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Q9ER74

- SALL1_MOUSE

UniProt

Q9ER74 - SALL1_MOUSE

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Protein
Sal-like protein 1
Gene
Sall1, Sal3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional repressor involved in organogenesis. Essential for ureteric bud invasion in kidney development. Homozygous deletion of SALL1 results in an incomplete ureteric bud outgrowth, a failure of tubule formation in the mesenchyme and an apoptosis of the mesenchyme.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri450 – 47223C2H2-type 1
Add
BLAST
Zinc fingeri478 – 50023C2H2-type 2
Add
BLAST
Zinc fingeri705 – 72723C2H2-type 3
Add
BLAST
Zinc fingeri733 – 75523C2H2-type 4
Add
BLAST
Zinc fingeri765 – 78723C2H2-type 5
Add
BLAST
Zinc fingeri1000 – 102223C2H2-type 6
Add
BLAST
Zinc fingeri1028 – 105023C2H2-type 7
Add
BLAST
Zinc fingeri1133 – 115523C2H2-type 8
Add
BLAST
Zinc fingeri1161 – 118323C2H2-type 9
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II transcription coactivator activity Source: BHF-UCL
  3. RNA polymerase II transcription factor binding Source: BHF-UCL
  4. chromatin binding Source: MGI
  5. enhancer sequence-specific DNA binding Source: BHF-UCL
  6. metal ion binding Source: UniProtKB-KW
  7. protein binding Source: MGI

GO - Biological processi

  1. branching involved in ureteric bud morphogenesis Source: UniProtKB
  2. embryonic digit morphogenesis Source: UniProtKB
  3. forelimb morphogenesis Source: MGI
  4. hindlimb morphogenesis Source: MGI
  5. histone deacetylation Source: GOC
  6. inductive cell-cell signaling Source: MGI
  7. kidney epithelium development Source: UniProtKB
  8. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
  9. negative regulation of ectoderm development Source: BHF-UCL
  10. negative regulation of mesoderm development Source: BHF-UCL
  11. negative regulation of smoothened signaling pathway Source: MGI
  12. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  13. negative regulation of transcription, DNA-templated Source: UniProtKB
  14. neural tube closure Source: MGI
  15. neural tube development Source: MGI
  16. olfactory bulb development Source: MGI
  17. olfactory bulb interneuron differentiation Source: UniProtKB
  18. olfactory nerve development Source: UniProtKB
  19. positive regulation of neuron differentiation Source: MGI
  20. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  21. regulation of neural precursor cell proliferation Source: MGI
  22. ureteric bud development Source: MGI
  23. ureteric bud invasion Source: UniProtKB
  24. ventricular septum development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sal-like protein 1
Alternative name(s):
Zinc finger protein Spalt-3
Short name:
Sal-3
Short name:
mSal-3
Gene namesi
Name:Sall1
Synonyms:Sal3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1889585. Sall1.

Subcellular locationi

GO - Cellular componenti

  1. NuRD complex Source: MGI
  2. heterochromatin Source: MGI
  3. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13221322Sal-like protein 1
PRO_0000047021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei594 – 5941Phosphoserine By similarity
Modified residuei596 – 5961Phosphoserine By similarity
Modified residuei940 – 9401Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9ER74.

PTM databases

PhosphoSiteiQ9ER74.

Expressioni

Tissue specificityi

Expressed in the metanephric mesenchyme surrounding ureteric bud.

Gene expression databases

CleanExiMM_SALL1.
GenevestigatoriQ9ER74.

Interactioni

Subunit structurei

Interacts with HDAC1, HDAC2, RBBP4, RBPP7, MTA1 and MTA2. Interacts with FAM58A By similarity. Probably associates with NuRD histone deacetylase complex (HDAC).

Protein-protein interaction databases

DIPiDIP-54906N.
IntActiQ9ER74. 6 interactions.
STRINGi10090.ENSMUSP00000034090.

Structurei

3D structure databases

ProteinModelPortaliQ9ER74.
SMRiQ9ER74. Positions 449-505, 707-787, 998-1183.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi133 – 1397Poly-Thr
Compositional biasi237 – 2404Poly-Gln
Compositional biasi1143 – 11464Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG293478.
HOVERGENiHBG058921.
InParanoidiQ9ER74.
PhylomeDBiQ9ER74.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ER74-1 [UniParc]FASTAAdd to Basket

