Reviewed, UniProtKB/Swiss-Prot Q9ER97 (NGB_MOUSE)

Names and origin

Protein names

Recommended name:
    Neuroglobin

Gene names

Name:

Ngb

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in oxygen transport in the brain.
Subunit structure	Monomer.
Tissue specificity	Predominantly expressed in brain.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	3D-structure
Gene Ontology (GO)
Biological process	oxygen transport Ref.1 Inferred from direct assay. Source: MGI
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Ref.1 Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 151

151

Neuroglobin

PRO_0000053392

Regions

Region

1 – 149

149

Globin

Sites

Metal binding

64

1

Iron (heme distal ligand) By similarity

Metal binding

96

1

Iron (heme proximal ligand) By similarity

Secondary structure

1

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151

Helix Strand Turn

Details...

Helix

6 – 17

12

Helix

20 – 34

15

Helix

36 – 41

6

Helix

52 – 55

4

Helix

59 – 77

19

Beta strand

82 – 85

4

Helix

86 – 99

14

Helix

105 – 121

17

Helix

122 – 124

3

Helix

127 – 145

19

Helix

146 – 148

3

Sequences

	Sequence		Length	Mass (Da)
	Q9ER97-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 377BBE4BF723CCF1	FASTA	151	17,037
	10 20 30 40 50 60 MERPESELIR QSWRVVSRSP LEHGTVLFAR LFALEPSLLP LFQYNGRQFS SPEDCLSSPE 70 80 90 100 110 120 FLDHIRKVML VIDAAVTNVE DLSSLEEYLT SLGRKHRAVG VRLSSFSTVG ESLLYMLEKC 130 140 150 LGPDFTPATR TAWSRLYGAV VQAMSRGWDG E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A vertebrate globin expressed in the brain." Burmester T., Weich B., Reinhardt S., Hankeln T. Nature 407:520-522(2000) [PubMed: 11029004] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[3]	"The heme environment of mouse neuroglobin. Evidence for the presence of two conformations of the heme pocket." Couture M., Burmester T., Hankeln T., Rousseau D.L. J. Biol. Chem. 276:36377-36382(2001) [PubMed: 11473111] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AJ245945 mRNA. Translation: CAC11135.1.
BC024263 mRNA. Translation: AAH24263.1.

IPI

IPI00111750.

RefSeq

NP_071859.1.

UniGene

Mm.41395

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1Q1F	X-ray	1.50	A	1-151	[»]
1W92	X-ray	1.70	A	1-151	[»]
2VRY	X-ray	1.87	A	1-151	[»]
3GK9	X-ray	1.80	A	1-151	[»]
3GKT	X-ray	1.86	A	1-151	[»]
3GLN	X-ray	2.26	A	1-151	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

Q9ER97.

Proteomic databases

PRIDE

Q9ER97.

Genome annotation databases

Ensembl

ENSMUST00000110177; ENSMUSP00000105806; ENSMUSG00000021032; Mus musculus. [Genome view]

GeneID

64242.

KEGG

mmu:64242.

UCSC

uc007oii.1. mouse.

Organism-specific databases

CTD

64242.

MGI

MGI:2151886. Ngb.

Phylogenomic databases

HOVERGEN

Q9ER97.

OrthoDB

EOG94N1C7

Gene expression databases

ArrayExpress

Q9ER97.

Bgee

Q9ER97.

CleanEx

MM_NGB.

Genevestigator

Q9ER97.

GermOnline

ENSMUSG00000021032. Mus musculus.

Family and domain databases

InterPro

IPR012292. Globin.
IPR009050. Globin-like.
IPR000971. Globin_subset.
[Graphical view]

Gene3D

G3DSA:1.10.490.10. Globin_related. 1 hit.

Pfam

PF00042. Globin. 1 hit.
[Graphical view]

PROSITE

PS01033. GLOBIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

319968.

SOURCE

Search...

Entry information

Entry name

NGB_MOUSE

Accession

Primary (citable) accession number: Q9ER97

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
Last sequence update:	March 1, 2001
Last modified:	November 24, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)