Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Exportin-2

Gene

Cse1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-2
Short name:
Exp2
Alternative name(s):
Chromosome segregation 1-like protein
Importin-alpha re-exporter
Gene namesi
Name:Cse1l
Synonyms:Xpo2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1339951. Cse1l.

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: Shuttles between the nucleus and the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 971971Exportin-2PRO_0000117288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei112 – 1121PhosphoserineBy similarity
Modified residuei574 – 5741N6-acetyllysineBy similarity
Modified residuei824 – 8241N6-acetyllysineBy similarity
Modified residuei931 – 9311PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9ERK4.
MaxQBiQ9ERK4.
PaxDbiQ9ERK4.
PeptideAtlasiQ9ERK4.
PRIDEiQ9ERK4.

PTM databases

iPTMnetiQ9ERK4.
PhosphoSiteiQ9ERK4.
SwissPalmiQ9ERK4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002718.
CleanExiMM_CSE1L.
ExpressionAtlasiQ9ERK4. baseline and differential.
GenevisibleiQ9ERK4. MM.

Interactioni

Subunit structurei

Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi225874. 6 interactions.
IntActiQ9ERK4. 6 interactions.
MINTiMINT-4092081.
STRINGi10090.ENSMUSP00000002790.

Structurei

3D structure databases

ProteinModelPortaliQ9ERK4.
SMRiQ9ERK4. Positions 6-934.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 10274Importin N-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the XPO2/CSE1 family.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1992. Eukaryota.
COG5657. LUCA.
GeneTreeiENSGT00550000074884.
HOGENOMiHOG000201317.
HOVERGENiHBG080050.
InParanoidiQ9ERK4.
KOiK18423.
OMAiSGQVEKK.
OrthoDBiEOG091G01TH.
PhylomeDBiQ9ERK4.
TreeFamiTF300473.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR005043. CAS_CSE1_C.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03378. CAS_CSE1. 1 hit.
PF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL
60 70 80 90 100
EKSQDNVIKV CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM
110 120 130 140 150
LSSPEQIQKQ LSDAISIIGR EDFPQKWPDL LTEMVNRFQS GDFHVINGVL
160 170 180 190 200
RTAHSLFKRY RHEFKSNELW TEIKLVLDAF ALPLTNLFKA TIELCSTHAN
210 220 230 240 250
DASALRILFS SLILISKLFY SLNFQDLPEF FEDNMETWMN NFHTLLTLDN
260 270 280 290 300
KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQRYL PRFVTAIWNL
310 320 330 340 350
LVTTGREVKY DLLVSNAIQF LASVCERPHY KNLFEDQNTL TSICEKVIVP
360 370 380 390 400
NMEFRAADEE AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP
410 420 430 440 450
VTGIFSGYVN SMLQEYAKNP SVNWKHKDAA IYLVTSLASK AQTQKHGITQ
460 470 480 490 500
ANELVNLTEF FVNHILPDLK SNNVNEFPVL KADGIKYIMI FRNQVPKEHL
510 520 530 540 550
LVSIPLLISH LEAESIVVHT YAAHALERLF TMRGSNNTTL FTAAEIAPFV
560 570 580 590 600
EILLTNLFKA LTLPGSSENE YIMKAIMRSF SLLQEAIIPY IPTLITQLTQ
610 620 630 640 650
KLLAVSKNPS KPHFNHYMFE AICLSIRITC KANPAAVVNF EEALFLVFTE
660 670 680 690 700
ILQNDVQEFI PYVFQVMSLL LETHKNDIPS SYMALFPHLL QPVLWERTGN
710 720 730 740 750
IPALVRLLQA FLERGSSTIA TAAADKIPGL LGVFQKLIAS KANDHQGFYL
760 770 780 790 800
LNSIIEHMPP ESVDQYRKQI FILLFQRLQN SKTTKFIKSF LVFINLYCIK
810 820 830 840 850
YGALALQEIF DGIQPKMFGM VLEKIIIPEI QKVSGNVEKK ICAVGITKLL
860 870 880 890 900
TECPPMMDTE YTKLWTPLLQ SLIGLFELPE DDSIPDEEHF IDIEDTPGYQ
910 920 930 940 950
TAFSQLAFAG KKEHDPVGQM VNNPKIHLAQ SLHKLSTACP GRVPSMVSTS
960 970
LNAEALQYLQ GYLQAASVTL L
Length:971
Mass (Da):110,455
Last modified:March 1, 2001 - v1
Checksum:i041335E17593F3F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301152 mRNA. Translation: AAG24636.1.
CCDSiCCDS17092.1.
RefSeqiNP_076054.1. NM_023565.3.
UniGeneiMm.22417.

Genome annotation databases

EnsembliENSMUST00000002790; ENSMUSP00000002790; ENSMUSG00000002718.
GeneIDi110750.
KEGGimmu:110750.
UCSCiuc008nys.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301152 mRNA. Translation: AAG24636.1.
CCDSiCCDS17092.1.
RefSeqiNP_076054.1. NM_023565.3.
UniGeneiMm.22417.

3D structure databases

ProteinModelPortaliQ9ERK4.
SMRiQ9ERK4. Positions 6-934.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225874. 6 interactions.
IntActiQ9ERK4. 6 interactions.
MINTiMINT-4092081.
STRINGi10090.ENSMUSP00000002790.

PTM databases

iPTMnetiQ9ERK4.
PhosphoSiteiQ9ERK4.
SwissPalmiQ9ERK4.

Proteomic databases

EPDiQ9ERK4.
MaxQBiQ9ERK4.
PaxDbiQ9ERK4.
PeptideAtlasiQ9ERK4.
PRIDEiQ9ERK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002790; ENSMUSP00000002790; ENSMUSG00000002718.
GeneIDi110750.
KEGGimmu:110750.
UCSCiuc008nys.2. mouse.

Organism-specific databases

CTDi1434.
MGIiMGI:1339951. Cse1l.

Phylogenomic databases

eggNOGiKOG1992. Eukaryota.
COG5657. LUCA.
GeneTreeiENSGT00550000074884.
HOGENOMiHOG000201317.
HOVERGENiHBG080050.
InParanoidiQ9ERK4.
KOiK18423.
OMAiSGQVEKK.
OrthoDBiEOG091G01TH.
PhylomeDBiQ9ERK4.
TreeFamiTF300473.

Miscellaneous databases

PROiQ9ERK4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002718.
CleanExiMM_CSE1L.
ExpressionAtlasiQ9ERK4. baseline and differential.
GenevisibleiQ9ERK4. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR005043. CAS_CSE1_C.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03378. CAS_CSE1. 1 hit.
PF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXPO2_MOUSE
AccessioniPrimary (citable) accession number: Q9ERK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.