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Protein

Protein phosphatase 1 regulatory subunit 1A

Gene

Ppp1r1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1A
Alternative name(s):
Protein phosphatase inhibitor 1
Short name:
I-1
Short name:
IPP-1
Gene namesi
Name:Ppp1r1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1889595. Ppp1r1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Protein phosphatase 1 regulatory subunit 1APRO_0000071478Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei35 – 351PhosphothreonineCombined sources
Modified residuei43 – 431PhosphoserineCombined sources
Modified residuei46 – 461PhosphoserineCombined sources
Modified residuei47 – 471PhosphoserineCombined sources
Modified residuei67 – 671PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation of Thr-35 is required for activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9ERT9.
PaxDbiQ9ERT9.
PRIDEiQ9ERT9.

PTM databases

iPTMnetiQ9ERT9.
PhosphoSiteiQ9ERT9.

Expressioni

Gene expression databases

BgeeiQ9ERT9.
GenevisibleiQ9ERT9. MM.

Interactioni

Subunit structurei

Interacts with PPP1R15A.By similarity

Protein-protein interaction databases

IntActiQ9ERT9. 1 interaction.
MINTiMINT-4098730.
STRINGi10090.ENSMUSP00000023133.

Structurei

3D structure databases

ProteinModelPortaliQ9ERT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 124Essential for activity
Regioni42 – 5413Essential for activityCuratedAdd
BLAST
Regioni143 – 17129Interaction with PPP1R15ABy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J0ZP. Eukaryota.
ENOG41125ZM. LUCA.
GeneTreeiENSGT00730000110965.
HOGENOMiHOG000115665.
HOVERGENiHBG096069.
InParanoidiQ9ERT9.
KOiK08050.
OMAiTGTQESC.
OrthoDBiEOG7VQJFK.
PhylomeDBiQ9ERT9.
TreeFamiTF332576.

Family and domain databases

InterProiIPR008466. PPI_1DARPP-32.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI
60 70 80 90 100
DEDRIPNSLL KSTLSMSPRQ RKKMTRTTPT MKELQTMVEH HLGQQKQGEE
110 120 130 140 150
PEGATESTGN QESCPPGIPD TGSASRPDTP GTAQKSAESN PKTQEQCGVE
160 170
PRTEDSSAHM LPLDSQGASL V
Length:171
Mass (Da):18,718
Last modified:March 1, 2001 - v1
Checksum:iF6981C75CA163F8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281676 mRNA. Translation: AAG15192.1.
BC025123 mRNA. Translation: AAH25123.1.
CCDSiCCDS37237.1.
RefSeqiNP_067366.1. NM_021391.3.
UniGeneiMm.143788.

Genome annotation databases

EnsembliENSMUST00000023133; ENSMUSP00000023133; ENSMUSG00000022490.
GeneIDi58200.
KEGGimmu:58200.
UCSCiuc007xyj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281676 mRNA. Translation: AAG15192.1.
BC025123 mRNA. Translation: AAH25123.1.
CCDSiCCDS37237.1.
RefSeqiNP_067366.1. NM_021391.3.
UniGeneiMm.143788.

3D structure databases

ProteinModelPortaliQ9ERT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ERT9. 1 interaction.
MINTiMINT-4098730.
STRINGi10090.ENSMUSP00000023133.

PTM databases

iPTMnetiQ9ERT9.
PhosphoSiteiQ9ERT9.

Proteomic databases

MaxQBiQ9ERT9.
PaxDbiQ9ERT9.
PRIDEiQ9ERT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023133; ENSMUSP00000023133; ENSMUSG00000022490.
GeneIDi58200.
KEGGimmu:58200.
UCSCiuc007xyj.1. mouse.

Organism-specific databases

CTDi5502.
MGIiMGI:1889595. Ppp1r1a.

Phylogenomic databases

eggNOGiENOG410J0ZP. Eukaryota.
ENOG41125ZM. LUCA.
GeneTreeiENSGT00730000110965.
HOGENOMiHOG000115665.
HOVERGENiHBG096069.
InParanoidiQ9ERT9.
KOiK08050.
OMAiTGTQESC.
OrthoDBiEOG7VQJFK.
PhylomeDBiQ9ERT9.
TreeFamiTF332576.

Miscellaneous databases

NextBioi314177.
PROiQ9ERT9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ERT9.
GenevisibleiQ9ERT9. MM.

Family and domain databases

InterProiIPR008466. PPI_1DARPP-32.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and genomic characterization of protein phosphatase inhibitor-1: a novel marker for mesothelium in the mouse."
    McLaren L., Boyle S., Mason J.O., Bard J.B.L.
    Mech. Dev. 96:237-241(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-35; SER-43; SER-46 AND SER-47, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney and Lung.

Entry informationi

Entry nameiPPR1A_MOUSE
AccessioniPrimary (citable) accession number: Q9ERT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.