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Protein

Potassium channel subfamily K member 12

Gene

Kcnk12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 12
Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 2
Short name:
THIK-2
Gene namesi
Name:Kcnk12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi68940. Kcnk12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Intramembranei114 – 134Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 212CytoplasmicSequence analysisAdd BLAST47
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Intramembranei243 – 263Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 430CytoplasmicSequence analysisAdd BLAST128

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017611 – 430Potassium channel subfamily K member 12Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ERS1.

Expressioni

Tissue specificityi

Highly expressed in most brain regions. Also expressed in other tissues such as lung, kidney, liver, stomach and spleen.1 Publication

Gene expression databases

BgeeiENSRNOG00000016110.
GenevisibleiQ9ERS1. RN.

Interactioni

Subunit structurei

Heterodimer.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021570.

Structurei

3D structure databases

ProteinModelPortaliQ9ERS1.
SMRiQ9ERS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 27Poly-Cys6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00860000133807.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
InParanoidiQ9ERS1.
KOiK04921.
OMAiNGYPRTV.
OrthoDBiEOG091G06SB.
PhylomeDBiQ9ERS1.
TreeFamiTF313947.

Family and domain databases

InterProiView protein in InterPro
IPR003280. 2pore_dom_K_chnl.
IPR005410. 2pore_dom_K_chnl_THIK.
IPR013099. K_chnl_dom.
PfamiView protein in Pfam
PF07885. Ion_trans_2. 2 hits.
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9ERS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRSPRPPP RRCRRRLPRP SCCCCCCRRS HLNEDTGRFV LLAALIGLYL
60 70 80 90 100
VAGATVFSAL ESPGEAEARA RWGATLRNFS AAHGVAEPEL RAFLRHYEAA
110 120 130 140 150
LAAGVRADAL RPRWDFPGAF YFVGTVVSTI GFGMTTPATV GGKAFLIAYG
160 170 180 190 200
LFGCAGTILF FNLFLERIIS LLAFIMRACR ERQLRRSGLL PATFRRGSAL
210 220 230 240 250
SEADSLAGWK PSVYHVLLIL GLFAVLLACC ASAMYTSVEG WDYVDSLYFC
260 270 280 290 300
FVTFSTIGFG DLVSSQHAAY RNQGLYRLGN FLFILLGVCC IYSLFNVISI
310 320 330 340 350
LIKQVLNWML RKLSCRCCTR CCPAPGAPLS RRNAITPGSR LRRRLAALGT
360 370 380 390 400
DPAARDSDAE GRRLSGELIS MRDLTASNKV SLALLQKQLS ETANGYPRSV
410 420 430
CVNTRQNGFS GGVGALGIMN NRLAETSASR
Length:430
Mass (Da):46,965
Last modified:March 1, 2001 - v1
Checksum:i69F1D16C6BFE7180
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287300 mRNA. Translation: AAG32311.1.
RefSeqiNP_071628.1. NM_022292.1.
UniGeneiRn.64577.

Genome annotation databases

EnsembliENSRNOT00000021570; ENSRNOP00000021570; ENSRNOG00000016110.
GeneIDi64119.
KEGGirno:64119.
UCSCiRGD:68940. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKCNKC_RAT
AccessioniPrimary (citable) accession number: Q9ERS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2001
Last modified: July 5, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families