Q9ERQ8 (CAH7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carbonic anhydrase 7
EC=4.2.1.1

Alternative name(s):
Carbonate dehydratase VII
Carbonic anhydrase VII
Short name=CA-VII

Gene names

Name:	Ca7
Synonyms:	Car7

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Carbonic anhydrase 7		PRO_0000077432
Regions
	Region	201 – 202	2	Substrate binding By similarity
Sites
	Active site	66	1	Proton acceptor By similarity
	Active site	130	1	By similarity
	Metal binding	96	1	Zinc; catalytic By similarity
	Metal binding	98	1	Zinc; catalytic By similarity
	Metal binding	121	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ERQ8 [UniParc]. Last modified August 16, 2005. Version 2. Checksum: B58E0E20CB840FA5	FASTA	264	29,915
	10 20 30 40 50 60 MTGHHCWGYG QDDGPSNWHK LYPIAQGDRQ SPINIISSQA VYSPSLQPLE LFYEACMSLS 70 80 90 100 110 120 ITNNGHSVQV DFNDSDDRTV VSGGPLEGPY RLKQLHFHWG KKRDMGSEHT VDGKSFPSEL 130 140 150 160 170 180 HLVHWNAKKY STFGEAAAAP DGLAVVGVFL ETGDEHPSMN RLTDALYMVR FKDTKAQFSC 190 200 210 220 230 240 FNPKCLLPTS RHYWTYPGSL TTPPLSESVT WIVLREPIRI SERQMEKFRS LLFTSEDDER 250 260 IHMVDNFRPP QPLKGRVVKA SFQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular identification of carbonic anhydrases (CA) and CA-related (CAR) genes." Chen Y., Huang C.-H. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo.
[3]	"Conservation of the deduced amino acid sequences of human and mouse carbonic anhydrase VII cDNAs." Ling B., Bergenhem N.C.H., Tashian R.E. Isozyme Bull. 28:32-32(1995) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-264. Strain: C57BL/6. Tissue: Brain.
[4]	"The catalytic properties of murine carbonic anhydrase VII." Earnhardt J.N., Qian M., Tu C., Lakkis M.M., Bergenhem N.C., Laipis P.J., Tashian R.E., Silverman D.N. Biochemistry 37:10837-10845(1998) [PubMed: 9692974] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY075021 mRNA. Translation: AAL78169.1. BC094913 mRNA. Translation: AAH94913.1. AF291660 mRNA. Translation: AAG16230.1.
IPI	IPI00187296.
RefSeq	NP_444300.1. NM_053070.3.
UniGene	Mm.129265.
3D structure databases
ProteinModelPortal	Q9ERQ8.
SMR	Q9ERQ8. Positions 5-262.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ERQ8.
Proteomic databases
PRIDE	Q9ERQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000056051; ENSMUSP00000052136; ENSMUSG00000031883.
GeneID	12354.
KEGG	mmu:12354.
UCSC	uc009nat.1. mouse.
Organism-specific databases
CTD	12354.
MGI	MGI:103100. Car7.
Phylogenomic databases
GeneTree	ENSGT00560000076828.
HOGENOM	HBG717384.
HOVERGEN	HBG002837.
InParanoid	Q9ERQ8.
OMA	HWGKKHS.
OrthoDB	EOG4H72C6.
PhylomeDB	Q9ERQ8.
Gene expression databases
ArrayExpress	Q9ERQ8.
Bgee	Q9ERQ8.
CleanEx	MM_CAR7.
Genevestigator	Q9ERQ8.
GermOnline	ENSMUSG00000031883. Mus musculus.
Family and domain databases
InterPro	IPR001148. a_carbonic_anhydrase. IPR023561. Carbonic_anhydrase_a-class. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018438. Carbonic_anhydrase_CA7. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
KO	K01672.
PANTHER	PTHR18952:SF26. Carbonic_anhydrase_CA7. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
SMART	SM01057. Carb_anhydrase. 1 hit. [Graphical view]
SUPFAM	SSF51069. Euk_COanhd. 1 hit.
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	281016.
SOURCE	Search...

Entry information

Entry name

CAH7_MOUSE

Accession

Primary (citable) accession number: Q9ERQ8
Secondary accession number(s): Q811X4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
Last sequence update:	August 16, 2005
Last modified:	January 25, 2012
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program