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Protein

Glia maturation factor gamma

Gene

Gmfg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • actin filament debranching Source: MGI
  • negative regulation of Arp2/3 complex-mediated actin nucleation Source: MGI
  • regulation of actin cytoskeleton reorganization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glia maturation factor gamma
Short name:
GMF-gamma
Gene namesi
Name:Gmfg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1927135. Gmfg.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002149482 – 142Glia maturation factor gammaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9ERL7.
MaxQBiQ9ERL7.
PaxDbiQ9ERL7.
PRIDEiQ9ERL7.

PTM databases

iPTMnetiQ9ERL7.
PhosphoSitePlusiQ9ERL7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060791.
CleanExiMM_GMFG.
ExpressionAtlasiQ9ERL7. baseline and differential.
GenevisibleiQ9ERL7. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211012. 2 interactors.
DIPiDIP-60543N.
STRINGi10090.ENSMUSP00000077889.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 10Combined sources4
Helixi12 – 22Combined sources11
Beta strandi30 – 37Combined sources8
Turni38 – 41Combined sources4
Beta strandi42 – 51Combined sources10
Helixi54 – 60Combined sources7
Beta strandi63 – 65Combined sources3
Beta strandi67 – 72Combined sources6
Beta strandi78 – 80Combined sources3
Beta strandi86 – 91Combined sources6
Beta strandi94 – 96Combined sources3
Helixi98 – 114Combined sources17
Beta strandi120 – 125Combined sources6
Helixi126 – 128Combined sources3
Helixi131 – 139Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VKKX-ray1.35A1-142[»]
1WFSNMR-A2-139[»]
4JD2X-ray3.08H1-142[»]
ProteinModelPortaliQ9ERL7.
SMRiQ9ERL7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ERL7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 139ADF-HPROSITE-ProRule annotationAdd BLAST136

Sequence similaritiesi

Contains 1 ADF-H domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1736. Eukaryota.
ENOG4111RK6. LUCA.
GeneTreeiENSGT00390000008920.
HOGENOMiHOG000175654.
HOVERGENiHBG003045.
InParanoidiQ9ERL7.
OMAiIVMKVDK.
OrthoDBiEOG091G0YYO.
PhylomeDBiQ9ERL7.
TreeFamiTF315147.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF.
IPR030076. GMFG.
[Graphical view]
PANTHERiPTHR11249. PTHR11249. 1 hit.
PTHR11249:SF4. PTHR11249:SF4. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PIRSFiPIRSF001788. GMF-beta. 1 hit.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ERL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSLVVCEV DPELKETLRK FRFRKETNNA AIIMKVDKDR QMVVLEDELQ
60 70 80 90 100
NISPEELKLE LPERQPRFVV YSYKYVHDDG RVSYPLCFIF SSPVGCKPEQ
110 120 130 140
QMMYAGSKNR LVQTAELTKV FEIRTTDDLT ETWLKEKLAF FR
Length:142
Mass (Da):16,748
Last modified:March 1, 2001 - v1
Checksum:i25367F2B49378710
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297221 mRNA. Translation: AAG22804.1.
AB097120 Genomic DNA. Translation: BAC76941.1.
AK002834 mRNA. Translation: BAB22392.1.
AK009967 mRNA. Translation: BAB26617.1.
AK014214 mRNA. Translation: BAB29210.1.
BC011488 mRNA. Translation: AAH11488.1.
CCDSiCCDS39859.1.
CCDS39860.1.
RefSeqiNP_001034281.1. NM_001039192.1.
NP_071307.1. NM_022024.2.
UniGeneiMm.194536.

Genome annotation databases

EnsembliENSMUST00000078845; ENSMUSP00000077889; ENSMUSG00000060791.
ENSMUST00000108292; ENSMUSP00000103927; ENSMUSG00000060791.
GeneIDi63986.
KEGGimmu:63986.
UCSCiuc009fyx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297221 mRNA. Translation: AAG22804.1.
AB097120 Genomic DNA. Translation: BAC76941.1.
AK002834 mRNA. Translation: BAB22392.1.
AK009967 mRNA. Translation: BAB26617.1.
AK014214 mRNA. Translation: BAB29210.1.
BC011488 mRNA. Translation: AAH11488.1.
CCDSiCCDS39859.1.
CCDS39860.1.
RefSeqiNP_001034281.1. NM_001039192.1.
NP_071307.1. NM_022024.2.
UniGeneiMm.194536.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VKKX-ray1.35A1-142[»]
1WFSNMR-A2-139[»]
4JD2X-ray3.08H1-142[»]
ProteinModelPortaliQ9ERL7.
SMRiQ9ERL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211012. 2 interactors.
DIPiDIP-60543N.
STRINGi10090.ENSMUSP00000077889.

PTM databases

iPTMnetiQ9ERL7.
PhosphoSitePlusiQ9ERL7.

Proteomic databases

EPDiQ9ERL7.
MaxQBiQ9ERL7.
PaxDbiQ9ERL7.
PRIDEiQ9ERL7.

Protocols and materials databases

DNASUi63986.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078845; ENSMUSP00000077889; ENSMUSG00000060791.
ENSMUST00000108292; ENSMUSP00000103927; ENSMUSG00000060791.
GeneIDi63986.
KEGGimmu:63986.
UCSCiuc009fyx.1. mouse.

Organism-specific databases

CTDi9535.
MGIiMGI:1927135. Gmfg.

Phylogenomic databases

eggNOGiKOG1736. Eukaryota.
ENOG4111RK6. LUCA.
GeneTreeiENSGT00390000008920.
HOGENOMiHOG000175654.
HOVERGENiHBG003045.
InParanoidiQ9ERL7.
OMAiIVMKVDK.
OrthoDBiEOG091G0YYO.
PhylomeDBiQ9ERL7.
TreeFamiTF315147.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiQ9ERL7.
PROiQ9ERL7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060791.
CleanExiMM_GMFG.
ExpressionAtlasiQ9ERL7. baseline and differential.
GenevisibleiQ9ERL7. MM.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF.
IPR030076. GMFG.
[Graphical view]
PANTHERiPTHR11249. PTHR11249. 1 hit.
PTHR11249:SF4. PTHR11249:SF4. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PIRSFiPIRSF001788. GMF-beta. 1 hit.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGMFG_MOUSE
AccessioniPrimary (citable) accession number: Q9ERL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.