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Protein

Solute carrier organic anion transporter family member 1C1

Gene

Slco1c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), estradiol-17-beta-glucuronide, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency (By similarity). May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-879518. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1C1
Alternative name(s):
Organic anion transporter 2
Short name:
OATP2
Organic anion transporter F
Short name:
OATP-F
Organic anion-transporting polypeptide 14
Short name:
OATP-14
Solute carrier family 21 member 14
Thyroxine transporter
Gene namesi
Name:Slco1c1
Synonyms:Oatp1c1, Oatpf, Slc21a14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1889679. Slco1c1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343CytoplasmicSequence analysisAdd
BLAST
Transmembranei44 – 6320Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 8219ExtracellularSequence analysisAdd
BLAST
Transmembranei83 – 10321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini104 – 1096CytoplasmicSequence analysis
Transmembranei110 – 13425Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini135 – 18753ExtracellularSequence analysisAdd
BLAST
Transmembranei188 – 21629Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini217 – 23519CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini257 – 27418ExtracellularSequence analysisAdd
BLAST
Transmembranei275 – 29925Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini300 – 35152CytoplasmicSequence analysisAdd
BLAST
Transmembranei352 – 37322Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini374 – 39320ExtracellularSequence analysisAdd
BLAST
Transmembranei394 – 41724Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini418 – 4214CytoplasmicSequence analysis
Transmembranei422 – 44524Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini446 – 557112ExtracellularSequence analysisAdd
BLAST
Transmembranei558 – 58023Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini581 – 5899CytoplasmicSequence analysis
Transmembranei590 – 61526Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini616 – 64934ExtracellularSequence analysisAdd
BLAST
Transmembranei650 – 66718Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini668 – 71548CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2073688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Solute carrier organic anion transporter family member 1C1PRO_0000191056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi479 ↔ 505PROSITE-ProRule annotation
Disulfide bondi483 ↔ 494PROSITE-ProRule annotation
Disulfide bondi485 ↔ 509PROSITE-ProRule annotation
Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence analysis
Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ERB5.
PRIDEiQ9ERB5.

PTM databases

PhosphoSiteiQ9ERB5.

Expressioni

Tissue specificityi

Highly expressed in cerebral microvessels (at protein level). Highly expressed in cerebral microvessels throughout the brain and in tanycytes of the third ventricle.1 Publication

Gene expression databases

BgeeiENSMUSG00000030235.
ExpressionAtlasiQ9ERB5. baseline and differential.
GenevisibleiQ9ERB5. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4998225.
STRINGi10090.ENSMUSP00000032362.

Structurei

3D structure databases

ProteinModelPortaliQ9ERB5.
SMRiQ9ERB5. Positions 477-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini473 – 52856Kazal-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi145 – 18844Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9ERB5.
KOiK08747.
OMAiYWPGKET.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9ERB5.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
IPR030764. OATP1C1.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PTHR11388:SF99. PTHR11388:SF99. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSSKENAH LFHKNSAQPA GGPSFTVGYP STEEARPCCG KLKVFLGALS
60 70 80 90 100
FVYFAKALAE GYLKSTVTQI ERRFEIPSSL VGIIDGSFEI GNLLVITFVS
110 120 130 140 150
YFGAKLHRPK IIGAGCLVMG FGTMLIAVPQ FFMEKYSYEK YERYSPSSNV
160 170 180 190 200
TPSISPCYLE SSSPSPSSIL GKSQNKISHE CVGDSSSSMW VYVFLGNLLR
210 220 230 240 250
GLGETPIQPL GIAYLDDFAS EDNAAFYIGC VQTVAIIGPI FGFLLGSLCA
260 270 280 290 300
KLYVDIGFVN LDHITITPKD PQWVGAWWLG YLIAGFLSLL AAVPFWCLPK
310 320 330 340 350
TLPRSQSREN SGSTSEKSKF IDDPIHYQMA PGDDKMKIME MAKDFLPSLK
360 370 380 390 400
TLFRNPVYIL YLCASTVQFN SLFGMVTYKP KYIEQQYGQS SSKANFVIGL
410 420 430 440 450
INIPAVALGI FSGGIVMKKF RLGICEATKL YLGSSVFGYL LFLSLFALGC
460 470 480 490 500
ENSSVAGLTV SYQGTKPVSY HERALFSDCN SRCKCSDSKW EPMCGDNGIT
510 520 530 540 550
YVSACLAGCQ SSSRSGKNII FSNCTCVGFA APKSGNWSGM MGRCQKDNGC
560 570 580 590 600
SQMFLYFLVI SVITSYTLSL GGIPGYILLL RCIQPQLKSF ALGIYTLAVR
610 620 630 640 650
VLAGIPAPVY FGVLIDTSCL KWGFKKCGSR GSCRLYDSHA FRHIYLGLTT
660 670 680 690 700
LLGTVSVFLS MAVLFVLKKK YVSKHSSLIT TREKIGMSSS IKKETCAARD
710
RGLQPKYWPG KETRL
Length:715
Mass (Da):78,320
Last modified:March 1, 2001 - v1
Checksum:i8659472884FAD7FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti603 – 6031Missing in BAC33495 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007379 mRNA. Translation: AAG09622.1.
AK048926 mRNA. Translation: BAC33495.1.
CCDSiCCDS20677.1.
RefSeqiNP_001171243.1. NM_001177772.1.
NP_067446.1. NM_021471.2.
UniGeneiMm.284495.

Genome annotation databases

EnsembliENSMUST00000032362; ENSMUSP00000032362; ENSMUSG00000030235.
GeneIDi58807.
KEGGimmu:58807.
UCSCiuc009eop.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007379 mRNA. Translation: AAG09622.1.
AK048926 mRNA. Translation: BAC33495.1.
CCDSiCCDS20677.1.
RefSeqiNP_001171243.1. NM_001177772.1.
NP_067446.1. NM_021471.2.
UniGeneiMm.284495.

3D structure databases

ProteinModelPortaliQ9ERB5.
SMRiQ9ERB5. Positions 477-509.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4998225.
STRINGi10090.ENSMUSP00000032362.

Chemistry

ChEMBLiCHEMBL2073688.

PTM databases

PhosphoSiteiQ9ERB5.

Proteomic databases

PaxDbiQ9ERB5.
PRIDEiQ9ERB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032362; ENSMUSP00000032362; ENSMUSG00000030235.
GeneIDi58807.
KEGGimmu:58807.
UCSCiuc009eop.2. mouse.

Organism-specific databases

CTDi53919.
MGIiMGI:1889679. Slco1c1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9ERB5.
KOiK08747.
OMAiYWPGKET.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9ERB5.

Enzyme and pathway databases

ReactomeiR-MMU-879518. Transport of organic anions.

Miscellaneous databases

PROiQ9ERB5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030235.
ExpressionAtlasiQ9ERB5. baseline and differential.
GenevisibleiQ9ERB5. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
IPR030764. OATP1C1.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PTHR11388:SF99. PTHR11388:SF99. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO1C1_MOUSE
AccessioniPrimary (citable) accession number: Q9ERB5
Secondary accession number(s): Q8BX54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.