Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9ER88 (RT29_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
28S ribosomal protein S29, mitochondrial

Short name=MRP-S29
Short name=S29mt
Alternative name(s):
Death-associated protein 3
Short name=DAP-3
Gene names
Name:Dap3
Synonyms:Mrps29
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in mediating interferon-gamma-induced cell death By similarity.

Subunit structure

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with KIAA0141. Interacts with NOA1 By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence caution

The sequence BAB29240.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAB29605.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAC27790.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAC40673.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic mitochondrial changes

Inferred from direct assay Ref.1. Source: MGI

   Cellular_componentmitochondrial matrix

Inferred from direct assay Ref.1. Source: MGI

mitochondrial ribosome

Inferred from electronic annotation. Source: InterPro

mitochondrion

Inferred from direct assay PubMed 18614015. Source: MGI

small ribosomal subunit

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9ER88-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9ER88-2)

The sequence of this isoform differs from the canonical sequence as follows:
     295-324: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1717Mitochondrion By similarity
Chain18 – 39137428S ribosomal protein S29, mitochondrial
PRO_0000087718

Amino acid modifications

Modified residue1681N6-acetyllysine By similarity
Modified residue2001N6-acetyllysine By similarity

Natural variations

Alternative sequence295 – 32430Missing in isoform 2.
VSP_008916

Experimental info

Sequence conflict901A → R in BAB29605. Ref.2
Sequence conflict1411H → N in BAC27790. Ref.2
Sequence conflict1771A → G in BAB29605. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 038AC9DA7A61FFF4

FASTA39144,699
        10         20         30         40         50         60 
MLTGITRLFS RVQKLDPRCF LHMSVQATQN SQVPAERPRT VSRTSDSDPA KHGEQHEGQH 

        70         80         90        100        110        120 
YSIPLQDLKT VFPHGLPPRY MMQVKTFGEA CLMVRKPALE LLGYLKNTNF AHPAVRYLLY 

       130        140        150        160        170        180 
GEKGTGKTLS LCHAVHFCAR HDWLILHIPD AHLWVKNCRE LLQSTHNKQR FDQPLEASTW 

       190        200        210        220        230        240 
LKNFKTTNER FLSQIKVQEK YVWNKRESTE KGSPLGEVVE QGLTRVRNAT DAVGVVLKEL 

       250        260        270        280        290        300 
KAQSALGLFH LLVAVDGVNA LWGRTTLKKE DRTLIAPEEL SLVHNLRKMV KNDWHGGAIV 

       310        320        330        340        350        360 
LSLSQTGSLF KSRTAYLPHE LLGKEGFNAL EPFLPILIPN YNPKEFESSF QYYLENNWLQ 

       370        380        390 
HEKASTEEGR KELRFLSNCN PEQLERLCAS L 

« Hide

Isoform 2 [UniParc].

Checksum: 2F708608DB27B4D1
Show »

FASTA36141,536

References

« Hide 'large scale' references
[1]"The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins."
Berger T., Brigl M., Herrmann J.M., Vielhauer V., Luckow B., Schloendorff D., Kretzler M.
J. Cell Sci. 113:3603-3612(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Embryonic kidney.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J, FVB/N and NOD.
Tissue: Embryo, Embryonic head, Olfactory bulb, Testis and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ250375 mRNA. Translation: CAC05583.1.
AK014889 mRNA. Translation: BAB29605.1. Different initiation.
AK014280 mRNA. Translation: BAB29240.3. Different initiation.
AK021250 mRNA. No translation available.
AK032275 mRNA. Translation: BAC27790.1. Different initiation.
AK088960 mRNA. Translation: BAC40673.1. Different initiation.
BC019566 mRNA. Translation: AAH19566.2.
RefSeqNP_001158005.1. NM_001164533.1.
NP_075370.2. NM_022994.3.
XP_006501925.1. XM_006501862.1. [Q9ER88-1]
XP_006501926.1. XM_006501863.1. [Q9ER88-1]
XP_006501927.1. XM_006501864.1. [Q9ER88-1]
XP_006501932.1. XM_006501869.1. [Q9ER88-1]
UniGeneMm.29028.
Mm.400397.

3D structure databases

ProteinModelPortalQ9ER88.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid211134. 8 interactions.
IntActQ9ER88. 2 interactions.
MINTMINT-1849208.
STRING10090.ENSMUSP00000088456.

PTM databases

PhosphoSiteQ9ER88.

Proteomic databases

MaxQBQ9ER88.
PaxDbQ9ER88.
PRIDEQ9ER88.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000107491; ENSMUSP00000103115; ENSMUSG00000068921.
ENSMUST00000173135; ENSMUSP00000134422; ENSMUSG00000068921. [Q9ER88-1]
GeneID65111.
KEGGmmu:65111.
UCSCuc008pxh.2. mouse. [Q9ER88-2]

Organism-specific databases

CTD7818.
MGIMGI:1929538. Dap3.

Phylogenomic databases

eggNOGNOG260931.
GeneTreeENSGT00390000015248.
HOVERGENHBG025946.
InParanoidQ9ER88.
KOK17408.
PhylomeDBQ9ER88.

Gene expression databases

ArrayExpressQ9ER88.
BgeeQ9ER88.
CleanExMM_DAP3.
GenevestigatorQ9ER88.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR019368. Ribosomal_S23/S29_mit.
IPR008092. Ribosomal_S29_mit.
[Graphical view]
PfamPF10236. DAP3. 1 hit.
[Graphical view]
PRINTSPR01716. DEATHASSOCP3.
ProtoNetSearch...

Other

NextBio320301.
PROQ9ER88.
SOURCESearch...

Entry information

Entry nameRT29_MOUSE
AccessionPrimary (citable) accession number: Q9ER88
Secondary accession number(s): Q8C2B2 expand/collapse secondary AC list , Q8CCQ8, Q8VCK8, Q9CRT4, Q9CS11, Q9D5V9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2001
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot