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Protein

Iroquois-class homeodomain protein IRX-6

Gene

Irx6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi141 – 20464Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-6
Alternative name(s):
Homeodomain protein IRXB3
Iroquois homeobox protein 6
Gene namesi
Name:Irx6
Synonyms:Irxb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1927642. Irx6.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Iroquois-class homeodomain protein IRX-6PRO_0000049163Add
BLAST

Proteomic databases

PRIDEiQ9ER75.

PTM databases

PhosphoSiteiQ9ER75.

Expressioni

Gene expression databases

BgeeiQ9ER75.
CleanExiMM_IRX6.
ExpressionAtlasiQ9ER75. differential.
GenevestigatoriQ9ER75.

Structurei

3D structure databases

ProteinModelPortaliQ9ER75.
SMRiQ9ER75. Positions 152-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi256 – 26712Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG310996.
GeneTreeiENSGT00750000117365.
HOVERGENiHBG006180.
InParanoidiQ9ER75.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ER75-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFSPFGHPY GSTSQFLVSA SSSATCCETA PRPVSDVASA STSASTLCCT
60 70 80 90 100
PYDSRLLGSA RPELGAALGI YGAPYAAAQS YPGYLTYGPE PPTLCGALNP
110 120 130 140 150
QYEFKDAAGS FAPSLTQPGA YYPYETTLGQ YQYDRYGGVE LSSAGRRKNA
160 170 180 190 200
TRESTSALKA WLHEHRKNPY PTKGEKIMLA IITKMTLTQV STWFANARRR
210 220 230 240 250
LKKENKMTWA PKNKGGEERK ADSGEDSLGC LNGDTKDATA SQEARGLRLS
260 270 280 290 300
DLEDLEEEEE EEEAEEEAAV SAARRLADFQ KSTQPLPAPC AAAQERCLES
310 320 330 340 350
RECGLGLPRF SFTEAPQSGE ADFITAEPGG PTMILHYPSG HKPRIWSLAH
360 370 380 390 400
TAAASAVESA PSTPPRAQSP ECHMIPRQPS SIRRLLVPRD SEGEEDSPAA
410 420 430
KAFGNSTFTL QGLPLNCAPY PRRREPEVRF QYPSGAEG
Length:438
Mass (Da):47,352
Last modified:July 27, 2011 - v2
Checksum:i51E5421FB653A0F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331P → S in CAC10403. (PubMed:11042145)Curated
Sequence conflicti33 – 331P → S in AAI30030. (PubMed:15489334)Curated
Sequence conflicti296 – 2961R → G in CAC10403. (PubMed:11042145)Curated
Sequence conflicti296 – 2961R → G in AAI30030. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271055 mRNA. Translation: CAC10403.1.
AC134337 Genomic DNA. No translation available.
BC130029 mRNA. Translation: AAI30030.1.
RefSeqiNP_001288066.1. NM_001301137.1.
UniGeneiMm.137247.

Genome annotation databases

EnsembliENSMUST00000167261; ENSMUSP00000127446; ENSMUSG00000031738.
GeneIDi64379.
UCSCiuc009muc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271055 mRNA. Translation: CAC10403.1.
AC134337 Genomic DNA. No translation available.
BC130029 mRNA. Translation: AAI30030.1.
RefSeqiNP_001288066.1. NM_001301137.1.
UniGeneiMm.137247.

3D structure databases

ProteinModelPortaliQ9ER75.
SMRiQ9ER75. Positions 152-201.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9ER75.

Proteomic databases

PRIDEiQ9ER75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167261; ENSMUSP00000127446; ENSMUSG00000031738.
GeneIDi64379.
UCSCiuc009muc.1. mouse.

Organism-specific databases

MGIiMGI:1927642. Irx6.

Phylogenomic databases

eggNOGiNOG310996.
GeneTreeiENSGT00750000117365.
HOVERGENiHBG006180.
InParanoidiQ9ER75.

Miscellaneous databases

PROiQ9ER75.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ER75.
CleanExiMM_IRX6.
ExpressionAtlasiQ9ER75. differential.
GenevestigatoriQ9ER75.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organization of mouse Iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development."
    Peters T., Dildrop R., Ausmeier K., Ruether U.
    Genome Res. 10:1453-1462(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
    Tissue: Heart.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiIRX6_MOUSE
AccessioniPrimary (citable) accession number: Q9ER75
Secondary accession number(s): A1L3D2, E9Q2V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.