Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 22

Gene

Znf22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation.1 Publication1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 7723C2H2-type 1PROSITE-ProRule annotationCuratedAdd
BLAST
Zinc fingeri83 – 10523C2H2-type 2PROSITE-ProRule annotationCuratedAdd
BLAST
Zinc fingeri111 – 13323C2H2-type 3PROSITE-ProRule annotationCuratedAdd
BLAST
Zinc fingeri139 – 16123C2H2-type 4PROSITE-ProRule annotationCuratedAdd
BLAST
Zinc fingeri167 – 18923C2H2-type 5PROSITE-ProRule annotationCuratedAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • odontogenesis Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 22
Alternative name(s):
Zinc finger protein 422
Zinc finger protein Krox-25
Zinc finger protein Krox-26
Gene namesi
Name:Znf22
Synonyms:Krox25, Krox26, Zfp422
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914505. Zfp422.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Zinc finger protein 22PRO_0000047349Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181N6-acetyllysine1 Publication
Modified residuei23 – 231N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9ERU3.
PaxDbiQ9ERU3.
PRIDEiQ9ERU3.

PTM databases

PhosphoSiteiQ9ERU3.

Expressioni

Tissue specificityi

Expressed predominantly in developing craniofacial bones and dental organs, and in molar tooth germs of postnatal animals. Also detected in embryonic heart, liver, thymus, kidney, brain, lung, muscle and calvaria. In the adult, highly expressed in lung, kidney, bone and incisors.3 Publications

Developmental stagei

In the embryo, expression is detected from day 7 with highest levels between days 11 and 15.2 Publications

Gene expression databases

BgeeiQ9ERU3.
CleanExiMM_ZFP422.
GenevisibleiQ9ERU3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9ERU3. 1 interaction.
MINTiMINT-4140652.
STRINGi10090.ENSMUSP00000078685.

Structurei

3D structure databases

ProteinModelPortaliQ9ERU3.
SMRiQ9ERU3. Positions 22-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotationCurated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 7723C2H2-type 1PROSITE-ProRule annotationCuratedAdd
BLAST
Zinc fingeri83 – 10523C2H2-type 2PROSITE-ProRule annotationCuratedAdd
BLAST
Zinc fingeri111 – 13323C2H2-type 3PROSITE-ProRule annotationCuratedAdd
BLAST
Zinc fingeri139 – 16123C2H2-type 4PROSITE-ProRule annotationCuratedAdd
BLAST
Zinc fingeri167 – 18923C2H2-type 5PROSITE-ProRule annotationCuratedAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121998.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9ERU3.
OMAiRGKNIRA.
OrthoDBiEOG7QG44V.
PhylomeDBiQ9ERU3.
TreeFamiTF350836.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLGKPKGGI SRSASQGKAY ESKRKTARQR QKWGVAIRFD SGLSRRRRNV
60 70 80 90 100
DEKPYKCAKC SKSFSQSSTL FQHKKIHTGK KSHKCADCGK SFFQSSNLIQ
110 120 130 140 150
HRRIHTGEKP YKCDECGERF KQSSNLIQHQ RIHTGEKPYC CDECGRCFSQ
160 170 180 190 200
SSHLIQHQRT HTGEKPYQCE ECDKCFSQSS HLRQHMKVHK EKKPHKRGKN
210 220 230
ARVKTHPVSW KRGKGRKAVA GIRQVKGATS GLFKKKK
Length:237
Mass (Da):27,294
Last modified:March 15, 2004 - v2
Checksum:i1653220411F3C7DD
GO

Sequence cautioni

The sequence AAG12466.1 differs from that shown. Reason: Frameshift at position 224. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921K → N in AAG12466 (PubMed:14706453).Curated
Sequence conflicti216 – 2161R → K (PubMed:14706453).Curated
Sequence conflicti216 – 2161R → K (PubMed:12489153).Curated
Sequence conflicti224 – 2241Q → R (PubMed:14706453).Curated
Sequence conflicti224 – 2241Q → R (PubMed:12489153).Curated
Sequence conflicti225 – 23713Missing (PubMed:12489153).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281634 mRNA. Translation: AAG12466.1. Frameshift.
AK082970 mRNA. Translation: BAC38716.1.
AK169251 mRNA. Translation: BAE41015.1.
BC018339 mRNA. Translation: AAH18339.1.
CCDSiCCDS20459.1.
RefSeqiNP_001289368.1. NM_001302439.1.
NP_001289369.1. NM_001302440.1.
NP_080333.1. NM_026057.3.
UniGeneiMm.18810.
Mm.465923.

Genome annotation databases

EnsembliENSMUST00000057540; ENSMUSP00000084926; ENSMUSG00000059878.
ENSMUST00000079749; ENSMUSP00000078685; ENSMUSG00000059878.
ENSMUST00000112880; ENSMUSP00000108501; ENSMUSG00000059878.
GeneIDi67255.
KEGGimmu:67255.
UCSCiuc009dkj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281634 mRNA. Translation: AAG12466.1. Frameshift.
AK082970 mRNA. Translation: BAC38716.1.
AK169251 mRNA. Translation: BAE41015.1.
BC018339 mRNA. Translation: AAH18339.1.
CCDSiCCDS20459.1.
RefSeqiNP_001289368.1. NM_001302439.1.
NP_001289369.1. NM_001302440.1.
NP_080333.1. NM_026057.3.
UniGeneiMm.18810.
Mm.465923.

3D structure databases

ProteinModelPortaliQ9ERU3.
SMRiQ9ERU3. Positions 22-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ERU3. 1 interaction.
MINTiMINT-4140652.
STRINGi10090.ENSMUSP00000078685.

PTM databases

PhosphoSiteiQ9ERU3.

Proteomic databases

MaxQBiQ9ERU3.
PaxDbiQ9ERU3.
PRIDEiQ9ERU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057540; ENSMUSP00000084926; ENSMUSG00000059878.
ENSMUST00000079749; ENSMUSP00000078685; ENSMUSG00000059878.
ENSMUST00000112880; ENSMUSP00000108501; ENSMUSG00000059878.
GeneIDi67255.
KEGGimmu:67255.
UCSCiuc009dkj.1. mouse.

Organism-specific databases

CTDi67255.
MGIiMGI:1914505. Zfp422.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121998.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9ERU3.
OMAiRGKNIRA.
OrthoDBiEOG7QG44V.
PhylomeDBiQ9ERU3.
TreeFamiTF350836.

Miscellaneous databases

NextBioi324022.
PROiQ9ERU3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ERU3.
CleanExiMM_ZFP422.
GenevisibleiQ9ERU3. MM.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25."
    Lee S.K., Kim Y.S., Lee S.S., Lee Y.J., Song I.S., Park S.C., Kozak C., Yamada Y.
    Genomics 83:243-253(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/cImported.
    Tissue: Craniofacial1 Publication.
  2. "Krox-26 is a novel C2H2 zinc finger transcription factor expressed in developing dental and osteogenic tissues."
    Ganss B., Teo W., Chen H., Poon T.
    Connect. Tissue Res. 43:161-166(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Spinal cord.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland1 Publication.
  5. "Developmental expression pattern and DNA-binding properties of the zinc finger transcription factor Krox-26."
    Teo W., Chen H., Poon T., Ganss B.
    Connect. Tissue Res. 44:161-166(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-18 AND LYS-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiZNF22_MOUSE
AccessioniPrimary (citable) accession number: Q9ERU3
Secondary accession number(s): Q3TF83, Q8VEK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: July 22, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.