ID   Q9ER67_MOUSE            Unreviewed;       616 AA.
AC   Q9ER67;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 146.
DE   SubName: Full=MAGE family member D2 {ECO:0000313|Ensembl:ENSMUSP00000026302.7};
DE   SubName: Full=Maged2 protein {ECO:0000313|EMBL:AAH58581.1};
GN   Name=Maged2 {ECO:0000313|Ensembl:ENSMUSP00000026302.7,
GN   ECO:0000313|MGI:MGI:1933391};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:CAC10356.1};
RN   [1] {ECO:0000313|EMBL:CAC10356.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Langnaese K., Wieacker P.;
RT   "Cloning a novel MAGE/Necdin related gene.";
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAH58581.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye {ECO:0000313|EMBL:AAH58581.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000026302.7, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000026302.7,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [5] {ECO:0000313|Ensembl:ENSMUSP00000026302.7}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000026302.7};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; BC058581; AAH58581.1; -; mRNA.
DR   EMBL; AJ277114; CAC10356.1; -; mRNA.
DR   RefSeq; NP_001186175.1; NM_001199246.1.
DR   RefSeq; NP_109625.1; NM_030700.2.
DR   RefSeq; XP_006529060.1; XM_006528997.1.
DR   RefSeq; XP_006529061.1; XM_006528998.3.
DR   RefSeq; XP_006529062.1; XM_006528999.3.
DR   IntAct; Q9ER67; 3.
DR   STRING; 10090.ENSMUSP00000026302; -.
DR   PaxDb; 10090-ENSMUSP00000026302; -.
DR   ProteomicsDB; 338893; -.
DR   Antibodypedia; 26825; 246 antibodies from 29 providers.
DR   DNASU; 80884; -.
DR   Ensembl; ENSMUST00000026302.13; ENSMUSP00000026302.7; ENSMUSG00000025268.16.
DR   Ensembl; ENSMUST00000112697.10; ENSMUSP00000108317.4; ENSMUSG00000025268.16.
DR   Ensembl; ENSMUST00000112699.9; ENSMUSP00000108319.3; ENSMUSG00000025268.16.
DR   Ensembl; ENSMUST00000112700.8; ENSMUSP00000108320.2; ENSMUSG00000025268.16.
DR   GeneID; 80884; -.
DR   KEGG; mmu:80884; -.
DR   UCSC; uc009uos.2; mouse.
DR   AGR; MGI:1933391; -.
DR   CTD; 10916; -.
DR   MGI; MGI:1933391; Maged2.
DR   VEuPathDB; HostDB:ENSMUSG00000025268; -.
DR   eggNOG; KOG4562; Eukaryota.
DR   GeneTree; ENSGT00940000161795; -.
DR   HOGENOM; CLU_032317_2_0_1; -.
DR   OMA; IDKSDHL; -.
DR   OrthoDB; 3128316at2759; -.
DR   TreeFam; TF352132; -.
DR   Reactome; R-MMU-114608; Platelet degranulation.
DR   BioGRID-ORCS; 80884; 1 hit in 76 CRISPR screens.
DR   ChiTaRS; Maged2; mouse.
DR   Proteomes; UP000000589; Chromosome X.
DR   Bgee; ENSMUSG00000025268; Expressed in embryonic facial prominence and 78 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005730; C:nucleolus; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; ISO:MGI.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0070294; P:renal sodium ion absorption; ISO:MGI.
DR   Gene3D; 1.10.10.1200; MAGE homology domain, winged helix WH1 motif; 1.
DR   Gene3D; 1.10.10.1210; MAGE homology domain, winged helix WH2 motif; 1.
DR   InterPro; IPR037445; MAGE.
DR   InterPro; IPR041898; MAGE_WH1.
DR   InterPro; IPR041899; MAGE_WH2.
DR   InterPro; IPR002190; MHD_dom.
DR   PANTHER; PTHR11736:SF11; MELANOMA-ASSOCIATED ANTIGEN D2; 1.
DR   PANTHER; PTHR11736; MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN; 1.
DR   Pfam; PF01454; MAGE; 1.
DR   SMART; SM01373; MAGE; 1.
DR   PROSITE; PS50838; MAGE; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:Q9ER67,
KW   ECO:0007829|MaxQB:Q9ER67};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          279..478
FT                   /note="MAGE"
FT                   /evidence="ECO:0000259|PROSITE:PS50838"
FT   REGION          1..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..189
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   616 AA;  65400 MW;  E7C2E7A30CD75E90 CRC64;
     MSDTSESGAD PARSQGKASE KDSGSVMQDL LTVTQNLEVS ETPKAEKAPE VSEAAKAPKA
     SGNPKATEVS KAPEASEAAA TQASPTTQLS ETQVLATENK SPAADTKTQK SDLQAMTMPT
     TPTKKVSCGT DPKVNTKAPE TEAPASQAGT DEPEPEGTAV QVQENQDTRP KVKAKNTQKG
     KHPDGEEDGN SDQSQASEAT GGRRVSKALM ASMARRASRG PIAFWARRAS RTRLAAWARR
     ALLSLRSPRA RRGKARRRAA KLQSSQEPEA PPPRDVALLQ GRANDLVKYL LAKDQTKIPI
     RRSDMLKDII KEYTDVYPEI IERAGYSLEK VFGIQLKEID KNDHLYILLS TLEPTDAGIL
     GTTKDSPKLG LLMVLLSIIF MNGNRSSEAV IWEVLRKLGL RPGIHHSLFG DVKKLITDEF
     VKQKYLDYAR VPNSNPPEYE FFWGLRSYYE TSKMKVLKFA CKVQKKDPKE WAAQYREAME
     ADLKAAAEAA AEAKARAEIR AQMGIGLGSE NAAGPCNWDE ADIGPWAKAR IQAGAETKAK
     AQGSGGANAS AGAGASTGTS VGASGSASAG ASAGASGGFS NNSSLTASLT FGLFAGLSGA
     GASTNSSSGA CGFSYK
//