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Protein

Receptor-interacting serine/threonine-protein kinase 4

Gene

Ripk4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in stratified epithelial development (By similarity). It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.By similarity2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51ATPPROSITE-ProRule annotation1
Active sitei143Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 36ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-interacting serine/threonine-protein kinase 4 (EC:2.7.11.1)
Alternative name(s):
Ankyrin repeat domain-containing protein 3
PKC-associated protein kinase
PKC-regulated protein kinase
Gene namesi
Name:Ripk4
Synonyms:Ankrd3, Pkk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1919638 Ripk4

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002737261 – 786Receptor-interacting serine/threonine-protein kinase 4Add BLAST786

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki51Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki145Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

May be phosphorylated by MAP3K2 and MAP3K3.2 Publications
Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-342 and Asp-380.1 Publication
Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei342 – 343Cleavage1 Publication2
Sitei380 – 381Cleavage1 Publication2

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9ERK0
PRIDEiQ9ERK0

PTM databases

iPTMnetiQ9ERK0
PhosphoSitePlusiQ9ERK0

Expressioni

Tissue specificityi

Ubiquitously expressed, with an abundant expression in the thymus, bone marrow, pro-B, pre-B and immature B cells and a weak expression in the spleen.1 Publication

Developmental stagei

Expressed at 10.5 dpc at diverse locations including the embryonic forebrain, otic vesicle, branchial arches, primitive gut, and genitourinary system. Transient expression in the ventral neural tube at 12.5 dpc. By 14.5 dpc, strong expression throughout the gastrointestinal tract was observed in the luminal tissues of the esophagus, stomach, duodenum, and intestines, as well as transient expression in the skin. Not expressed in kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000005251
CleanExiMM_RIPK4
ExpressionAtlasiQ9ERK0 baseline and differential
GenevisibleiQ9ERK0 MM

Interactioni

Subunit structurei

Interacts with PRKCB. Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF7Q6Q0C02EBI-6116422,EBI-307556From Homo sapiens.

Protein-protein interaction databases

IntActiQ9ERK0, 2 interactors
MINTiQ9ERK0
STRINGi10090.ENSMUSP00000019386

Structurei

3D structure databases

ProteinModelPortaliQ9ERK0
SMRiQ9ERK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST265
Repeati439 – 468ANK 1Add BLAST30
Repeati472 – 501ANK 2Add BLAST30
Repeati505 – 534ANK 3Add BLAST30
Repeati538 – 567ANK 4Add BLAST30
Repeati571 – 601ANK 5Add BLAST31
Repeati605 – 634ANK 6Add BLAST30
Repeati638 – 667ANK 7Add BLAST30
Repeati671 – 700ANK 8Add BLAST30
Repeati704 – 734ANK 9Add BLAST31
Repeati736 – 765ANK 10Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi305 – 392Ser-richAdd BLAST88

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
KOG0504 Eukaryota
COG0515 LUCA
COG0666 LUCA
GeneTreeiENSGT00550000074536
HOGENOMiHOG000294086
HOVERGENiHBG061582
InParanoidiQ9ERK0
KOiK08848
OMAiACQHGQE
OrthoDBiEOG091G0505
PhylomeDBiQ9ERK0
TreeFamiTF106506

Family and domain databases

CDDicd00204 ANK, 3 hits
Gene3Di1.25.40.20, 4 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12796 Ank_2, 3 hits
PF00069 Pkinase, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 10 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ERK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGEGRGRWA LGLLRTFDAG EFAGWEKVGS GGFGQVYKVR HVHWKTWLAI
60 70 80 90 100
KCSPSLHVDD RERMELLEEA KKMEMAKFRY ILPVYGICQE PVGLVMEYME
110 120 130 140 150
TGSLEKLLAS EPLPWDLRFR IVHETAVGMN FLHCMSPPLL HLDLKPANIL
160 170 180 190 200
LDAHYHVKIS DFGLAKCNGM SHSHDLSMDG LFGTIAYLPP ERIREKSRLF
210 220 230 240 250
DTKHDVYSFA IVIWGVLTQK KPFADEKNIL HIMMKVVKGH RPELPPICRP
260 270 280 290 300
RPRACASLIG LMQRCWHADP QVRPTFQEIT SETEDLCEKP DEEVKDLAHE
310 320 330 340 350
PGEKSSLESK SEARPESSRL KRASAPPFDN DCSLSELLSQ LDSGISQTLE
360 370 380 390 400
GPEELSRSSS ECKLPSSSSG KRLSGVSSVD SAFSSRGSLS LSFEREASTG
410 420 430 440 450
DLGPTDIQKK KLVDAIISGD TSRLMKILQP QDVDLVLDSS ASLLHLAVEA
460 470 480 490 500
GQEECVKWLL LNNANPNLTN RKGSTPLHMA VERKGRGIVE LLLARKTSVN
510 520 530 540 550
AKDEDQWTAL HFAAQNGDEA STRLLLEKNA SVNEVDFEGR TPMHVACQHG
560 570 580 590 600
QENIVRTLLR RGVDVGLQGK DAWLPLHYAA WQGHLPIVKL LAKQPGVSVN
610 620 630 640 650
AQTLDGRTPL HLAAQRGHYR VARILIDLCS DVNICSLQAQ TPLHVAAETG
660 670 680 690 700
HTSTARLLLH RGAGKEALTS EGYTALHLAA QNGHLATVKL LIEEKADVMA
710 720 730 740 750
RGPLNQTALH LAAARGHSEV VEELVSADLI DLSDEQGLSA LHLAAQGRHS
760 770 780
QTVETLLKHG AHINLQSLKF QGGQSSAATL LRRSKT
Length:786
Mass (Da):86,613
Last modified:March 1, 2002 - v2
Checksum:i66CE2C25EE96A40C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti718S → T in BAE26294 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302127 mRNA Translation: AAG30871.2
AK145203 mRNA Translation: BAE26294.1
BC057871 mRNA Translation: AAH57871.1
CCDSiCCDS28360.1
RefSeqiNP_076152.2, NM_023663.6
UniGeneiMm.35290

Genome annotation databases

EnsembliENSMUST00000019386; ENSMUSP00000019386; ENSMUSG00000005251
GeneIDi72388
KEGGimmu:72388
UCSCiuc008adn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRIPK4_MOUSE
AccessioniPrimary (citable) accession number: Q9ERK0
Secondary accession number(s): Q3UM04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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