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Q9ERS7

- ILRL2_MOUSE

UniProt

Q9ERS7 - ILRL2_MOUSE

Protein

Interleukin-1 receptor-like 2

Gene

Il1rl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Receptor for the interleukin IL36G. Binding to the agonist leads to the activation of NF-kappa-B By similarity.By similarity

    GO - Molecular functioni

    1. cytokine receptor activity Source: MGI
    2. interleukin-1, Type I, activating receptor activity Source: InterPro

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: GOC
    2. positive regulation of interleukin-6 production Source: MGI
    3. positive regulation of T cell differentiation Source: MGI
    4. regulation of inflammatory response Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-1 receptor-like 2
    Alternative name(s):
    IL-36 receptor
    Interleukin-1 receptor-related protein 2
    Short name:
    IL-1Rrp2
    Short name:
    IL1R-rp2
    Gene namesi
    Name:Il1rl2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1913107. Il1rl2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 574553Interleukin-1 receptor-like 2PRO_0000015446Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi44 ↔ 97PROSITE-ProRule annotation
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi149 ↔ 199PROSITE-ProRule annotation
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi252 ↔ 319PROSITE-ProRule annotation
    Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9ERS7.

    PTM databases

    PhosphoSiteiQ9ERS7.

    Expressioni

    Gene expression databases

    BgeeiQ9ERS7.
    CleanExiMM_IL1RL2.
    GenevestigatoriQ9ERS7.

    Interactioni

    Subunit structurei

    Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ERS7.
    SMRiQ9ERS7. Positions 38-334, 384-540.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 338317ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini360 – 574215CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei339 – 35921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 11389Ig-like C2-type 1Add
    BLAST
    Domaini132 – 21584Ig-like C2-type 2Add
    BLAST
    Domaini225 – 32197Ig-like C2-type 3Add
    BLAST
    Domaini384 – 542159TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the interleukin-1 receptor family.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40914.
    GeneTreeiENSGT00680000099639.
    HOGENOMiHOG000253916.
    HOVERGENiHBG052103.
    InParanoidiQ9ERS7.
    KOiK05172.
    OMAiFTEQSQC.
    OrthoDBiEOG7H1JK3.
    PhylomeDBiQ9ERS7.
    TreeFamiTF325519.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    3.40.50.10140. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR004076. IL-1_rcpt_I-typ.
    IPR004074. IL-1_rcpt_I/II-typ.
    IPR000157. TIR_dom.
    [Graphical view]
    PANTHERiPTHR11890. PTHR11890. 1 hit.
    PfamiPF01582. TIR. 1 hit.
    [Graphical view]
    PRINTSiPR01538. INTRLEUKN1R1.
    PR01536. INTRLKN1R12F.
    SMARTiSM00409. IG. 2 hits.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS50835. IG_LIKE. 2 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ERS7-1 [UniParc]FASTAAdd to Basket

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    MGVTSLLFCG VFFLLLLFVA ADTCEDIFMH NVIISEGQPF PFNCTYPPET    50
    NGAVNLTWYK TPSKSPVSNN RHLRVHQDQT WILFLPLTLE DSGIYQCVIR 100
    NAHNCYQIAV NLTVLKNHWC DSSMEGSPVN SPDVYQQILP IGKSGSLNCH 150
    LYFPESCALD SIKWYKGCEE IKAGKKYSPS GAKLLVNNVA VEDGGSYACS 200
    ARLTHLGRHF TIRNYIAVNT KEVEYGRRIP NITYPKNNSI EVPLGSTLIV 250
    NCNITDTKEN TNLRCWRVNN TLVDDYYKDS KRIQEGIETN VSLRDQIRYT 300
    VNITFLKVKM EDYGRPFTCH AGVSAAYIIL IYPVPDFRAY LLGGLMAFLL 350
    LVVSVLFIYN SFKIDIMLWY RSAFHTAQAP DDEKLYDAYV LYPKYPRGSQ 400
    GHDVDTLVLK ILPEVLEKQC GYKLFIFGRD EFPGQAVASV IDENIKLCRR 450
    LMVFVAPESS SFGFLKNLSE EQIAVYNALI QHGMKVILIE LEKVKDYSTM 500
    PESIQYIRQK HGAIQWDGDF TEQSQCAKTK FWKKVRYHMP PRRYPASSPV 550
    QLLGHIPCNC KAGKCNAATG LITP 574
    Length:574
    Mass (Da):65,108
    Last modified:March 1, 2001 - v1
    Checksum:iA677A77BBFA50A76
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF284433 mRNA. Translation: AAG21367.1.
    CCDSiCCDS14910.1.
    RefSeqiNP_573456.1. NM_133193.3.
    XP_006495671.1. XM_006495608.1.
    XP_006495672.1. XM_006495609.1.
    XP_006495673.1. XM_006495610.1.
    XP_006495674.1. XM_006495611.1.
    UniGeneiMm.155583.

    Genome annotation databases

    EnsembliENSMUST00000095020; ENSMUSP00000092630; ENSMUSG00000070942.
    GeneIDi107527.
    KEGGimmu:107527.
    UCSCiuc007atx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF284433 mRNA. Translation: AAG21367.1 .
    CCDSi CCDS14910.1.
    RefSeqi NP_573456.1. NM_133193.3.
    XP_006495671.1. XM_006495608.1.
    XP_006495672.1. XM_006495609.1.
    XP_006495673.1. XM_006495610.1.
    XP_006495674.1. XM_006495611.1.
    UniGenei Mm.155583.

    3D structure databases

    ProteinModelPortali Q9ERS7.
    SMRi Q9ERS7. Positions 38-334, 384-540.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9ERS7.

    Proteomic databases

    PRIDEi Q9ERS7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095020 ; ENSMUSP00000092630 ; ENSMUSG00000070942 .
    GeneIDi 107527.
    KEGGi mmu:107527.
    UCSCi uc007atx.1. mouse.

    Organism-specific databases

    CTDi 8808.
    MGIi MGI:1913107. Il1rl2.

    Phylogenomic databases

    eggNOGi NOG40914.
    GeneTreei ENSGT00680000099639.
    HOGENOMi HOG000253916.
    HOVERGENi HBG052103.
    InParanoidi Q9ERS7.
    KOi K05172.
    OMAi FTEQSQC.
    OrthoDBi EOG7H1JK3.
    PhylomeDBi Q9ERS7.
    TreeFami TF325519.

    Miscellaneous databases

    NextBioi 358984.
    PROi Q9ERS7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ERS7.
    CleanExi MM_IL1RL2.
    Genevestigatori Q9ERS7.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    3.40.50.10140. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR004076. IL-1_rcpt_I-typ.
    IPR004074. IL-1_rcpt_I/II-typ.
    IPR000157. TIR_dom.
    [Graphical view ]
    PANTHERi PTHR11890. PTHR11890. 1 hit.
    Pfami PF01582. TIR. 1 hit.
    [Graphical view ]
    PRINTSi PR01538. INTRLEUKN1R1.
    PR01536. INTRLKN1R12F.
    SMARTi SM00409. IG. 2 hits.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS50835. IG_LIKE. 2 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling."
      Born T.L., Smith D.E., Garka K.E., Renshaw B.R., Bertles J.S., Sims J.E.
      J. Biol. Chem. 275:29946-29954(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiILRL2_MOUSE
    AccessioniPrimary (citable) accession number: Q9ERS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3