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Protein

Regulatory solute carrier protein family 1 member 1

Gene

Rsc1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (By similarity). Regulates the expression of SLC5A1 in a tissue-specific manner and is specifically involved in its regulation in the small intestine.By similarity1 Publication

GO - Biological processi

  • intestinal absorption Source: MGI
  • negative regulation of transport Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory solute carrier protein family 1 member 1
Alternative name(s):
Regulatory subunit of SGLT1
Transporter regulator RS1
Short name:
mRS1
Gene namesi
Name:Rsc1a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3526447. Rsc1a1.

Subcellular locationi

GO - Cellular componenti

  • brush border Source: MGI
  • cell junction Source: MGI
  • Golgi apparatus Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • membrane Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice show a specific phenotype: first, a post-transcriptional up-regulation of SLC5A1 in the small intestine, with an increased d-glucose absorption rate and capacity; second, an increased food intake that results in a visceral type of obesity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Regulatory solute carrier protein family 1 member 1PRO_0000324151Add
BLAST

Proteomic databases

MaxQBiQ9ER99.
PaxDbiQ9ER99.
PRIDEiQ9ER99.

PTM databases

PhosphoSiteiQ9ER99.

Expressioni

Tissue specificityi

Expressed in epithelial and subepithelial cells of small intestine.1 Publication

Gene expression databases

ExpressionAtlasiQ9ER99. baseline and differential.
GenevisibleiQ9ER99. MM.

Interactioni

Subunit structurei

Interacts with YRDC.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101408.

Structurei

3D structure databases

ProteinModelPortaliQ9ER99.
SMRiQ9ER99. Positions 536-573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini536 – 57641UBAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 UBA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJPT. Eukaryota.
ENOG4111B03. LUCA.
GeneTreeiENSGT00390000005744.
HOGENOMiHOG000049187.
HOVERGENiHBG101192.
InParanoidiQ9ER99.
OrthoDBiEOG77HDD7.
PhylomeDBiQ9ER99.
TreeFamiTF335675.

Family and domain databases

InterProiIPR015940. UBA.
[Graphical view]
SMARTiSM00165. UBA. 1 hit.
[Graphical view]
PROSITEiPS50030. UBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ER99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLPTSDGF DHPAPSGQSP EVGSPTSLAR SVSASVCAIK PGDPNSIESL
60 70 80 90 100
AMEATKASAE FQTNSKKTDP PPLQVLPDLA SSAEQSLAMP FHKSSKEAVV
110 120 130 140 150
AGNLEKSVEK GTQGLRVYLH TRQDASLTLT TTGMREPQIF AEEKSWHPEN
160 170 180 190 200
QTPSPVNGLQ QHRETGSVQR EAGQQSVPQD QGCLCDAEDL ELHEEVVSLE
210 220 230 240 250
ALRKGELQRH AHLPSAEKGL PASGLCSCPC SEALMEVDTA EQSLVAMCSS
260 270 280 290 300
TGRQDAVIKS PSVAHLASDN PTMEVETLQS NPSCEPVEHS ILTRELQLPE
310 320 330 340 350
DNVDMSTMDN KDDNSSSLLS GHGQPSVESA EEFCSSVTVA LKELHELLVI
360 370 380 390 400
SCKPASEESP EHVTCQSEIG AESQPSVSDL SGRRVQSVHL TPSDQYSQGS
410 420 430 440 450
CHQATSESGK TEIVGTAPCA AVEDEASTSF EGLGDGLSPD REDVRRSTES
460 470 480 490 500
ARKSCSVAIT SAKLSEQLPC TSGVEIAPEL AASEGAHSQP SEHVHNPGPD
510 520 530 540 550
RPETSSVCPG AGLPRSGLDQ PPTQSLSTPS VLPPFIFPAA DVDRILGAGF
560 570 580
TLQEALGALH RVGGNADLAL LVLLAKNIVV PT
Length:582
Mass (Da):61,251
Last modified:November 24, 2009 - v2
Checksum:iF51458B600B9E82E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351R → H in AAI50753 (PubMed:15489334).Curated
Sequence conflicti141 – 1411A → V in AAI50753 (PubMed:15489334).Curated
Sequence conflicti185 – 1851C → G in AAI50753 (PubMed:15489334).Curated
Sequence conflicti201 – 2011A → T in AAI50753 (PubMed:15489334).Curated
Sequence conflicti323 – 3231G → S in AAI50753 (PubMed:15489334).Curated
Sequence conflicti381 – 3811S → P in AAI50753 (PubMed:15489334).Curated
Sequence conflicti440 – 4401D → G in AAI50753 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11917 Genomic DNA. Translation: CAA72676.2.
AL671733 Genomic DNA. Translation: CAM27071.1.
CH466615 Genomic DNA. Translation: EDL13393.1.
BC031491 mRNA. No translation available.
BC150752 mRNA. Translation: AAI50753.1.
AK006435 mRNA. Translation: BAB24588.1.
CCDSiCCDS18879.1.
RefSeqiNP_076033.4. NM_023544.5.
UniGeneiMm.441022.
Mm.480049.

