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Q9ERA0

- TFCP2_MOUSE

UniProt

Q9ERA0 - TFCP2_MOUSE

Protein

Alpha-globin transcription factor CP2

Gene

Tfcp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Binds a variety of cellular promoters including fibrinogen, alpha-globin promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 By similarity. Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: MGI
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-globin transcription factor CP2
    Gene namesi
    Name:Tfcp2
    Synonyms:Tcfcp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:98509. Tfcp2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Alpha-globin transcription factor CP2PRO_0000228002Add
    BLAST

    Proteomic databases

    MaxQBiQ9ERA0.
    PaxDbiQ9ERA0.
    PRIDEiQ9ERA0.

    PTM databases

    PhosphoSiteiQ9ERA0.

    Expressioni

    Gene expression databases

    BgeeiQ9ERA0.
    CleanExiMM_TCFCP2.
    GenevestigatoriQ9ERA0.

    Interactioni

    Subunit structurei

    Binds to DNA as a dimer. Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1. Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi204014. 3 interactions.
    IntActiQ9ERA0. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ERA0.
    SMRiQ9ERA0. Positions 321-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 386254DNA-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the grh/CP2 family. CP2 subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG275458.
    GeneTreeiENSGT00740000115287.
    HOGENOMiHOG000230625.
    HOVERGENiHBG053805.
    KOiK09275.
    OMAiDEVCFVL.
    OrthoDBiEOG7FBRHB.
    PhylomeDBiQ9ERA0.
    TreeFamiTF314132.

    Family and domain databases

    InterProiIPR007604. CP2.
    IPR013761. SAM/pointed.
    [Graphical view]
    PfamiPF04516. CP2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ERA0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK    50
    QEESSLPPDN ENEILPFQYV LCAATSPAVK LHDETLTYLN QGQSYEIRML 100
    DNRKLGELPE LNGKLVKSIF RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL 150
    DIDIPMSVGV IDPRANPTQL NTVEFLWDPS KRTSVFIQVH CISTEFTMRK 200
    HGGEKGVPFR VQIDTFKENG NGEYTEHLHS ASCQIKVFKP KGADRKQKID 250
    REKMEKRTPH EKEKYQPSYE TTILTECSPW PEITYVNNSP SPGFNSSHSS 300
    FSLGEGNGSP NHQPEPPPPV TDNLLPTTTP QEAQQWLHRN RFSTFTRLFT 350
    NFSGADLLKL TRDDVIQICG PADGIRLFNA LKGRMVRPRL TIYVCQESLQ 400
    LREQQPQPQP QPQKQEDGDS NGTFFVYHAI YLEELTAVEL TEKIAQLFSI 450
    SPHQISQIYK QGPTGIHVVI SDEMVQNFQE EACFILDTME AETSDSYHVI 500
    LK 502
    Length:502
    Mass (Da):57,031
    Last modified:March 1, 2001 - v1
    Checksum:i02D43CAA95CDF495
    GO
    Isoform 2 (identifier: Q9ERA0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         474-502: MVQNFQEEACFILDTMEAETSDSYHVILK → VVLSCLILPGTELWSSGRTAGTLNCLALPFL

    Note: No experimental confirmation available.

    Show »
    Length:504
    Mass (Da):56,884
    Checksum:iD53015C81567A103
    GO
    Isoform 3 (identifier: Q9ERA0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         354-355: Missing.

    Show »
    Length:500
    Mass (Da):56,903
    Checksum:iD323CB8CE4872858
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei354 – 3552Missing in isoform 3. 1 PublicationVSP_017649
    Alternative sequencei474 – 50229MVQNF…HVILK → VVLSCLILPGTELWSSGRTA GTLNCLALPFL in isoform 2. 1 PublicationVSP_017650Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84809 mRNA. Translation: AAF99390.1.
    AK146503 mRNA. Translation: BAE27218.1.
    AK147898 mRNA. Translation: BAE28214.1.
    AK158682 mRNA. Translation: BAE34609.1.
    BC022131 mRNA. Translation: AAH22131.1.
    CCDSiCCDS27840.1. [Q9ERA0-1]
    PIRiB42030.
    RefSeqiNP_001276532.1. NM_001289603.1. [Q9ERA0-3]
    NP_258437.1. NM_033476.3. [Q9ERA0-1]
    UniGeneiMm.219040.

