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Q9ER88

- RT29_MOUSE

UniProt

Q9ER88 - RT29_MOUSE

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Protein

28S ribosomal protein S29, mitochondrial

Gene

Dap3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in mediating interferon-gamma-induced cell death.By similarity

GO - Biological processi

  1. apoptotic mitochondrial changes Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_270125. Mitochondrial translation elongation.
REACT_270158. Mitochondrial translation termination.
REACT_271096. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S29, mitochondrial
Short name:
MRP-S29
Short name:
S29mt
Alternative name(s):
Death-associated protein 3
Short name:
DAP-3
Gene namesi
Name:Dap3
Synonyms:Mrps29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1929538. Dap3.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: MGI
  2. mitochondrial ribosome Source: InterPro
  3. mitochondrion Source: MGI
  4. small ribosomal subunit Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1717MitochondrionBy similarityAdd
BLAST
Chaini18 – 39137428S ribosomal protein S29, mitochondrialPRO_0000087718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei168 – 1681N6-acetyllysineBy similarity
Modified residuei200 – 2001N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9ER88.
PaxDbiQ9ER88.
PRIDEiQ9ER88.

PTM databases

PhosphoSiteiQ9ER88.

Expressioni

Gene expression databases

BgeeiQ9ER88.
CleanExiMM_DAP3.
ExpressionAtlasiQ9ER88. baseline and differential.
GenevestigatoriQ9ER88.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with KIAA0141. Interacts with NOA1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211134. 8 interactions.
IntActiQ9ER88. 2 interactions.
MINTiMINT-1849208.
STRINGi10090.ENSMUSP00000088456.

Structurei

3D structure databases

ProteinModelPortaliQ9ER88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG260931.
GeneTreeiENSGT00390000015248.
HOVERGENiHBG025946.
InParanoidiQ9ER88.
KOiK17408.
PhylomeDBiQ9ER88.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR019368. Ribosomal_S23/S29_mit.
IPR008092. Ribosomal_S29_mit.
[Graphical view]
PfamiPF10236. DAP3. 1 hit.
[Graphical view]
PRINTSiPR01716. DEATHASSOCP3.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ER88-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTGITRLFS RVQKLDPRCF LHMSVQATQN SQVPAERPRT VSRTSDSDPA
60 70 80 90 100
KHGEQHEGQH YSIPLQDLKT VFPHGLPPRY MMQVKTFGEA CLMVRKPALE
110 120 130 140 150
LLGYLKNTNF AHPAVRYLLY GEKGTGKTLS LCHAVHFCAR HDWLILHIPD
160 170 180 190 200
AHLWVKNCRE LLQSTHNKQR FDQPLEASTW LKNFKTTNER FLSQIKVQEK
210 220 230 240 250
YVWNKRESTE KGSPLGEVVE QGLTRVRNAT DAVGVVLKEL KAQSALGLFH
260 270 280 290 300
LLVAVDGVNA LWGRTTLKKE DRTLIAPEEL SLVHNLRKMV KNDWHGGAIV
310 320 330 340 350
LSLSQTGSLF KSRTAYLPHE LLGKEGFNAL EPFLPILIPN YNPKEFESSF
360 370 380 390
QYYLENNWLQ HEKASTEEGR KELRFLSNCN PEQLERLCAS L
Length:391
Mass (Da):44,699
Last modified:March 1, 2001 - v1
Checksum:i038AC9DA7A61FFF4
GO
Isoform 2 (identifier: Q9ER88-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-324: Missing.

Note: No experimental confirmation available.

Show »
Length:361
Mass (Da):41,536
Checksum:i2F708608DB27B4D1
GO

Sequence cautioni

The sequence BAB29240.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB29605.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC27790.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC40673.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901A → R in BAB29605. (PubMed:16141072)Curated
Sequence conflicti141 – 1411H → N in BAC27790. (PubMed:16141072)Curated
Sequence conflicti177 – 1771A → G in BAB29605. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei295 – 32430Missing in isoform 2. 1 PublicationVSP_008916Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250375 mRNA. Translation: CAC05583.1.
AK014889 mRNA. Translation: BAB29605.1. Different initiation.
AK014280 mRNA. Translation: BAB29240.3. Different initiation.
AK021250 mRNA. No translation available.
AK032275 mRNA. Translation: BAC27790.1. Different initiation.
AK088960 mRNA. Translation: BAC40673.1. Different initiation.
BC019566 mRNA. Translation: AAH19566.2.
RefSeqiNP_001158005.1. NM_001164533.1.
NP_075370.2. NM_022994.3.
XP_006501925.1. XM_006501862.1. [Q9ER88-1]
XP_006501926.1. XM_006501863.1. [Q9ER88-1]
XP_006501927.1. XM_006501864.1. [Q9ER88-1]
XP_006501932.1. XM_006501869.1. [Q9ER88-1]
UniGeneiMm.29028.
Mm.400397.

