true2004-05-102024-01-24161P2RY6_MOUSECloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder.Lazarowski E.R.Rochelle L.G.O'Neal W.K.Ribeiro C.M.P.Grubb B.R.Zhang V.Harden T.K.Boucher R.C.2001J. Pharmacol. Exp. Ther.29743-49NUCLEOTIDE SEQUENCE129/SvEvThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Teamdoi:10.1101/gr.25965042004Genome Res.142121-2127NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]C57BL/6JMammary gland12 sites, No reported glycans2 sites310 antibodies from 35 providersmouseP2ry6EukaryotaG alpha (q) signalling eventsP2Y receptors2 hits in 79 CRISPR screensProteinExpressed in stroma of bone marrow and 128 other cell types or tissuesbaseline and differentialMMRhodopsin 7-helix transmembrane proteinsGPCR_RhodpsnGPCR_Rhodpsn_7TMP2Y6_rcptP2Y PURINOCEPTOR 6PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR7tm_1GPCRRHODOPSNP2Y6PRNOCPTRP2YPURNOCPTRFamily A G protein-coupled receptor-likeG_PROTEIN_RECEP_F1_2P2Y purinoceptor 6P2Y6P2ry6Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C (By similarity).Belongs to the G-protein coupled receptor 1 family.P2Y purinoceptor 6367211328Extracellular27Helical; Name=12848Cytoplasmic4962Helical; Name=26383Extracellular84101Helical; Name=3102122Cytoplasmic123144Helical; Name=4145165Extracellular166194Helical; Name=5195215Cytoplasmic216236Helical; Name=6237257Extracellular258280Helical; Name=7281303Cytoplasmic304N-linked (GlcNAc...) asparagine5N-linked (GlcNAc...) asparagine173991772001-03-01136721c512fe7a7f5a7b069fc2ff352b31d6dcMEQDNGTIQAPGLPPTTCVYREDFKRLLLTPVYSVVLVVGLPLNICVIAQICASRRTLTRSAVYTLNLALADLMYACSLPLLIYNYARGDHWPFGDLACRFVRFLFYANLHGSILFLTCISFQRYLGICHPLASWHKRGGRRAAWVVCGVVWLAVTAQCLPTAVFAATGIQRNRTVCYDLSPPILSTRYLPYGMALTVIGFLLPFIALLACYCRMARRLCRQDGPAGPVAQERRSKAARMAVVVAAVFAISFLPFHITKTAYLAVRSTPGVSCPVLETFAAAYKGTRPFASVNSVLDPILFYFTQQKFRRQPHDLLQRLTAKWQRQRVtruetruetruetruetruetruetrue