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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Gene

Ndufa13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) cell death pathway. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: MGI
  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB
  • NADH dehydrogenase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Alternative name(s):
Cell death regulatory protein GRIM-19
Complex I-B16.6
Short name:
CI-B16.6
Gene associated with retinoic and interferon-induced mortality 19 protein
Short name:
GRIM-19
Short name:
Gene associated with retinoic and IFN-induced mortality 19 protein
NADH-ubiquinone oxidoreductase B16.6 subunit
Gene namesi
Name:Ndufa13
Synonyms:Grim19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914434. Ndufa13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5122HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrial membrane Source: MGI
  • mitochondrial respiratory chain Source: UniProtKB
  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 144143NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13PRO_0000118805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9ERS2.
MaxQBiQ9ERS2.
PaxDbiQ9ERS2.
PeptideAtlasiQ9ERS2.
PRIDEiQ9ERS2.

PTM databases

iPTMnetiQ9ERS2.
PhosphoSiteiQ9ERS2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036199.
GenevisibleiQ9ERS2. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4 (By similarity). Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi212001. 3 interactions.
IntActiQ9ERS2. 5 interactions.
MINTiMINT-1860835.
STRINGi10090.ENSMUSP00000105796.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA13 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3300. Eukaryota.
ENOG4111KIB. LUCA.
GeneTreeiENSGT00390000000719.
HOGENOMiHOG000195836.
HOVERGENiHBG019074.
InParanoidiQ9ERS2.
KOiK11353.
OMAiVFHTDRW.
OrthoDBiEOG091G0MHM.
PhylomeDBiQ9ERS2.
TreeFamiTF315182.

Family and domain databases

InterProiIPR009346. GRIM-19.
[Graphical view]
PANTHERiPTHR12966. PTHR12966. 1 hit.
PfamiPF06212. GRIM-19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ERS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASKVKQDM PPPGGYGPID YKRNLPRRGL SGYSMFAVGI GALIFGYWRM
60 70 80 90 100
MRWNQERRRL LIEDLEARIA LMPLFQAEKD RRTLQILREN LEEEAIIMKD
110 120 130 140
VPNWKVGESV FHTTRWVPPL IGEMYGLRTK EEMSNANFGF TWYT
Length:144
Mass (Da):16,860
Last modified:January 23, 2007 - v3
Checksum:i8F69E9CF49384E37
GO

Sequence cautioni

The sequence BAB22505 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 63SKV → TTI in BAB22505 (PubMed:16141072).Curated
Sequence conflicti14 – 152GG → EE in BAB22505 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286698 mRNA. Translation: AAG28168.1.
AK012422 mRNA. Translation: BAB28227.1.
AK010517 mRNA. Translation: BAB26999.1.
AK002999 mRNA. Translation: BAB22505.1. Different initiation.
AK003012 mRNA. No translation available.
BC034899 mRNA. Translation: AAH34899.1.
BC037149 mRNA. Translation: AAH37149.1.
BC055435 mRNA. Translation: AAH55435.1.
CCDSiCCDS22353.1.
RefSeqiNP_075801.1. NM_023312.2.
UniGeneiMm.21162.

Genome annotation databases

EnsembliENSMUST00000110167; ENSMUSP00000105796; ENSMUSG00000036199.
GeneIDi67184.
KEGGimmu:67184.
UCSCiuc009lyd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286698 mRNA. Translation: AAG28168.1.
AK012422 mRNA. Translation: BAB28227.1.
AK010517 mRNA. Translation: BAB26999.1.
AK002999 mRNA. Translation: BAB22505.1. Different initiation.
AK003012 mRNA. No translation available.
BC034899 mRNA. Translation: AAH34899.1.
BC037149 mRNA. Translation: AAH37149.1.
BC055435 mRNA. Translation: AAH55435.1.
CCDSiCCDS22353.1.
RefSeqiNP_075801.1. NM_023312.2.
UniGeneiMm.21162.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212001. 3 interactions.
IntActiQ9ERS2. 5 interactions.
MINTiMINT-1860835.
STRINGi10090.ENSMUSP00000105796.

PTM databases

iPTMnetiQ9ERS2.
PhosphoSiteiQ9ERS2.

Proteomic databases

EPDiQ9ERS2.
MaxQBiQ9ERS2.
PaxDbiQ9ERS2.
PeptideAtlasiQ9ERS2.
PRIDEiQ9ERS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110167; ENSMUSP00000105796; ENSMUSG00000036199.
GeneIDi67184.
KEGGimmu:67184.
UCSCiuc009lyd.1. mouse.

Organism-specific databases

CTDi51079.
MGIiMGI:1914434. Ndufa13.

Phylogenomic databases

eggNOGiKOG3300. Eukaryota.
ENOG4111KIB. LUCA.
GeneTreeiENSGT00390000000719.
HOGENOMiHOG000195836.
HOVERGENiHBG019074.
InParanoidiQ9ERS2.
KOiK11353.
OMAiVFHTDRW.
OrthoDBiEOG091G0MHM.
PhylomeDBiQ9ERS2.
TreeFamiTF315182.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ9ERS2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036199.
GenevisibleiQ9ERS2. MM.

Family and domain databases

InterProiIPR009346. GRIM-19.
[Graphical view]
PANTHERiPTHR12966. PTHR12966. 1 hit.
PfamiPF06212. GRIM-19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUAD_MOUSE
AccessioniPrimary (citable) accession number: Q9ERS2
Secondary accession number(s): Q9DC98, Q9DCA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.