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Q9ER74

- SALL1_MOUSE

UniProt

Q9ER74 - SALL1_MOUSE

Protein

Sal-like protein 1

Gene

Sall1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Transcriptional repressor involved in organogenesis. Essential for ureteric bud invasion in kidney development. Homozygous deletion of SALL1 results in an incomplete ureteric bud outgrowth, a failure of tubule formation in the mesenchyme and an apoptosis of the mesenchyme.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri450 – 47223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri478 – 50023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri705 – 72723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri733 – 75523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri765 – 78723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1000 – 102223C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1028 – 105023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1133 – 115523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1161 – 118323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. enhancer sequence-specific DNA binding Source: BHF-UCL
    4. metal ion binding Source: UniProtKB-KW
    5. protein binding Source: MGI
    6. RNA polymerase II transcription coactivator activity Source: BHF-UCL
    7. RNA polymerase II transcription factor binding Source: BHF-UCL

    GO - Biological processi

    1. branching involved in ureteric bud morphogenesis Source: UniProtKB
    2. embryonic digit morphogenesis Source: UniProtKB
    3. forelimb morphogenesis Source: MGI
    4. hindlimb morphogenesis Source: MGI
    5. histone deacetylation Source: GOC
    6. inductive cell-cell signaling Source: MGI
    7. kidney epithelium development Source: UniProtKB
    8. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
    9. negative regulation of ectoderm development Source: BHF-UCL
    10. negative regulation of mesoderm development Source: BHF-UCL
    11. negative regulation of smoothened signaling pathway Source: MGI
    12. negative regulation of transcription, DNA-templated Source: UniProtKB
    13. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    14. neural tube closure Source: MGI
    15. neural tube development Source: MGI
    16. olfactory bulb development Source: MGI
    17. olfactory bulb interneuron differentiation Source: UniProtKB
    18. olfactory nerve development Source: UniProtKB
    19. positive regulation of neuron differentiation Source: MGI
    20. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    21. regulation of neural precursor cell proliferation Source: MGI
    22. ureteric bud development Source: MGI
    23. ureteric bud invasion Source: UniProtKB
    24. ventricular septum development Source: UniProtKB

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sal-like protein 1
    Alternative name(s):
    Zinc finger protein Spalt-3
    Short name:
    Sal-3
    Short name:
    mSal-3
    Gene namesi
    Name:Sall1
    Synonyms:Sal3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1889585. Sall1.

    Subcellular locationi

    GO - Cellular componenti

    1. heterochromatin Source: MGI
    2. nucleus Source: BHF-UCL
    3. NuRD complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13221322Sal-like protein 1PRO_0000047021Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei594 – 5941PhosphoserineBy similarity
    Modified residuei596 – 5961PhosphoserineBy similarity
    Modified residuei940 – 9401PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9ER74.

    PTM databases

    PhosphoSiteiQ9ER74.

    Expressioni

    Tissue specificityi

    Expressed in the metanephric mesenchyme surrounding ureteric bud.

    Gene expression databases

    CleanExiMM_SALL1.
    GenevestigatoriQ9ER74.

    Interactioni

    Subunit structurei

    Interacts with HDAC1, HDAC2, RBBP4, RBPP7, MTA1 and MTA2. Interacts with FAM58A By similarity. Probably associates with NuRD histone deacetylase complex (HDAC).By similarity

    Protein-protein interaction databases

    DIPiDIP-54906N.
    IntActiQ9ER74. 6 interactions.
    STRINGi10090.ENSMUSP00000034090.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ER74.
    SMRiQ9ER74. Positions 449-505, 707-787, 998-1183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi133 – 1397Poly-Thr
    Compositional biasi237 – 2404Poly-Gln
    Compositional biasi1143 – 11464Poly-Ser

