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Protein

28S ribosomal protein S29, mitochondrial

Gene

Dap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in mediating interferon-gamma-induced cell death.By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: MGI

GO - Biological processi

  1. apoptotic mitochondrial changes Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_292710. Mitochondrial translation elongation.
REACT_344470. Mitochondrial translation termination.
REACT_350780. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S29, mitochondrial
Short name:
MRP-S29
Short name:
S29mt
Alternative name(s):
Death-associated protein 3
Short name:
DAP-3
Gene namesi
Name:Dap3
Synonyms:Mrps29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1929538. Dap3.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: MGI
  2. mitochondrial ribosome Source: InterPro
  3. mitochondrion Source: MGI
  4. nucleolus Source: MGI
  5. nucleoplasm Source: MGI
  6. nucleus Source: MGI
  7. small ribosomal subunit Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1717MitochondrionBy similarityAdd
BLAST
Chaini18 – 39137428S ribosomal protein S29, mitochondrialPRO_0000087718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei168 – 1681N6-acetyllysineBy similarity
Modified residuei200 – 2001N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9ER88.
PaxDbiQ9ER88.
PRIDEiQ9ER88.

PTM databases

PhosphoSiteiQ9ER88.

Expressioni

Gene expression databases

BgeeiQ9ER88.
CleanExiMM_DAP3.
ExpressionAtlasiQ9ER88. baseline and differential.
GenevestigatoriQ9ER88.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with KIAA0141. Interacts with NOA1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211134. 8 interactions.
IntActiQ9ER88. 2 interactions.
MINTiMINT-1849208.
STRINGi10090.ENSMUSP00000088456.

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG260931.
GeneTreeiENSGT00390000015248.
HOVERGENiHBG025946.
InParanoidiQ9ER88.
KOiK17408.
PhylomeDBiQ9ER88.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR019368. Ribosomal_S23/S29_mit.
IPR008092. Ribosomal_S29_mit.
[Graphical view]
PfamiPF10236. DAP3. 1 hit.
[Graphical view]
PRINTSiPR01716. DEATHASSOCP3.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ER88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTGITRLFS RVQKLDPRCF LHMSVQATQN SQVPAERPRT VSRTSDSDPA
60 70 80 90 100
KHGEQHEGQH YSIPLQDLKT VFPHGLPPRY MMQVKTFGEA CLMVRKPALE
110 120 130 140 150
LLGYLKNTNF AHPAVRYLLY GEKGTGKTLS LCHAVHFCAR HDWLILHIPD
160 170 180 190 200
AHLWVKNCRE LLQSTHNKQR FDQPLEASTW LKNFKTTNER FLSQIKVQEK
210 220 230 240 250
YVWNKRESTE KGSPLGEVVE QGLTRVRNAT DAVGVVLKEL KAQSALGLFH
260 270 280 290 300
LLVAVDGVNA LWGRTTLKKE DRTLIAPEEL SLVHNLRKMV KNDWHGGAIV
310 320 330 340 350
LSLSQTGSLF KSRTAYLPHE LLGKEGFNAL EPFLPILIPN YNPKEFESSF
360 370 380 390
QYYLENNWLQ HEKASTEEGR KELRFLSNCN PEQLERLCAS L
Length:391
Mass (Da):44,699
Last modified:February 28, 2001 - v1
Checksum:i038AC9DA7A61FFF4
GO
Isoform 2 (identifier: Q9ER88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-324: Missing.

Note: No experimental confirmation available.

