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Protein

X-linked interleukin-1 receptor accessory protein-like 2

Gene

Il1rapl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
X-linked interleukin-1 receptor accessory protein-like 2
Short name:
IL-1 receptor accessory protein-like 2
Short name:
IL-1-RAPL-2
Short name:
IL-1RAPL-2
Short name:
IL1RAPL-2
Alternative name(s):
IL1RAPL-2-related protein
Three immunoglobulin domain-containing IL-1 receptor-related 1
Short name:
TIGIRR-1
Gene namesi
Name:Il1rapl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1913106. Il1rapl2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 354338ExtracellularSequence analysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST
Topological domaini376 – 686311CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 686670X-linked interleukin-1 receptor accessory protein-like 2PRO_0000015460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 116PROSITE-ProRule annotation
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence analysis
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi162 ↔ 214PROSITE-ProRule annotation
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi265 ↔ 331PROSITE-ProRule annotation
Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ERS6.
PRIDEiQ9ERS6.

PTM databases

iPTMnetiQ9ERS6.
PhosphoSiteiQ9ERS6.

Expressioni

Tissue specificityi

Detected in fetal brain after day 12.5, in particular in parts of the diencephalon and in the basal plate of the spinal cord. In postnatal brain detected in cerebral cortex, olfactory bulb, in the CA1 region of the hippocampus and in Purkinje cells of the Xth cerebellar lobule.1 Publication

Gene expression databases

BgeeiQ9ERS6.
CleanExiMM_IL1RAPL2.
ExpressionAtlasiQ9ERS6. baseline and differential.
GenevisibleiQ9ERS6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074917.

Structurei

3D structure databases

ProteinModelPortaliQ9ERS6.
SMRiQ9ERS6. Positions 31-349, 400-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 132101Ig-like C2-type 1Add
BLAST
Domaini141 – 23292Ig-like C2-type 2Add
BLAST
Domaini239 – 347109Ig-like C2-type 3Add
BLAST
Domaini400 – 559160TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3G. Eukaryota.
ENOG4110Z8K. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000092977.
HOVERGENiHBG052148.
InParanoidiQ9ERS6.
KOiK05170.
OMAiHEMPTTT.
OrthoDBiEOG7CVPXJ.
PhylomeDBiQ9ERS6.
TreeFamiTF333913.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004077. IL-1_rcpt_II-typ.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01539. INTRLEUKN1R2.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ERS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLPLLLALV VCSAVSTNLK MVSKRNSVDG CIDWSVDLKT YMALAGEPVR
60 70 80 90 100
VKCALFYSYI RTNYSMAQST GLRLMWYRNK GDLEEPIIFS EVRMSKEEDA
110 120 130 140 150
IWFHSAEEQD SGFYTCVLRN STYCMKVSMS LTVAENESGL CYNSRIRYLE
160 170 180 190 200
KSEVTKRKEI SCPDMDDFKK SDQEPDVVWY KECKPKMWRS IIIQKGNALL
210 220 230 240 250
IQEVQEEDGG NYTCELKYEG KLVRRTTELK VTALLTDKPP KPLFPMENQP
260 270 280 290 300
SVIDVQLGKP LNIPCKAFFG FSGESGPMIY WMKGEKFIEE LAGHIREGEI
310 320 330 340 350
RLLKEHLGEK EVELTLIFDS VVEADLANYT CHVENRNGRK HASVLLRKKD
360 370 380 390 400
LIYKIELAGG LGAIFLLLIL LLVVYKCYNI ELMLFYRQRF GGDETTDDNK
410 420 430 440 450
EYDAYLSYTK VDQDTLDCDN TEEEQFALEI LPDVLEKHYG YKLFIPERDL
460 470 480 490 500
IPSGTYIEDL TRCVEQSRRL IIVLTPDYIL RRGWSIFELE SRLHNMLVSG
510 520 530 540 550
EIKVILIECT ELKGKVNCQE VESLKHNIKL LSLIKWKGPK SSKLNSKFWK
560 570 580 590 600
HLVYEMPIKK KEMLSHCHVL DSAEQGLFGE LQPIPSIAMT STSATMVPSQ
610 620 630 640 650
ADLPEFHHSD SMQMRHCCRG YQHEMPANTL SVPSLGNHHT YCNLPLTLLN
660 670 680
GQLPLNNSLK ETEEFSRNNP LLPLTSKELS FTSDIW
Length:686
Mass (Da):78,798
Last modified:March 1, 2001 - v1
Checksum:i36160D1CDE9B8264
GO
Isoform 2 (identifier: Q9ERS6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     350-354: DLIYK → GILFS
     355-686: Missing.

