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Protein

Receptor-transporting protein 4

Gene

Rtp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (By similarity). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (PubMed:18836069).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-transporting protein 4
Alternative name(s):
28 kDa interferon-responsive protein
Gene namesi
Name:Rtp4
Synonyms:Ifrg28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1915025. Rtp4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 227227CytoplasmicSequence analysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Receptor-transporting protein 4PRO_0000181996Add
BLAST

Proteomic databases

MaxQBiQ9ER80.
PaxDbiQ9ER80.
PRIDEiQ9ER80.

PTM databases

iPTMnetiQ9ER80.
PhosphoSiteiQ9ER80.

Expressioni

Tissue specificityi

Expressed at low levels in olfactory neurons.1 Publication

Inductioni

By interferons.

Gene expression databases

BgeeiQ9ER80.
CleanExiMM_RTP4.
GenevisibleiQ9ER80. MM.

Interactioni

Subunit structurei

Interacts with TASR16 (By similarity). Interacts with OPRD1 and OPRM1; the interaction promotes cell surface localization of the OPDR1-OPRM1 heterodimer (PubMed:18836069).By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-46418N.
STRINGi10090.ENSMUSP00000041091.

Structurei

3D structure databases

ProteinModelPortaliQ9ER80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH22. Eukaryota.
ENOG4111X4F. LUCA.
GeneTreeiENSGT00530000063222.
HOGENOMiHOG000236274.
HOVERGENiHBG073235.
InParanoidiQ9ER80.
OMAiECASCTR.
OrthoDBiEOG70S769.
PhylomeDBiQ9ER80.
TreeFamiTF333246.

Family and domain databases

InterProiIPR026096. R-trans_p.
IPR026690. RTP4.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR14402. PTHR14402. 1 hit.
PTHR14402:SF8. PTHR14402:SF8. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]
SMARTiSM01328. zf-3CxxC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ER80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFPDDFSTW EQTFQELMQE EKPGAKWSLH LDKNIVPDGA ALGWRQHQQT
60 70 80 90 100
VLGRFQCSRC CRSWTSAQVM ILCHMYPDTL KSQGQARMRI FGQKCQKCFG
110 120 130 140 150
CQFETPKFST EIIKRILNNL VNYILQRYYG HRKIALTSNA SLGEKVTLDG
160 170 180 190 200
PHDTRNCEAC SLNSHGRCAL AHKVKPPRSP SPLPKSSSPS KSCPPPPQTR
210 220 230 240
NTDFGNKTFQ DFGNRTFQGC REPPQREIEP PLFLFLSIAA FALFSLFTR
Length:249
Mass (Da):28,392
Last modified:March 1, 2001 - v1
Checksum:i2C79B36ED6F042D4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851K → N in AAT70673 (PubMed:15550249).Curated
Sequence conflicti185 – 1851K → N in BAB31041 (PubMed:16141072).Curated
Sequence conflicti209 – 2091F → L in AAT70673 (PubMed:15550249).Curated
Sequence conflicti209 – 2091F → L in BAB31041 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251364 mRNA. Translation: CAC13976.1.
AY562228 mRNA. Translation: AAT70673.1.
AK007477 mRNA. Translation: BAB25057.1.
AK018021 mRNA. Translation: BAB31041.1.
CCDSiCCDS28079.1.
RefSeqiNP_075875.3. NM_023386.5.
XP_006522554.1. XM_006522491.2.
UniGeneiMm.475107.

Genome annotation databases

EnsembliENSMUST00000038423; ENSMUSP00000041091; ENSMUSG00000033355.
GeneIDi67775.
KEGGimmu:67775.
UCSCiuc007ytw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251364 mRNA. Translation: CAC13976.1.
AY562228 mRNA. Translation: AAT70673.1.
AK007477 mRNA. Translation: BAB25057.1.
AK018021 mRNA. Translation: BAB31041.1.
CCDSiCCDS28079.1.
RefSeqiNP_075875.3. NM_023386.5.
XP_006522554.1. XM_006522491.2.
UniGeneiMm.475107.

3D structure databases

ProteinModelPortaliQ9ER80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46418N.
STRINGi10090.ENSMUSP00000041091.

PTM databases

iPTMnetiQ9ER80.
PhosphoSiteiQ9ER80.

Proteomic databases

MaxQBiQ9ER80.
PaxDbiQ9ER80.
PRIDEiQ9ER80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038423; ENSMUSP00000041091; ENSMUSG00000033355.
GeneIDi67775.
KEGGimmu:67775.
UCSCiuc007ytw.2. mouse.

Organism-specific databases

CTDi64108.
MGIiMGI:1915025. Rtp4.

Phylogenomic databases

eggNOGiENOG410IH22. Eukaryota.
ENOG4111X4F. LUCA.
GeneTreeiENSGT00530000063222.
HOGENOMiHOG000236274.
HOVERGENiHBG073235.
InParanoidiQ9ER80.
OMAiECASCTR.
OrthoDBiEOG70S769.
PhylomeDBiQ9ER80.
TreeFamiTF333246.

Miscellaneous databases

ChiTaRSiRtp4. mouse.
PROiQ9ER80.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ER80.
CleanExiMM_RTP4.
GenevisibleiQ9ER80. MM.

Family and domain databases

InterProiIPR026096. R-trans_p.
IPR026690. RTP4.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR14402. PTHR14402. 1 hit.
PTHR14402:SF8. PTHR14402:SF8. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]
SMARTiSM01328. zf-3CxxC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of ifrg15 and ifrg28, two newly identified interferon responsive gene."
    Meritet J.F., Dron M., Tovey M.G.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2J.
  2. "RTP family members induce functional expression of mammalian odorant receptors."
    Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.
    Cell 119:679-691(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas and Thymus.
  4. "Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4."
    Decaillot F.M., Rozenfeld R., Gupta A., Devi L.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:16045-16050(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH OPRD1 AND OPRM1.

Entry informationi

Entry nameiRTP4_MOUSE
AccessioniPrimary (citable) accession number: Q9ER80
Secondary accession number(s): Q9D3D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.