Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9ERS7

- ILRL2_MOUSE

UniProt

Q9ERS7 - ILRL2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Interleukin-1 receptor-like 2

Gene

Il1rl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.2 Publications

GO - Molecular functioni

  1. cytokine receptor activity Source: MGI
  2. interleukin-1, Type I, activating receptor activity Source: InterPro

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: GOC
  2. positive regulation of interleukin-6 production Source: MGI
  3. positive regulation of T cell differentiation Source: MGI
  4. regulation of inflammatory response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 2
Alternative name(s):
IL-36 receptor
Interleukin-1 receptor-related protein 2
Short name:
IL-1Rrp2
Short name:
IL1R-rp2
Gene namesi
Name:Il1rl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1913107. Il1rl2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 338317ExtracellularSequence AnalysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence AnalysisAdd
BLAST
Topological domaini360 – 574215CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Complete protection from imiquimodum (IMQ)-induced skin pathology observed in wild-type mice, including hyperkeratosis, acanthosis, neutrophil recruitment, and expansion of IL-17-producing T cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 574553Interleukin-1 receptor-like 2PRO_0000015446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi44 ↔ 97PROSITE-ProRule annotation
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi149 ↔ 199PROSITE-ProRule annotation
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi252 ↔ 319PROSITE-ProRule annotation
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9ERS7.

PTM databases

PhosphoSiteiQ9ERS7.

Expressioni

Tissue specificityi

Expressed in bone marrow-derived dendritic cells, splenic CD4+ T cells, bone marrow-derived macrophages and bone marrow-derived neutrophils.1 Publication

Gene expression databases

BgeeiQ9ERS7.
CleanExiMM_IL1RL2.
ExpressionAtlasiQ9ERS7. baseline and differential.
GenevestigatoriQ9ERS7.

Interactioni

Subunit structurei

Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9ERS7.
SMRiQ9ERS7. Positions 38-334, 384-540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11389Ig-like C2-type 1Add
BLAST
Domaini132 – 21584Ig-like C2-type 2Add
BLAST
Domaini225 – 32197Ig-like C2-type 3Add
BLAST
Domaini384 – 542159TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40914.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiQ9ERS7.
KOiK05172.
OMAiFTEQSQC.
OrthoDBiEOG7H1JK3.
PhylomeDBiQ9ERS7.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ERS7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGVTSLLFCG VFFLLLLFVA ADTCEDIFMH NVIISEGQPF PFNCTYPPET
60 70 80 90 100
NGAVNLTWYK TPSKSPVSNN RHLRVHQDQT WILFLPLTLE DSGIYQCVIR
110 120 130 140 150
NAHNCYQIAV NLTVLKNHWC DSSMEGSPVN SPDVYQQILP IGKSGSLNCH
160 170 180 190 200
LYFPESCALD SIKWYKGCEE IKAGKKYSPS GAKLLVNNVA VEDGGSYACS
210 220 230 240 250
ARLTHLGRHF TIRNYIAVNT KEVEYGRRIP NITYPKNNSI EVPLGSTLIV
260 270 280 290 300
NCNITDTKEN TNLRCWRVNN TLVDDYYKDS KRIQEGIETN VSLRDQIRYT
310 320 330 340 350
VNITFLKVKM EDYGRPFTCH AGVSAAYIIL IYPVPDFRAY LLGGLMAFLL
360 370 380 390 400
LVVSVLFIYN SFKIDIMLWY RSAFHTAQAP DDEKLYDAYV LYPKYPRGSQ
410 420 430 440 450
GHDVDTLVLK ILPEVLEKQC GYKLFIFGRD EFPGQAVASV IDENIKLCRR
460 470 480 490 500
LMVFVAPESS SFGFLKNLSE EQIAVYNALI QHGMKVILIE LEKVKDYSTM
510 520 530 540 550
PESIQYIRQK HGAIQWDGDF TEQSQCAKTK FWKKVRYHMP PRRYPASSPV
560 570
QLLGHIPCNC KAGKCNAATG LITP
Length:574
Mass (Da):65,108
Last modified:March 1, 2001 - v1
Checksum:iA677A77BBFA50A76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284433 mRNA. Translation: AAG21367.1.
CCDSiCCDS14910.1.
RefSeqiNP_573456.1. NM_133193.3.
XP_006495671.1. XM_006495608.1.
XP_006495672.1. XM_006495609.1.
XP_006495673.1. XM_006495610.1.
XP_006495674.1. XM_006495611.1.
UniGeneiMm.155583.

Genome annotation databases

EnsembliENSMUST00000095020; ENSMUSP00000092630; ENSMUSG00000070942.
GeneIDi107527.
KEGGimmu:107527.
UCSCiuc007atx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284433 mRNA. Translation: AAG21367.1 .
CCDSi CCDS14910.1.
RefSeqi NP_573456.1. NM_133193.3.
XP_006495671.1. XM_006495608.1.
XP_006495672.1. XM_006495609.1.
XP_006495673.1. XM_006495610.1.
XP_006495674.1. XM_006495611.1.
UniGenei Mm.155583.

3D structure databases

ProteinModelPortali Q9ERS7.
SMRi Q9ERS7. Positions 38-334, 384-540.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9ERS7.

Proteomic databases

PRIDEi Q9ERS7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095020 ; ENSMUSP00000092630 ; ENSMUSG00000070942 .
GeneIDi 107527.
KEGGi mmu:107527.
UCSCi uc007atx.1. mouse.

Organism-specific databases

CTDi 8808.
MGIi MGI:1913107. Il1rl2.

Phylogenomic databases

eggNOGi NOG40914.
GeneTreei ENSGT00760000119071.
HOGENOMi HOG000253916.
HOVERGENi HBG052103.
InParanoidi Q9ERS7.
KOi K05172.
OMAi FTEQSQC.
OrthoDBi EOG7H1JK3.
PhylomeDBi Q9ERS7.
TreeFami TF325519.

Miscellaneous databases

NextBioi 358984.
PROi Q9ERS7.
SOURCEi Search...

Gene expression databases

Bgeei Q9ERS7.
CleanExi MM_IL1RL2.
ExpressionAtlasi Q9ERS7. baseline and differential.
Genevestigatori Q9ERS7.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view ]
PANTHERi PTHR11890. PTHR11890. 1 hit.
Pfami PF01582. TIR. 1 hit.
[Graphical view ]
PRINTSi PR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTi SM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling."
    Born T.L., Smith D.E., Garka K.E., Renshaw B.R., Bertles J.S., Sims J.E.
    J. Biol. Chem. 275:29946-29954(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: FUNCTION, TISSUE SPECIFICITY.
  3. "Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."
    Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M., Gabel C.A., Sims J.E.
    J. Biol. Chem. 286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IL1RAP.
  4. "Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk."
    Tortola L., Rosenwald E., Abel B., Blumberg H., Schafer M., Coyle A.J., Renauld J.C., Werner S., Kisielow J., Kopf M.
    J. Clin. Invest. 122:3965-3976(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiILRL2_MOUSE
AccessioniPrimary (citable) accession number: Q9ERS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3