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Protein

Tumor necrosis factor receptor superfamily member 22

Gene

Tnfrsf22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway.1 Publication

GO - Molecular functioni

  • receptor activity Source: UniProtKB
  • TRAIL binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 22
Alternative name(s):
Decoy TRAIL receptor 2
TNF receptor family member SOBa
TNF receptor homolog 2
Tumor necrosis factor receptor p60 homolog 2
Gene namesi
Name:Tnfrsf22
Synonyms:Dctrailr2, Tnfrh2, Tnfrsf1al2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1930270. Tnfrsf22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence analysisAdd
BLAST
Transmembranei21 – 4121Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini42 – 198157ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Tumor necrosis factor receptor superfamily member 22PRO_0000058937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 59PROSITE-ProRule annotation
Disulfide bondi60 ↔ 73PROSITE-ProRule annotation
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Disulfide bondi63 ↔ 82PROSITE-ProRule annotation
Disulfide bondi85 ↔ 100PROSITE-ProRule annotation
Disulfide bondi103 ↔ 116PROSITE-ProRule annotation
Disulfide bondi106 ↔ 124PROSITE-ProRule annotation
Disulfide bondi126 ↔ 141PROSITE-ProRule annotation
Disulfide bondi144 ↔ 157PROSITE-ProRule annotation
Disulfide bondi147 ↔ 165PROSITE-ProRule annotation
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ER62.
PRIDEiQ9ER62.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000010751.
ExpressionAtlasiQ9ER62. baseline and differential.
GenevisibleiQ9ER62. MM.

Interactioni

GO - Molecular functioni

  • TRAIL binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081432.

Structurei

3D structure databases

ProteinModelPortaliQ9ER62.
SMRiQ9ER62. Positions 60-166, 170-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati47 – 8236TNFR-Cys 1Add
BLAST
Repeati84 – 12441TNFR-Cys 2Add
BLAST
Repeati125 – 16541TNFR-Cys 3Add
BLAST

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1NE. Eukaryota.
ENOG4111ZZM. LUCA.
GeneTreeiENSGT00730000110985.
HOGENOMiHOG000132999.
HOVERGENiHBG085073.
InParanoidiQ9ER62.
KOiK05158.
OMAiRECACED.
OrthoDBiEOG091G0X13.
PhylomeDBiQ9ER62.
TreeFamiTF333916.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ER62-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGFFCSLVS SLSRWFLWRR LLLLLLLLLL NLPLQVKFAM LELHSFKCPA
60 70 80 90 100
GEYWSKDVCC KNCSAGTFVK APCEIPHTQG QCEKCHPGTF TEKDNYLDAC
110 120 130 140 150
ILCSTCDKDQ EMVADCSATS DRKCQCRTGL YYYDPKFPES CRPCTKCPQG
160 170 180 190
IPVLQECNST ANTVCSSSVS NPRNRLFLLL SPLSVLIVSV VVFRIIRR
Length:198
Mass (Da):22,375
Last modified:June 27, 2003 - v3
Checksum:iEBF8F52961EA9983
GO
Isoform 2 (identifier: Q9ER62-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-198: NPRNRLFLLLSPLSVLIVSVVVFRIIRR → RRSASVAWPI

Show »
Length:180
Mass (Da):20,227
Checksum:iF8F56E165ADD53FA
GO

Sequence cautioni

The sequence BAB28502 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAC16406 differs from that shown. Reason: Frameshift at position 38. Curated
The sequence CAC27353 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121L → V in AAL05073 (PubMed:12466268).Curated
Sequence conflicti24 – 241L → C in CAC16406 (PubMed:11063728).Curated
Sequence conflicti27 – 304LLLL → CVV in CAC16406 (PubMed:11063728).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei171 – 19828NPRNR…RIIRR → RRSASVAWPI in isoform 2. 3 PublicationsVSP_007648Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278265 mRNA. Translation: CAC16406.1. Frameshift.
AJ276505 Genomic DNA. Translation: CAC27353.1. Sequence problems.
AY165626 mRNA. Translation: AAN87806.1.
AY165627 mRNA. Translation: AAN87807.1.
AY046551 mRNA. Translation: AAL05073.1.
AK012838 mRNA. Translation: BAB28502.2. Different initiation.
CCDSiCCDS22043.1. [Q9ER62-2]
CCDS80846.1. [Q9ER62-1]
RefSeqiNP_001298074.1. NM_001311145.1. [Q9ER62-1]
NP_076169.2. NM_023680.4. [Q9ER62-2]
UniGeneiMm.261384.

Genome annotation databases

EnsembliENSMUST00000075588; ENSMUSP00000075018; ENSMUSG00000010751. [Q9ER62-1]
ENSMUST00000084396; ENSMUSP00000081432; ENSMUSG00000010751. [Q9ER62-2]
ENSMUST00000146692; ENSMUSP00000119297; ENSMUSG00000010751. [Q9ER62-2]
GeneIDi79202.
KEGGimmu:79202.
UCSCiuc009kps.1. mouse. [Q9ER62-2]
uc009kpt.1. mouse. [Q9ER62-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278265 mRNA. Translation: CAC16406.1. Frameshift.
AJ276505 Genomic DNA. Translation: CAC27353.1. Sequence problems.
AY165626 mRNA. Translation: AAN87806.1.
AY165627 mRNA. Translation: AAN87807.1.
AY046551 mRNA. Translation: AAL05073.1.
AK012838 mRNA. Translation: BAB28502.2. Different initiation.
CCDSiCCDS22043.1. [Q9ER62-2]
CCDS80846.1. [Q9ER62-1]
RefSeqiNP_001298074.1. NM_001311145.1. [Q9ER62-1]
NP_076169.2. NM_023680.4. [Q9ER62-2]
UniGeneiMm.261384.

3D structure databases

ProteinModelPortaliQ9ER62.
SMRiQ9ER62. Positions 60-166, 170-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081432.

Proteomic databases

PaxDbiQ9ER62.
PRIDEiQ9ER62.

Protocols and materials databases

DNASUi79202.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075588; ENSMUSP00000075018; ENSMUSG00000010751. [Q9ER62-1]
ENSMUST00000084396; ENSMUSP00000081432; ENSMUSG00000010751. [Q9ER62-2]
ENSMUST00000146692; ENSMUSP00000119297; ENSMUSG00000010751. [Q9ER62-2]
GeneIDi79202.
KEGGimmu:79202.
UCSCiuc009kps.1. mouse. [Q9ER62-2]
uc009kpt.1. mouse. [Q9ER62-1]

Organism-specific databases

CTDi79202.
MGIiMGI:1930270. Tnfrsf22.

Phylogenomic databases

eggNOGiENOG410J1NE. Eukaryota.
ENOG4111ZZM. LUCA.
GeneTreeiENSGT00730000110985.
HOGENOMiHOG000132999.
HOVERGENiHBG085073.
InParanoidiQ9ER62.
KOiK05158.
OMAiRECACED.
OrthoDBiEOG091G0X13.
PhylomeDBiQ9ER62.
TreeFamiTF333916.

Miscellaneous databases

PROiQ9ER62.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010751.
ExpressionAtlasiQ9ER62. baseline and differential.
GenevisibleiQ9ER62. MM.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR22_MOUSE
AccessioniPrimary (citable) accession number: Q9ER62
Secondary accession number(s): Q8VHB9, Q9CZA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 27, 2003
Last modified: September 7, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.