Genome annotation databases

EnsembliENSMUST00000105782; ENSMUSP00000101408; ENSMUSG00000040715.
ENSMUST00000177592; ENSMUSP00000136018; ENSMUSG00000078515.
GeneIDi69994.
KEGGimmu:69994.
UCSCiuc012dod.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11917 Genomic DNA. Translation: CAA72676.2.
AL671733 Genomic DNA. Translation: CAM27071.1.
CH466615 Genomic DNA. Translation: EDL13393.1.
BC031491 mRNA. No translation available.
BC150752 mRNA. Translation: AAI50753.1.
AK006435 mRNA. Translation: BAB24588.1.
CCDSiCCDS18879.1.
RefSeqiNP_076033.4. NM_023544.5.
UniGeneiMm.441022.
Mm.480049.

3D structure databases

ProteinModelPortaliQ9ER99.
SMRiQ9ER99. Positions 536-573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101408.

PTM databases

PhosphoSiteiQ9ER99.

Proteomic databases

MaxQBiQ9ER99.
PaxDbiQ9ER99.
PRIDEiQ9ER99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105782; ENSMUSP00000101408; ENSMUSG00000040715.
ENSMUST00000177592; ENSMUSP00000136018; ENSMUSG00000078515.
GeneIDi69994.
KEGGimmu:69994.
UCSCiuc012dod.1. mouse.

Organism-specific databases

CTDi6248.
MGIiMGI:3526447. Rsc1a1.

Phylogenomic databases

eggNOGiENOG410IJPT. Eukaryota.
ENOG4111B03. LUCA.
GeneTreeiENSGT00390000005744.
HOGENOMiHOG000049187.
HOVERGENiHBG101192.
InParanoidiQ9ER99.
OrthoDBiEOG77HDD7.
PhylomeDBiQ9ER99.
TreeFamiTF335675.

Miscellaneous databases

PROiQ9ER99.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ9ER99. baseline and differential.
GenevisibleiQ9ER99. MM.

Family and domain databases

InterProiIPR015940. UBA.
[Graphical view]
SMARTiSM00165. UBA. 1 hit.
[Graphical view]
PROSITEiPS50030. UBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Baumgarten K., Gorboulev V., Koepsell H.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Mammary tumor.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 358-582.
    Strain: C57BL/6J.
    Tissue: Testis.
  6. "Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity."
    Osswald C., Baumgarten K., Stuempel F., Gorboulev V., Akimjanova M., Knobeloch K.-P., Horak I., Kluge R., Joost H.G., Koepsell H.
    Mol. Cell. Biol. 25:78-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity."
    Jiang W., Prokopenko O., Wong L., Inouye M., Mirochnitchenko O.
    Mol. Cell. Biol. 25:6496-6508(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH YRDC.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart and Testis.

Entry informationi

Entry nameiRSCA1_MOUSE
AccessioniPrimary (citable) accession number: Q9ER99
Secondary accession number(s): B1AUM1
, B2RWX9, Q78HA0, Q9CVU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 24, 2009
Last modified: June 8, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.