Q9ERC3 (SRTD3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SERTA domain-containing protein 3

Alternative name(s):
Replication protein-binding trans-activator
Short name=RPA-binding trans-activator

Gene names

Name:	Sertad3
Synonyms:	Rbt1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Strong transcriptional co-activator By similarity.
Subunit structure	Interacts with RPA2 By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 SERTA domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of cell growth Inferred from sequence alignment PubMed 16098148. Source: MGI positive regulation of transcription, DNA-dependent Inferred from direct assay PubMed 16098148. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from sequence alignment PubMed 16098148. Source: MGI nucleus Inferred from sequence alignment PubMed 16098148. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	SERTA domain-containing protein 3		PRO_0000191616
Regions
	Domain	27 – 74	48	SERTA

Sequences

	Sequence		Length	Mass (Da)
	Q9ERC3 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: CFF6FA4C0A91D7E7	FASTA	197	21,935
	10 20 30 40 50 60 MGGLKRKHSD LEEEEEEEKW DWSPTALRSY QQALLRISLD KVQRSLGPRA PSLRRHVLIH 70 80 90 100 110 120 NTLQQLQAAI RLAPAPALPP EPLFLGEEDF SLSTTIGSIL RELDTSMDEM EPPLNPAASS 130 140 150 160 170 180 SPQNEIVSQA DPVFLEALSS RYLGDSGLDD FFLDIDTSAV EKDVALPPPE PPHSLFCSPG 190 SWEWNELDHI MEIILGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of mouse RBT1 cDNA." Cho J.M., Alaoui-Jamali M.A. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF317202 mRNA. Translation: AAG30951.1. BC034886 mRNA. Translation: AAH34886.1.
IPI	IPI00112201.
RefSeq	NP_573473.1. NM_133210.2.
UniGene	Mm.200120.
3D structure databases
ProteinModelPortal	Q9ERC3.
ModBase	Search...
PTM databases
PhosphoSite	Q9ERC3.
Proteomic databases
PRIDE	Q9ERC3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000068641; ENSMUSP00000068187; ENSMUSG00000055200.
GeneID	170742.
KEGG	mmu:170742.
Organism-specific databases
CTD	29946.
MGI	MGI:2180697. Sertad3.
Phylogenomic databases
eggNOG	NOG46358.
GeneTree	ENSGT00530000064099.
HOGENOM	HOG000133073.
HOVERGEN	HBG055009.
InParanoid	Q9ERC3.
OMA	EDEKWDW.
OrthoDB	EOG4V9TS2.
Gene expression databases
ArrayExpress	Q9ERC3.
Bgee	Q9ERC3.
CleanEx	MM_SERTAD3.
Genevestigator	Q9ERC3.
GermOnline	ENSMUSG00000055200. Mus musculus.
Family and domain databases
InterPro	IPR009263. SERTA. [Graphical view]
Pfam	PF06031. SERTA. 1 hit. [Graphical view]
PROSITE	PS51053. SERTA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	370302.
SOURCE	Search...

Entry information

Entry name

SRTD3_MOUSE

Accession

Primary (citable) accession number: Q9ERC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program