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Q9ERB0

- SNP29_MOUSE

UniProt

Q9ERB0 - SNP29_MOUSE

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Protein

Synaptosomal-associated protein 29

Gene

Snap29

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

SNAREs, Soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Probably involved in multiple membrane trafficking steps (By similarity).By similarity

GO - Biological processi

  1. autophagic vacuole fusion Source: UniProtKB
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 29
Short name:
SNAP-29
Alternative name(s):
Golgi SNARE of 32 kDa
Short name:
Gs32
Soluble 29 kDa NSF attachment protein
Vesicle-membrane fusion protein SNAP-29
Gene namesi
Name:Snap29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1914724. Snap29.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity. Cell junctionsynapsesynaptosome By similarity
Note: Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. centrosome Source: Ensembl
  3. neuron projection Source: UniProtKB-KW
  4. SNARE complex Source: UniProtKB
  5. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Synaptosomal-associated protein 29PRO_0000213602Add
BLAST

Proteomic databases

MaxQBiQ9ERB0.
PaxDbiQ9ERB0.
PRIDEiQ9ERB0.

PTM databases

PhosphoSiteiQ9ERB0.

Expressioni

Gene expression databases

BgeeiQ9ERB0.
CleanExiMM_SNAP29.
GenevestigatoriQ9ERB0.

Interactioni

Subunit structurei

Forms a SNARE complex, composed of VAMP8, SNAP29 and STX17, involved in fusion of autophagosome with lysosome. Interacts with multiple syntaxins including STX6 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-60853N.
MINTiMINT-4998219.

Structurei

3D structure databases

ProteinModelPortaliQ9ERB0.
SMRiQ9ERB0. Positions 54-110, 204-260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini198 – 26063t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili76 – 10732Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SNAP-25 family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG244202.
GeneTreeiENSGT00510000048053.
HOGENOMiHOG000046806.
HOVERGENiHBG057045.
InParanoidiQ9ERB0.
KOiK08509.
OMAiAYPRSYN.
OrthoDBiEOG7FNC8G.
PhylomeDBiQ9ERB0.
TreeFamiTF320226.

Family and domain databases

InterProiIPR000928. SNAP-25.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF00835. SNAP-25. 1 hit.
PF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 2 hits.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ERB0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGYPKSYNP FDDDVEEEDT RPAPWKDVRD LPDGPDAPID RQQYLRQEVL
60 70 80 90 100
RRAEATAAST SRSLSLMYES EKIGVASSEE LVRQRGVLEH TEKMVDKMDQ
110 120 130 140 150
DLKMSQKHIN SIKSVFGGFI NYFKSKPVEP PPEQNGSIVS QPNSRLKEAI
160 170 180 190 200
NTSKDQENKY QASHPNLRRL QDAELDSVPK EPSSTVNTEV YPKNSTLRTY
210 220 230 240 250
HQKIDSNLDE LSVGLGHLKD IALGMQTEIE EQDDILDRLT TKVDKLDVNI
260
KSTEKKVRQL
Length:260
Mass (Da):29,572
Last modified:March 1, 2001 - v1
Checksum:iDD813A78C605576F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1842SS → FF in BAB23769. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY008722 mRNA. Translation: AAG32076.1.
AK005042 mRNA. Translation: BAB23769.1.
AK007065 mRNA. Translation: BAB24850.1.
AK039203 mRNA. Translation: BAC30277.1.
AK147845 mRNA. Translation: BAE28177.1.
BC030066 mRNA. Translation: AAH30066.1.
CCDSiCCDS28001.1.
RefSeqiNP_075837.3. NM_023348.4.
UniGeneiMm.271992.

Genome annotation databases

EnsembliENSMUST00000023449; ENSMUSP00000023449; ENSMUSG00000022765.
GeneIDi67474.
KEGGimmu:67474.
UCSCiuc007yku.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY008722 mRNA. Translation: AAG32076.1 .
AK005042 mRNA. Translation: BAB23769.1 .
AK007065 mRNA. Translation: BAB24850.1 .
AK039203 mRNA. Translation: BAC30277.1 .
AK147845 mRNA. Translation: BAE28177.1 .
BC030066 mRNA. Translation: AAH30066.1 .
CCDSi CCDS28001.1.
RefSeqi NP_075837.3. NM_023348.4.
UniGenei Mm.271992.

3D structure databases

ProteinModelPortali Q9ERB0.
SMRi Q9ERB0. Positions 54-110, 204-260.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60853N.
MINTi MINT-4998219.

PTM databases

PhosphoSitei Q9ERB0.

Proteomic databases

MaxQBi Q9ERB0.
PaxDbi Q9ERB0.
PRIDEi Q9ERB0.

Protocols and materials databases

DNASUi 67474.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023449 ; ENSMUSP00000023449 ; ENSMUSG00000022765 .
GeneIDi 67474.
KEGGi mmu:67474.
UCSCi uc007yku.1. mouse.

Organism-specific databases

CTDi 9342.
MGIi MGI:1914724. Snap29.

Phylogenomic databases

eggNOGi NOG244202.
GeneTreei ENSGT00510000048053.
HOGENOMi HOG000046806.
HOVERGENi HBG057045.
InParanoidi Q9ERB0.
KOi K08509.
OMAi AYPRSYN.
OrthoDBi EOG7FNC8G.
PhylomeDBi Q9ERB0.
TreeFami TF320226.

Miscellaneous databases

ChiTaRSi SNAP29. mouse.
NextBioi 324690.
PROi Q9ERB0.
SOURCEi Search...

Gene expression databases

Bgeei Q9ERB0.
CleanExi MM_SNAP29.
Genevestigatori Q9ERB0.

Family and domain databases

InterProi IPR000928. SNAP-25.
IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF00835. SNAP-25. 1 hit.
PF05739. SNARE. 1 hit.
[Graphical view ]
SMARTi SM00397. t_SNARE. 2 hits.
[Graphical view ]
PROSITEi PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Bui T.D., Hong W.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus, Liver and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSNP29_MOUSE
AccessioniPrimary (citable) accession number: Q9ERB0
Secondary accession number(s): Q3UGN0, Q9DBC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3