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Protein

Mesothelin

Gene

Msln

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Membrane-anchored forms may play a role in cellular adhesion.By similarity
Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation.By similarity

GO - Biological processi

  • cell-matrix adhesion Source: GO_Central
  • pancreas development Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Mesothelin
Alternative name(s):
Pre-pro-megakaryocyte-potentiating factor
Protein expressed in renal carcinoma
Cleaved into the following 2 chains:
Gene namesi
Name:Msln
Synonyms:Erc, Mpf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi69333. Msln.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • cell surface Source: RGD
  • extracellular space Source: RGD
  • Golgi apparatus Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000025356636 – 600MesothelinAdd BLAST565
ChainiPRO_000025356736 – 288Megakaryocyte-potentiating factorAdd BLAST253
ChainiPRO_0000253568298 – 600Mesothelin, cleaved formAdd BLAST303
PropeptideiPRO_0000253569601 – 625Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202PhosphoserineBy similarity1
Disulfide bondi304 ↔ 328By similarity
Glycosylationi390N-linked (GlcNAc...)Sequence analysis1
Glycosylationi488N-linked (GlcNAc...)Sequence analysis1
Glycosylationi517N-linked (GlcNAc...)Sequence analysis1
Lipidationi600GPI-anchor amidated serineSequence analysis1

Post-translational modificationi

Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ERA7.
PRIDEiQ9ERA7.

Expressioni

Tissue specificityi

Specifically expressed in lung. Overexpressed in hereditary renal carcinoma developed by Eker rats.1 Publication

Gene expression databases

BgeeiENSRNOG00000019445.
GenevisibleiQ9ERA7. RN.

Interactioni

Subunit structurei

Interacts with MUC16.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026395.

Family & Domainsi

Sequence similaritiesi

Belongs to the mesothelin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIJH. Eukaryota.
ENOG4111HFW. LUCA.
GeneTreeiENSGT00530000064019.
HOGENOMiHOG000113666.
HOVERGENiHBG081988.
InParanoidiQ9ERA7.
KOiK20733.
OMAiCDLPGRF.
OrthoDBiEOG091G04V4.
PhylomeDBiQ9ERA7.
TreeFamiTF331713.

Family and domain databases

InterProiIPR010335. Mesothelin.
IPR026664. Stereocilin-rel.
[Graphical view]
PANTHERiPTHR23412. PTHR23412. 1 hit.
PfamiPF06060. Mesothelin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ERA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPTAQPLL GSCGSPICSR SFLLLLLSLG WLPLLQTQTT RTSQEAALLH
60 70 80 90 100
AVTGTVDFAS LPTGLFLGLM CDEVSGLSMG HAKELAMAVR QKNIVLQVHQ
110 120 130 140 150
LRCLARRLPK HLTNEELDAL PLDLLLFLNP AMFPGQQACA HFFSLISKAN
160 170 180 190 200
VNVLPRRSLE RQRLLTGALK CQGVYGFQVS ETDARALGGL ACDLPGEFVA
210 220 230 240 250
KSSEVLLPWL ARCGGPLDQG QAKAVREVLR SGRAPYGPPS TWSVSTLDAL
260 270 280 290 300
QGLLVVLDES IVHSIPKDVI TEWLQGISRE PSRLGSKWTV THPRFRRDTE
310 320 330 340 350
QKACPPGKEP NVVDENLIFY QNWELEACVD GTLLAGQMDL VNEIPFTYEQ
360 370 380 390 400
LSIFKHKLDK TYPQGYPESL IKQLGHFFRY VSPEDIRQWN VTSPDTVNTL
410 420 430 440 450
LKVSKGQKMD AQVIALVACY LRGGGKLDED IVKALDNIPL SYLCDFSPQD
460 470 480 490 500
LHAIPSSVMW LVGLHDLDKC SQRHLGILYQ KACSAFQNVS GLEYFEKIRT
510 520 530 540 550
FLGGASREDL RALSQHNVSM DIATFKKLQV DALVGLSVAE VQKLLGPHIG
560 570 580 590 600
DLKTEEDKSP VRDWLFRQQQ KDLDSLGLGL QGGIPNGYLI LDFNVREAFS
610 620
SGAPLLGPGF VFAWIPALLS ALRLS
Length:625
Mass (Da):68,883
Last modified:October 17, 2006 - v2
Checksum:i3ECEF77F88BE2127
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70M → T in BAB13512 (PubMed:10944454).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87351 mRNA. Translation: BAB13512.1.
BC070934 mRNA. Translation: AAH70934.1.
PIRiJC7362.
RefSeqiNP_113846.1. NM_031658.1.
XP_006246083.1. XM_006246021.3.
XP_006246084.1. XM_006246022.2.
UniGeneiRn.18607.

Genome annotation databases

EnsembliENSRNOT00000026395; ENSRNOP00000026395; ENSRNOG00000019445.
GeneIDi60333.
KEGGirno:60333.
UCSCiRGD:69333. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87351 mRNA. Translation: BAB13512.1.
BC070934 mRNA. Translation: AAH70934.1.
PIRiJC7362.
RefSeqiNP_113846.1. NM_031658.1.
XP_006246083.1. XM_006246021.3.
XP_006246084.1. XM_006246022.2.
UniGeneiRn.18607.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026395.

Proteomic databases

PaxDbiQ9ERA7.
PRIDEiQ9ERA7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026395; ENSRNOP00000026395; ENSRNOG00000019445.
GeneIDi60333.
KEGGirno:60333.
UCSCiRGD:69333. rat.

Organism-specific databases

CTDi10232.
RGDi69333. Msln.

Phylogenomic databases

eggNOGiENOG410IIJH. Eukaryota.
ENOG4111HFW. LUCA.
GeneTreeiENSGT00530000064019.
HOGENOMiHOG000113666.
HOVERGENiHBG081988.
InParanoidiQ9ERA7.
KOiK20733.
OMAiCDLPGRF.
OrthoDBiEOG091G04V4.
PhylomeDBiQ9ERA7.
TreeFamiTF331713.

Miscellaneous databases

PROiQ9ERA7.

Gene expression databases

BgeeiENSRNOG00000019445.
GenevisibleiQ9ERA7. RN.

Family and domain databases

InterProiIPR010335. Mesothelin.
IPR026664. Stereocilin-rel.
[Graphical view]
PANTHERiPTHR23412. PTHR23412. 1 hit.
PfamiPF06060. Mesothelin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSLN_RAT
AccessioniPrimary (citable) accession number: Q9ERA7
Secondary accession number(s): Q6IRG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.