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Protein

Potassium channel subfamily K member 13

Gene

Kcnk13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potassium channel displaying weak inward rectification in symmetrical K+ solution.

Miscellaneous

Weakly sensitive to low extracellular pH. Activated by arachidonic acid; inhibited by halothane and Ba++.

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 13
Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 1
Short name:
THIK-1
Gene namesi
Name:Kcnk13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68941. Kcnk13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Intramembranei95 – 115Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 193CytoplasmicSequence analysisAdd BLAST48
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Intramembranei224 – 244Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 405CytoplasmicSequence analysisAdd BLAST122

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017641 – 405Potassium channel subfamily K member 13Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ERS0.
PRIDEiQ9ERS0.

Expressioni

Tissue specificityi

Ubiquitous. In brain expression is rather low and restricted to the olfactory bulb and tubercle, to the ventromedial hypothalamic nucleus, lateral septal nucleus dorsal, lateral mammillary nucleus, lateral parabrachial nuclei, reticular nucleus and reunions nuclei.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067310.

Structurei

3D structure databases

ProteinModelPortaliQ9ERS0.
SMRiQ9ERS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
HOVERGENiHBG052238.
InParanoidiQ9ERS0.
KOiK04922.
PhylomeDBiQ9ERS0.

Family and domain databases

InterProiView protein in InterPro
IPR003280. 2pore_dom_K_chnl.
IPR005410. 2pore_dom_K_chnl_THIK.
IPR013099. K_chnl_dom.
PfamiView protein in Pfam
PF07885. Ion_trans_2. 2 hits.
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9ERS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGCSCSP GHLNEDNARF LLLAGLILLY LLGGAAVFSA LELAQELQAK
60 70 80 90 100
QRWEERLANF SRGHNLSREE LRGFLRHYEE ATKAGIRMDS VRPRWDFTGA
110 120 130 140 150
FYFVGTVVTT IGFGMTTPAT TGGKVFLIFY GLIGCASTIL FFNLFLERLI
160 170 180 190 200
TVIAYVMRTC HHQQLRRRGT VARDNRKAPR KGEADSLAGW KPSVYYVMLI
210 220 230 240 250
LCLASVAISC GASALYTTME GWSYFDSVYF CFVASSTIGF GDLVSSQNAQ
260 270 280 290 300
YENEGLYRFV NFFFILMGVC CIYSMFNVIS ILIKQTVNWI LRKLDSGCFP
310 320 330 340 350
QCQRGLLRSR RNVVMPGNIR NRCNISIETD GVMESDTDGR RLSGEMISMK
360 370 380 390 400
DTNKVSLAIL QKQLSEMANG GPHQTSTSSR DDEFSGGVGA FAVMNNRLAE

TSGDR
Length:405
Mass (Da):45,081
Last modified:March 1, 2001 - v1
Checksum:i441EB3EB2EC28C62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287301 mRNA. Translation: AAG32312.1.
RefSeqiNP_071629.1. NM_022293.1.
UniGeneiRn.53793.

Genome annotation databases

GeneIDi64120.
KEGGirno:64120.
UCSCiRGD:68941. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287301 mRNA. Translation: AAG32312.1.
RefSeqiNP_071629.1. NM_022293.1.
UniGeneiRn.53793.

3D structure databases

ProteinModelPortaliQ9ERS0.
SMRiQ9ERS0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067310.

Proteomic databases

PaxDbiQ9ERS0.
PRIDEiQ9ERS0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64120.
KEGGirno:64120.
UCSCiRGD:68941. rat.

Organism-specific databases

CTDi56659.
RGDi68941. Kcnk13.

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
HOVERGENiHBG052238.
InParanoidiQ9ERS0.
KOiK04922.
PhylomeDBiQ9ERS0.

Miscellaneous databases

PROiPR:Q9ERS0.

Family and domain databases

InterProiView protein in InterPro
IPR003280. 2pore_dom_K_chnl.
IPR005410. 2pore_dom_K_chnl_THIK.
IPR013099. K_chnl_dom.
PfamiView protein in Pfam
PF07885. Ion_trans_2. 2 hits.
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNKD_RAT
AccessioniPrimary (citable) accession number: Q9ERS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2001
Last modified: May 10, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.