Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 22

Gene

Znf22

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 8228C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri83 – 11028C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri111 – 13828C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 16628C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri167 – 19428C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • odontogenesis Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 22
Alternative name(s):
Zinc finger protein Krox-25
Gene namesi
Name:Znf22
Synonyms:Krox25, Zfp422
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620229. Zfp422.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Zinc finger protein 22PRO_0000047350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181N6-acetyllysineBy similarity
Modified residuei23 – 231N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9ERU2.
PRIDEiQ9ERU2.

PTM databases

iPTMnetiQ9ERU2.

Expressioni

Tissue specificityi

Highly expressed in the ameloblast layer of mandibular incisors, moderately expressed in submandibular gland, calvaria, kidney and lung, and expressed at low levels in brain and thymus.1 Publication

Developmental stagei

Highly expressed in presecretory ameloblasts with very high expression in secretory ameloblasts. Expression decreases in the maturation stage and is very low in the late maturation stage.1 Publication

Gene expression databases

GenevisibleiQ9ERU2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018050.

Structurei

3D structure databases

ProteinModelPortaliQ9ERU2.
SMRiQ9ERU2. Positions 52-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotationCurated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 8228C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri83 – 11028C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri111 – 13828C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 16628C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri167 – 19428C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9ERU2.
OMAiTHLVSSW.
OrthoDBiEOG7QG44V.
PhylomeDBiQ9ERU2.
TreeFamiTF350836.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLGKPKGGI SRSASQGKTY ESKRKTARQR QKWGVAIRFD SGLSRRRRNV
60 70 80 90 100
DEKPYKCTKC SKSFSQSSTL FQHKKIHTGK KSHKCADCGK SFFQSSNLIQ
110 120 130 140 150
HRRIHTGEKP YKCDECGERF KQSSNLIQHQ RIHTGEKPYC CDECGRCFSQ
160 170 180 190 200
SSHLIQHQRT HTGEKPYQCE ECDKCFSQSS HLRQHMKVHK EKKSHKRGKN
210 220 230
ARAKTHPVSW KRGKGRKAVA GLRQVKGAAS GLFKKKK
Length:237
Mass (Da):27,286
Last modified:January 24, 2006 - v2
Checksum:i9945E6C00AEC6624
GO

Sequence cautioni

The sequence AAG12467.1 differs from that shown. Reason: Frameshift at position 224. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61P → PQ in AAG12467 (PubMed:14706453).Curated
Sequence conflicti15 – 151S → T in AAG12467 (PubMed:14706453).Curated
Sequence conflicti23 – 231K → R in AAG12467 (PubMed:14706453).Curated
Sequence conflicti140 – 1401C → Y in AAG12467 (PubMed:14706453).Curated
Sequence conflicti179 – 1791S → N in AAG12467 (PubMed:14706453).Curated
Sequence conflicti190 – 1901K → Q in AAG12467 (PubMed:14706453).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281635 mRNA. Translation: AAG12467.1. Frameshift.
BC090354 mRNA. Translation: AAH90354.1.
RefSeqiNP_001012763.1. NM_001012745.1.
XP_006237249.1. XM_006237187.2.
XP_006237251.1. XM_006237189.2.
XP_006237252.1. XM_006237190.2.
XP_008761471.1. XM_008763249.1.
UniGeneiRn.105961.

Genome annotation databases

EnsembliENSRNOT00000018050; ENSRNOP00000018050; ENSRNOG00000013379.
GeneIDi360389.
KEGGirno:360389.
UCSCiRGD:620229. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281635 mRNA. Translation: AAG12467.1. Frameshift.
BC090354 mRNA. Translation: AAH90354.1.
RefSeqiNP_001012763.1. NM_001012745.1.
XP_006237249.1. XM_006237187.2.
XP_006237251.1. XM_006237189.2.
XP_006237252.1. XM_006237190.2.
XP_008761471.1. XM_008763249.1.
UniGeneiRn.105961.

3D structure databases

ProteinModelPortaliQ9ERU2.
SMRiQ9ERU2. Positions 52-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018050.

PTM databases

iPTMnetiQ9ERU2.

Proteomic databases

PaxDbiQ9ERU2.
PRIDEiQ9ERU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018050; ENSRNOP00000018050; ENSRNOG00000013379.
GeneIDi360389.
KEGGirno:360389.
UCSCiRGD:620229. rat.

Organism-specific databases

CTDi67255.
RGDi620229. Zfp422.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9ERU2.
OMAiTHLVSSW.
OrthoDBiEOG7QG44V.
PhylomeDBiQ9ERU2.
TreeFamiTF350836.

Miscellaneous databases

PROiQ9ERU2.

Gene expression databases

GenevisibleiQ9ERU2. RN.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25."
    Lee S.K., Kim Y.S., Lee S.S., Lee Y.J., Song I.S., Park S.C., Kozak C., Yamada Y.
    Genomics 83:243-253(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Sprague-DawleyImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZNF22_RAT
AccessioniPrimary (citable) accession number: Q9ERU2
Secondary accession number(s): Q5EAN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 24, 2006
Last modified: June 8, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.