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Protein

Solute carrier organic anion transporter family member 1C1

Gene

Slco1c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), estradiol-17-beta-glucuronide, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency (By similarity). May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-879518 Transport of organic anions

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1C1
Alternative name(s):
Organic anion transporter 2
Short name:
OATP2
Organic anion transporter F
Short name:
OATP-F
Organic anion-transporting polypeptide 14
Short name:
OATP-14
Solute carrier family 21 member 14
Thyroxine transporter
Gene namesi
Name:Slco1c1
Synonyms:Oatp1c1, Oatpf, Slc21a14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1889679 Slco1c1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
Transmembranei44 – 63Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini64 – 82ExtracellularSequence analysisAdd BLAST19
Transmembranei83 – 103Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini104 – 109CytoplasmicSequence analysis6
Transmembranei110 – 134Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini135 – 187ExtracellularSequence analysisAdd BLAST53
Transmembranei188 – 216Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini217 – 235CytoplasmicSequence analysisAdd BLAST19
Transmembranei236 – 256Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini257 – 274ExtracellularSequence analysisAdd BLAST18
Transmembranei275 – 299Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini300 – 351CytoplasmicSequence analysisAdd BLAST52
Transmembranei352 – 373Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini374 – 393ExtracellularSequence analysisAdd BLAST20
Transmembranei394 – 417Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini418 – 421CytoplasmicSequence analysis4
Transmembranei422 – 445Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini446 – 557ExtracellularSequence analysisAdd BLAST112
Transmembranei558 – 580Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini581 – 589CytoplasmicSequence analysis9
Transmembranei590 – 615Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini616 – 649ExtracellularSequence analysisAdd BLAST34
Transmembranei650 – 667Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini668 – 715CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073688

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910561 – 715Solute carrier organic anion transporter family member 1C1Add BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi479 ↔ 505PROSITE-ProRule annotation
Disulfide bondi483 ↔ 494PROSITE-ProRule annotation
Disulfide bondi485 ↔ 509PROSITE-ProRule annotation
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi536N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ERB5
PRIDEiQ9ERB5

PTM databases

PhosphoSitePlusiQ9ERB5
SwissPalmiQ9ERB5

Expressioni

Tissue specificityi

Highly expressed in cerebral microvessels (at protein level). Highly expressed in cerebral microvessels throughout the brain and in tanycytes of the third ventricle.1 Publication

Gene expression databases

BgeeiENSMUSG00000030235
ExpressionAtlasiQ9ERB5 baseline and differential
GenevisibleiQ9ERB5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032362

Structurei

3D structure databases

ProteinModelPortaliQ9ERB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini473 – 528Kazal-likePROSITE-ProRule annotationAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi145 – 188Ser-richAdd BLAST44

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG063896
InParanoidiQ9ERB5
KOiK08747
OMAiDASSSMW
OrthoDBiEOG091G08QD
PhylomeDBiQ9ERB5

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
IPR030764 OATP1C1
PANTHERiPTHR11388 PTHR11388, 1 hit
PTHR11388:SF99 PTHR11388:SF99, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 5 hits
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ERB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSSKENAH LFHKNSAQPA GGPSFTVGYP STEEARPCCG KLKVFLGALS
60 70 80 90 100
FVYFAKALAE GYLKSTVTQI ERRFEIPSSL VGIIDGSFEI GNLLVITFVS
110 120 130 140 150
YFGAKLHRPK IIGAGCLVMG FGTMLIAVPQ FFMEKYSYEK YERYSPSSNV
160 170 180 190 200
TPSISPCYLE SSSPSPSSIL GKSQNKISHE CVGDSSSSMW VYVFLGNLLR
210 220 230 240 250
GLGETPIQPL GIAYLDDFAS EDNAAFYIGC VQTVAIIGPI FGFLLGSLCA
260 270 280 290 300
KLYVDIGFVN LDHITITPKD PQWVGAWWLG YLIAGFLSLL AAVPFWCLPK
310 320 330 340 350
TLPRSQSREN SGSTSEKSKF IDDPIHYQMA PGDDKMKIME MAKDFLPSLK
360 370 380 390 400
TLFRNPVYIL YLCASTVQFN SLFGMVTYKP KYIEQQYGQS SSKANFVIGL
410 420 430 440 450
INIPAVALGI FSGGIVMKKF RLGICEATKL YLGSSVFGYL LFLSLFALGC
460 470 480 490 500
ENSSVAGLTV SYQGTKPVSY HERALFSDCN SRCKCSDSKW EPMCGDNGIT
510 520 530 540 550
YVSACLAGCQ SSSRSGKNII FSNCTCVGFA APKSGNWSGM MGRCQKDNGC
560 570 580 590 600
SQMFLYFLVI SVITSYTLSL GGIPGYILLL RCIQPQLKSF ALGIYTLAVR
610 620 630 640 650
VLAGIPAPVY FGVLIDTSCL KWGFKKCGSR GSCRLYDSHA FRHIYLGLTT
660 670 680 690 700
LLGTVSVFLS MAVLFVLKKK YVSKHSSLIT TREKIGMSSS IKKETCAARD
710
RGLQPKYWPG KETRL
Length:715
Mass (Da):78,320
Last modified:March 1, 2001 - v1
Checksum:i8659472884FAD7FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti603Missing in BAC33495 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007379 mRNA Translation: AAG09622.1
AK048926 mRNA Translation: BAC33495.1
CCDSiCCDS20677.1
RefSeqiNP_001171243.1, NM_001177772.1
NP_067446.1, NM_021471.2
UniGeneiMm.284495

Genome annotation databases

EnsembliENSMUST00000032362; ENSMUSP00000032362; ENSMUSG00000030235
GeneIDi58807
KEGGimmu:58807
UCSCiuc009eop.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSO1C1_MOUSE
AccessioniPrimary (citable) accession number: Q9ERB5
Secondary accession number(s): Q8BX54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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