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Protein

P2Y purinoceptor 6

Gene

P2ry6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  • pyrimidine nucleotide binding Source: MGI
  • UDP-activated nucleotide receptor activity Source: MGI

GO - Biological processi

  • cellular response to organic cyclic compound Source: MGI
  • cellular response to prostaglandin E stimulus Source: MGI
  • positive regulation of smooth muscle cell migration Source: Ensembl
  • transepithelial chloride transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_326987. P2Y receptors.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 6
Short name:
P2Y6
Gene namesi
Name:P2ry6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2673874. P2ry6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 6214CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei63 – 8321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini84 – 10118ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 14422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini166 – 19429ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini216 – 23621CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 28023ExtracellularSequence AnalysisAdd
BLAST
Transmembranei281 – 30323Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini304 – 32825CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328P2Y purinoceptor 6PRO_0000070029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 177PROSITE-ProRule annotation
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ERK9.
PRIDEiQ9ERK9.

Expressioni

Gene expression databases

BgeeiQ9ERK9.
CleanExiMM_P2RY6.
ExpressionAtlasiQ9ERK9. baseline and differential.
GenevestigatoriQ9ERK9.

Structurei

3D structure databases

ProteinModelPortaliQ9ERK9.
SMRiQ9ERK9. Positions 27-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149481.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiQ9ERK9.
KOiK04272.
OMAiFQRYLGI.
OrthoDBiEOG7P2XSD.
PhylomeDBiQ9ERK9.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF16. PTHR24231:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQDNGTIQA PGLPPTTCVY REDFKRLLLT PVYSVVLVVG LPLNICVIAQ
60 70 80 90 100
ICASRRTLTR SAVYTLNLAL ADLMYACSLP LLIYNYARGD HWPFGDLACR
110 120 130 140 150
FVRFLFYANL HGSILFLTCI SFQRYLGICH PLASWHKRGG RRAAWVVCGV
160 170 180 190 200
VWLAVTAQCL PTAVFAATGI QRNRTVCYDL SPPILSTRYL PYGMALTVIG
210 220 230 240 250
FLLPFIALLA CYCRMARRLC RQDGPAGPVA QERRSKAARM AVVVAAVFAI
260 270 280 290 300
SFLPFHITKT AYLAVRSTPG VSCPVLETFA AAYKGTRPFA SVNSVLDPIL
310 320
FYFTQQKFRR QPHDLLQRLT AKWQRQRV
Length:328
Mass (Da):36,721
Last modified:March 1, 2001 - v1
Checksum:i00F9DF5ADADF903E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298899 Genomic DNA. Translation: AAG24619.1.
BC027331 mRNA. Translation: AAH27331.1.
BC064095 mRNA. Translation: AAH64095.1.
CCDSiCCDS21507.1.
RefSeqiNP_898991.1. NM_183168.2.
XP_006507703.1. XM_006507640.2.
UniGeneiMm.235193.

Genome annotation databases

EnsembliENSMUST00000060174; ENSMUSP00000055697; ENSMUSG00000048779.
GeneIDi233571.
KEGGimmu:233571.
UCSCiuc009inw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298899 Genomic DNA. Translation: AAG24619.1.
BC027331 mRNA. Translation: AAH27331.1.
BC064095 mRNA. Translation: AAH64095.1.
CCDSiCCDS21507.1.
RefSeqiNP_898991.1. NM_183168.2.
XP_006507703.1. XM_006507640.2.
UniGeneiMm.235193.

3D structure databases

ProteinModelPortaliQ9ERK9.
SMRiQ9ERK9. Positions 27-310.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi326.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9ERK9.
PRIDEiQ9ERK9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060174; ENSMUSP00000055697; ENSMUSG00000048779.
GeneIDi233571.
KEGGimmu:233571.
UCSCiuc009inw.2. mouse.

Organism-specific databases

CTDi5031.
MGIiMGI:2673874. P2ry6.

Phylogenomic databases

eggNOGiNOG149481.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiQ9ERK9.
KOiK04272.
OMAiFQRYLGI.
OrthoDBiEOG7P2XSD.
PhylomeDBiQ9ERK9.
TreeFamiTF330775.

Enzyme and pathway databases

ReactomeiREACT_326987. P2Y receptors.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi381764.
PROiQ9ERK9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ERK9.
CleanExiMM_P2RY6.
ExpressionAtlasiQ9ERK9. baseline and differential.
GenevestigatoriQ9ERK9.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF16. PTHR24231:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder."
    Lazarowski E.R., Rochelle L.G., O'Neal W.K., Ribeiro C.M.P., Grubb B.R., Zhang V., Harden T.K., Boucher R.C.
    J. Pharmacol. Exp. Ther. 297:43-49(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvEv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiP2RY6_MOUSE
AccessioniPrimary (citable) accession number: Q9ERK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: May 27, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.