Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9ERB0

- SNP29_MOUSE

UniProt

Q9ERB0 - SNP29_MOUSE

Protein

Synaptosomal-associated protein 29

Gene

Snap29

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    SNAREs, Soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Probably involved in multiple membrane trafficking steps By similarity.By similarity

    GO - Biological processi

    1. autophagic vacuole fusion Source: UniProtKB
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptosomal-associated protein 29
    Short name:
    SNAP-29
    Alternative name(s):
    Golgi SNARE of 32 kDa
    Short name:
    Gs32
    Soluble 29 kDa NSF attachment protein
    Vesicle-membrane fusion protein SNAP-29
    Gene namesi
    Name:Snap29
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1914724. Snap29.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity. Cell junctionsynapsesynaptosome By similarity
    Note: Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. neuron projection Source: UniProtKB-SubCell
    3. nucleus Source: Ensembl
    4. SNARE complex Source: UniProtKB
    5. synapse Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Membrane, Synapse, Synaptosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Synaptosomal-associated protein 29PRO_0000213602Add
    BLAST

    Proteomic databases

    MaxQBiQ9ERB0.
    PaxDbiQ9ERB0.
    PRIDEiQ9ERB0.

    PTM databases

    PhosphoSiteiQ9ERB0.

    Expressioni

    Gene expression databases

    BgeeiQ9ERB0.
    CleanExiMM_SNAP29.
    GenevestigatoriQ9ERB0.

    Interactioni

    Subunit structurei

    Forms a SNARE complex, composed of VAMP8, SNAP29 and STX17, involved in fusion of autophagosome with lysosome. Interacts with multiple syntaxins including STX6 By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-60853N.
    MINTiMINT-4998219.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ERB0.
    SMRiQ9ERB0. Positions 54-110, 204-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini198 – 26063t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili76 – 10732Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SNAP-25 family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG244202.
    GeneTreeiENSGT00510000048053.
    HOGENOMiHOG000046806.
    HOVERGENiHBG057045.
    InParanoidiQ9ERB0.
    KOiK08509.
    OMAiAYPRSYN.
    OrthoDBiEOG7FNC8G.
    PhylomeDBiQ9ERB0.
    TreeFamiTF320226.

    Family and domain databases

    InterProiIPR000928. SNAP-25.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF00835. SNAP-25. 1 hit.
    PF05739. SNARE. 1 hit.
    [Graphical view]
    SMARTiSM00397. t_SNARE. 2 hits.
    [Graphical view]
    PROSITEiPS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ERB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGYPKSYNP FDDDVEEEDT RPAPWKDVRD LPDGPDAPID RQQYLRQEVL    50
    RRAEATAAST SRSLSLMYES EKIGVASSEE LVRQRGVLEH TEKMVDKMDQ 100
    DLKMSQKHIN SIKSVFGGFI NYFKSKPVEP PPEQNGSIVS QPNSRLKEAI 150
    NTSKDQENKY QASHPNLRRL QDAELDSVPK EPSSTVNTEV YPKNSTLRTY 200
    HQKIDSNLDE LSVGLGHLKD IALGMQTEIE EQDDILDRLT TKVDKLDVNI 250
    KSTEKKVRQL 260
    Length:260
    Mass (Da):29,572
    Last modified:March 1, 2001 - v1
    Checksum:iDD813A78C605576F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti183 – 1842SS → FF in BAB23769. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY008722 mRNA. Translation: AAG32076.1.
    AK005042 mRNA. Translation: BAB23769.1.
    AK007065 mRNA. Translation: BAB24850.1.
    AK039203 mRNA. Translation: BAC30277.1.
    AK147845 mRNA. Translation: BAE28177.1.
    BC030066 mRNA. Translation: AAH30066.1.
    CCDSiCCDS28001.1.
    RefSeqiNP_075837.3. NM_023348.4.
    UniGeneiMm.271992.

    Genome annotation databases

    EnsembliENSMUST00000023449; ENSMUSP00000023449; ENSMUSG00000022765.
    GeneIDi67474.
    KEGGimmu:67474.
    UCSCiuc007yku.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY008722 mRNA. Translation: AAG32076.1 .
    AK005042 mRNA. Translation: BAB23769.1 .
    AK007065 mRNA. Translation: BAB24850.1 .
    AK039203 mRNA. Translation: BAC30277.1 .
    AK147845 mRNA. Translation: BAE28177.1 .
    BC030066 mRNA. Translation: AAH30066.1 .
    CCDSi CCDS28001.1.
    RefSeqi NP_075837.3. NM_023348.4.
    UniGenei Mm.271992.

    3D structure databases

    ProteinModelPortali Q9ERB0.
    SMRi Q9ERB0. Positions 54-110, 204-260.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60853N.
    MINTi MINT-4998219.

    PTM databases

    PhosphoSitei Q9ERB0.

    Proteomic databases

    MaxQBi Q9ERB0.
    PaxDbi Q9ERB0.
    PRIDEi Q9ERB0.

    Protocols and materials databases

    DNASUi 67474.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023449 ; ENSMUSP00000023449 ; ENSMUSG00000022765 .
    GeneIDi 67474.
    KEGGi mmu:67474.
    UCSCi uc007yku.1. mouse.

    Organism-specific databases

    CTDi 9342.
    MGIi MGI:1914724. Snap29.

    Phylogenomic databases

    eggNOGi NOG244202.
    GeneTreei ENSGT00510000048053.
    HOGENOMi HOG000046806.
    HOVERGENi HBG057045.
    InParanoidi Q9ERB0.
    KOi K08509.
    OMAi AYPRSYN.
    OrthoDBi EOG7FNC8G.
    PhylomeDBi Q9ERB0.
    TreeFami TF320226.

    Miscellaneous databases

    ChiTaRSi SNAP29. mouse.
    NextBioi 324690.
    PROi Q9ERB0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ERB0.
    CleanExi MM_SNAP29.
    Genevestigatori Q9ERB0.

    Family and domain databases

    InterProi IPR000928. SNAP-25.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF00835. SNAP-25. 1 hit.
    PF05739. SNARE. 1 hit.
    [Graphical view ]
    SMARTi SM00397. t_SNARE. 2 hits.
    [Graphical view ]
    PROSITEi PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Bui T.D., Hong W.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hypothalamus, Liver and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiSNP29_MOUSE
    AccessioniPrimary (citable) accession number: Q9ERB0
    Secondary accession number(s): Q3UGN0, Q9DBC5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3