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Q9ERH6

- MOAP1_MOUSE

UniProt

Q9ERH6 - MOAP1_MOUSE

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Protein

Modulator of apoptosis 1

Gene

Moap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation By similarity.By similarity

GO - Biological processi

  1. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  2. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  3. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  4. positive regulation of apoptotic process Source: Ensembl
  5. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
  6. protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Modulator of apoptosis 1
Short name:
MAP-1
Gene namesi
Name:Moap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1915555. Moap1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. mitochondrial outer membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Modulator of apoptosis 1PRO_0000155207Add
BLAST

Post-translational modificationi

Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9ERH6.
PaxDbiQ9ERH6.
PRIDEiQ9ERH6.

PTM databases

PhosphoSiteiQ9ERH6.

Expressioni

Tissue specificityi

Widely expressed, including in the brain. High expression levels in testis.1 Publication

Gene expression databases

BgeeiQ9ERH6.
CleanExiMM_MOAP1.
GenevestigatoriQ9ERH6.

Interactioni

Subunit structurei

Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization By similarity. Interacts with TRIM39 By similarity. Interacts with RASSF6.By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043336.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni120 – 1278BH3-like
Regioni204 – 2074RASSF1-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi335 – 3406Poly-Glu

Domaini

The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction By similarity.By similarity

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

eggNOGiNOG145999.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000013079.
HOVERGENiHBG052488.
InParanoidiQ9ERH6.
OMAiIPEMWAP.
OrthoDBiEOG708VZW.
PhylomeDBiQ9ERH6.
TreeFamiTF335054.

Family and domain databases

InterProiIPR026523. PNMA.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 1 hit.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLRLLEDWC RGMDMNPRKA LLVAGIPPTC GVADIEEALQ AGLAPLGEHR
60 70 80 90 100
LLGRMFRRDE NKNVALIGLT VETGSALVPK EIPAKGGVWR VIFKPPDTDS
110 120 130 140 150
DFLCRLNEFL KGEGMTMGEL TRVLGNRNDP LGLDPGIMIP EIRAPMLAQA
160 170 180 190 200
LNEALKPTLQ YLRYKKLSVF SGRDPPGPGE EEFESWMFHT SQVMKTWQVS
210 220 230 240 250
DVEKRRRLIE SLRGPAFEII RVLKINNPFI TVAECLKTLE TIFGIIDNPR
260 270 280 290 300
ALQVKYLTTY QKTDEKLSAY VLRLEPLLQK LVQKGAIEKE VVNQARLDQV
310 320 330 340 350
IAGAVHKSVR RELGLPEGSP APGLLQLLTL IKDKEAEEEE VLLQAELEGY

CT
Length:352
Mass (Da):39,404
Last modified:March 1, 2001 - v1
Checksum:i8F4630D080495D98
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571R → K in AAH55374. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305551 mRNA. Translation: AAG31787.1.
AK019599 mRNA. Translation: BAB31810.1.
BC014715 mRNA. Translation: AAH14715.1.
BC055374 mRNA. Translation: AAH55374.1.
CCDSiCCDS26122.1.
RefSeqiNP_001136409.1. NM_001142937.2.
NP_071718.1. NM_022323.7.
UniGeneiMm.291222.
Mm.489678.

Genome annotation databases

EnsembliENSMUST00000173760; ENSMUSP00000133459; ENSMUSG00000096458.
ENSMUST00000178384; ENSMUSP00000137010; ENSMUSG00000096458.
GeneIDi64113.
KEGGimmu:64113.
UCSCiuc011yqo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305551 mRNA. Translation: AAG31787.1 .
AK019599 mRNA. Translation: BAB31810.1 .
BC014715 mRNA. Translation: AAH14715.1 .
BC055374 mRNA. Translation: AAH55374.1 .
CCDSi CCDS26122.1.
RefSeqi NP_001136409.1. NM_001142937.2.
NP_071718.1. NM_022323.7.
UniGenei Mm.291222.
Mm.489678.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000043336.

PTM databases

PhosphoSitei Q9ERH6.

Proteomic databases

MaxQBi Q9ERH6.
PaxDbi Q9ERH6.
PRIDEi Q9ERH6.

Protocols and materials databases

DNASUi 64113.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000173760 ; ENSMUSP00000133459 ; ENSMUSG00000096458 .
ENSMUST00000178384 ; ENSMUSP00000137010 ; ENSMUSG00000096458 .
GeneIDi 64113.
KEGGi mmu:64113.
UCSCi uc011yqo.2. mouse.

Organism-specific databases

CTDi 64112.
MGIi MGI:1915555. Moap1.

Phylogenomic databases

eggNOGi NOG145999.
GeneTreei ENSGT00530000062986.
HOGENOMi HOG000013079.
HOVERGENi HBG052488.
InParanoidi Q9ERH6.
OMAi IPEMWAP.
OrthoDBi EOG708VZW.
PhylomeDBi Q9ERH6.
TreeFami TF335054.

Miscellaneous databases

NextBioi 319919.
PROi Q9ERH6.
SOURCEi Search...

Gene expression databases

Bgeei Q9ERH6.
CleanExi MM_MOAP1.
Genevestigatori Q9ERH6.

Family and domain databases

InterProi IPR026523. PNMA.
[Graphical view ]
PANTHERi PTHR23095. PTHR23095. 1 hit.
Pfami PF14893. PNMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains."
    Tan K.O., Tan K.M.L., Chan S.-L., Yee K.S.Y., Bevort M., Ang K.C., Yu V.C.
    J. Biol. Chem. 276:2802-2807(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6NCr.
    Tissue: Hematopoietic and Kidney.
  4. "RASSF6 is a novel member of the RASSF family of tumor suppressors."
    Allen N.P., Donninger H., Vos M.D., Eckfeld K., Hesson L., Gordon L., Birrer M.J., Latif F., Clark G.J.
    Oncogene 26:6203-6211(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RASSF6.
  5. "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner."
    Takaji M., Komatsu Y., Watakabe A., Hashikawa T., Yamamori T.
    Cereb. Cortex 19:2865-2879(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiMOAP1_MOUSE
AccessioniPrimary (citable) accession number: Q9ERH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3