    Genome annotation databases

    EnsembliENSMUST00000009877; ENSMUSP00000009877; ENSMUSG00000009733. [Q9ERA0-1]
    GeneIDi21422.
    KEGGimmu:21422.
    UCSCiuc007xrl.1. mouse. [Q9ERA0-1]
    uc007xrm.1. mouse. [Q9ERA0-2]
    uc011zzo.1. mouse. [Q9ERA0-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84809 mRNA. Translation: AAF99390.1 .
    AK146503 mRNA. Translation: BAE27218.1 .
    AK147898 mRNA. Translation: BAE28214.1 .
    AK158682 mRNA. Translation: BAE34609.1 .
    BC022131 mRNA. Translation: AAH22131.1 .
    CCDSi CCDS27840.1. [Q9ERA0-1 ]
    PIRi B42030.
    RefSeqi NP_001276532.1. NM_001289603.1. [Q9ERA0-3 ]
    NP_258437.1. NM_033476.3. [Q9ERA0-1 ]
    UniGenei Mm.219040.

    3D structure databases

    ProteinModelPortali Q9ERA0.
    SMRi Q9ERA0. Positions 321-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204014. 3 interactions.
    IntActi Q9ERA0. 2 interactions.

    PTM databases

    PhosphoSitei Q9ERA0.

    Proteomic databases

    MaxQBi Q9ERA0.
    PaxDbi Q9ERA0.
    PRIDEi Q9ERA0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000009877 ; ENSMUSP00000009877 ; ENSMUSG00000009733 . [Q9ERA0-1 ]
    GeneIDi 21422.
    KEGGi mmu:21422.
    UCSCi uc007xrl.1. mouse. [Q9ERA0-1 ]
    uc007xrm.1. mouse. [Q9ERA0-2 ]
    uc011zzo.1. mouse. [Q9ERA0-3 ]

    Organism-specific databases

    CTDi 7024.
    MGIi MGI:98509. Tfcp2.

    Phylogenomic databases

    eggNOGi NOG275458.
    GeneTreei ENSGT00740000115287.
    HOGENOMi HOG000230625.
    HOVERGENi HBG053805.
    KOi K09275.
    OMAi DEVCFVL.
    OrthoDBi EOG7FBRHB.
    PhylomeDBi Q9ERA0.
    TreeFami TF314132.

    Miscellaneous databases

    NextBioi 300738.
    PROi Q9ERA0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ERA0.
    CleanExi MM_TCFCP2.
    Genevestigatori Q9ERA0.

    Family and domain databases

    InterProi IPR007604. CP2.
    IPR013761. SAM/pointed.
    [Graphical view ]
    Pfami PF04516. CP2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the alpha-globin transcription factor CP2."
      Lim L.C., Swendeman S.L., Sheffery M.
      Mol. Cell. Biol. 12:828-835(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Heart, Melanocyte and Visual cortex.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: FVB/N.
      Tissue: Liver.
    4. "Erythroid cell-specific alpha-globin gene regulation by the CP2 transcription factor family."
      Kang H.C., Chae J.H., Lee Y.H., Park M.-A., Shin J.H., Kim S.-H., Ye S.-K., Cho Y.S., Fiering S., Kim C.G.
      Mol. Cell. Biol. 25:6005-6020(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UBP1 AND PIAS1.
      Strain: DBA/2.
      Tissue: Erythroleukemia.

    Entry informationi

    Entry nameiTFCP2_MOUSE
    AccessioniPrimary (citable) accession number: Q9ERA0
    Secondary accession number(s): Q3UGJ4, Q8VC13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3