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Q9ER75

- IRX6_MOUSE

UniProt

Q9ER75 - IRX6_MOUSE

Protein

Iroquois-class homeodomain protein IRX-6

Gene

Irx6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi141 – 20464Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iroquois-class homeodomain protein IRX-6
    Alternative name(s):
    Homeodomain protein IRXB3
    Iroquois homeobox protein 6
    Gene namesi
    Name:Irx6
    Synonyms:Irxb3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1927642. Irx6.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438Iroquois-class homeodomain protein IRX-6PRO_0000049163Add
    BLAST

    Proteomic databases

    PRIDEiQ9ER75.

    PTM databases

    PhosphoSiteiQ9ER75.

    Expressioni

    Gene expression databases

    BgeeiQ9ER75.
    CleanExiMM_IRX6.
    GenevestigatoriQ9ER75.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ER75.
    SMRiQ9ER75. Positions 152-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi256 – 26712Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TALE/IRO homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG310996.
    GeneTreeiENSGT00750000117365.
    HOVERGENiHBG006180.
    InParanoidiA1L3D2.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    IPR003893. Iroquois_homeo.
    [Graphical view]
    PfamiPF05920. Homeobox_KN. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00548. IRO. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ER75-1 [UniParc]FASTAAdd to Basket

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    MAFSPFGHPY GSTSQFLVSA SSSATCCETA PRPVSDVASA STSASTLCCT    50
    PYDSRLLGSA RPELGAALGI YGAPYAAAQS YPGYLTYGPE PPTLCGALNP 100
    QYEFKDAAGS FAPSLTQPGA YYPYETTLGQ YQYDRYGGVE LSSAGRRKNA 150
    TRESTSALKA WLHEHRKNPY PTKGEKIMLA IITKMTLTQV STWFANARRR 200
    LKKENKMTWA PKNKGGEERK ADSGEDSLGC LNGDTKDATA SQEARGLRLS 250
    DLEDLEEEEE EEEAEEEAAV SAARRLADFQ KSTQPLPAPC AAAQERCLES 300
    RECGLGLPRF SFTEAPQSGE ADFITAEPGG PTMILHYPSG HKPRIWSLAH 350
    TAAASAVESA PSTPPRAQSP ECHMIPRQPS SIRRLLVPRD SEGEEDSPAA 400
    KAFGNSTFTL QGLPLNCAPY PRRREPEVRF QYPSGAEG 438
    Length:438
    Mass (Da):47,352
    Last modified:July 27, 2011 - v2
    Checksum:i51E5421FB653A0F0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331P → S in CAC10403. (PubMed:11042145)Curated
    Sequence conflicti33 – 331P → S in AAI30030. (PubMed:15489334)Curated
    Sequence conflicti296 – 2961R → G in CAC10403. (PubMed:11042145)Curated
    Sequence conflicti296 – 2961R → G in AAI30030. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271055 mRNA. Translation: CAC10403.1.
    AC134337 Genomic DNA. No translation available.
    BC130029 mRNA. Translation: AAI30030.1.
    RefSeqiXP_006531325.1. XM_006531262.1.
    UniGeneiMm.137247.

    Genome annotation databases

    EnsembliENSMUST00000167261; ENSMUSP00000127446; ENSMUSG00000031738.
    GeneIDi64379.
    KEGGimmu:64379.
    UCSCiuc009muc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271055 mRNA. Translation: CAC10403.1 .
    AC134337 Genomic DNA. No translation available.
    BC130029 mRNA. Translation: AAI30030.1 .
    RefSeqi XP_006531325.1. XM_006531262.1.
    UniGenei Mm.137247.

    3D structure databases

    ProteinModelPortali Q9ER75.
    SMRi Q9ER75. Positions 152-201.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9ER75.

    Proteomic databases

    PRIDEi Q9ER75.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000167261 ; ENSMUSP00000127446 ; ENSMUSG00000031738 .
    GeneIDi 64379.
    KEGGi mmu:64379.
    UCSCi uc009muc.1. mouse.

    Organism-specific databases

    CTDi 79190.
    MGIi MGI:1927642. Irx6.

    Phylogenomic databases

    eggNOGi NOG310996.
    GeneTreei ENSGT00750000117365.
    HOVERGENi HBG006180.
    InParanoidi A1L3D2.

    Miscellaneous databases

    PROi Q9ER75.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ER75.
    CleanExi MM_IRX6.
    Genevestigatori Q9ER75.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    IPR003893. Iroquois_homeo.
    [Graphical view ]
    Pfami PF05920. Homeobox_KN. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00548. IRO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization of mouse Iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development."
      Peters T., Dildrop R., Ausmeier K., Ruether U.
      Genome Res. 10:1453-1462(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NIH Swiss.
      Tissue: Heart.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiIRX6_MOUSE
    AccessioniPrimary (citable) accession number: Q9ER75
    Secondary accession number(s): A1L3D2, E9Q2V2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3