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Protein

C-Jun-amino-terminal kinase-interacting protein 2

Gene

Mapk8ip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • behavioral fear response Source: BHF-UCL
  • dendrite morphogenesis Source: BHF-UCL
  • excitatory postsynaptic potential Source: BHF-UCL
  • JNK cascade Source: MGI
  • MAPK cascade Source: MGI
  • mating behavior Source: BHF-UCL
  • nonassociative learning Source: BHF-UCL
  • positive regulation of stress-activated MAPK cascade Source: Ensembl
  • regulation of AMPA receptor activity Source: BHF-UCL
  • regulation of JNK cascade Source: UniProtKB
  • regulation of NMDA receptor activity Source: BHF-UCL
  • regulation of receptor activity Source: BHF-UCL
  • regulation of synaptic transmission, glutamatergic Source: BHF-UCL
  • social behavior Source: BHF-UCL

Names & Taxonomyi

Protein namesi
Recommended name:
C-Jun-amino-terminal kinase-interacting protein 2
Short name:
JIP-2
Short name:
JNK-interacting protein 2
Alternative name(s):
Islet-brain-2
Short name:
IB-2
JNK MAP kinase scaffold protein 2
Mitogen-activated protein kinase 8-interacting protein 2
Gene namesi
Name:Mapk8ip2
Synonyms:Ib2, Jip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1926555. Mapk8ip2.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002206321 – 830C-Jun-amino-terminal kinase-interacting protein 2Add BLAST830

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ERE9.
PaxDbiQ9ERE9.
PRIDEiQ9ERE9.

PTM databases

iPTMnetiQ9ERE9.
PhosphoSitePlusiQ9ERE9.

Expressioni

Tissue specificityi

Highly expressed in brain. Expressed in all neurons. Also expressed in testis, primarily in the epididymal epidermis.

Inductioni

Upon neuron differentiation.

Gene expression databases

BgeeiENSMUSG00000022619.
ExpressionAtlasiQ9ERE9. baseline and differential.
GenevisibleiQ9ERE9. MM.

Interactioni

Subunit structurei

Forms homo-or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely JNK1, JNK2, JNK3, MAP2K7, MAP3K10, MAP3K11, MAP3K12 and MAPK13 (By similarity). Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Binds the TPR motif-containing C-terminal of kinesin light chain. Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Interacts with DCLK2. Interacts with FGF13; enables the interaction with MAPK13 and may regulate the MAPK8IP2 scaffolding activity. Interacts with TIAM1 and TIAM2.By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • kinesin binding Source: UniProtKB
  • protein complex binding Source: Ensembl
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi208626. 3 interactors.
IntActiQ9ERE9. 7 interactors.
STRINGi10090.ENSMUSP00000023291.

Structurei

3D structure databases

ProteinModelPortaliQ9ERE9.
SMRiQ9ERE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini610 – 671SH3PROSITE-ProRule annotationAdd BLAST62
Domaini683 – 819PIDPROSITE-ProRule annotationAdd BLAST137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 278JNK-binding domain (JBD)Add BLAST168
Regioni242 – 504Necessary for interaction with FGF13By similarityAdd BLAST263

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 36Asp/Glu-rich (acidic)7
Compositional biasi85 – 104Asp/Glu-rich (acidic)Add BLAST20
Compositional biasi154 – 157Poly-Asn4
Compositional biasi282 – 293Ser-richAdd BLAST12
Compositional biasi420 – 437Pro-richAdd BLAST18
Compositional biasi472 – 487Asp/Glu-rich (acidic)Add BLAST16

Sequence similaritiesi

Belongs to the JIP scaffold family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG3775. Eukaryota.
ENOG410ZFRJ. LUCA.
GeneTreeiENSGT00390000003908.
HOGENOMiHOG000231470.
HOVERGENiHBG018568.
InParanoidiQ9ERE9.
KOiK04435.
OMAiHKHRPTT.
OrthoDBiEOG091G0T9G.
PhylomeDBiQ9ERE9.
TreeFamiTF325073.

Family and domain databases

CDDicd11942. SH3_JIP2. 1 hit.
Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR035637. JIP2_SH3.
IPR011993. PH-like_dom_sf.
IPR006020. PTB/PI_dom.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00640. PID. 1 hit.
PF14604. SH3_9. 1 hit.
SMARTiView protein in SMART
SM00462. PTB. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS01179. PID. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ERE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY
60 70 80 90 100
DSDHCEKDSL SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE DDEEEEEEEE
110 120 130 140 150
EEEDGDRQGK AGGGPGSQAL AGDSLIPSPS LEESHKLRPT TLHLTTLGAQ
160 170 180 190 200
DSLNNNNGGF TSAPPSSWQE TVLRSPAQEP LKELPAPLLP AEEERHEVQS
210 220 230 240 250
LARPGCDCEG NQPPEPPASS GGASPSSDPG IEADLRSHSS GGHEGRRSSQ
260 270 280 290 300
ELSSPGSDSE DAGGARLGRM ISSISETELE LSSDGGSSSG RSSHLTNSIE
310 320 330 340 350
EASSPASEPE PEPEPLHEPP RRPAFLPVGQ DDTNSEYESG SESEPDLSED
360 370 380 390 400
ADSPWLLSNL VSRMISEGSS PIRCPGQCLS PAPRLPEEAA SQANSVPQDC
410 420 430 440 450
QDPEAGPHVE LVDMDTLCGP PPPAPAAPRL GPAQPGPCLF LSNPTRDTIT
460 470 480 490 500
PLWATPGRTA RPGRSCSAAC SEEEEEDEEE DEEDEEDAED SVVPPGSRTT
510 520 530 540 550
GSTAPLDASL VYDAVKYTLV VDEHTQLELV SLRRCAGLGN DSEEDSSCEA
560 570 580 590 600
SEEEAGATLL GSDQVPEDAS PDSPDLTFSK KFLNVFVNST SRSSSTESFG
610 620 630 640 650
LFSCVVNGEE REQTHRAVFR FIPRHPDELE LDVDDPVLVE AEEDDFWFRG
660 670 680 690 700
FNMRTGERGV FPAFYAHAVP GPAKDLLGSK RSPCWVDRFD VQFLGSVEVP
710 720 730 740 750
CHQGNGILCA AMQKIATARK LTVHLRPPAS CDLEISLRGV KLSLSGGGPE
760 770 780 790 800
FQRCSHFFQM KNISFCGCHP RNSCYFGFIT KHPLLSRFAC HVFVSQESMR
810 820 830
PVARSVGRAF LEYYQEHLAF ACPTEDIYLE
Length:830
Mass (Da):89,900
Last modified:March 1, 2001 - v1
Checksum:i7EC8EAD19A90163C
GO

Sequence cautioni

The sequence AK014339 differs from that shown. Reason: Erroneous termination at position 701. Translated as Cys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216P → Q in AK014339 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF310135 mRNA. Translation: AAG31800.1.
AK014339 mRNA. No translation available.
CCDSiCCDS27752.1.
RefSeqiNP_068740.3. NM_021921.3.
UniGeneiMm.173337.
Mm.482169.

Genome annotation databases

EnsembliENSMUST00000023291; ENSMUSP00000023291; ENSMUSG00000022619.
GeneIDi60597.
KEGGimmu:60597.
UCSCiuc007xgx.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiJIP2_MOUSE
AccessioniPrimary (citable) accession number: Q9ERE9
Secondary accession number(s): Q9CXI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families