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Protein

Carbonic anhydrase 7

Gene

Ca7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Proton acceptorBy similarity1
Metal bindingi96Zinc; catalyticBy similarity1
Metal bindingi98Zinc; catalyticBy similarity1
Metal bindingi121Zinc; catalyticBy similarity1
Active sitei130By similarity1

GO - Molecular functioni

  • carbonate dehydratase activity Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • one-carbon metabolic process Source: InterPro
  • positive regulation of cellular pH reduction Source: MGI
  • positive regulation of synaptic transmission, GABAergic Source: MGI
  • regulation of chloride transport Source: MGI

Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1475029 Reversible hydration of carbon dioxide

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 7 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VII
Carbonic anhydrase VII
Short name:
CA-VII
Gene namesi
Name:Ca7
Synonyms:Car7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:103100 Car7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2216

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774321 – 264Carbonic anhydrase 7Add BLAST264

Proteomic databases

PaxDbiQ9ERQ8
PRIDEiQ9ERQ8

PTM databases

PhosphoSitePlusiQ9ERQ8

Expressioni

Gene expression databases

BgeeiENSMUSG00000031883
CleanExiMM_CAR7
ExpressionAtlasiQ9ERQ8 baseline and differential
GenevisibleiQ9ERQ8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052136

Chemistry databases

BindingDBiQ9ERQ8

Structurei

3D structure databases

ProteinModelPortaliQ9ERQ8
SMRiQ9ERQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 262Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 202Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiQ9ERQ8
KOiK01672
OMAiLYMVKFK
OrthoDBiEOG091G0XFM
PhylomeDBiQ9ERQ8
TreeFamiTF316425

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ERQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGHHCWGYG QDDGPSNWHK LYPIAQGDRQ SPINIISSQA VYSPSLQPLE
60 70 80 90 100
LFYEACMSLS ITNNGHSVQV DFNDSDDRTV VSGGPLEGPY RLKQLHFHWG
110 120 130 140 150
KKRDMGSEHT VDGKSFPSEL HLVHWNAKKY STFGEAAAAP DGLAVVGVFL
160 170 180 190 200
ETGDEHPSMN RLTDALYMVR FKDTKAQFSC FNPKCLLPTS RHYWTYPGSL
210 220 230 240 250
TTPPLSESVT WIVLREPIRI SERQMEKFRS LLFTSEDDER IHMVDNFRPP
260
QPLKGRVVKA SFQA
Length:264
Mass (Da):29,915
Last modified:August 16, 2005 - v2
Checksum:iB58E0E20CB840FA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY075021 mRNA Translation: AAL78169.1
BC094913 mRNA Translation: AAH94913.1
AF291660 mRNA Translation: AAG16230.1
CCDSiCCDS22581.1
RefSeqiNP_001288093.1, NM_001301164.1
NP_001288094.1, NM_001301165.1
NP_444300.1, NM_053070.3
UniGeneiMm.129265

Genome annotation databases

EnsembliENSMUST00000056051; ENSMUSP00000052136; ENSMUSG00000031883
GeneIDi12354
KEGGimmu:12354
UCSCiuc009nat.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCAH7_MOUSE
AccessioniPrimary (citable) accession number: Q9ERQ8
Secondary accession number(s): Q811X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: August 16, 2005
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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