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Protein
Submitted name:

Neuropeptide Y/peptide YY-Y2 receptor

Gene

Npy2r

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • neuropeptide Y receptor activity Source: RGD
  • peptide YY receptor activity Source: RGD

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  • aging Source: RGD
  • behavioral fear response Source: RGD
  • cardiac left ventricle morphogenesis Source: Ensembl
  • negative regulation of cAMP biosynthetic process Source: RGD
  • negative regulation of excitatory postsynaptic potential Source: RGD
  • negative regulation of feeding behavior Source: RGD
  • negative regulation of neurological system process Source: RGD
  • negative regulation of secretion Source: RGD
  • negative regulation of synaptic transmission Source: RGD
  • negative regulation of synaptic transmission, glutamatergic Source: RGD
  • nitric oxide mediated signal transduction Source: RGD
  • outflow tract morphogenesis Source: Ensembl
  • positive regulation of cell-substrate adhesion Source: RGD
  • positive regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of dopamine secretion Source: RGD
  • positive regulation of peptide secretion Source: RGD
  • positive regulation of smooth muscle contraction Source: RGD
  • regulation of sensory perception of pain Source: RGD
  • secretion Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, NeuropeptideImported, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuropeptide Y/peptide YY-Y2 receptorImported
Submitted name:
Protein Npy2rImported
Submitted name:
RCG62488Imported
Gene namesi
Name:Npy2rImported
ORF Names:rCG_62488Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620475. Npy2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei54 – 7623HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Transmembranei128 – 14619HelicalSequence analysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence analysisAdd
BLAST
Transmembranei218 – 23922HelicalSequence analysisAdd
BLAST
Transmembranei269 – 29123HelicalSequence analysisAdd
BLAST
Transmembranei303 – 32422HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: RGD
  • intracellular Source: GOC
  • membrane Source: RGD
  • nonmotile primary cilium Source: Ensembl
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3309.
GuidetoPHARMACOLOGYi306.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067147.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 325259G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOVERGENiHBG105675.
KOiK04205.
OMAiEKSMYGT.
OrthoDBiEOG7P02JG.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001358. NPY2_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01014. NRPEPTIDEY2R.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLGAEADE NQTVEVKVEL YGSGPTTPRG ELPPDPEPEL IDSTKLVEVQ
60 70 80 90 100
VVLILAYCSI ILLGVVGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN
110 120 130 140 150
TLCLPFTLTY TLMGEWKMGP VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR
160 170 180 190 200
CIVYHLESKI SKQISFLIIG LAWGVSALLA SPLAIFREYS LIEIIPDFEI
210 220 230 240 250
VACTEKWPGE EKSVYGTVYS LSTLLILYVL PLGIISFSYT RIWSKLKNHV
260 270 280 290 300
SPGAASDHYH QRRHKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSHVLDL
310 320 330 340 350
KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH
360 370 380
SEVSMTFKAK KNLEVKKNNG LTDSFSEATN V
Length:381
Mass (Da):42,510
Last modified:March 1, 2001 - v1
Checksum:i659327904B288BC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07012007 Genomic DNA. No translation available.
AY004257 mRNA. Translation: AAF89094.1.
CH473976 Genomic DNA. Translation: EDM00847.1.
RefSeqiNP_076458.1. NM_023968.1.
XP_006232596.1. XM_006232534.2.
XP_008759335.1. XM_008761113.1.
UniGeneiRn.64505.

Genome annotation databases

EnsembliENSRNOT00000072029; ENSRNOP00000067147; ENSRNOG00000049213.
GeneIDi66024.
KEGGirno:66024.
UCSCiRGD:620475. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07012007 Genomic DNA. No translation available.
AY004257 mRNA. Translation: AAF89094.1.
CH473976 Genomic DNA. Translation: EDM00847.1.
RefSeqiNP_076458.1. NM_023968.1.
XP_006232596.1. XM_006232534.2.
XP_008759335.1. XM_008761113.1.
UniGeneiRn.64505.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067147.

Chemistry

ChEMBLiCHEMBL3309.
GuidetoPHARMACOLOGYi306.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000072029; ENSRNOP00000067147; ENSRNOG00000049213.
GeneIDi66024.
KEGGirno:66024.
UCSCiRGD:620475. rat.

Organism-specific databases

CTDi4887.
RGDi620475. Npy2r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOVERGENiHBG105675.
KOiK04205.
OMAiEKSMYGT.
OrthoDBiEOG7P02JG.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi614326.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001358. NPY2_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01014. NRPEPTIDEY2R.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning."
    Goumain M., Voisin T., Lorinet A.M., Ducroc R., Tsocas A., Roze C., Rouet-Benzineb P., Herzog H., Balasubramaniam A., Laburthe M.
    Mol. Pharmacol. 60:124-134(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
    Tissue: Small intestineImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ9ERC0_RAT
AccessioniPrimary (citable) accession number: Q9ERC0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.