Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WD repeat-containing protein 7

Gene

Wdr7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 7
Alternative name(s):
TGF-beta resistance-associated protein TRAG
Gene namesi
Name:Wdr7
Synonyms:Trag
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi619836. Wdr7.

Subcellular locationi

GO - Cellular componenti

  • synaptic vesicle Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14881488WD repeat-containing protein 7PRO_0000051355Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei935 – 9351PhosphoserineBy similarity
Modified residuei1454 – 14541PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ERH3.
PRIDEiQ9ERH3.

PTM databases

iPTMnetiQ9ERH3.
PhosphoSiteiQ9ERH3.
SwissPalmiQ9ERH3.

Expressioni

Gene expression databases

ExpressionAtlasiQ9ERH3. baseline and differential.
GenevisibleiQ9ERH3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025325.

Structurei

3D structure databases

ProteinModelPortaliQ9ERH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati17 – 5640WD 1Add
BLAST
Repeati62 – 10443WD 2Add
BLAST
Repeati156 – 19944WD 3Add
BLAST
Repeati324 – 36643WD 4Add
BLAST
Repeati404 – 44340WD 5Add
BLAST
Repeati462 – 50746WD 6Add
BLAST
Repeati558 – 59740WD 7Add
BLAST
Repeati1349 – 138840WD 8Add
BLAST
Repeati1390 – 143041WD 9Add
BLAST

Sequence similaritiesi

Contains 9 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4155. Eukaryota.
ENOG410XP1Z. LUCA.
GeneTreeiENSGT00520000055590.
HOGENOMiHOG000001566.
HOVERGENiHBG067501.
InParanoidiQ9ERH3.
PhylomeDBiQ9ERH3.
TreeFamiTF313196.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR016024. ARM-type_fold.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ERH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGNSLVLPI VLWGRKAPTH CISSILLTDD GGTIVTGCHD GQICLWDLSE
60 70 80 90 100
ELEVNPRALL FGHTAAITCL SKACASGDKQ YTVSASANGE MCLWDVNDGR
110 120 130 140 150
CIEFTKLACT HTGIQFYQFS VGNQREGRLL CHGHYPEILV VDATSLEVLY
160 170 180 190 200
SLVSKISPDW ISSMSIIRSH RTQEDTVVAL SVTGILKVWI VTSEISGLQD
210 220 230 240 250
TEPIFEEESK PIYCQNCQSL SFCAFTQRSL LVVCSKYWRV FDAGDYSLLC
260 270 280 290 300
SGPSEDGQTW TGGDFVSADK VIIWTENGQS YIYKLPASCL PASDSFRSDV
310 320 330 340 350
GKAVENLIPP VQHSLLDQKD RELVICPPVT RFFYGCKEYL HKLLIQGDSS
360 370 380 390 400
GRLSIWNIAD IADKQEANEG LKTTTCISLQ DAFDKLKPCP AGIIDQLSVI
410 420 430 440 450
PNSNEPLKVT ASVYIPAHGR LVCGREDGSI IIVPATQTAI VQLLQGEHML
460 470 480 490 500
RRGWPPHRTL RGHRNKVTCL LYPHQVSARY DQRYLISGGV DFSVIIWDIF
510 520 530 540 550
SGEMKHIFCV HGGEITQLLV PPENCSARVQ HCVCSVASDH SVGLLSLREK
560 570 580 590 600
KCIMLASRHL FPIQVIKWRP SDDYLVVGCT DGSVCVWQMD TGALDRCAMG
610 620 630 640 650
ITAVEILNAC DEAVPAAVDS LSHPAVNLKQ AMTRRSLAAL KNMAHHKLQT
660 670 680 690 700
LATNLLASEA SDKGNLPKYS HNSLMVQAIK TNLTDPDIHV LFFDVEALII
710 720 730 740 750
QLLTEEASRP NTALISPENL QKASGSSDKG GSFLTGKRAA VLFQQVKETI
760 770 780 790 800
KENIKEHLLD EEEDEEEVMR QRREESDPEY RASKSKPLTL LEYNLTMDTA
810 820 830 840 850
KLFMSCLHAW GLNEVLDEVC LDRLGMLKPH CTVSFGLLSR GGHMSLMLPG
860 870 880 890 900
YNQAAGKLLQ AKAEAGRKGP ATESVGKGTY TVSRAVTTQH LLSIISLANT
910 920 930 940 950
LMSMTNATFI GDHMKKGPTR PPRPGTPDLS KARDSPPASS NIVQGQIKQA
960 970 980 990 1000
AAPVSARSAA DHSGSASASP ALRTCFLVNE GWSQLAAMHC VMLPDLLGLG
1010 1020 1030 1040 1050
KFRPPLLEML ARRWQDRCLE VREAAQALLL AELRRIEQAG RKETIDTWAP
1060 1070 1080 1090 1100
YLPQYMDHVI SPGVTAEAMQ TMAAAPDASG PEAKVQEEEH DLVDDDITTG
1110 1120 1130 1140 1150
CLSSVPQMKK MSTSYEERRK QATAIVLLGV IGAEFGAEIE PPKLLTRPRS
1160 1170 1180 1190 1200
SSQIPEGFGL TSGGSNYSLA RHTCKALTFL LLQPPSPKLP PHSTIRRTAI
1210 1220 1230 1240 1250
DLIGRGFTVW EPYMDVSAVL MGLLELCADA EKQLANITMG LPLSPAADSA
1260 1270 1280 1290 1300
RSARHALSLI ATARPPAFIT TIAKEVHRHT ALAANTQSQQ SIHTTTLARA
1310 1320 1330 1340 1350
KGEILRVIEI LIEKMPTDVV DLLVEVMDII MYCLEGSLVK KKGLQECFPA
1360 1370 1380 1390 1400
ICRFYMVSYY ERSHRIAVGA RHGSVALYDI RTGKCQTIHG HKGPITAVSF
1410 1420 1430 1440 1450
APDGRYLATY SNTDSHISFW QMNTSLLGSI GMLNSAPQLR CIKTYQVPPV
1460 1470 1480
QPASPGSHNA LRLARLIWTS NRNVILMAHD GKEHRFMV
Length:1,488
Mass (Da):163,191
Last modified:March 1, 2001 - v1
Checksum:iA675E5A2F3C09803
GO
Isoform 2 (identifier: Q9ERH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     950-980: Missing.

