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Protein

Tripartite motif-containing protein 54

Gene

Trim54

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May bind and stabilize microtubules during myotubes formation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 8257RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri121 – 16343B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • microtubule binding Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 54
Alternative name(s):
Muscle-specific RING finger protein
Short name:
MuRF
Muscle-specific RING finger protein 3
Short name:
MuRF-3
Short name:
MuRF3
RING finger protein 30
Gene namesi
Name:Trim54
Synonyms:Murf, Rnf30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1889623. Trim54.

Subcellular locationi

GO - Cellular componenti

  • microtubule Source: UniProtKB-KW
  • microtubule associated complex Source: MGI
  • Z disc Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Tripartite motif-containing protein 54PRO_0000056283Add
BLAST

Proteomic databases

MaxQBiQ9ERP3.
PaxDbiQ9ERP3.
PRIDEiQ9ERP3.

PTM databases

iPTMnetiQ9ERP3.
PhosphoSiteiQ9ERP3.

Expressioni

Tissue specificityi

Selectively expressed in heart and skeletal muscle (at protein level). Also detected in lung and brain at much lower level.1 Publication

Developmental stagei

At E8.5 expressed in the developing cardiac region. At E10.5 expression is restricted to the cardiac region and myotome of the somites. Pre-natal expression is muscle-specific.1 Publication

Gene expression databases

BgeeiQ9ERP3.
CleanExiMM_TRIM54.
ExpressionAtlasiQ9ERP3. baseline and differential.
GenevisibleiQ9ERP3. MM.

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with TRIM63 and probably with TRIM55 (By similarity). Interacts with tubulin.By similarity1 Publication

GO - Molecular functioni

  • microtubule binding Source: MGI

Protein-protein interaction databases

BioGridi208426. 2 interactions.
DIPiDIP-60890N.
STRINGi10090.ENSMUSP00000013771.

Structurei

3D structure databases

ProteinModelPortaliQ9ERP3.
SMRiQ9ERP3. Positions 17-108, 122-168, 218-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini271 – 32959COSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 21144Mediates microtubule-binding and homooligomerizationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili194 – 25865Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 8257RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri121 – 16343B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG3. Eukaryota.
ENOG410YBZG. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000231156.
HOVERGENiHBG071242.
InParanoidiQ9ERP3.
KOiK10653.
OMAiGYESMDQ.
OrthoDBiEOG7VDXPK.
PhylomeDBiQ9ERP3.
TreeFamiTF331669.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51262. COS. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTVGFKPL LGDAHNMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC
60 70 80 90 100
ANDVFQASNP LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL
110 120 130 140 150
VENIIDIYKQ ESSRPLHAKA EQHLMCEEHE DEKINIYCLS CEVPTCSLCK
160 170 180 190 200
VFGAHKDCEV APLPTIYKRQ KSELSDGIAM LVAGNDRVQA VITQMEEVCQ
210 220 230 240 250
TIEDNSRRQK QLLNQRFETL CAVLEERKGE LLQALAREQE EKLQRVRGLI
260 270 280 290 300
RQYGDHLEGS SKLVESAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG
310 320 330 340 350
RPEPGYESME QFSVSVEHVA EMLRTIDFQP GAAGDEEDDD MALDGEEGNA
360
GLEEERLDVP EGSGLH
Length:366
Mass (Da):41,131
Last modified:March 1, 2001 - v1
Checksum:i6CD3429162D5BEFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294790 mRNA. Translation: AAG03076.1.
CCDSiCCDS19173.1.
RefSeqiNP_067422.1. NM_021447.2.
UniGeneiMm.143796.
Mm.402047.

Genome annotation databases

EnsembliENSMUST00000013771; ENSMUSP00000013771; ENSMUSG00000062077.
GeneIDi58522.
KEGGimmu:58522.
UCSCiuc008wxd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294790 mRNA. Translation: AAG03076.1.
CCDSiCCDS19173.1.
RefSeqiNP_067422.1. NM_021447.2.
UniGeneiMm.143796.
Mm.402047.

3D structure databases

ProteinModelPortaliQ9ERP3.
SMRiQ9ERP3. Positions 17-108, 122-168, 218-274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208426. 2 interactions.
DIPiDIP-60890N.
STRINGi10090.ENSMUSP00000013771.

PTM databases

iPTMnetiQ9ERP3.
PhosphoSiteiQ9ERP3.

Proteomic databases

MaxQBiQ9ERP3.
PaxDbiQ9ERP3.
PRIDEiQ9ERP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013771; ENSMUSP00000013771; ENSMUSG00000062077.
GeneIDi58522.
KEGGimmu:58522.
UCSCiuc008wxd.2. mouse.

Organism-specific databases

CTDi57159.
MGIiMGI:1889623. Trim54.

Phylogenomic databases

eggNOGiENOG410ITG3. Eukaryota.
ENOG410YBZG. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000231156.
HOVERGENiHBG071242.
InParanoidiQ9ERP3.
KOiK10653.
OMAiGYESMDQ.
OrthoDBiEOG7VDXPK.
PhylomeDBiQ9ERP3.
TreeFamiTF331669.

Miscellaneous databases

PROiQ9ERP3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ERP3.
CleanExiMM_TRIM54.
ExpressionAtlasiQ9ERP3. baseline and differential.
GenevisibleiQ9ERP3. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51262. COS. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein."
    Spencer J.A., Eliazer S., Ilaria R.L. Jr., Richardson J.A., Olson E.N.
    J. Cell Biol. 150:771-784(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, OLIGOMERIZATION, INTERACTION WITH MICROTUBULES, FUNCTION.
    Tissue: Heart muscle.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry nameiTRI54_MOUSE
AccessioniPrimary (citable) accession number: Q9ERP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.