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Q9ER75 (IRX6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Iroquois-class homeodomain protein IRX-6
Alternative name(s):
Homeodomain protein IRXB3
Iroquois homeobox protein 6
Gene names
Name:Irx6
Synonyms:Irxb3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the TALE/IRO homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Iroquois-class homeodomain protein IRX-6
PRO_0000049163

Regions

DNA binding141 – 20464Homeobox; TALE-type
Compositional bias256 – 26712Poly-Glu

Experimental info

Sequence conflict331P → S in CAC10403. Ref.1
Sequence conflict331P → S in AAI30030. Ref.3
Sequence conflict2961R → G in CAC10403. Ref.1
Sequence conflict2961R → G in AAI30030. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9ER75 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 51E5421FB653A0F0

FASTA43847,352
        10         20         30         40         50         60 
MAFSPFGHPY GSTSQFLVSA SSSATCCETA PRPVSDVASA STSASTLCCT PYDSRLLGSA 

        70         80         90        100        110        120 
RPELGAALGI YGAPYAAAQS YPGYLTYGPE PPTLCGALNP QYEFKDAAGS FAPSLTQPGA 

       130        140        150        160        170        180 
YYPYETTLGQ YQYDRYGGVE LSSAGRRKNA TRESTSALKA WLHEHRKNPY PTKGEKIMLA 

       190        200        210        220        230        240 
IITKMTLTQV STWFANARRR LKKENKMTWA PKNKGGEERK ADSGEDSLGC LNGDTKDATA 

       250        260        270        280        290        300 
SQEARGLRLS DLEDLEEEEE EEEAEEEAAV SAARRLADFQ KSTQPLPAPC AAAQERCLES 

       310        320        330        340        350        360 
RECGLGLPRF SFTEAPQSGE ADFITAEPGG PTMILHYPSG HKPRIWSLAH TAAASAVESA 

       370        380        390        400        410        420 
PSTPPRAQSP ECHMIPRQPS SIRRLLVPRD SEGEEDSPAA KAFGNSTFTL QGLPLNCAPY 

       430 
PRRREPEVRF QYPSGAEG 

« Hide

References

« Hide 'large scale' references
[1]"Organization of mouse Iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development."
Peters T., Dildrop R., Ausmeier K., Ruether U.
Genome Res. 10:1453-1462(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NIH Swiss.
Tissue: Heart.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ271055 mRNA. Translation: CAC10403.1.
AC134337 Genomic DNA. No translation available.
BC130029 mRNA. Translation: AAI30030.1.
RefSeqXP_006531325.1. XM_006531262.1.
UniGeneMm.137247.

3D structure databases

ProteinModelPortalQ9ER75.
SMRQ9ER75. Positions 152-201.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9ER75.

Proteomic databases

PRIDEQ9ER75.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000167261; ENSMUSP00000127446; ENSMUSG00000031738.
GeneID64379.
KEGGmmu:64379.
UCSCuc009muc.1. mouse.

Organism-specific databases

CTD79190.
MGIMGI:1927642. Irx6.

Phylogenomic databases

eggNOGNOG310996.
GeneTreeENSGT00750000117365.
HOVERGENHBG006180.
InParanoidA1L3D2.

Gene expression databases

BgeeQ9ER75.
CleanExMM_IRX6.
GenevestigatorQ9ER75.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9ER75.
SOURCESearch...

Entry information

Entry nameIRX6_MOUSE
AccessionPrimary (citable) accession number: Q9ER75
Secondary accession number(s): A1L3D2, E9Q2V2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot