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Q9ER74

- SALL1_MOUSE

UniProt

Q9ER74 - SALL1_MOUSE

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Protein

Sal-like protein 1

Gene

Sall1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional repressor involved in organogenesis. Essential for ureteric bud invasion in kidney development. Homozygous deletion of SALL1 results in an incomplete ureteric bud outgrowth, a failure of tubule formation in the mesenchyme and an apoptosis of the mesenchyme.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri450 – 47223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 72723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri733 – 75523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri765 – 78723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1000 – 102223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1028 – 105023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1133 – 115523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1161 – 118323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. enhancer sequence-specific DNA binding Source: BHF-UCL
  4. metal ion binding Source: UniProtKB-KW
  5. RNA polymerase II transcription coactivator activity Source: BHF-UCL
  6. RNA polymerase II transcription factor binding Source: BHF-UCL

GO - Biological processi

  1. branching involved in ureteric bud morphogenesis Source: UniProtKB
  2. embryonic digit morphogenesis Source: UniProtKB
  3. forelimb morphogenesis Source: MGI
  4. hindlimb morphogenesis Source: MGI
  5. histone deacetylation Source: GOC
  6. inductive cell-cell signaling Source: MGI
  7. kidney epithelium development Source: UniProtKB
  8. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
  9. negative regulation of ectoderm development Source: BHF-UCL
  10. negative regulation of mesoderm development Source: BHF-UCL
  11. negative regulation of smoothened signaling pathway Source: MGI
  12. negative regulation of transcription, DNA-templated Source: UniProtKB
  13. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  14. neural tube closure Source: MGI
  15. neural tube development Source: MGI
  16. olfactory bulb development Source: MGI
  17. olfactory bulb interneuron differentiation Source: UniProtKB
  18. olfactory nerve development Source: UniProtKB
  19. positive regulation of neuron differentiation Source: MGI
  20. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  21. regulation of neural precursor cell proliferation Source: MGI
  22. ureteric bud development Source: MGI
  23. ureteric bud invasion Source: UniProtKB
  24. ventricular septum development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sal-like protein 1
Alternative name(s):
Zinc finger protein Spalt-3
Short name:
Sal-3
Short name:
mSal-3
Gene namesi
Name:Sall1
Synonyms:Sal3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1889585. Sall1.

Subcellular locationi

GO - Cellular componenti

  1. heterochromatin Source: MGI
  2. nucleus Source: BHF-UCL
  3. NuRD complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13221322Sal-like protein 1PRO_0000047021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei594 – 5941PhosphoserineBy similarity
Modified residuei596 – 5961PhosphoserineBy similarity
Modified residuei940 – 9401PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ER74.
PRIDEiQ9ER74.

PTM databases

PhosphoSiteiQ9ER74.

Expressioni

Tissue specificityi

Expressed in the metanephric mesenchyme surrounding ureteric bud.

Gene expression databases

CleanExiMM_SALL1.
GenevestigatoriQ9ER74.

Interactioni

Subunit structurei

Interacts with HDAC1, HDAC2, RBBP4, RBPP7, MTA1 and MTA2. Interacts with FAM58A (By similarity). Probably associates with NuRD histone deacetylase complex (HDAC).By similarity

Protein-protein interaction databases

DIPiDIP-54906N.
IntActiQ9ER74. 6 interactions.
STRINGi10090.ENSMUSP00000034090.

Structurei

3D structure databases

ProteinModelPortaliQ9ER74.
SMRiQ9ER74. Positions 449-505, 707-787, 998-1183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi133 – 1397Poly-Thr
Compositional biasi237 – 2404Poly-Gln
Compositional biasi1143 – 11464Poly-Ser

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri450 – 47223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 72723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri733 – 75523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri765 – 78723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1000 – 102223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1028 – 105023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1133 – 115523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1161 – 118323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG293478.
HOVERGENiHBG058921.
InParanoidiQ9ER74.
PhylomeDBiQ9ER74.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ER74-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRRKQAKPQ HFQSDPEVAS LPRRDGDTEK GQPSRPTKSK DAHVCGRCCA
60 70 80 90 100
EFFELSDLLL HKKSCTKNQL VLIVNESPAS PAKTFPPGPS LNDPDDQMKD
110 120 130 140 150
AANKADQEDC SDLSEPKGLD REESMEVEVP VATTTTTTTG GSGGSGGSTL
160 170 180 190 200
SGVTNITTPS CHSGCSSGTS AITTSLPQLG DLTTLGNFSV INSNVIIENL
210 220 230 240 250
QSTKVAVAQF SQEARCGGAS GGKLLISTLM EQLLALQQQQ IHQLQLIEQI
260 270 280 290 300
RHQILLLASQ SADLPAAPSI PSQGTLRTSA NPLTTLSSHL SQQLAVAAGL
310 320 330 340 350
AQSLASQSAN ISGVKQLPHV QLPQSSSGTS IVPPSGGTSP NMSIVTAAVP
360 370 380 390 400
TPSSEKVASN AGASHVSSPA VSASSSPAFA ISSLLSPESN PLLPQPTPAN
410 420 430 440 450
AVFPTPLPNI ATTAEDLNSL SALAQQRKSK PPNVTAFEAK STSDEAFFKH
460 470 480 490 500
KCRFCAKVFG SDSALQIHLR SHTGERPFKC NICGNRFSTK GNLKVHFQRH
510 520 530 540 550
KEKYPHIQMN PYPVPEHLDN VPTSTGIPYG MSIPSEKPVT SWLDTKPVLP
560 570 580 590 600
TLTTSVGLPL PPTLPSLTPF IKTEEPAPIP ISHSAASPQG SVKSDSGAPD
610 620 630 640 650
LATRNPSGVP EEVEGSAVPP FGGKGEESNM ASSAVPTAGN STLNSPVADG
660 670 680 690 700
GPGGTTFTNP LLPLMSEQFK AKFPFGGLLD SAQASETSKL QQLVENIDKK
710 720 730 740 750
ATDPNECIIC HRVLSCQSAL KMHYRTHTGE RPFKCKICGR AFTTKGNLKT
760 770 780 790 800
HYSVHRAMPP LRVQHSCPIC QKKFTNAVVL QQHIRMHMGG QIPNTPVPDN
810 820 830 840 850
YPESMESDTG SFDEKNFDDL DNFSDENMEE CPEGSIPDTP KSADASQDSL
860 870 880 890 900
SSSPLPLEMS SIAALENQMK MINAGLAEQL QASLKSVENG SMEGDVLTND
910 920 930 940 950
SSSVGGDMES QSAGSPAISE STSSMQALSP SNSTQEFHKS PGMEEKPQRV
960 970 980 990 1000
GPGEFANGLS PTPVNGGALD LTSSHAEKII KEDSLGILFP FRDRGKFKNT
1010 1020 1030 1040 1050
ACDICGKTFA CQSALDIHYR SHTKERPFIC TVCNRGFSTK GNLKQHMLTH
1060 1070 1080 1090 1100
QMRDLPSQLF EPSSNLGPNQ NSAVIPANSL SSLIKTEVNG FVHVSPQDSK
1110 1120 1130 1140 1150
DAPTSHVPQG PLSSSATSPV LLPALPRRTP KQHYCNTCGK TFSSSSALQI
1160 1170 1180 1190 1200
HERTHTGEKP FACTICGRAF TTKGNLKVHM GTHMWNSTPA RRGRRLSVDG
1210 1220 1230 1240 1250
PMTFLGGNPV KFPEMFQKDL AARSGSGDPS SFWNQYTAAL SNGLAMKANE
1260 1270 1280 1290 1300
ISVIQNGGIP PIPGSLGSGS SPISGLTGNV EKLGNSEPSA PLAGLEKMAS
1310 1320
SENGTNFRFT RFVEDSKEIV TS
Length:1,322
Mass (Da):140,230
Last modified:March 1, 2001 - v1
Checksum:iDF4FEF7FEA0B9F5C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651C → S(PubMed:11688560)Curated
Sequence conflicti167 – 1671S → T(PubMed:11688560)Curated
Sequence conflicti1271 – 12711S → SS in BAB55673. (PubMed:11688560)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271914, AJ271915 Genomic DNA. Translation: CAC09602.1.
AB051409 mRNA. Translation: BAB55673.1.
UniGeneiMm.214361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271914 , AJ271915 Genomic DNA. Translation: CAC09602.1 .
AB051409 mRNA. Translation: BAB55673.1 .
UniGenei Mm.214361.

3D structure databases

ProteinModelPortali Q9ER74.
SMRi Q9ER74. Positions 449-505, 707-787, 998-1183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-54906N.
IntActi Q9ER74. 6 interactions.
STRINGi 10090.ENSMUSP00000034090.

PTM databases

PhosphoSitei Q9ER74.

Proteomic databases

MaxQBi Q9ER74.
PRIDEi Q9ER74.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1889585. Sall1.

Phylogenomic databases

eggNOGi NOG293478.
HOVERGENi HBG058921.
InParanoidi Q9ER74.
PhylomeDBi Q9ER74.

Miscellaneous databases

PROi Q9ER74.
SOURCEi Search...

Gene expression databases

CleanExi MM_SALL1.
Genevestigatori Q9ER74.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, chromosomal localization, and expression of the murine SALL1 ortholog Sall-1."
    Buck A., Archangelo L., Dixkens C., Kohlhase J.
    Cytogenet. Cell Genet. 89:150-153(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Ola.
  2. "Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development."
    Nishinakamura R., Matsumoto Y., Nakao K., Nakamura K., Sato A., Copeland N.G., Gilbert D.J., Jenkins N.A., Scully S., Lacey D.L., Katsuki M., Asashima M., Yokota T.
    Development 128:3105-3115(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Murine sall1 represses transcription by recruiting a histone deacetylase complex."
    Kiefer S.M., McDill B.W., Yang J., Rauchman M.
    J. Biol. Chem. 277:14869-14876(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ASSOCIATION WITH HDAC.

Entry informationi

Entry nameiSALL1_MOUSE
AccessioniPrimary (citable) accession number: Q9ER74
Secondary accession number(s): Q920R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3