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri450 – 47223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri478 – 50023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri705 – 72723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri733 – 75523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri765 – 78723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1000 – 102223C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1028 – 105023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1133 – 115523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1161 – 118323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG293478.
    HOVERGENiHBG058921.
    InParanoidiQ9ER74.
    PhylomeDBiQ9ER74.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ER74-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRRKQAKPQ HFQSDPEVAS LPRRDGDTEK GQPSRPTKSK DAHVCGRCCA     50
    EFFELSDLLL HKKSCTKNQL VLIVNESPAS PAKTFPPGPS LNDPDDQMKD 100
    AANKADQEDC SDLSEPKGLD REESMEVEVP VATTTTTTTG GSGGSGGSTL 150
    SGVTNITTPS CHSGCSSGTS AITTSLPQLG DLTTLGNFSV INSNVIIENL 200
    QSTKVAVAQF SQEARCGGAS GGKLLISTLM EQLLALQQQQ IHQLQLIEQI 250
    RHQILLLASQ SADLPAAPSI PSQGTLRTSA NPLTTLSSHL SQQLAVAAGL 300
    AQSLASQSAN ISGVKQLPHV QLPQSSSGTS IVPPSGGTSP NMSIVTAAVP 350
    TPSSEKVASN AGASHVSSPA VSASSSPAFA ISSLLSPESN PLLPQPTPAN 400
    AVFPTPLPNI ATTAEDLNSL SALAQQRKSK PPNVTAFEAK STSDEAFFKH 450
    KCRFCAKVFG SDSALQIHLR SHTGERPFKC NICGNRFSTK GNLKVHFQRH 500
    KEKYPHIQMN PYPVPEHLDN VPTSTGIPYG MSIPSEKPVT SWLDTKPVLP 550
    TLTTSVGLPL PPTLPSLTPF IKTEEPAPIP ISHSAASPQG SVKSDSGAPD 600
    LATRNPSGVP EEVEGSAVPP FGGKGEESNM ASSAVPTAGN STLNSPVADG 650
    GPGGTTFTNP LLPLMSEQFK AKFPFGGLLD SAQASETSKL QQLVENIDKK 700
    ATDPNECIIC HRVLSCQSAL KMHYRTHTGE RPFKCKICGR AFTTKGNLKT 750
    HYSVHRAMPP LRVQHSCPIC QKKFTNAVVL QQHIRMHMGG QIPNTPVPDN 800
    YPESMESDTG SFDEKNFDDL DNFSDENMEE CPEGSIPDTP KSADASQDSL 850
    SSSPLPLEMS SIAALENQMK MINAGLAEQL QASLKSVENG SMEGDVLTND 900
    SSSVGGDMES QSAGSPAISE STSSMQALSP SNSTQEFHKS PGMEEKPQRV 950
    GPGEFANGLS PTPVNGGALD LTSSHAEKII KEDSLGILFP FRDRGKFKNT 1000
    ACDICGKTFA CQSALDIHYR SHTKERPFIC TVCNRGFSTK GNLKQHMLTH 1050
    QMRDLPSQLF EPSSNLGPNQ NSAVIPANSL SSLIKTEVNG FVHVSPQDSK 1100
    DAPTSHVPQG PLSSSATSPV LLPALPRRTP KQHYCNTCGK TFSSSSALQI 1150
    HERTHTGEKP FACTICGRAF TTKGNLKVHM GTHMWNSTPA RRGRRLSVDG 1200
    PMTFLGGNPV KFPEMFQKDL AARSGSGDPS SFWNQYTAAL SNGLAMKANE 1250
    ISVIQNGGIP PIPGSLGSGS SPISGLTGNV EKLGNSEPSA PLAGLEKMAS 1300
    SENGTNFRFT RFVEDSKEIV TS 1322
    Length:1,322
    Mass (Da):140,230
    Last modified:March 1, 2001 - v1
    Checksum:iDF4FEF7FEA0B9F5C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti165 – 1651C → S(PubMed:11688560)Curated
    Sequence conflicti167 – 1671S → T(PubMed:11688560)Curated
    Sequence conflicti1271 – 12711S → SS in BAB55673. (PubMed:11688560)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271914, AJ271915 Genomic DNA. Translation: CAC09602.1.
    AB051409 mRNA. Translation: BAB55673.1.
    UniGeneiMm.214361.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271914 , AJ271915 Genomic DNA. Translation: CAC09602.1 .
    AB051409 mRNA. Translation: BAB55673.1 .
    UniGenei Mm.214361.

    3D structure databases

    ProteinModelPortali Q9ER74.
    SMRi Q9ER74. Positions 449-505, 707-787, 998-1183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-54906N.
    IntActi Q9ER74. 6 interactions.
    STRINGi 10090.ENSMUSP00000034090.

    PTM databases

    PhosphoSitei Q9ER74.

    Proteomic databases

    PRIDEi Q9ER74.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1889585. Sall1.

    Phylogenomic databases

    eggNOGi NOG293478.
    HOVERGENi HBG058921.
    InParanoidi Q9ER74.
    PhylomeDBi Q9ER74.

    Miscellaneous databases

    PROi Q9ER74.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_SALL1.
    Genevestigatori Q9ER74.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, chromosomal localization, and expression of the murine SALL1 ortholog Sall-1."
      Buck A., Archangelo L., Dixkens C., Kohlhase J.
      Cytogenet. Cell Genet. 89:150-153(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Ola.
    2. "Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development."
      Nishinakamura R., Matsumoto Y., Nakao K., Nakamura K., Sato A., Copeland N.G., Gilbert D.J., Jenkins N.A., Scully S., Lacey D.L., Katsuki M., Asashima M., Yokota T.
      Development 128:3105-3115(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Murine sall1 represses transcription by recruiting a histone deacetylase complex."
      Kiefer S.M., McDill B.W., Yang J., Rauchman M.
      J. Biol. Chem. 277:14869-14876(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ASSOCIATION WITH HDAC.

    Entry informationi

    Entry nameiSALL1_MOUSE
    AccessioniPrimary (citable) accession number: Q9ER74
    Secondary accession number(s): Q920R5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3