Show »
Length:1,457
Mass (Da):160,193
Checksum:i5E4AEA13BCFF33B2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei950 – 98031Missing in isoform 2. 1 PublicationVSP_015276Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192379 mRNA. Translation: AAL03984.1.
AF305813 mRNA. Translation: AAG31140.1.
RefSeqiNP_076465.1. NM_023975.1. [Q9ERH3-1]
XP_008770393.1. XM_008772171.1. [Q9ERH3-1]
UniGeneiRn.211985.

Genome annotation databases

EnsembliENSRNOT00000025325; ENSRNOP00000025325; ENSRNOG00000018387. [Q9ERH3-1]
GeneIDi66031.
KEGGirno:66031.
UCSCiRGD:619836. rat. [Q9ERH3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192379 mRNA. Translation: AAL03984.1.
AF305813 mRNA. Translation: AAG31140.1.
RefSeqiNP_076465.1. NM_023975.1. [Q9ERH3-1]
XP_008770393.1. XM_008772171.1. [Q9ERH3-1]
UniGeneiRn.211985.

3D structure databases

ProteinModelPortaliQ9ERH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025325.

PTM databases

iPTMnetiQ9ERH3.
PhosphoSiteiQ9ERH3.
SwissPalmiQ9ERH3.

Proteomic databases

PaxDbiQ9ERH3.
PRIDEiQ9ERH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025325; ENSRNOP00000025325; ENSRNOG00000018387. [Q9ERH3-1]
GeneIDi66031.
KEGGirno:66031.
UCSCiRGD:619836. rat. [Q9ERH3-1]

Organism-specific databases

CTDi23335.
RGDi619836. Wdr7.

Phylogenomic databases

eggNOGiKOG4155. Eukaryota.
ENOG410XP1Z. LUCA.
GeneTreeiENSGT00520000055590.
HOGENOMiHOG000001566.
HOVERGENiHBG067501.
InParanoidiQ9ERH3.
PhylomeDBiQ9ERH3.
TreeFamiTF313196.

Miscellaneous databases

PROiQ9ERH3.

Gene expression databases

ExpressionAtlasiQ9ERH3. baseline and differential.
GenevisibleiQ9ERH3. RN.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR016024. ARM-type_fold.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TRAG: a novel gene associated with TGF-beta resistance."
    Sanders S., Thorgeirsson S.S.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWDR7_RAT
AccessioniPrimary (citable) accession number: Q9ERH3
Secondary accession number(s): Q920I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.