Genome annotation databases

EnsembliENSMUST00000107491; ENSMUSP00000103115; ENSMUSG00000068921.
ENSMUST00000173135; ENSMUSP00000134422; ENSMUSG00000068921. [Q9ER88-1]
GeneIDi65111.
KEGGimmu:65111.
UCSCiuc008pxh.2. mouse. [Q9ER88-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250375 mRNA. Translation: CAC05583.1 .
AK014889 mRNA. Translation: BAB29605.1 . Different initiation.
AK014280 mRNA. Translation: BAB29240.3 . Different initiation.
AK021250 mRNA. No translation available.
AK032275 mRNA. Translation: BAC27790.1 . Different initiation.
AK088960 mRNA. Translation: BAC40673.1 . Different initiation.
BC019566 mRNA. Translation: AAH19566.2 .
RefSeqi NP_001158005.1. NM_001164533.1.
NP_075370.2. NM_022994.3.
XP_006501925.1. XM_006501862.1. [Q9ER88-1 ]
XP_006501926.1. XM_006501863.1. [Q9ER88-1 ]
XP_006501927.1. XM_006501864.1. [Q9ER88-1 ]
XP_006501932.1. XM_006501869.1. [Q9ER88-1 ]
UniGenei Mm.29028.
Mm.400397.

3D structure databases

ProteinModelPortali Q9ER88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211134. 8 interactions.
IntActi Q9ER88. 2 interactions.
MINTi MINT-1849208.
STRINGi 10090.ENSMUSP00000088456.

PTM databases

PhosphoSitei Q9ER88.

Proteomic databases

MaxQBi Q9ER88.
PaxDbi Q9ER88.
PRIDEi Q9ER88.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107491 ; ENSMUSP00000103115 ; ENSMUSG00000068921 .
ENSMUST00000173135 ; ENSMUSP00000134422 ; ENSMUSG00000068921 . [Q9ER88-1 ]
GeneIDi 65111.
KEGGi mmu:65111.
UCSCi uc008pxh.2. mouse. [Q9ER88-2 ]

Organism-specific databases

CTDi 7818.
MGIi MGI:1929538. Dap3.

Phylogenomic databases

eggNOGi NOG260931.
GeneTreei ENSGT00390000015248.
HOVERGENi HBG025946.
InParanoidi Q9ER88.
KOi K17408.
PhylomeDBi Q9ER88.

Enzyme and pathway databases

Reactomei REACT_270125. Mitochondrial translation elongation.
REACT_270158. Mitochondrial translation termination.
REACT_271096. Mitochondrial translation initiation.

Miscellaneous databases

NextBioi 320301.
PROi Q9ER88.
SOURCEi Search...

Gene expression databases

Bgeei Q9ER88.
CleanExi MM_DAP3.
ExpressionAtlasi Q9ER88. baseline and differential.
Genevestigatori Q9ER88.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR019368. Ribosomal_S23/S29_mit.
IPR008092. Ribosomal_S29_mit.
[Graphical view ]
Pfami PF10236. DAP3. 1 hit.
[Graphical view ]
PRINTSi PR01716. DEATHASSOCP3.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins."
    Berger T., Brigl M., Herrmann J.M., Vielhauer V., Luckow B., Schloendorff D., Kretzler M.
    J. Cell Sci. 113:3603-3612(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Embryonic kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J, FVB/N and NOD.
    Tissue: Embryo, Embryonic head, Olfactory bulb, Testis and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiRT29_MOUSE
AccessioniPrimary (citable) accession number: Q9ER88
Secondary accession number(s): Q8C2B2
, Q8CCQ8, Q8VCK8, Q9CRT4, Q9CS11, Q9D5V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3