« Hide

MSRRKQAKPQ HFQSDPEVAS LPRRDGDTEK GQPSRPTKSK DAHVCGRCCA     50
EFFELSDLLL HKKSCTKNQL VLIVNESPAS PAKTFPPGPS LNDPDDQMKD 100
AANKADQEDC SDLSEPKGLD REESMEVEVP VATTTTTTTG GSGGSGGSTL 150
SGVTNITTPS CHSGCSSGTS AITTSLPQLG DLTTLGNFSV INSNVIIENL 200
QSTKVAVAQF SQEARCGGAS GGKLLISTLM EQLLALQQQQ IHQLQLIEQI 250
RHQILLLASQ SADLPAAPSI PSQGTLRTSA NPLTTLSSHL SQQLAVAAGL 300
AQSLASQSAN ISGVKQLPHV QLPQSSSGTS IVPPSGGTSP NMSIVTAAVP 350
TPSSEKVASN AGASHVSSPA VSASSSPAFA ISSLLSPESN PLLPQPTPAN 400
AVFPTPLPNI ATTAEDLNSL SALAQQRKSK PPNVTAFEAK STSDEAFFKH 450
KCRFCAKVFG SDSALQIHLR SHTGERPFKC NICGNRFSTK GNLKVHFQRH 500
KEKYPHIQMN PYPVPEHLDN VPTSTGIPYG MSIPSEKPVT SWLDTKPVLP 550
TLTTSVGLPL PPTLPSLTPF IKTEEPAPIP ISHSAASPQG SVKSDSGAPD 600
LATRNPSGVP EEVEGSAVPP FGGKGEESNM ASSAVPTAGN STLNSPVADG 650
GPGGTTFTNP LLPLMSEQFK AKFPFGGLLD SAQASETSKL QQLVENIDKK 700
ATDPNECIIC HRVLSCQSAL KMHYRTHTGE RPFKCKICGR AFTTKGNLKT 750
HYSVHRAMPP LRVQHSCPIC QKKFTNAVVL QQHIRMHMGG QIPNTPVPDN 800
YPESMESDTG SFDEKNFDDL DNFSDENMEE CPEGSIPDTP KSADASQDSL 850
SSSPLPLEMS SIAALENQMK MINAGLAEQL QASLKSVENG SMEGDVLTND 900
SSSVGGDMES QSAGSPAISE STSSMQALSP SNSTQEFHKS PGMEEKPQRV 950
GPGEFANGLS PTPVNGGALD LTSSHAEKII KEDSLGILFP FRDRGKFKNT 1000
ACDICGKTFA CQSALDIHYR SHTKERPFIC TVCNRGFSTK GNLKQHMLTH 1050
QMRDLPSQLF EPSSNLGPNQ NSAVIPANSL SSLIKTEVNG FVHVSPQDSK 1100
DAPTSHVPQG PLSSSATSPV LLPALPRRTP KQHYCNTCGK TFSSSSALQI 1150
HERTHTGEKP FACTICGRAF TTKGNLKVHM GTHMWNSTPA RRGRRLSVDG 1200
PMTFLGGNPV KFPEMFQKDL AARSGSGDPS SFWNQYTAAL SNGLAMKANE 1250
ISVIQNGGIP PIPGSLGSGS SPISGLTGNV EKLGNSEPSA PLAGLEKMAS 1300
SENGTNFRFT RFVEDSKEIV TS 1322
Length:1,322
Mass (Da):140,230
Last modified:March 1, 2001 - v1
Checksum:iDF4FEF7FEA0B9F5C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651C → S1 Publication
Sequence conflicti167 – 1671S → T1 Publication
Sequence conflicti1271 – 12711S → SS in BAB55673. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271914, AJ271915 Genomic DNA. Translation: CAC09602.1.
AB051409 mRNA. Translation: BAB55673.1.
UniGeneiMm.214361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271914 , AJ271915 Genomic DNA. Translation: CAC09602.1 .
AB051409 mRNA. Translation: BAB55673.1 .
UniGenei Mm.214361.

3D structure databases

ProteinModelPortali Q9ER74.
SMRi Q9ER74. Positions 449-505, 707-787, 998-1183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-54906N.
IntActi Q9ER74. 6 interactions.
STRINGi 10090.ENSMUSP00000034090.

PTM databases

PhosphoSitei Q9ER74.

Proteomic databases

PRIDEi Q9ER74.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1889585. Sall1.

Phylogenomic databases

eggNOGi NOG293478.
HOVERGENi HBG058921.
InParanoidi Q9ER74.
PhylomeDBi Q9ER74.

Miscellaneous databases

PROi Q9ER74.
SOURCEi Search...

Gene expression databases

CleanExi MM_SALL1.
Genevestigatori Q9ER74.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, chromosomal localization, and expression of the murine SALL1 ortholog Sall-1."
    Buck A., Archangelo L., Dixkens C., Kohlhase J.
    Cytogenet. Cell Genet. 89:150-153(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Ola.
  2. "Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development."
    Nishinakamura R., Matsumoto Y., Nakao K., Nakamura K., Sato A., Copeland N.G., Gilbert D.J., Jenkins N.A., Scully S., Lacey D.L., Katsuki M., Asashima M., Yokota T.
    Development 128:3105-3115(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Murine sall1 represses transcription by recruiting a histone deacetylase complex."
    Kiefer S.M., McDill B.W., Yang J., Rauchman M.
    J. Biol. Chem. 277:14869-14876(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ASSOCIATION WITH HDAC.

Entry informationi

Entry nameiSALL1_MOUSE
AccessioniPrimary (citable) accession number: Q9ER74
Secondary accession number(s): Q920R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2001
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi