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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Gene

Ndufa13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.By similarity

GO - Molecular functioni

  • ATP binding Source: MGI
  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB
  • NADH dehydrogenase activity Source: MGI

GO - Biological processi

Keywordsi

Biological processApoptosis, Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Alternative name(s):
Cell death regulatory protein GRIM-19
Complex I-B16.6
Short name:
CI-B16.6
Gene associated with retinoic and interferon-induced mortality 19 protein
Short name:
GRIM-19
Short name:
Gene associated with retinoic and IFN-induced mortality 19 protein
NADH-ubiquinone oxidoreductase B16.6 subunit
Gene namesi
Name:Ndufa13
Synonyms:Grim19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914434 Ndufa13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 51HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001188052 – 144NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13Add BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9ERS2
MaxQBiQ9ERS2
PaxDbiQ9ERS2
PeptideAtlasiQ9ERS2
PRIDEiQ9ERS2

PTM databases

iPTMnetiQ9ERS2
PhosphoSitePlusiQ9ERS2

Expressioni

Gene expression databases

BgeeiENSMUSG00000036199
GenevisibleiQ9ERS2 MM

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.By similarity

Protein-protein interaction databases

BioGridi212001, 4 interactors
CORUMiQ9ERS2
IntActiQ9ERS2, 5 interactors
MINTiQ9ERS2
STRINGi10090.ENSMUSP00000105796

Structurei

3D structure databases

SMRiQ9ERS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA13 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3300 Eukaryota
ENOG4111KIB LUCA
GeneTreeiENSGT00390000000719
HOGENOMiHOG000195836
HOVERGENiHBG019074
InParanoidiQ9ERS2
KOiK11353
OMAiSGYSMFG
OrthoDBiEOG091G0MHM
PhylomeDBiQ9ERS2
TreeFamiTF315182

Family and domain databases

InterProiView protein in InterPro
IPR009346 GRIM-19
PANTHERiPTHR12966 PTHR12966, 1 hit
PfamiView protein in Pfam
PF06212 GRIM-19, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ERS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASKVKQDM PPPGGYGPID YKRNLPRRGL SGYSMFAVGI GALIFGYWRM
60 70 80 90 100
MRWNQERRRL LIEDLEARIA LMPLFQAEKD RRTLQILREN LEEEAIIMKD
110 120 130 140
VPNWKVGESV FHTTRWVPPL IGEMYGLRTK EEMSNANFGF TWYT
Length:144
Mass (Da):16,860
Last modified:January 23, 2007 - v3
Checksum:i8F69E9CF49384E37
GO

Sequence cautioni

The sequence BAB22505 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 6SKV → TTI in BAB22505 (PubMed:16141072).Curated3
Sequence conflicti14 – 15GG → EE in BAB22505 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286698 mRNA Translation: AAG28168.1
AK012422 mRNA Translation: BAB28227.1
AK010517 mRNA Translation: BAB26999.1
AK002999 mRNA Translation: BAB22505.1 Different initiation.
AK003012 mRNA No translation available.
BC034899 mRNA Translation: AAH34899.1
BC037149 mRNA Translation: AAH37149.1
BC055435 mRNA Translation: AAH55435.1
CCDSiCCDS22353.1
RefSeqiNP_075801.1, NM_023312.2
XP_017168432.1, XM_017312943.1
UniGeneiMm.21162

Genome annotation databases

EnsembliENSMUST00000110167; ENSMUSP00000105796; ENSMUSG00000036199
GeneIDi67184
KEGGimmu:67184
UCSCiuc009lyd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNDUAD_MOUSE
AccessioniPrimary (citable) accession number: Q9ERS2
Secondary accession number(s): Q9DC98, Q9DCA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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