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Protein

Gamma-parvin

Gene

Parvg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-parvin
Gene namesi
Name:Parvg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2158329. Parvg.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Gamma-parvinPRO_0000121586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9ERD8.
MaxQBiQ9ERD8.
PaxDbiQ9ERD8.
PRIDEiQ9ERD8.

PTM databases

iPTMnetiQ9ERD8.
PhosphoSiteiQ9ERD8.

Expressioni

Tissue specificityi

Expressed strongly in spleen and testis, moderately in lung and weakly in brain and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000022439.
CleanExiMM_PARVG.
ExpressionAtlasiQ9ERD8. baseline and differential.
GenevisibleiQ9ERD8. MM.

Interactioni

Subunit structurei

Interacts with integrin-linked protein kinase and actin.By similarity

Protein-protein interaction databases

BioGridi211027. 1 interaction.
IntActiQ9ERD8. 1 interaction.
STRINGi10090.ENSMUSP00000131443.

Structurei

3D structure databases

ProteinModelPortaliQ9ERD8.
SMRiQ9ERD8. Positions 197-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 151108CH 1PROSITE-ProRule annotationAdd
BLAST
Domaini210 – 317108CH 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the parvin family.Curated
Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3631. Eukaryota.
ENOG410XQWH. LUCA.
GeneTreeiENSGT00390000009673.
HOGENOMiHOG000247027.
HOVERGENiHBG053517.
InParanoidiQ9ERD8.
KOiK06275.
TreeFamiTF314025.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR028433. Parvin.
[Graphical view]
PANTHERiPTHR12114. PTHR12114. 1 hit.
PfamiPF00307. CH. 2 hits.
[Graphical view]
PIRSFiPIRSF039131. Parvin. 1 hit.
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS50021. CH. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELEFLYDLL QLPKEVAQPT EEELPRGGKK KYLSPNSKRN PKFEELQKVL
60 70 80 90 100
MEWINTTLLP EHIVVRSLEE DMFDGLILHH LFQKLASLKL EVEEISLTSA
110 120 130 140 150
SQRHKLGVIL EAVNQNLQVE EKQAKWSVET IFNKDLLATL HLLVALAKRF
160 170 180 190 200
QPDLPLPDNV QVEVIHIEST KTGLKSDKQV EQLTECKSHK DQPLQDAFDE
210 220 230 240 250
LFKLAPEKVH AVQEAIVSFV NQKLERLGLS VQSLDTQFAD GVILLLLIGQ
260 270 280 290 300
LEGFFLHLKE FYLTPSSPTE MLHNVTLALD LLKDEGLFSY PVNPEDIVNK
310 320 330
DAKSTLRILY SLFQKHSLRA EGGGAHHATP N
Length:331
Mass (Da):37,603
Last modified:July 27, 2011 - v2
Checksum:i4EEA891D144444F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31L → S in AAH11200 (PubMed:19468303).Curated
Sequence conflicti40 – 401N → S in AAG29542 (PubMed:11171322).Curated
Sequence conflicti259 – 2591K → T in AAH11200 (PubMed:19468303).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312712 mRNA. Translation: AAG29542.1.
AK040914 mRNA. Translation: BAC30741.1.
AK079881 mRNA. Translation: BAC37772.1.
AL626769 Genomic DNA. Translation: CAO78118.1.
BC011200 mRNA. Translation: AAH11200.1.
CCDSiCCDS27710.1.
RefSeqiNP_001155972.1. NM_001162500.1.
NP_071716.3. NM_022321.4.
XP_011244008.1. XM_011245706.1.
UniGeneiMm.251356.

Genome annotation databases

EnsembliENSMUST00000023074; ENSMUSP00000023074; ENSMUSG00000022439.
GeneIDi64099.
KEGGimmu:64099.
UCSCiuc007xbz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312712 mRNA. Translation: AAG29542.1.
AK040914 mRNA. Translation: BAC30741.1.
AK079881 mRNA. Translation: BAC37772.1.
AL626769 Genomic DNA. Translation: CAO78118.1.
BC011200 mRNA. Translation: AAH11200.1.
CCDSiCCDS27710.1.
RefSeqiNP_001155972.1. NM_001162500.1.
NP_071716.3. NM_022321.4.
XP_011244008.1. XM_011245706.1.
UniGeneiMm.251356.

3D structure databases

ProteinModelPortaliQ9ERD8.
SMRiQ9ERD8. Positions 197-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211027. 1 interaction.
IntActiQ9ERD8. 1 interaction.
STRINGi10090.ENSMUSP00000131443.

PTM databases

iPTMnetiQ9ERD8.
PhosphoSiteiQ9ERD8.

Proteomic databases

EPDiQ9ERD8.
MaxQBiQ9ERD8.
PaxDbiQ9ERD8.
PRIDEiQ9ERD8.

Protocols and materials databases

DNASUi64099.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023074; ENSMUSP00000023074; ENSMUSG00000022439.
GeneIDi64099.
KEGGimmu:64099.
UCSCiuc007xbz.2. mouse.

Organism-specific databases

CTDi64098.
MGIiMGI:2158329. Parvg.

Phylogenomic databases

eggNOGiKOG3631. Eukaryota.
ENOG410XQWH. LUCA.
GeneTreeiENSGT00390000009673.
HOGENOMiHOG000247027.
HOVERGENiHBG053517.
InParanoidiQ9ERD8.
KOiK06275.
TreeFamiTF314025.

Miscellaneous databases

PROiQ9ERD8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022439.
CleanExiMM_PARVG.
ExpressionAtlasiQ9ERD8. baseline and differential.
GenevisibleiQ9ERD8. MM.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR028433. Parvin.
[Graphical view]
PANTHERiPTHR12114. PTHR12114. 1 hit.
PfamiPF00307. CH. 2 hits.
[Graphical view]
PIRSFiPIRSF039131. Parvin. 1 hit.
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS50021. CH. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPARVG_MOUSE
AccessioniPrimary (citable) accession number: Q9ERD8
Secondary accession number(s): Q8BH45, Q91X89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.