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Protein

Keratin, type II cuticular Hb1

Gene

Krt81

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb1By similarity
Alternative name(s):
Keratin-811 Publication
Short name:
K81
Type II hair keratin Hb1
Gene namesi
Name:Krt81Imported
Synonyms:Krt2-19Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1928858. Krt81.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Keratin, type II cuticular Hb1PRO_0000361690Add
BLAST

Proteomic databases

MaxQBiQ9ERE2.
PaxDbiQ9ERE2.
PRIDEiQ9ERE2.

PTM databases

PhosphoSiteiQ9ERE2.

Expressioni

Tissue specificityi

Expressed in dorsal skin.1 Publication

Gene expression databases

BgeeiQ9ERE2.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056525.

Structurei

3D structure databases

ProteinModelPortaliQ9ERE2.
SMRiQ9ERE2. Positions 106-254, 272-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 106106HeadBy similarityAdd
BLAST
Regioni107 – 413307RodBy similarityAdd
BLAST
Regioni107 – 14135Coil 1ABy similarityAdd
BLAST
Regioni142 – 15110Linker 1By similarity
Regioni152 – 252101Coil 1BBy similarityAdd
BLAST
Regioni253 – 26917Linker 12By similarityAdd
BLAST
Regioni270 – 413144Coil 2By similarityAdd
BLAST
Regioni414 – 48168TailBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence Analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG149039.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ9ERE2.
KOiK07605.
OMAiSCISACR.
OrthoDBiEOG7B05CW.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCGSGFCGR AFSCASACGP RPGRCCISAA PYRGISCYRG LSGGFGSQSV
60 70 80 90 100
CGAFRSGSCG RSFGYRSGGI CGPSPPCITT VSVNESLLTP LNLEIDPNAQ
110 120 130 140 150
CVKHEEKEQI KCLNSKFAAF IDKVRFLEQQ NKLLETKWQF YQNRKCCESN
160 170 180 190 200
MEPLFEGYIE ALRREAECVE ADSGRLAAEL NHAQESMEGY KKRYEEEVSL
210 220 230 240 250
RATAENEFVA LKKDVDCAYL RKSDLEANAE ALTQETDFLR RMYDEETRIL
260 270 280 290 300
HSHISDTSIV VKMDNSRDLN MDCVVAEIKA QYDDIASRSR AEAESWYRTK
310 320 330 340 350
CEEIKATVIR HGETLRRTRE EINELNRMIQ RLTAEIENAK CQNTKLEAAV
360 370 380 390 400
TQSEQQGEAA LADARCKLAE LEGALQKAKQ DMACLLKEYQ EVMNSKLGLD
410 420 430 440 450
VEITTYRRLL EGEEQRLCEG VGAVNVCVSS SRGGVVCGDL CVSGSRPVIG
460 470 480
SACSAPCSGN LAVNTGLCAP CGSAVSCGRK C
Length:481
Mass (Da):52,863
Last modified:October 16, 2013 - v2
Checksum:iDEF13B624C76C80A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103674 Genomic DNA. No translation available.
AC157583 Genomic DNA. No translation available.
AF312018 mRNA. Translation: AAG34120.1.
CCDSiCCDS49734.1.
RefSeqiNP_001159629.1. NM_001166157.1.
UniGeneiMm.347934.

Genome annotation databases

EnsembliENSMUST00000061185; ENSMUSP00000056525; ENSMUSG00000067615.
GeneIDi64818.
KEGGimmu:64818.
UCSCiuc007xth.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103674 Genomic DNA. No translation available.
AC157583 Genomic DNA. No translation available.
AF312018 mRNA. Translation: AAG34120.1.
CCDSiCCDS49734.1.
RefSeqiNP_001159629.1. NM_001166157.1.
UniGeneiMm.347934.

3D structure databases

ProteinModelPortaliQ9ERE2.
SMRiQ9ERE2. Positions 106-254, 272-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056525.

PTM databases

PhosphoSiteiQ9ERE2.

Proteomic databases

MaxQBiQ9ERE2.
PaxDbiQ9ERE2.
PRIDEiQ9ERE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061185; ENSMUSP00000056525; ENSMUSG00000067615.
GeneIDi64818.
KEGGimmu:64818.
UCSCiuc007xth.2. mouse.

Organism-specific databases

CTDi3887.
MGIiMGI:1928858. Krt81.

Phylogenomic databases

eggNOGiNOG149039.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ9ERE2.
KOiK07605.
OMAiSCISACR.
OrthoDBiEOG7B05CW.
TreeFamiTF317854.

Miscellaneous databases

NextBioi320191.
PROiQ9ERE2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ERE2.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Hague (Hag): a new mouse hair mutation with an unstable semidominant allele."
    Poirier C., Yoshiki A., Fujiwara K., Guenet J.-L., Kusakabe M.
    Genetics 162:831-840(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 92-481, TISSUE SPECIFICITY.
    Strain: C3H/HeNImported.
    Tissue: Dorsal skin1 Publication.

Entry informationi

Entry nameiKRT81_MOUSE
AccessioniPrimary (citable) accession number: Q9ERE2
Secondary accession number(s): E9QLY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 16, 2013
Last modified: July 22, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.