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Protein

Potassium channel subfamily K member 12

Gene

Kcnk12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 12
Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 2
Short name:
THIK-2
Gene namesi
Name:Kcnk12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi68940. Kcnk12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence analysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST
Intramembranei114 – 13421Pore-forming; Name=Pore-forming 1Sequence analysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Topological domaini166 – 21247CytoplasmicSequence analysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST
Intramembranei243 – 26321Pore-forming; Name=Pore-forming 2Sequence analysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence analysisAdd
BLAST
Topological domaini303 – 430128CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Potassium channel subfamily K member 12PRO_0000101761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ERS1.

Expressioni

Tissue specificityi

Highly expressed in most brain regions. Also expressed in other tissues such as lung, kidney, liver, stomach and spleen.1 Publication

Gene expression databases

GenevisibleiQ9ERS1. RN.

Interactioni

Subunit structurei

Heterodimer.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021570.

Structurei

3D structure databases

ProteinModelPortaliQ9ERS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 276Poly-Cys

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
InParanoidiQ9ERS1.
KOiK04921.
OMAiMISMRDL.
OrthoDBiEOG7DC24D.
PhylomeDBiQ9ERS1.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR005410. 2pore_dom_K_chnl_THIK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9ERS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRSPRPPP RRCRRRLPRP SCCCCCCRRS HLNEDTGRFV LLAALIGLYL
60 70 80 90 100
VAGATVFSAL ESPGEAEARA RWGATLRNFS AAHGVAEPEL RAFLRHYEAA
110 120 130 140 150
LAAGVRADAL RPRWDFPGAF YFVGTVVSTI GFGMTTPATV GGKAFLIAYG
160 170 180 190 200
LFGCAGTILF FNLFLERIIS LLAFIMRACR ERQLRRSGLL PATFRRGSAL
210 220 230 240 250
SEADSLAGWK PSVYHVLLIL GLFAVLLACC ASAMYTSVEG WDYVDSLYFC
260 270 280 290 300
FVTFSTIGFG DLVSSQHAAY RNQGLYRLGN FLFILLGVCC IYSLFNVISI
310 320 330 340 350
LIKQVLNWML RKLSCRCCTR CCPAPGAPLS RRNAITPGSR LRRRLAALGT
360 370 380 390 400
DPAARDSDAE GRRLSGELIS MRDLTASNKV SLALLQKQLS ETANGYPRSV
410 420 430
CVNTRQNGFS GGVGALGIMN NRLAETSASR
Length:430
Mass (Da):46,965
Last modified:March 1, 2001 - v1
Checksum:i69F1D16C6BFE7180
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287300 mRNA. Translation: AAG32311.1.
RefSeqiNP_071628.1. NM_022292.1.
UniGeneiRn.64577.

Genome annotation databases

EnsembliENSRNOT00000021570; ENSRNOP00000021570; ENSRNOG00000016110.
GeneIDi64119.
KEGGirno:64119.
UCSCiRGD:68940. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287300 mRNA. Translation: AAG32311.1.
RefSeqiNP_071628.1. NM_022292.1.
UniGeneiRn.64577.

3D structure databases

ProteinModelPortaliQ9ERS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021570.

Proteomic databases

PaxDbiQ9ERS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021570; ENSRNOP00000021570; ENSRNOG00000016110.
GeneIDi64119.
KEGGirno:64119.
UCSCiRGD:68940. rat.

Organism-specific databases

CTDi56660.
RGDi68940. Kcnk12.

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
InParanoidiQ9ERS1.
KOiK04921.
OMAiMISMRDL.
OrthoDBiEOG7DC24D.
PhylomeDBiQ9ERS1.
TreeFamiTF313947.

Miscellaneous databases

NextBioi612753.
PROiQ9ERS1.

Gene expression databases

GenevisibleiQ9ERS1. RN.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR005410. 2pore_dom_K_chnl_THIK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiKCNKC_RAT
AccessioniPrimary (citable) accession number: Q9ERS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.