Show »
Length:361
Mass (Da):41,536
Checksum:i2F708608DB27B4D1
GO

Sequence cautioni

The sequence BAB29240.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB29605.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC27790.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC40673.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901A → R in BAB29605 (PubMed:16141072).Curated
Sequence conflicti141 – 1411H → N in BAC27790 (PubMed:16141072).Curated
Sequence conflicti177 – 1771A → G in BAB29605 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei295 – 32430Missing in isoform 2. 1 PublicationVSP_008916Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250375 mRNA. Translation: CAC05583.1.
AK014889 mRNA. Translation: BAB29605.1. Different initiation.
AK014280 mRNA. Translation: BAB29240.3. Different initiation.
AK021250 mRNA. No translation available.
AK032275 mRNA. Translation: BAC27790.1. Different initiation.
AK088960 mRNA. Translation: BAC40673.1. Different initiation.
BC019566 mRNA. Translation: AAH19566.2.
RefSeqiNP_001158005.1. NM_001164533.1.
NP_075370.2. NM_022994.3.
XP_006501925.1. XM_006501862.2. [Q9ER88-1]
XP_006501926.1. XM_006501863.2. [Q9ER88-1]
XP_006501927.1. XM_006501864.2. [Q9ER88-1]
XP_006501932.1. XM_006501869.2. [Q9ER88-1]
UniGeneiMm.29028.
Mm.400397.

Genome annotation databases

EnsembliENSMUST00000173135; ENSMUSP00000134422; ENSMUSG00000068921. [Q9ER88-1]
GeneIDi65111.
KEGGimmu:65111.
UCSCiuc008pxh.2. mouse. [Q9ER88-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250375 mRNA. Translation: CAC05583.1.
AK014889 mRNA. Translation: BAB29605.1. Different initiation.
AK014280 mRNA. Translation: BAB29240.3. Different initiation.
AK021250 mRNA. No translation available.
AK032275 mRNA. Translation: BAC27790.1. Different initiation.
AK088960 mRNA. Translation: BAC40673.1. Different initiation.
BC019566 mRNA. Translation: AAH19566.2.
RefSeqiNP_001158005.1. NM_001164533.1.
NP_075370.2. NM_022994.3.
XP_006501925.1. XM_006501862.2. [Q9ER88-1]
XP_006501926.1. XM_006501863.2. [Q9ER88-1]
XP_006501927.1. XM_006501864.2. [Q9ER88-1]
XP_006501932.1. XM_006501869.2. [Q9ER88-1]
UniGeneiMm.29028.
Mm.400397.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211134. 8 interactions.
IntActiQ9ER88. 2 interactions.
MINTiMINT-1849208.
STRINGi10090.ENSMUSP00000088456.

PTM databases

PhosphoSiteiQ9ER88.

Proteomic databases

MaxQBiQ9ER88.
PaxDbiQ9ER88.
PRIDEiQ9ER88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000173135; ENSMUSP00000134422; ENSMUSG00000068921. [Q9ER88-1]
GeneIDi65111.
KEGGimmu:65111.
UCSCiuc008pxh.2. mouse. [Q9ER88-2]

Organism-specific databases

CTDi7818.
MGIiMGI:1929538. Dap3.

Phylogenomic databases

eggNOGiNOG260931.
GeneTreeiENSGT00390000015248.
HOVERGENiHBG025946.
InParanoidiQ9ER88.
KOiK17408.
PhylomeDBiQ9ER88.

Enzyme and pathway databases

ReactomeiREACT_292710. Mitochondrial translation elongation.
REACT_344470. Mitochondrial translation termination.
REACT_350780. Mitochondrial translation initiation.

Miscellaneous databases

NextBioi320301.
PROiQ9ER88.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ER88.
CleanExiMM_DAP3.
ExpressionAtlasiQ9ER88. baseline and differential.
GenevestigatoriQ9ER88.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR019368. Ribosomal_S23/S29_mit.
IPR008092. Ribosomal_S29_mit.
[Graphical view]
PfamiPF10236. DAP3. 1 hit.
[Graphical view]
PRINTSiPR01716. DEATHASSOCP3.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins."
    Berger T., Brigl M., Herrmann J.M., Vielhauer V., Luckow B., Schloendorff D., Kretzler M.
    J. Cell Sci. 113:3603-3612(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Embryonic kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J, FVB/N and NOD.
    Tissue: Embryo, Embryonic head, Olfactory bulb, Testis and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiRT29_MOUSE
AccessioniPrimary (citable) accession number: Q9ER88
Secondary accession number(s): Q8C2B2
, Q8CCQ8, Q8VCK8, Q9CRT4, Q9CS11, Q9D5V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2002
Last sequence update: February 28, 2001
Last modified: March 31, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.