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Protein

Retinol dehydrogenase 14

Gene

Rdh14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei190SubstrateBy similarity1
Active sitei215Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 57NADPBy similarity7

GO - Molecular functioni

  • alcohol dehydrogenase (NADP+) activity Source: MGI

GO - Biological processi

  • retinol metabolic process Source: MGI

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-5365859 RA biosynthesis pathway

Chemistry databases

SwissLipidsiSLP:000001820

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 14 (EC:1.1.1.-)
Alternative name(s):
Alcohol dehydrogenase PAN2
Gene namesi
Name:Rdh14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1920402 Rdh14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547711 – 334Retinol dehydrogenase 14Add BLAST334

Proteomic databases

EPDiQ9ERI6
MaxQBiQ9ERI6
PaxDbiQ9ERI6
PeptideAtlasiQ9ERI6
PRIDEiQ9ERI6

PTM databases

iPTMnetiQ9ERI6
PhosphoSitePlusiQ9ERI6
SwissPalmiQ9ERI6

Expressioni

Gene expression databases

BgeeiENSMUSG00000020621
CleanExiMM_RDH14
GenevisibleiQ9ERI6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020947

Structurei

3D structure databases

ProteinModelPortaliQ9ERI6
SMRiQ9ERI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1208 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00760000119068
HOVERGENiHBG078800
InParanoidiQ9ERI6
KOiK11162
OMAiIMGCRDR
OrthoDBiEOG091G0FGA
PhylomeDBiQ9ERI6
TreeFamiTF105429

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ERI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVASVAAAL LAALGGALWL AARRFSGPRN QRQQGGGDPG LMHGKTVLIT
60 70 80 90 100
GANSGLGRAT AAELLRLGAR VIMGCRDRAR AEEAAGQLRQ ELCQAGGAGP
110 120 130 140 150
DGTDGQLVVK ELDLASLRSV RAFCQELLQE EPRLDVLINN AGVFHCPYTK
160 170 180 190 200
TEDGFEMQFG VNHLGHFLLT NLLLGLLKSS APSRIVVVSS KLYKYGEINF
210 220 230 240 250
EDLNSEQSYN KSFCYSRSKL ANILFTRELA RRLEGTNVTV NVLHPGIVRT
260 270 280 290 300
NLGRHIHIPL LARPLFNLVS WAFFKTPLEG AQTSIYLACS PDVEGVSGRY
310 320 330
FGDCKEEELL PKAMDESVAR KLWDISEVMV GILK
Length:334
Mass (Da):36,366
Last modified:March 1, 2001 - v1
Checksum:iA05653655E70802D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303831 mRNA Translation: AAG30904.1
BC020094 mRNA Translation: AAH20094.1
CCDSiCCDS25811.1
RefSeqiNP_076186.1, NM_023697.2
UniGeneiMm.119343

Genome annotation databases

EnsembliENSMUST00000020947; ENSMUSP00000020947; ENSMUSG00000020621
GeneIDi105014
KEGGimmu:105014
UCSCiuc007nar.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRDH14_MOUSE
AccessioniPrimary (citable) accession number: Q9ERI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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