databases

    ProteinModelPortali Q9ERU3.
    SMRi Q9ERU3. Positions 24-192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9ERU3. 1 interaction.
    MINTi MINT-4140652.

    PTM databases

    PhosphoSitei Q9ERU3.

    Proteomic databases

    PaxDbi Q9ERU3.
    PRIDEi Q9ERU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057540 ; ENSMUSP00000084926 ; ENSMUSG00000059878 .
    ENSMUST00000079749 ; ENSMUSP00000078685 ; ENSMUSG00000059878 .
    ENSMUST00000112880 ; ENSMUSP00000108501 ; ENSMUSG00000059878 .
    GeneIDi 67255.
    KEGGi mmu:67255.
    UCSCi uc009dkj.1. mouse.

    Organism-specific databases

    CTDi 67255.
    MGIi MGI:1914505. Zfp422.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00740000115574.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9ERU3.
    OMAi THLVSSW.
    OrthoDBi EOG7QG44V.
    PhylomeDBi Q9ERU3.
    TreeFami TF350836.

    Miscellaneous databases

    NextBioi 324022.
    PROi Q9ERU3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ERU3.
    CleanExi MM_ZFP422.
    Genevestigatori Q9ERU3.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25."
      Lee S.K., Kim Y.S., Lee S.S., Lee Y.J., Song I.S., Park S.C., Kozak C., Yamada Y.
      Genomics 83:243-253(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: BALB/cImported.
      Tissue: Craniofacial1 Publication.
    2. "Krox-26 is a novel C2H2 zinc finger transcription factor expressed in developing dental and osteogenic tissues."
      Ganss B., Teo W., Chen H., Poon T.
      Connect. Tissue Res. 43:161-166(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney and Spinal cord.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland1 Publication.
    5. "Developmental expression pattern and DNA-binding properties of the zinc finger transcription factor Krox-26."
      Teo W., Chen H., Poon T., Ganss B.
      Connect. Tissue Res. 44:161-166(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-18 AND LYS-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiZNF22_MOUSE
    AccessioniPrimary (citable) accession number: Q9ERU3
    Secondary accession number(s): Q3TF83, Q8VEK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: March 15, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3