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Protein

Retinol dehydrogenase 14

Gene

Rdh14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei190 – 1901SubstrateBy similarity
Active sitei215 – 2151Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 577NADPBy similarity

GO - Molecular functioni

  • alcohol dehydrogenase (NADP+) activity Source: MGI

GO - Biological processi

  • osteoblast differentiation Source: MGI
  • retinol metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-MMU-5365859. RA biosynthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 14 (EC:1.1.1.-)
Alternative name(s):
Alcohol dehydrogenase PAN2
Gene namesi
Name:Rdh14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1920402. Rdh14.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • lysosomal membrane Source: MGI
  • membrane Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Retinol dehydrogenase 14PRO_0000054771Add
BLAST

Proteomic databases

EPDiQ9ERI6.
MaxQBiQ9ERI6.
PaxDbiQ9ERI6.
PRIDEiQ9ERI6.

PTM databases

PhosphoSiteiQ9ERI6.

Expressioni

Gene expression databases

BgeeiQ9ERI6.
CleanExiMM_RDH14.
GenevisibleiQ9ERI6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020947.

Structurei

3D structure databases

ProteinModelPortaliQ9ERI6.
SMRiQ9ERI6. Positions 45-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG078800.
InParanoidiQ9ERI6.
KOiK11162.
OMAiGDPGLMH.
OrthoDBiEOG73Z2TK.
PhylomeDBiQ9ERI6.
TreeFamiTF105429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ERI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVASVAAAL LAALGGALWL AARRFSGPRN QRQQGGGDPG LMHGKTVLIT
60 70 80 90 100
GANSGLGRAT AAELLRLGAR VIMGCRDRAR AEEAAGQLRQ ELCQAGGAGP
110 120 130 140 150
DGTDGQLVVK ELDLASLRSV RAFCQELLQE EPRLDVLINN AGVFHCPYTK
160 170 180 190 200
TEDGFEMQFG VNHLGHFLLT NLLLGLLKSS APSRIVVVSS KLYKYGEINF
210 220 230 240 250
EDLNSEQSYN KSFCYSRSKL ANILFTRELA RRLEGTNVTV NVLHPGIVRT
260 270 280 290 300
NLGRHIHIPL LARPLFNLVS WAFFKTPLEG AQTSIYLACS PDVEGVSGRY
310 320 330
FGDCKEEELL PKAMDESVAR KLWDISEVMV GILK
Length:334
Mass (Da):36,366
Last modified:March 1, 2001 - v1
Checksum:iA05653655E70802D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303831 mRNA. Translation: AAG30904.1.
BC020094 mRNA. Translation: AAH20094.1.
CCDSiCCDS25811.1.
RefSeqiNP_076186.1. NM_023697.2.
UniGeneiMm.119343.

Genome annotation databases

EnsembliENSMUST00000020947; ENSMUSP00000020947; ENSMUSG00000020621.
GeneIDi105014.
KEGGimmu:105014.
UCSCiuc007nar.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303831 mRNA. Translation: AAG30904.1.
BC020094 mRNA. Translation: AAH20094.1.
CCDSiCCDS25811.1.
RefSeqiNP_076186.1. NM_023697.2.
UniGeneiMm.119343.

3D structure databases

ProteinModelPortaliQ9ERI6.
SMRiQ9ERI6. Positions 45-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020947.

PTM databases

PhosphoSiteiQ9ERI6.

Proteomic databases

EPDiQ9ERI6.
MaxQBiQ9ERI6.
PaxDbiQ9ERI6.
PRIDEiQ9ERI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020947; ENSMUSP00000020947; ENSMUSG00000020621.
GeneIDi105014.
KEGGimmu:105014.
UCSCiuc007nar.2. mouse.

Organism-specific databases

CTDi57665.
MGIiMGI:1920402. Rdh14.

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG078800.
InParanoidiQ9ERI6.
KOiK11162.
OMAiGDPGLMH.
OrthoDBiEOG73Z2TK.
PhylomeDBiQ9ERI6.
TreeFamiTF105429.

Enzyme and pathway databases

ReactomeiR-MMU-5365859. RA biosynthesis pathway.

Miscellaneous databases

NextBioi357402.
PROiQ9ERI6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ERI6.
CleanExiMM_RDH14.
GenevisibleiQ9ERI6. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse Pan2 cDNA: a novel member of the short chain alcohol dehydrogenase superfamily."
    Li K.X., Brereton P.S., Obeyesekere V.R., Krozowski Z.S.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Fetus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiRDH14_MOUSE
AccessioniPrimary (citable) accession number: Q9ERI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2001
Last modified: April 13, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.