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Protein

Interleukin-1 receptor-like 2

Gene

Il1rl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.2 Publications

GO - Molecular functioni

  • cytokine receptor activity Source: MGI
  • interleukin-1, Type I, activating receptor activity Source: InterPro

GO - Biological processi

  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • positive regulation of interleukin-6 production Source: MGI
  • positive regulation of T cell differentiation Source: MGI
  • regulation of inflammatory response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 2
Alternative name(s):
IL-36 receptor
Interleukin-1 receptor-related protein 2
Short name:
IL-1Rrp2
Short name:
IL1R-rp2
Gene namesi
Name:Il1rl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1913107. Il1rl2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 338ExtracellularSequence analysisAdd BLAST317
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 574CytoplasmicSequence analysisAdd BLAST215

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Complete protection from imiquimodum (IMQ)-induced skin pathology observed in wild-type mice, including hyperkeratosis, acanthosis, neutrophil recruitment, and expansion of IL-17-producing T-cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001544622 – 574Interleukin-1 receptor-like 2Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi44 ↔ 97PROSITE-ProRule annotation
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi149 ↔ 199PROSITE-ProRule annotation
Glycosylationi231N-linked (GlcNAc...)Sequence analysis1
Glycosylationi237N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi252 ↔ 319PROSITE-ProRule annotation
Glycosylationi253N-linked (GlcNAc...)Sequence analysis1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi290N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ERS7.
PRIDEiQ9ERS7.

PTM databases

PhosphoSitePlusiQ9ERS7.

Expressioni

Tissue specificityi

Expressed in bone marrow-derived dendritic cells, splenic CD4+ T-cells, bone marrow-derived macrophages and bone marrow-derived neutrophils.1 Publication

Gene expression databases

BgeeiENSMUSG00000070942.
CleanExiMM_IL1RL2.
ExpressionAtlasiQ9ERS7. baseline and differential.
GenevisibleiQ9ERS7. MM.

Interactioni

Subunit structurei

Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092630.

Structurei

3D structure databases

ProteinModelPortaliQ9ERS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 113Ig-like C2-type 1Add BLAST89
Domaini132 – 215Ig-like C2-type 2Add BLAST84
Domaini225 – 321Ig-like C2-type 3Add BLAST97
Domaini384 – 542TIRPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQBC. Eukaryota.
ENOG410Z3W1. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiQ9ERS7.
KOiK05172.
OMAiFTEQSQC.
OrthoDBiEOG091G03IT.
PhylomeDBiQ9ERS7.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF13895. Ig_2. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ERS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVTSLLFCG VFFLLLLFVA ADTCEDIFMH NVIISEGQPF PFNCTYPPET
60 70 80 90 100
NGAVNLTWYK TPSKSPVSNN RHLRVHQDQT WILFLPLTLE DSGIYQCVIR
110 120 130 140 150
NAHNCYQIAV NLTVLKNHWC DSSMEGSPVN SPDVYQQILP IGKSGSLNCH
160 170 180 190 200
LYFPESCALD SIKWYKGCEE IKAGKKYSPS GAKLLVNNVA VEDGGSYACS
210 220 230 240 250
ARLTHLGRHF TIRNYIAVNT KEVEYGRRIP NITYPKNNSI EVPLGSTLIV
260 270 280 290 300
NCNITDTKEN TNLRCWRVNN TLVDDYYKDS KRIQEGIETN VSLRDQIRYT
310 320 330 340 350
VNITFLKVKM EDYGRPFTCH AGVSAAYIIL IYPVPDFRAY LLGGLMAFLL
360 370 380 390 400
LVVSVLFIYN SFKIDIMLWY RSAFHTAQAP DDEKLYDAYV LYPKYPRGSQ
410 420 430 440 450
GHDVDTLVLK ILPEVLEKQC GYKLFIFGRD EFPGQAVASV IDENIKLCRR
460 470 480 490 500
LMVFVAPESS SFGFLKNLSE EQIAVYNALI QHGMKVILIE LEKVKDYSTM
510 520 530 540 550
PESIQYIRQK HGAIQWDGDF TEQSQCAKTK FWKKVRYHMP PRRYPASSPV
560 570
QLLGHIPCNC KAGKCNAATG LITP
Length:574
Mass (Da):65,108
Last modified:March 1, 2001 - v1
Checksum:iA677A77BBFA50A76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284433 mRNA. Translation: AAG21367.1.
CCDSiCCDS14910.1.
RefSeqiNP_573456.1. NM_133193.3.
XP_006495671.1. XM_006495608.3.
XP_006495672.1. XM_006495609.3.
XP_006495673.1. XM_006495610.3.
XP_006495674.1. XM_006495611.3.
UniGeneiMm.155583.

Genome annotation databases

EnsembliENSMUST00000095020; ENSMUSP00000092630; ENSMUSG00000070942.
ENSMUST00000194296; ENSMUSP00000142248; ENSMUSG00000070942.
GeneIDi107527.
KEGGimmu:107527.
UCSCiuc007atx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284433 mRNA. Translation: AAG21367.1.
CCDSiCCDS14910.1.
RefSeqiNP_573456.1. NM_133193.3.
XP_006495671.1. XM_006495608.3.
XP_006495672.1. XM_006495609.3.
XP_006495673.1. XM_006495610.3.
XP_006495674.1. XM_006495611.3.
UniGeneiMm.155583.

3D structure databases

ProteinModelPortaliQ9ERS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092630.

PTM databases

PhosphoSitePlusiQ9ERS7.

Proteomic databases

PaxDbiQ9ERS7.
PRIDEiQ9ERS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095020; ENSMUSP00000092630; ENSMUSG00000070942.
ENSMUST00000194296; ENSMUSP00000142248; ENSMUSG00000070942.
GeneIDi107527.
KEGGimmu:107527.
UCSCiuc007atx.1. mouse.

Organism-specific databases

CTDi8808.
MGIiMGI:1913107. Il1rl2.

Phylogenomic databases

eggNOGiENOG410IQBC. Eukaryota.
ENOG410Z3W1. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiQ9ERS7.
KOiK05172.
OMAiFTEQSQC.
OrthoDBiEOG091G03IT.
PhylomeDBiQ9ERS7.
TreeFamiTF325519.

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

PROiQ9ERS7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070942.
CleanExiMM_IL1RL2.
ExpressionAtlasiQ9ERS7. baseline and differential.
GenevisibleiQ9ERS7. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF13895. Ig_2. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiILRL2_MOUSE
AccessioniPrimary (citable) accession number: Q9ERS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.