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Protein

Keratin, type II cuticular Hb1

Gene

Krt81

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb1By similarity
Alternative name(s):
Keratin-811 Publication
Short name:
K81
Type II hair keratin Hb1
Gene namesi
Name:Krt81Imported
Synonyms:Krt2-19Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1928858 Krt81

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003616901 – 481Keratin, type II cuticular Hb1Add BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9ERE2
PaxDbiQ9ERE2
PeptideAtlasiQ9ERE2
PRIDEiQ9ERE2

PTM databases

iPTMnetiQ9ERE2
PhosphoSitePlusiQ9ERE2

Expressioni

Tissue specificityi

Expressed in dorsal skin.1 Publication

Gene expression databases

BgeeiENSMUSG00000067615
GenevisibleiQ9ERE2 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

BioGridi211105, 1 interactor
STRINGi10090.ENSMUSP00000056525

Structurei

3D structure databases

ProteinModelPortaliQ9ERE2
SMRiQ9ERE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 417IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 106HeadBy similarityAdd BLAST106
Regioni107 – 141Coil 1ABy similarityAdd BLAST35
Regioni142 – 151Linker 1By similarity10
Regioni152 – 252Coil 1BBy similarityAdd BLAST101
Regioni253 – 269Linker 12By similarityAdd BLAST17
Regioni270 – 413Coil 2By similarityAdd BLAST144
Regioni414 – 481TailBy similarityAdd BLAST68

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH1H Eukaryota
ENOG41113GZ LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ9ERE2
KOiK07605
OMAiCGFSTVG
OrthoDBiEOG091G06FG
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ERE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCGSGFCGR AFSCASACGP RPGRCCISAA PYRGISCYRG LSGGFGSQSV
60 70 80 90 100
CGAFRSGSCG RSFGYRSGGI CGPSPPCITT VSVNESLLTP LNLEIDPNAQ
110 120 130 140 150
CVKHEEKEQI KCLNSKFAAF IDKVRFLEQQ NKLLETKWQF YQNRKCCESN
160 170 180 190 200
MEPLFEGYIE ALRREAECVE ADSGRLAAEL NHAQESMEGY KKRYEEEVSL
210 220 230 240 250
RATAENEFVA LKKDVDCAYL RKSDLEANAE ALTQETDFLR RMYDEETRIL
260 270 280 290 300
HSHISDTSIV VKMDNSRDLN MDCVVAEIKA QYDDIASRSR AEAESWYRTK
310 320 330 340 350
CEEIKATVIR HGETLRRTRE EINELNRMIQ RLTAEIENAK CQNTKLEAAV
360 370 380 390 400
TQSEQQGEAA LADARCKLAE LEGALQKAKQ DMACLLKEYQ EVMNSKLGLD
410 420 430 440 450
VEITTYRRLL EGEEQRLCEG VGAVNVCVSS SRGGVVCGDL CVSGSRPVIG
460 470 480
SACSAPCSGN LAVNTGLCAP CGSAVSCGRK C
Length:481
Mass (Da):52,863
Last modified:October 16, 2013 - v2
Checksum:iDEF13B624C76C80A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103674 Genomic DNA No translation available.
AC157583 Genomic DNA No translation available.
AF312018 mRNA Translation: AAG34120.1
CCDSiCCDS49734.1
RefSeqiNP_001159629.1, NM_001166157.1
UniGeneiMm.347934

Genome annotation databases

EnsembliENSMUST00000061185; ENSMUSP00000056525; ENSMUSG00000067615
GeneIDi64818
KEGGimmu:64818
UCSCiuc007xth.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKRT81_MOUSE
AccessioniPrimary (citable) accession number: Q9ERE2
Secondary accession number(s): E9QLY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 16, 2013
Last modified: May 23, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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