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Protein

28S ribosomal protein S29, mitochondrial

Gene

Dap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mediating interferon-gamma-induced cell death.By similarity

GO - Molecular functioni

GO - Biological processi

  • apoptotic mitochondrial changes Source: MGI

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S29, mitochondrial
Short name:
MRP-S29
Short name:
S29mt
Alternative name(s):
Death-associated protein 3
Short name:
DAP-3
Gene namesi
Name:Dap3
Synonyms:Mrps29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1929538 Dap3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 17MitochondrionBy similarityAdd BLAST17
ChainiPRO_000008771818 – 39128S ribosomal protein S29, mitochondrialAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168N6-acetyllysineBy similarity1
Modified residuei200N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9ER88
PaxDbiQ9ER88
PeptideAtlasiQ9ER88
PRIDEiQ9ER88

PTM databases

iPTMnetiQ9ER88
PhosphoSitePlusiQ9ER88
SwissPalmiQ9ER88

Expressioni

Gene expression databases

BgeeiENSMUSG00000068921
CleanExiMM_DAP3
ExpressionAtlasiQ9ER88 baseline and differential
GenevisibleiQ9ER88 MM

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with KIAA0141. Interacts with NOA1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9ER88, 2 interactors
MINTiQ9ER88
STRINGi10090.ENSMUSP00000088456

Structurei

3D structure databases

ProteinModelPortaliQ9ER88
SMRiQ9ER88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3928 Eukaryota
ENOG410XSDC LUCA
GeneTreeiENSGT00390000015248
HOVERGENiHBG025946
InParanoidiQ9ER88
KOiK17408
PhylomeDBiQ9ER88

Family and domain databases

InterProiView protein in InterPro
IPR019368 Ribosomal_S23/S29_mit
IPR008092 Ribosomal_S29_mit
PANTHERiPTHR12810 PTHR12810, 1 hit
PfamiView protein in Pfam
PF10236 DAP3, 1 hit
PRINTSiPR01716 DEATHASSOCP3

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ER88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTGITRLFS RVQKLDPRCF LHMSVQATQN SQVPAERPRT VSRTSDSDPA
60 70 80 90 100
KHGEQHEGQH YSIPLQDLKT VFPHGLPPRY MMQVKTFGEA CLMVRKPALE
110 120 130 140 150
LLGYLKNTNF AHPAVRYLLY GEKGTGKTLS LCHAVHFCAR HDWLILHIPD
160 170 180 190 200
AHLWVKNCRE LLQSTHNKQR FDQPLEASTW LKNFKTTNER FLSQIKVQEK
210 220 230 240 250
YVWNKRESTE KGSPLGEVVE QGLTRVRNAT DAVGVVLKEL KAQSALGLFH
260 270 280 290 300
LLVAVDGVNA LWGRTTLKKE DRTLIAPEEL SLVHNLRKMV KNDWHGGAIV
310 320 330 340 350
LSLSQTGSLF KSRTAYLPHE LLGKEGFNAL EPFLPILIPN YNPKEFESSF
360 370 380 390
QYYLENNWLQ HEKASTEEGR KELRFLSNCN PEQLERLCAS L
Length:391
Mass (Da):44,699
Last modified:March 1, 2001 - v1
Checksum:i038AC9DA7A61FFF4
GO
Isoform 2 (identifier: Q9ER88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-324: Missing.

Note: No experimental confirmation available.
Show »
Length:361
Mass (Da):41,536
Checksum:i2F708608DB27B4D1
GO

Sequence cautioni

The sequence BAB29240 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB29605 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC27790 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC40673 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90A → R in BAB29605 (PubMed:16141072).Curated1
Sequence conflicti141H → N in BAC27790 (PubMed:16141072).Curated1
Sequence conflicti177A → G in BAB29605 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008916295 – 324Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250375 mRNA Translation: CAC05583.1
AK014889 mRNA Translation: BAB29605.1 Different initiation.
AK014280 mRNA Translation: BAB29240.3 Different initiation.
AK021250 mRNA No translation available.
AK032275 mRNA Translation: BAC27790.1 Different initiation.
AK088960 mRNA Translation: BAC40673.1 Different initiation.
BC019566 mRNA Translation: AAH19566.2
RefSeqiNP_001158005.1, NM_001164533.1
NP_075370.2, NM_022994.3
XP_006501925.1, XM_006501862.3 [Q9ER88-1]
XP_006501926.1, XM_006501863.3 [Q9ER88-1]
XP_006501927.1, XM_006501864.3 [Q9ER88-1]
XP_006501932.1, XM_006501869.3 [Q9ER88-1]
UniGeneiMm.29028
Mm.400397

Genome annotation databases

EnsembliENSMUST00000173135; ENSMUSP00000134422; ENSMUSG00000068921 [Q9ER88-1]
GeneIDi65111
KEGGimmu:65111
UCSCiuc008pxh.2 mouse [Q9ER88-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRT29_MOUSE
AccessioniPrimary (citable) accession number: Q9ER88
Secondary accession number(s): Q8C2B2
, Q8CCQ8, Q8VCK8, Q9CRT4, Q9CS11, Q9D5V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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