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Q9ERK9 (P2RY6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P2Y purinoceptor 6

Short name=P2Y6
Gene names
Name:P2ry6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328P2Y purinoceptor 6
PRO_0000070029

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 4821Helical; Name=1; Potential
Topological domain49 – 6214Cytoplasmic Potential
Transmembrane63 – 8321Helical; Name=2; Potential
Topological domain84 – 10118Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 14422Cytoplasmic Potential
Transmembrane145 – 16521Helical; Name=4; Potential
Topological domain166 – 19429Extracellular Potential
Transmembrane195 – 21521Helical; Name=5; Potential
Topological domain216 – 23621Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 28023Extracellular Potential
Transmembrane281 – 30323Helical; Name=7; Potential
Topological domain304 – 32825Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 177 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ERK9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 00F9DF5ADADF903E

FASTA32836,721
        10         20         30         40         50         60 
MEQDNGTIQA PGLPPTTCVY REDFKRLLLT PVYSVVLVVG LPLNICVIAQ ICASRRTLTR 

        70         80         90        100        110        120 
SAVYTLNLAL ADLMYACSLP LLIYNYARGD HWPFGDLACR FVRFLFYANL HGSILFLTCI 

       130        140        150        160        170        180 
SFQRYLGICH PLASWHKRGG RRAAWVVCGV VWLAVTAQCL PTAVFAATGI QRNRTVCYDL 

       190        200        210        220        230        240 
SPPILSTRYL PYGMALTVIG FLLPFIALLA CYCRMARRLC RQDGPAGPVA QERRSKAARM 

       250        260        270        280        290        300 
AVVVAAVFAI SFLPFHITKT AYLAVRSTPG VSCPVLETFA AAYKGTRPFA SVNSVLDPIL 

       310        320 
FYFTQQKFRR QPHDLLQRLT AKWQRQRV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder."
Lazarowski E.R., Rochelle L.G., O'Neal W.K., Ribeiro C.M.P., Grubb B.R., Zhang V., Harden T.K., Boucher R.C.
J. Pharmacol. Exp. Ther. 297:43-49(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/SvEv.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF298899 Genomic DNA. Translation: AAG24619.1.
BC027331 mRNA. Translation: AAH27331.1.
BC064095 mRNA. Translation: AAH64095.1.
CCDSCCDS21507.1.
RefSeqNP_898991.1. NM_183168.2.
XP_006507703.1. XM_006507640.1.
UniGeneMm.235193.

3D structure databases

ProteinModelPortalQ9ERK9.
SMRQ9ERK9. Positions 27-310.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY326.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbQ9ERK9.
PRIDEQ9ERK9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000060174; ENSMUSP00000055697; ENSMUSG00000048779.
GeneID233571.
KEGGmmu:233571.
UCSCuc009inw.2. mouse.

Organism-specific databases

CTD5031.
MGIMGI:2673874. P2ry6.

Phylogenomic databases

eggNOGNOG149481.
GeneTreeENSGT00750000117601.
HOGENOMHOG000231307.
HOVERGENHBG101120.
InParanoidQ9ERK9.
KOK04272.
OMAFQRYLGI.
OrthoDBEOG7P2XSD.
PhylomeDBQ9ERK9.
TreeFamTF330775.

Gene expression databases

ArrayExpressQ9ERK9.
BgeeQ9ERK9.
CleanExMM_P2RY6.
GenevestigatorQ9ERK9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
[Graphical view]
PANTHERPTHR24231:SF16. PTHR24231:SF16. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio381764.
PROQ9ERK9.
SOURCESearch...

Entry information

Entry nameP2RY6_MOUSE
AccessionPrimary (citable) accession number: Q9ERK9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries