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Protein

Guanylate cyclase soluble subunit alpha-1

Gene

Gucy1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Has also activity with Mn2+ (in vitro).By similarity

Enzyme regulationi

Activated by nitric oxide in the presence of magnesium or manganese ions.By similarity

GO - Molecular functioni

GO - Biological processi

  • cGMP biosynthetic process Source: MGI
  • intracellular signal transduction Source: InterPro
  • positive regulation of cGMP biosynthetic process Source: MGI
  • regulation of blood pressure Source: MGI
  • relaxation of vascular smooth muscle Source: MGI
  • response to defense-related host nitric oxide production Source: MGI
  • signal transduction Source: GO_Central

Keywordsi

Molecular functionLyase
Biological processcGMP biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase soluble subunit alpha-1 (EC:4.6.1.2By similarity)
Short name:
GCS-alpha-1
Alternative name(s):
Guanylate cyclase soluble subunit alpha-3
Short name:
GCS-alpha-3
Soluble guanylate cyclase large subunit
Gene namesi
Name:Gucy1a1
Synonyms:Gucy1a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1926562 Gucy1a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000741111 – 691Guanylate cyclase soluble subunit alpha-1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ERL9
PaxDbiQ9ERL9
PeptideAtlasiQ9ERL9
PRIDEiQ9ERL9

PTM databases

iPTMnetiQ9ERL9
PhosphoSitePlusiQ9ERL9

Expressioni

Gene expression databases

BgeeiENSMUSG00000033910
CleanExiMM_GUCY1A3
ExpressionAtlasiQ9ERL9 baseline and differential
GenevisibleiQ9ERL9 MM

Interactioni

Subunit structurei

The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1B1.By similarity

Protein-protein interaction databases

IntActiQ9ERL9, 1 interactor
MINTiQ9ERL9
STRINGi10090.ENSMUSP00000048918

Structurei

3D structure databases

ProteinModelPortaliQ9ERL9
SMRiQ9ERL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini480 – 607Guanylate cyclasePROSITE-ProRule annotationAdd BLAST128

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4171 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000118959
HOGENOMiHOG000220903
HOVERGENiHBG106603
InParanoidiQ9ERL9
KOiK12318
OMAiKLIFPEF
OrthoDBiEOG091G04KV
TreeFamiTF351403

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
3.90.1520.10, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR038158 H-NOX_domain_sf
IPR011645 HNOB_dom_associated
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
PF07701 HNOBA, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ERL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFCRKFKDLK ITGECPFSLL APGQVPKEPT EEVAGGSEGC QATLPICQYF
60 70 80 90 100
PEKNAEGSLP QRKTSRNRVY LHTLAESICK LIFPECERLN LALQRTLAKH
110 120 130 140 150
KIEENRKSSE KEDLEKIIAE EAIAAGAPVE ALKDSLGEEL FKICYEEDEH
160 170 180 190 200
ILGVVGGTLK DFLNSFSTLL KQSSHCQEAE RRGRLEDASI LCLDKDQDFL
210 220 230 240 250
NVYYFFPKRT TALLLPGIIK AAARILYESH VEVSLMPPCF RSDCTEFVNQ
260 270 280 290 300
PYLLYSVHVK STKPSLSPGK PQSSLVIPAS LFCKTFPFHF MLDRDLAILQ
310 320 330 340 350
LGNGIRRLVN KRDFQGKPNF EEFFEILTPK INQTFSGIMT MLNMQFVIRV
360 370 380 390 400
RRWDNSVKKS SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL
410 420 430 440 450
SDIPIHNALR DVVLIGEQAR AQDGLKKRLG KLKATLEHAH QALEEEKKRT
460 470 480 490 500
VDLLCSIFPS EVAQQLWQGQ IVQAKKFSEV TMLFSDIVGF TAICSQCSPL
510 520 530 540 550
QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHR ESDTHAVQIA
560 570 580 590 600
LMALKMMELS NEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN
610 620 630 640 650
VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSDI
660 670 680 690
PGICHFLDAY HHQGPNSKPW FQDKDVEDGN ANFLGKASGI D
Length:691
Mass (Da):77,588
Last modified:July 27, 2011 - v2
Checksum:iFF8DD0C3CB0BBD7F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti690I → V in AAG17446 (PubMed:10984516).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297082 mRNA Translation: AAG17446.1
AK004815 mRNA Translation: BAB23586.1
AK028558 mRNA Translation: BAC26009.1
BC057327 mRNA Translation: AAH57327.1
BC094310 mRNA Translation: AAH94310.1
CCDSiCCDS17429.1
RefSeqiNP_068696.2, NM_021896.5
XP_006501906.1, XM_006501843.3
XP_011238486.1, XM_011240184.1
UniGeneiMm.143831

Genome annotation databases

EnsembliENSMUST00000048976; ENSMUSP00000048918; ENSMUSG00000033910
ENSMUST00000193924; ENSMUSP00000142138; ENSMUSG00000033910
GeneIDi60596
KEGGimmu:60596
UCSCiuc008pou.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGCYA1_MOUSE
AccessioniPrimary (citable) accession number: Q9ERL9
Secondary accession number(s): Q6GTG0, Q9DBQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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