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Q9ERQ8

- CAH7_MOUSE

UniProt

Q9ERQ8 - CAH7_MOUSE

Protein

Carbonic anhydrase 7

Gene

Ca7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    Reversible hydration of carbon dioxide.

    Catalytic activityi

    H2CO3 = CO2 + H2O.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei66 – 661Proton acceptorBy similarity
    Metal bindingi96 – 961Zinc; catalyticBy similarity
    Metal bindingi98 – 981Zinc; catalyticBy similarity
    Metal bindingi121 – 1211Zinc; catalyticBy similarity
    Active sitei130 – 1301By similarity

    GO - Molecular functioni

    1. carbonate dehydratase activity Source: MGI
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. one-carbon metabolic process Source: InterPro
    2. positive regulation of cellular pH reduction Source: MGI
    3. positive regulation of synaptic transmission, GABAergic Source: MGI
    4. regulation of chloride transport Source: MGI

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_199096. Reversible hydration of carbon dioxide.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbonic anhydrase 7 (EC:4.2.1.1)
    Alternative name(s):
    Carbonate dehydratase VII
    Carbonic anhydrase VII
    Short name:
    CA-VII
    Gene namesi
    Name:Ca7
    Synonyms:Car7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:103100. Car7.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytosol Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Carbonic anhydrase 7PRO_0000077432Add
    BLAST

    Proteomic databases

    PRIDEiQ9ERQ8.

    PTM databases

    PhosphoSiteiQ9ERQ8.

    Expressioni

    Gene expression databases

    BgeeiQ9ERQ8.
    CleanExiMM_CAR7.
    GenevestigatoriQ9ERQ8.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ERQ8.
    SMRiQ9ERQ8. Positions 5-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni201 – 2022Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the alpha-carbonic anhydrase family.Curated

    Phylogenomic databases

    eggNOGiCOG3338.
    GeneTreeiENSGT00750000117305.
    HOGENOMiHOG000112637.
    HOVERGENiHBG002837.
    InParanoidiQ9ERQ8.
    KOiK01672.
    OMAiLVHWNAR.
    OrthoDBiEOG7WMCK7.
    PhylomeDBiQ9ERQ8.
    TreeFamiTF316425.

    Family and domain databases

    Gene3Di3.10.200.10. 1 hit.
    InterProiIPR001148. Carbonic_anhydrase_a.
    IPR023561. Carbonic_anhydrase_a-class.
    IPR018338. Carbonic_anhydrase_a-class_CS.
    IPR018438. Carbonic_anhydrase_CA7.
    [Graphical view]
    PANTHERiPTHR18952. PTHR18952. 1 hit.
    PTHR18952:SF26. PTHR18952:SF26. 1 hit.
    PfamiPF00194. Carb_anhydrase. 1 hit.
    [Graphical view]
    SMARTiSM01057. Carb_anhydrase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51069. SSF51069. 1 hit.
    PROSITEiPS00162. ALPHA_CA_1. 1 hit.
    PS51144. ALPHA_CA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ERQ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGHHCWGYG QDDGPSNWHK LYPIAQGDRQ SPINIISSQA VYSPSLQPLE    50
    LFYEACMSLS ITNNGHSVQV DFNDSDDRTV VSGGPLEGPY RLKQLHFHWG 100
    KKRDMGSEHT VDGKSFPSEL HLVHWNAKKY STFGEAAAAP DGLAVVGVFL 150
    ETGDEHPSMN RLTDALYMVR FKDTKAQFSC FNPKCLLPTS RHYWTYPGSL 200
    TTPPLSESVT WIVLREPIRI SERQMEKFRS LLFTSEDDER IHMVDNFRPP 250
    QPLKGRVVKA SFQA 264
    Length:264
    Mass (Da):29,915
    Last modified:August 16, 2005 - v2
    Checksum:iB58E0E20CB840FA5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY075021 mRNA. Translation: AAL78169.1.
    BC094913 mRNA. Translation: AAH94913.1.
    AF291660 mRNA. Translation: AAG16230.1.
    CCDSiCCDS22581.1.
    RefSeqiNP_444300.1. NM_053070.3.
    UniGeneiMm.129265.

    Genome annotation databases

    EnsembliENSMUST00000056051; ENSMUSP00000052136; ENSMUSG00000031883.
    GeneIDi12354.
    KEGGimmu:12354.
    UCSCiuc009nat.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY075021 mRNA. Translation: AAL78169.1 .
    BC094913 mRNA. Translation: AAH94913.1 .
    AF291660 mRNA. Translation: AAG16230.1 .
    CCDSi CCDS22581.1.
    RefSeqi NP_444300.1. NM_053070.3.
    UniGenei Mm.129265.

    3D structure databases

    ProteinModelPortali Q9ERQ8.
    SMRi Q9ERQ8. Positions 5-262.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9ERQ8.
    ChEMBLi CHEMBL2216.

    PTM databases

    PhosphoSitei Q9ERQ8.

    Proteomic databases

    PRIDEi Q9ERQ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000056051 ; ENSMUSP00000052136 ; ENSMUSG00000031883 .
    GeneIDi 12354.
    KEGGi mmu:12354.
    UCSCi uc009nat.1. mouse.

    Organism-specific databases

    CTDi 12354.
    MGIi MGI:103100. Car7.

    Phylogenomic databases

    eggNOGi COG3338.
    GeneTreei ENSGT00750000117305.
    HOGENOMi HOG000112637.
    HOVERGENi HBG002837.
    InParanoidi Q9ERQ8.
    KOi K01672.
    OMAi LVHWNAR.
    OrthoDBi EOG7WMCK7.
    PhylomeDBi Q9ERQ8.
    TreeFami TF316425.

    Enzyme and pathway databases

    Reactomei REACT_199096. Reversible hydration of carbon dioxide.

    Miscellaneous databases

    NextBioi 281016.
    PROi Q9ERQ8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ERQ8.
    CleanExi MM_CAR7.
    Genevestigatori Q9ERQ8.

    Family and domain databases

    Gene3Di 3.10.200.10. 1 hit.
    InterProi IPR001148. Carbonic_anhydrase_a.
    IPR023561. Carbonic_anhydrase_a-class.
    IPR018338. Carbonic_anhydrase_a-class_CS.
    IPR018438. Carbonic_anhydrase_CA7.
    [Graphical view ]
    PANTHERi PTHR18952. PTHR18952. 1 hit.
    PTHR18952:SF26. PTHR18952:SF26. 1 hit.
    Pfami PF00194. Carb_anhydrase. 1 hit.
    [Graphical view ]
    SMARTi SM01057. Carb_anhydrase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51069. SSF51069. 1 hit.
    PROSITEi PS00162. ALPHA_CA_1. 1 hit.
    PS51144. ALPHA_CA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular identification of carbonic anhydrases (CA) and CA-related (CAR) genes."
      Chen Y., Huang C.-H.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. "Conservation of the deduced amino acid sequences of human and mouse carbonic anhydrase VII cDNAs."
      Ling B., Bergenhem N.C.H., Tashian R.E.
      Isozyme Bull. 28:32-32(1995)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-264.
      Strain: C57BL/6.
      Tissue: Brain.
    4. Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiCAH7_MOUSE
    AccessioniPrimary (citable) accession number: Q9ERQ8
    Secondary accession number(s): Q811X4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3