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Protein

Tripartite motif-containing protein 54

Gene

Trim54

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May bind and stabilize microtubules during myotubes formation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 82RING-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri121 – 163B box-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

  • microtubule binding Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 54
Alternative name(s):
Muscle-specific RING finger protein
Short name:
MuRF
Muscle-specific RING finger protein 3
Short name:
MuRF-3
Short name:
MuRF3
RING finger protein 30
Gene namesi
Name:Trim54
Synonyms:Murf, Rnf30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1889623. Trim54.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562831 – 366Tripartite motif-containing protein 54Add BLAST366

Proteomic databases

MaxQBiQ9ERP3.
PaxDbiQ9ERP3.
PRIDEiQ9ERP3.

PTM databases

iPTMnetiQ9ERP3.
PhosphoSitePlusiQ9ERP3.

Expressioni

Tissue specificityi

Selectively expressed in heart and skeletal muscle (at protein level). Also detected in lung and brain at much lower level.1 Publication

Developmental stagei

At E8.5 expressed in the developing cardiac region. At E10.5 expression is restricted to the cardiac region and myotome of the somites. Pre-natal expression is muscle-specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000062077.
CleanExiMM_TRIM54.
ExpressionAtlasiQ9ERP3. baseline and differential.
GenevisibleiQ9ERP3. MM.

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with TRIM63 and probably with TRIM55 (By similarity). Interacts with tubulin.By similarity1 Publication

GO - Molecular functioni

  • microtubule binding Source: MGI

Protein-protein interaction databases

BioGridi208426. 2 interactors.
DIPiDIP-60890N.
STRINGi10090.ENSMUSP00000013771.

Structurei

3D structure databases

ProteinModelPortaliQ9ERP3.
SMRiQ9ERP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini271 – 329COSPROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 211Mediates microtubule-binding and homooligomerizationAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili194 – 258Sequence analysisAdd BLAST65

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 82RING-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri121 – 163B box-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG3. Eukaryota.
ENOG410YBZG. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000231156.
HOVERGENiHBG071242.
InParanoidiQ9ERP3.
KOiK10653.
OMAiSMEQFSV.
OrthoDBiEOG091G071N.
PhylomeDBiQ9ERP3.
TreeFamiTF331669.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR017903. COS_domain.
IPR033492. TRIM54.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PANTHERiPTHR24103:SF486. PTHR24103:SF486. 1 hit.
PfamiView protein in Pfam
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
SMARTiView protein in SMART
SM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS51262. COS. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ERP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTVGFKPL LGDAHNMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC
60 70 80 90 100
ANDVFQASNP LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL
110 120 130 140 150
VENIIDIYKQ ESSRPLHAKA EQHLMCEEHE DEKINIYCLS CEVPTCSLCK
160 170 180 190 200
VFGAHKDCEV APLPTIYKRQ KSELSDGIAM LVAGNDRVQA VITQMEEVCQ
210 220 230 240 250
TIEDNSRRQK QLLNQRFETL CAVLEERKGE LLQALAREQE EKLQRVRGLI
260 270 280 290 300
RQYGDHLEGS SKLVESAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG
310 320 330 340 350
RPEPGYESME QFSVSVEHVA EMLRTIDFQP GAAGDEEDDD MALDGEEGNA
360
GLEEERLDVP EGSGLH
Length:366
Mass (Da):41,131
Last modified:March 1, 2001 - v1
Checksum:i6CD3429162D5BEFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294790 mRNA. Translation: AAG03076.1.
CCDSiCCDS19173.1.
RefSeqiNP_067422.1. NM_021447.2.
UniGeneiMm.143796.
Mm.402047.

Genome annotation databases

EnsembliENSMUST00000013771; ENSMUSP00000013771; ENSMUSG00000062077.
GeneIDi58522.
KEGGimmu:58522.
UCSCiuc008wxd.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiTRI54_MOUSE
AccessioniPrimary (citable) accession number: Q9ERP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2001
Last modified: August 30, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot