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Q9ERS7

- ILRL2_MOUSE

UniProt

Q9ERS7 - ILRL2_MOUSE

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Protein
Interleukin-1 receptor-like 2
Gene
Il1rl2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for the interleukin IL36G. Binding to the agonist leads to the activation of NF-kappa-B By similarity.

GO - Molecular functioni

  1. cytokine receptor activity Source: MGI
  2. interleukin-1, Type I, activating receptor activity Source: InterPro

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: GOC
  2. positive regulation of T cell differentiation Source: MGI
  3. positive regulation of interleukin-6 production Source: MGI
  4. regulation of inflammatory response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 2
Alternative name(s):
IL-36 receptor
Interleukin-1 receptor-related protein 2
Short name:
IL-1Rrp2
Short name:
IL1R-rp2
Gene namesi
Name:Il1rl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1913107. Il1rl2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 338317Extracellular Reviewed prediction
Add
BLAST
Transmembranei339 – 35921Helical; Reviewed prediction
Add
BLAST
Topological domaini360 – 574215Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 574553Interleukin-1 receptor-like 2
PRO_0000015446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi44 ↔ 97 By similarity
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi111 – 1111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi149 ↔ 199 By similarity
Glycosylationi231 – 2311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi237 – 2371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi252 ↔ 319 By similarity
Glycosylationi253 – 2531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi290 – 2901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9ERS7.

PTM databases

PhosphoSiteiQ9ERS7.

Expressioni

Gene expression databases

BgeeiQ9ERS7.
CleanExiMM_IL1RL2.
GenevestigatoriQ9ERS7.

Interactioni

Subunit structurei

Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9ERS7.
SMRiQ9ERS7. Positions 38-334, 384-540.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11389Ig-like C2-type 1
Add
BLAST
Domaini132 – 21584Ig-like C2-type 2
Add
BLAST
Domaini225 – 32197Ig-like C2-type 3
Add
BLAST
Domaini384 – 542159TIR
Add
BLAST

Sequence similaritiesi

Contains 1 TIR domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40914.
GeneTreeiENSGT00680000099639.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiQ9ERS7.
KOiK05172.
OMAiFTEQSQC.
OrthoDBiEOG7H1JK3.
PhylomeDBiQ9ERS7.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ERS7-1 [UniParc]FASTAAdd to Basket

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MGVTSLLFCG VFFLLLLFVA ADTCEDIFMH NVIISEGQPF PFNCTYPPET    50
NGAVNLTWYK TPSKSPVSNN RHLRVHQDQT WILFLPLTLE DSGIYQCVIR 100
NAHNCYQIAV NLTVLKNHWC DSSMEGSPVN SPDVYQQILP IGKSGSLNCH 150
LYFPESCALD SIKWYKGCEE IKAGKKYSPS GAKLLVNNVA VEDGGSYACS 200
ARLTHLGRHF TIRNYIAVNT KEVEYGRRIP NITYPKNNSI EVPLGSTLIV 250
NCNITDTKEN TNLRCWRVNN TLVDDYYKDS KRIQEGIETN VSLRDQIRYT 300
VNITFLKVKM EDYGRPFTCH AGVSAAYIIL IYPVPDFRAY LLGGLMAFLL 350
LVVSVLFIYN SFKIDIMLWY RSAFHTAQAP DDEKLYDAYV LYPKYPRGSQ 400
GHDVDTLVLK ILPEVLEKQC GYKLFIFGRD EFPGQAVASV IDENIKLCRR 450
LMVFVAPESS SFGFLKNLSE EQIAVYNALI QHGMKVILIE LEKVKDYSTM 500
PESIQYIRQK HGAIQWDGDF TEQSQCAKTK FWKKVRYHMP PRRYPASSPV 550
QLLGHIPCNC KAGKCNAATG LITP 574
Length:574
Mass (Da):65,108
Last modified:March 1, 2001 - v1
Checksum:iA677A77BBFA50A76
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF284433 mRNA. Translation: AAG21367.1.
CCDSiCCDS14910.1.
RefSeqiNP_573456.1. NM_133193.3.
XP_006495671.1. XM_006495608.1.
XP_006495672.1. XM_006495609.1.
XP_006495673.1. XM_006495610.1.
XP_006495674.1. XM_006495611.1.
UniGeneiMm.155583.

Genome annotation databases

EnsembliENSMUST00000095020; ENSMUSP00000092630; ENSMUSG00000070942.
GeneIDi107527.
KEGGimmu:107527.
UCSCiuc007atx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF284433 mRNA. Translation: AAG21367.1 .
CCDSi CCDS14910.1.
RefSeqi NP_573456.1. NM_133193.3.
XP_006495671.1. XM_006495608.1.
XP_006495672.1. XM_006495609.1.
XP_006495673.1. XM_006495610.1.
XP_006495674.1. XM_006495611.1.
UniGenei Mm.155583.

3D structure databases

ProteinModelPortali Q9ERS7.
SMRi Q9ERS7. Positions 38-334, 384-540.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9ERS7.

Proteomic databases

PRIDEi Q9ERS7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095020 ; ENSMUSP00000092630 ; ENSMUSG00000070942 .
GeneIDi 107527.
KEGGi mmu:107527.
UCSCi uc007atx.1. mouse.

Organism-specific databases

CTDi 8808.
MGIi MGI:1913107. Il1rl2.

Phylogenomic databases

eggNOGi NOG40914.
GeneTreei ENSGT00680000099639.
HOGENOMi HOG000253916.
HOVERGENi HBG052103.
InParanoidi Q9ERS7.
KOi K05172.
OMAi FTEQSQC.
OrthoDBi EOG7H1JK3.
PhylomeDBi Q9ERS7.
TreeFami TF325519.

Miscellaneous databases

NextBioi 358984.
PROi Q9ERS7.
SOURCEi Search...

Gene expression databases

Bgeei Q9ERS7.
CleanExi MM_IL1RL2.
Genevestigatori Q9ERS7.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view ]
PANTHERi PTHR11890. PTHR11890. 1 hit.
Pfami PF01582. TIR. 1 hit.
[Graphical view ]
PRINTSi PR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTi SM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling."
    Born T.L., Smith D.E., Garka K.E., Renshaw B.R., Bertles J.S., Sims J.E.
    J. Biol. Chem. 275:29946-29954(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiILRL2_MOUSE
AccessioniPrimary (citable) accession number: Q9ERS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi