ID   Q9ERL0_MOUSE            Unreviewed;       547 AA.
AC   Q9ERL0;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 159.
DE   SubName: Full=Btk-PH-domain binding protein {ECO:0000313|EMBL:AAG22079.1};
DE   SubName: Full=Myeloid/lymphoid or mixed-lineage leukemia (Trithorax homolog, Drosophila) translocated to, 1 {ECO:0000313|EMBL:AAH53005.1};
DE   SubName: Full=Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 {ECO:0000313|Ensembl:ENSMUSP00000025053.9};
GN   Name=Mllt1 {ECO:0000313|EMBL:AAH53005.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000025053.9,
GN   ECO:0000313|MGI:MGI:1927238};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAG22079.1};
RN   [1] {ECO:0000313|EMBL:BAE25964.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE33866.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33866.1}, and Lung
RC   {ECO:0000313|EMBL:BAE25964.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAE25964.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE33866.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33866.1}, and Lung
RC   {ECO:0000313|EMBL:BAE25964.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAE25964.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE33866.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33866.1}, and Lung
RC   {ECO:0000313|EMBL:BAE25964.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:AAG22079.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/c {ECO:0000313|EMBL:AAG22079.1};
RX   PubMed=11007757; DOI=10.1093/intimm/12.10.1397;
RA   Kikuchi Y., Hirano M., Seto M., Takatsu K.;
RT   "Identification and characterization of a molecule, BAM11, that associates
RT   with the pleckstrin homology domain of mouse Btk.";
RL   Int. Immunol. 12:1397-1408(2000).
RN   [5] {ECO:0000313|EMBL:BAE25964.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE33866.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33866.1}, and Lung
RC   {ECO:0000313|EMBL:BAE25964.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [6] {ECO:0000313|EMBL:BAE25964.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE33866.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33866.1}, and Lung
RC   {ECO:0000313|EMBL:BAE25964.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [7] {ECO:0000313|EMBL:AAH53005.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH53005.1};
RC   TISSUE=Mouse {ECO:0000313|EMBL:AAH53005.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8] {ECO:0000313|EMBL:BAE25964.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE33866.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33866.1}, and Lung
RC   {ECO:0000313|EMBL:BAE25964.1};
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA   Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA   Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA   Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA   Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:BAE25964.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE33866.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33866.1}, and Lung
RC   {ECO:0000313|EMBL:BAE25964.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [10] {ECO:0000313|EMBL:BAE25964.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAE33866.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33866.1}, and Lung
RC   {ECO:0000313|EMBL:BAE25964.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [11] {ECO:0000313|Ensembl:ENSMUSP00000025053.9, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000025053.9,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [12] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [13] {ECO:0000313|Ensembl:ENSMUSP00000025053.9}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000025053.9};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00376}.
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DR   EMBL; AF298887; AAG22079.1; -; mRNA.
DR   EMBL; BC053005; AAH53005.1; -; mRNA.
DR   EMBL; AK144605; BAE25964.1; -; mRNA.
DR   EMBL; AK156820; BAE33866.1; -; mRNA.
DR   RefSeq; NP_071723.1; NM_022328.2.
DR   IntAct; Q9ERL0; 22.
DR   STRING; 10090.ENSMUSP00000025053; -.
DR   PaxDb; 10090-ENSMUSP00000025053; -.
DR   ProteomicsDB; 339067; -.
DR   Antibodypedia; 11832; 157 antibodies from 25 providers.
DR   DNASU; 64144; -.
DR   Ensembl; ENSMUST00000025053.10; ENSMUSP00000025053.9; ENSMUSG00000024212.10.
DR   GeneID; 64144; -.
DR   UCSC; uc008ddk.1; mouse.
DR   AGR; MGI:1927238; -.
DR   CTD; 4298; -.
DR   MGI; MGI:1927238; Mllt1.
DR   VEuPathDB; HostDB:ENSMUSG00000024212; -.
DR   eggNOG; KOG3149; Eukaryota.
DR   GeneTree; ENSGT00940000158800; -.
DR   HOGENOM; CLU_036086_0_0_1; -.
DR   OMA; FEIQHFV; -.
DR   OrthoDB; 4267365at2759; -.
DR   TreeFam; TF314586; -.
DR   Reactome; R-MMU-112382; Formation of RNA Pol II elongation complex.
DR   Reactome; R-MMU-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-MMU-75955; RNA Polymerase II Transcription Elongation.
DR   BioGRID-ORCS; 64144; 13 hits in 85 CRISPR screens.
DR   ChiTaRS; Mllt1; mouse.
DR   Proteomes; UP000000589; Chromosome 17.
DR   Bgee; ENSMUSG00000024212; Expressed in ventricular zone and 247 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0008023; C:transcription elongation factor complex; ISO:MGI.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0070577; F:lysine-acetylated histone binding; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd16906; YEATS_AF-9_like; 1.
DR   Gene3D; 1.20.1270.290; -; 1.
DR   Gene3D; 2.60.40.1970; YEATS domain; 1.
DR   InterPro; IPR040930; AF-9_AHD.
DR   InterPro; IPR038704; YEAST_sf.
DR   InterPro; IPR005033; YEATS.
DR   PANTHER; PTHR47827; AHD DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47827:SF4; PROTEIN ENL; 1.
DR   Pfam; PF17793; AHD; 1.
DR   Pfam; PF03366; YEATS; 1.
DR   PROSITE; PS51037; YEATS; 1.
PE   1: Evidence at protein level;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00376};
KW   Proteomics identification {ECO:0007829|EPD:Q9ERL0,
KW   ECO:0007829|MaxQB:Q9ERL0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          483..543
FT                   /note="AF-9 ANC1 homology"
FT                   /evidence="ECO:0000259|Pfam:PF17793"
FT   REGION          153..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..256
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..353
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..393
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..437
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        444..459
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   547 AA;  60786 MW;  2F0DF472D5E12FF1 CRC64;
     MDNQCTVQVK LELGHRAQLR KKPTTEGFTH DWMVFVRGPE QCDIQHFVEK VIFRLHDSFP
     KPKRVCKEPP YKVEESGYAG FIMLIEVYFK NKEEPRKVCF TYDLFLNLEG NPPVNHLRCE
     KLTFNNPTTE FRCKLLMAGG VMVMPEGADT VSRPSPDYPM LPTIPLSAFS DPKKNKPSHG
     SKDANKESGK ASKPHKVARE HRERPRKDSE SRSCSKEPER EPKSAKDAAR KLPKEEKAPV
     PKAAFKEPKM ALKETKLESL SPKGVPQPPT LPKASSKRPA ATDSPKLSAK KPKKSGSKGT
     RRAPGTSPRA SSFPDKKVAR DKNSKGDKGK AESEPREAKR TLQTEDSNSE DEASFRSESA
     QSSPANASSS SDSSSDSDFE PSQNHSQGPL RSMVEDLQSE GSDEDDSSSG EENTGKANPG
     RESRLSFSDS ESDNSADSCL PGREPLPPQK PPPPSSKVSG RRSPEPCSKP EKMLKKATYD
     KAYTDELVEL HRRLMALRER NVLQQIVNLI EETGHFNVTN TTFDFDLFSL DESTVRKLQS
     CLEAVAT
//