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Protein

P2Y purinoceptor 6

Gene

P2ry6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  • pyrimidine nucleotide binding Source: MGI
  • UDP-activated nucleotide receptor activity Source: MGI

GO - Biological processi

  • cellular response to organic cyclic compound Source: MGI
  • cellular response to prostaglandin E stimulus Source: MGI
  • positive regulation of smooth muscle cell migration Source: Ensembl
  • transepithelial chloride transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-417957. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 6
Short name:
P2Y6
Gene namesi
Name:P2ry6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2673874. P2ry6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 62CytoplasmicSequence analysisAdd BLAST14
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 101ExtracellularSequence analysisAdd BLAST18
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 144CytoplasmicSequence analysisAdd BLAST22
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 194ExtracellularSequence analysisAdd BLAST29
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 236CytoplasmicSequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 280ExtracellularSequence analysisAdd BLAST23
Transmembranei281 – 303Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini304 – 328CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700291 – 328P2Y purinoceptor 6Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 177PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9ERK9.
PaxDbiQ9ERK9.
PRIDEiQ9ERK9.

PTM databases

PhosphoSitePlusiQ9ERK9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048779.
CleanExiMM_P2RY6.
ExpressionAtlasiQ9ERK9. baseline and differential.
GenevisibleiQ9ERK9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055697.

Structurei

3D structure databases

ProteinModelPortaliQ9ERK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJR4. Eukaryota.
ENOG410YAZW. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiQ9ERK9.
KOiK04272.
OMAiRPFASAN.
OrthoDBiEOG091G0DD3.
PhylomeDBiQ9ERK9.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF16. PTHR24231:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQDNGTIQA PGLPPTTCVY REDFKRLLLT PVYSVVLVVG LPLNICVIAQ
60 70 80 90 100
ICASRRTLTR SAVYTLNLAL ADLMYACSLP LLIYNYARGD HWPFGDLACR
110 120 130 140 150
FVRFLFYANL HGSILFLTCI SFQRYLGICH PLASWHKRGG RRAAWVVCGV
160 170 180 190 200
VWLAVTAQCL PTAVFAATGI QRNRTVCYDL SPPILSTRYL PYGMALTVIG
210 220 230 240 250
FLLPFIALLA CYCRMARRLC RQDGPAGPVA QERRSKAARM AVVVAAVFAI
260 270 280 290 300
SFLPFHITKT AYLAVRSTPG VSCPVLETFA AAYKGTRPFA SVNSVLDPIL
310 320
FYFTQQKFRR QPHDLLQRLT AKWQRQRV
Length:328
Mass (Da):36,721
Last modified:March 1, 2001 - v1
Checksum:i00F9DF5ADADF903E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298899 Genomic DNA. Translation: AAG24619.1.
BC027331 mRNA. Translation: AAH27331.1.
BC064095 mRNA. Translation: AAH64095.1.
CCDSiCCDS21507.1.
RefSeqiNP_898991.1. NM_183168.2.
XP_006507703.1. XM_006507640.3.
XP_011240041.1. XM_011241739.2.
UniGeneiMm.235193.

Genome annotation databases

EnsembliENSMUST00000060174; ENSMUSP00000055697; ENSMUSG00000048779.
GeneIDi233571.
KEGGimmu:233571.
UCSCiuc009inw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298899 Genomic DNA. Translation: AAG24619.1.
BC027331 mRNA. Translation: AAH27331.1.
BC064095 mRNA. Translation: AAH64095.1.
CCDSiCCDS21507.1.
RefSeqiNP_898991.1. NM_183168.2.
XP_006507703.1. XM_006507640.3.
XP_011240041.1. XM_011241739.2.
UniGeneiMm.235193.

3D structure databases

ProteinModelPortaliQ9ERK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055697.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9ERK9.

Proteomic databases

MaxQBiQ9ERK9.
PaxDbiQ9ERK9.
PRIDEiQ9ERK9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060174; ENSMUSP00000055697; ENSMUSG00000048779.
GeneIDi233571.
KEGGimmu:233571.
UCSCiuc009inw.2. mouse.

Organism-specific databases

CTDi5031.
MGIiMGI:2673874. P2ry6.

Phylogenomic databases

eggNOGiENOG410IJR4. Eukaryota.
ENOG410YAZW. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiQ9ERK9.
KOiK04272.
OMAiRPFASAN.
OrthoDBiEOG091G0DD3.
PhylomeDBiQ9ERK9.
TreeFamiTF330775.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-417957. P2Y receptors.

Miscellaneous databases

PROiQ9ERK9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048779.
CleanExiMM_P2RY6.
ExpressionAtlasiQ9ERK9. baseline and differential.
GenevisibleiQ9ERK9. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF16. PTHR24231:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RY6_MOUSE
AccessioniPrimary (citable) accession number: Q9ERK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.