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Protein

Elongator complex protein 4

Gene

Elp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 4
Alternative name(s):
PAX6 neighbor gene protein
Gene namesi
Name:Elp4
Synonyms:Paxneb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1925016 Elp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002840051 – 422Elongator complex protein 4Add BLAST422

Proteomic databases

EPDiQ9ER73
MaxQBiQ9ER73
PaxDbiQ9ER73
PeptideAtlasiQ9ER73
PRIDEiQ9ER73

PTM databases

iPTMnetiQ9ER73
PhosphoSitePlusiQ9ER73

Expressioni

Gene expression databases

BgeeiENSMUSG00000027167
CleanExiMM_ELP4
ExpressionAtlasiQ9ER73 baseline and differential
GenevisibleiQ9ER73 MM

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator), which consists of ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116575

Structurei

3D structure databases

ProteinModelPortaliQ9ER73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELP4 family.Curated

Phylogenomic databases

eggNOGiKOG3949 Eukaryota
ENOG410XP5H LUCA
GeneTreeiENSGT00390000001443
HOGENOMiHOG000007516
HOVERGENiHBG104285
InParanoidiQ9ER73
KOiK11375
OMAiLNNLICD
OrthoDBiEOG091G0DND
PhylomeDBiQ9ER73
TreeFamiTF320797

Family and domain databases

InterProiView protein in InterPro
IPR008728 Elongator_complex_protein_4
PANTHERiPTHR12896 PTHR12896, 1 hit
PfamiView protein in Pfam
PF05625 PAXNEB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ER73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAADTCGAG TLSSRSVASE AGQGGTSSFQ RKGKASGGPG GGPRLLSIAG
60 70 80 90 100
TRPSVRNGQL LVSTGLPALD QLLGGGLAVG TLLLIEEDKY NIYSPLLFKY
110 120 130 140 150
FMAEGIINGH TLLVASAKEN PAKILQELPA PLLDDNSKKE LEDVHSAKTP
160 170 180 190 200
EPNVNMKIAW RYQLQPKMEV GPVSSSRFGH YYDLSKRIPW ELLQSSKWHG
210 220 230 240 250
FFLPEHISPD LKGESCFLSC GYMRLLEFIQ KSVYAEGFDG ANPQKKQKNI
260 270 280 290 300
LRIGIQNLGS PLWGDDICCK ENCDNNHRLT KFLYILRGLL RSSLSACIIT
310 320 330 340 350
MPAHLVQNKS ITTRVRNLSD TVVGLESFIG SERETNPLYK DYHGLIHIRK
360 370 380 390 400
IPRLNNLTCD ESDVKDLAFK LKRKLFTIER LHLPPDLSDT VGRSSKQDLA
410 420
ASTARLGAGC SSMAEGKKHL DF
Length:422
Mass (Da):46,325
Last modified:May 1, 2007 - v2
Checksum:i87DD0F4209C0032F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti404A → T in BAC28555 (PubMed:16141072).Curated1
Sequence conflicti409G → D in BAC37523 (PubMed:16141072).Curated1
Sequence conflicti415E → K in CAC08202 (PubMed:11889558).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276004 mRNA Translation: CAC08202.1
AK020742 mRNA Translation: BAB32197.1
AK034040 mRNA Translation: BAC28555.1
AK034529 mRNA Translation: BAC28743.1
AK037104 mRNA Translation: BAC29704.1
AK039447 mRNA Translation: BAC30351.1
AK039758 mRNA Translation: BAC30441.1
AK079069 mRNA Translation: BAC37523.1
AK168964 mRNA Translation: BAE40769.1
AL512589 Genomic DNA No translation available.
AL590380 Genomic DNA No translation available.
CCDSiCCDS16500.1
RefSeqiNP_076365.2, NM_023876.4
UniGeneiMm.33870
Mm.3608

Genome annotation databases

EnsembliENSMUST00000122965; ENSMUSP00000116575; ENSMUSG00000027167
GeneIDi77766
KEGGimmu:77766
UCSCiuc008lld.1 mouse

Similar proteinsi

Entry informationi

Entry nameiELP4_MOUSE
AccessioniPrimary (citable) accession number: Q9ER73
Secondary accession number(s): Q8BGM1
, Q8BVB1, Q8BZN8, Q9CTR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: March 28, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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