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Protein

P2Y purinoceptor 6

Gene

P2ry6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  • pyrimidine nucleotide binding Source: MGI
  • UDP-activated nucleotide receptor activity Source: MGI

GO - Biological processi

  • cellular response to organic cyclic compound Source: MGI
  • cellular response to prostaglandin E stimulus Source: MGI
  • positive regulation of smooth muscle cell migration Source: Ensembl
  • transepithelial chloride transport Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-417957 P2Y receptors

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 6
Short name:
P2Y6
Gene namesi
Name:P2ry6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2673874 P2ry6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 62CytoplasmicSequence analysisAdd BLAST14
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 101ExtracellularSequence analysisAdd BLAST18
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 144CytoplasmicSequence analysisAdd BLAST22
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 194ExtracellularSequence analysisAdd BLAST29
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 236CytoplasmicSequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 280ExtracellularSequence analysisAdd BLAST23
Transmembranei281 – 303Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini304 – 328CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700291 – 328P2Y purinoceptor 6Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 177PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9ERK9
PaxDbiQ9ERK9
PRIDEiQ9ERK9

PTM databases

PhosphoSitePlusiQ9ERK9

Expressioni

Gene expression databases

BgeeiENSMUSG00000048779
CleanExiMM_P2RY6
ExpressionAtlasiQ9ERK9 baseline and differential
GenevisibleiQ9ERK9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055697

Structurei

3D structure databases

ProteinModelPortaliQ9ERK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJR4 Eukaryota
ENOG410YAZW LUCA
GeneTreeiENSGT00910000144002
HOGENOMiHOG000231307
HOVERGENiHBG101120
InParanoidiQ9ERK9
KOiK04272
OMAiILFYFTQ
OrthoDBiEOG091G0DD3
PhylomeDBiQ9ERK9
TreeFamiTF330775

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001973 P2Y6_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01068 P2Y6PRNOCPTR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ERK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQDNGTIQA PGLPPTTCVY REDFKRLLLT PVYSVVLVVG LPLNICVIAQ
60 70 80 90 100
ICASRRTLTR SAVYTLNLAL ADLMYACSLP LLIYNYARGD HWPFGDLACR
110 120 130 140 150
FVRFLFYANL HGSILFLTCI SFQRYLGICH PLASWHKRGG RRAAWVVCGV
160 170 180 190 200
VWLAVTAQCL PTAVFAATGI QRNRTVCYDL SPPILSTRYL PYGMALTVIG
210 220 230 240 250
FLLPFIALLA CYCRMARRLC RQDGPAGPVA QERRSKAARM AVVVAAVFAI
260 270 280 290 300
SFLPFHITKT AYLAVRSTPG VSCPVLETFA AAYKGTRPFA SVNSVLDPIL
310 320
FYFTQQKFRR QPHDLLQRLT AKWQRQRV
Length:328
Mass (Da):36,721
Last modified:March 1, 2001 - v1
Checksum:i00F9DF5ADADF903E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298899 Genomic DNA Translation: AAG24619.1
BC027331 mRNA Translation: AAH27331.1
BC064095 mRNA Translation: AAH64095.1
CCDSiCCDS21507.1
RefSeqiNP_898991.1, NM_183168.2
XP_006507703.1, XM_006507640.3
XP_011240041.1, XM_011241739.2
UniGeneiMm.235193

Genome annotation databases

EnsembliENSMUST00000060174; ENSMUSP00000055697; ENSMUSG00000048779
GeneIDi233571
KEGGimmu:233571
UCSCiuc009inw.2 mouse

Similar proteinsi

Entry informationi

Entry nameiP2RY6_MOUSE
AccessioniPrimary (citable) accession number: Q9ERK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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