Note: may be due to an intron retention.
Show »
Length:354
Mass (Da):40,558
Checksum:i42F57DECAB6945B0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei350 – 3545DLIYK → GILFS in isoform 2. 1 PublicationVSP_008056
Alternative sequencei355 – 686332Missing in isoform 2. 1 PublicationVSP_008057Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284437 mRNA. Translation: AAG21371.1.
AJ277831 mRNA. Translation: CAC10559.1.
CCDSiCCDS30429.1. [Q9ERS6-1]
RefSeqiNP_109613.1. NM_030688.2. [Q9ERS6-1]
UniGeneiMm.328321.

Genome annotation databases

EnsembliENSMUST00000075471; ENSMUSP00000074917; ENSMUSG00000059203. [Q9ERS6-1]
ENSMUST00000113063; ENSMUSP00000108686; ENSMUSG00000059203. [Q9ERS6-1]
GeneIDi60367.
KEGGimmu:60367.
UCSCiuc009ujt.1. mouse. [Q9ERS6-2]
uc009ujv.1. mouse. [Q9ERS6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284437 mRNA. Translation: AAG21371.1.
AJ277831 mRNA. Translation: CAC10559.1.
CCDSiCCDS30429.1. [Q9ERS6-1]
RefSeqiNP_109613.1. NM_030688.2. [Q9ERS6-1]
UniGeneiMm.328321.

3D structure databases

ProteinModelPortaliQ9ERS6.
SMRiQ9ERS6. Positions 31-349, 400-557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074917.

PTM databases

iPTMnetiQ9ERS6.
PhosphoSiteiQ9ERS6.

Proteomic databases

PaxDbiQ9ERS6.
PRIDEiQ9ERS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075471; ENSMUSP00000074917; ENSMUSG00000059203. [Q9ERS6-1]
ENSMUST00000113063; ENSMUSP00000108686; ENSMUSG00000059203. [Q9ERS6-1]
GeneIDi60367.
KEGGimmu:60367.
UCSCiuc009ujt.1. mouse. [Q9ERS6-2]
uc009ujv.1. mouse. [Q9ERS6-1]

Organism-specific databases

CTDi26280.
MGIiMGI:1913106. Il1rapl2.

Phylogenomic databases

eggNOGiENOG410IF3G. Eukaryota.
ENOG4110Z8K. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000092977.
HOVERGENiHBG052148.
InParanoidiQ9ERS6.
KOiK05170.
OMAiHEMPTTT.
OrthoDBiEOG7CVPXJ.
PhylomeDBiQ9ERS6.
TreeFamiTF333913.

Miscellaneous databases

ChiTaRSiIl1rapl2. mouse.
PROiQ9ERS6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ERS6.
CleanExiMM_IL1RAPL2.
ExpressionAtlasiQ9ERS6. baseline and differential.
GenevisibleiQ9ERS6. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004077. IL-1_rcpt_II-typ.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01539. INTRLEUKN1R2.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling."
    Born T.L., Smith D.E., Garka K.E., Renshaw B.R., Bertles J.S., Sims J.E.
    J. Biol. Chem. 275:29946-29954(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain and Liver.
  2. "IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system."
    Ferrante M.I., Ghiani M., Bulfone A., Franco B.
    Gene 275:217-221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiIRPL2_MOUSE
AccessioniPrimary (citable) accession number: Q9ERS6
Secondary accession number(s): Q9ER66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.