Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9ERE2 (KRT81_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type II cuticular Hb1
Alternative name(s):
Keratin-81
Short name=K81
Type II hair keratin Hb1
Gene names
Name:Krt81
Synonyms:Krt2-19
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins.

Tissue specificity

Expressed in dorsal skin. Ref.2

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from electronic annotation. Source: InterPro

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 481481Keratin, type II cuticular Hb1
PRO_0000361690

Regions

Region1 – 106106Head By similarity
Region107 – 413307Rod By similarity
Region107 – 14135Coil 1A By similarity
Region142 – 15110Linker 1 By similarity
Region152 – 252101Coil 1B By similarity
Region253 – 26917Linker 12 By similarity
Region270 – 413144Coil 2 By similarity
Region414 – 48168Tail By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ERE2 [UniParc].

Last modified October 16, 2013. Version 2.
Checksum: DEF13B624C76C80A

FASTA48152,863
        10         20         30         40         50         60 
MTCGSGFCGR AFSCASACGP RPGRCCISAA PYRGISCYRG LSGGFGSQSV CGAFRSGSCG 

        70         80         90        100        110        120 
RSFGYRSGGI CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKHEEKEQI KCLNSKFAAF 

       130        140        150        160        170        180 
IDKVRFLEQQ NKLLETKWQF YQNRKCCESN MEPLFEGYIE ALRREAECVE ADSGRLAAEL 

       190        200        210        220        230        240 
NHAQESMEGY KKRYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANAE ALTQETDFLR 

       250        260        270        280        290        300 
RMYDEETRIL HSHISDTSIV VKMDNSRDLN MDCVVAEIKA QYDDIASRSR AEAESWYRTK 

       310        320        330        340        350        360 
CEEIKATVIR HGETLRRTRE EINELNRMIQ RLTAEIENAK CQNTKLEAAV TQSEQQGEAA 

       370        380        390        400        410        420 
LADARCKLAE LEGALQKAKQ DMACLLKEYQ EVMNSKLGLD VEITTYRRLL EGEEQRLCEG 

       430        440        450        460        470        480 
VGAVNVCVSS SRGGVVCGDL CVSGSRPVIG SACSAPCSGN LAVNTGLCAP CGSAVSCGRK 


C 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"Hague (Hag): a new mouse hair mutation with an unstable semidominant allele."
Poirier C., Yoshiki A., Fujiwara K., Guenet J.-L., Kusakabe M.
Genetics 162:831-840(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 92-481, TISSUE SPECIFICITY.
Strain: C3H/HeN.
Tissue: Dorsal skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC103674 Genomic DNA. No translation available.
AC157583 Genomic DNA. No translation available.
AF312018 mRNA. Translation: AAG34120.1.
CCDSCCDS49734.1.
RefSeqNP_001159629.1. NM_001166157.1.
UniGeneMm.347934.

3D structure databases

ProteinModelPortalQ9ERE2.
SMRQ9ERE2. Positions 106-254, 272-412.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000056525.

PTM databases

PhosphoSiteQ9ERE2.

Proteomic databases

PaxDbQ9ERE2.
PRIDEQ9ERE2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061185; ENSMUSP00000056525; ENSMUSG00000067615.
GeneID64818.
KEGGmmu:64818.

Organism-specific databases

CTD3887.
MGIMGI:1928858. Krt81.

Phylogenomic databases

eggNOGNOG149039.
GeneTreeENSGT00670000097789.
HOGENOMHOG000230976.
HOVERGENHBG013015.
InParanoidQ9ERE2.
KOK07605.
OMANTETMME.
OrthoDBEOG7B05CW.
TreeFamTF317854.

Gene expression databases

BgeeQ9ERE2.
GenevestigatorQ9ERE2.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01276. TYPE2KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio320191.
SOURCESearch...

Entry information

Entry nameKRT81_MOUSE
AccessionPrimary (citable) accession number: Q9ERE2
Secondary accession number(s): E9QLY5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 16, 2013
Last modified: July 9, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot