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Protein
Submitted name:

Neuropeptide Y receptor Y2

Gene

Npy2r

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • neuropeptide Y receptor activity Source: RGD
  • peptide YY receptor activity Source: RGD

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  • aging Source: RGD
  • behavioral fear response Source: RGD
  • cardiac left ventricle morphogenesis Source: Ensembl
  • negative regulation of cAMP-mediated signaling Source: RGD
  • negative regulation of excitatory postsynaptic potential Source: RGD
  • negative regulation of feeding behavior Source: RGD
  • negative regulation of neurological system process Source: RGD
  • negative regulation of secretion Source: RGD
  • negative regulation of synaptic transmission Source: RGD
  • negative regulation of synaptic transmission, glutamatergic Source: RGD
  • nitric oxide mediated signal transduction Source: RGD
  • outflow tract morphogenesis Source: Ensembl
  • positive regulation of cell-substrate adhesion Source: RGD
  • positive regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of dopamine secretion Source: RGD
  • positive regulation of peptide secretion Source: RGD
  • positive regulation of smooth muscle contraction Source: RGD
  • regulation of sensory perception of pain Source: RGD
  • secretion Source: RGD

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, NeuropeptideImported, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Submitted name:
Neuropeptide Y receptor Y2Imported
Submitted name:
Neuropeptide Y/peptide YY-Y2 receptorImported
Submitted name:
RCG62488Imported
Gene namesi
Name:Npy2rImported
ORF Names:rCG_62488Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi620475 Npy2r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei54 – 76HelicalSequence analysisAdd BLAST23
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei128 – 146HelicalSequence analysisAdd BLAST19
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Transmembranei218 – 239HelicalSequence analysisAdd BLAST22
Transmembranei269 – 291HelicalSequence analysisAdd BLAST23
Transmembranei303 – 324HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3309
GuidetoPHARMACOLOGYi306

Expressioni

Gene expression databases

BgeeiENSRNOG00000049213

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067147

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 325G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST259

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00900000140797
HOVERGENiHBG105675
KOiK04205
OMAiAFQCEQR
OrthoDBiEOG091G0C6Q

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001358 NPY2_rcpt
IPR000611 NPY_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01014 NRPEPTIDEY2R
PR01012 NRPEPTIDEYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ERC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLGAEADE NQTVEVKVEL YGSGPTTPRG ELPPDPEPEL IDSTKLVEVQ
60 70 80 90 100
VVLILAYCSI ILLGVVGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN
110 120 130 140 150
TLCLPFTLTY TLMGEWKMGP VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR
160 170 180 190 200
CIVYHLESKI SKQISFLIIG LAWGVSALLA SPLAIFREYS LIEIIPDFEI
210 220 230 240 250
VACTEKWPGE EKSVYGTVYS LSTLLILYVL PLGIISFSYT RIWSKLKNHV
260 270 280 290 300
SPGAASDHYH QRRHKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSHVLDL
310 320 330 340 350
KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH
360 370 380
SEVSMTFKAK KNLEVKKNNG LTDSFSEATN V
Length:381
Mass (Da):42,510
Last modified:March 1, 2001 - v1
Checksum:i659327904B288BC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07012007 Genomic DNA No translation available.
AY004257 mRNA Translation: AAF89094.1
CH473976 Genomic DNA Translation: EDM00847.1
RefSeqiNP_076458.1, NM_023968.1
XP_006232596.1, XM_006232534.3
XP_008759335.1, XM_008761113.2
UniGeneiRn.64505

Genome annotation databases

EnsembliENSRNOT00000072029; ENSRNOP00000067147; ENSRNOG00000049213
GeneIDi66024
KEGGirno:66024
UCSCiRGD:620475 rat

Entry informationi

Entry nameiQ9ERC0_RAT
AccessioniPrimary (citable) accession number: Q9ERC0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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