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Protein

Tumor necrosis factor receptor superfamily member 22

Gene

Tnfrsf22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway.1 Publication

GO - Molecular functioni

  • nerve growth factor binding Source: GO_Central
  • receptor activity Source: UniProtKB
  • TRAIL binding Source: UniProtKB
  • tumor necrosis factor-activated receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 22
Alternative name(s):
Decoy TRAIL receptor 2
TNF receptor family member SOBa
TNF receptor homolog 2
Tumor necrosis factor receptor p60 homolog 2
Gene namesi
Name:Tnfrsf22
Synonyms:Dctrailr2, Tnfrh2, Tnfrsf1al2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1930270 Tnfrsf22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini42 – 198ExtracellularSequence analysisAdd BLAST157

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000589371 – 198Tumor necrosis factor receptor superfamily member 22Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 59PROSITE-ProRule annotation
Disulfide bondi60 ↔ 73PROSITE-ProRule annotation
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi63 ↔ 82PROSITE-ProRule annotation
Disulfide bondi85 ↔ 100PROSITE-ProRule annotation
Disulfide bondi103 ↔ 116PROSITE-ProRule annotation
Disulfide bondi106 ↔ 124PROSITE-ProRule annotation
Disulfide bondi126 ↔ 141PROSITE-ProRule annotation
Disulfide bondi144 ↔ 157PROSITE-ProRule annotation
Disulfide bondi147 ↔ 165PROSITE-ProRule annotation
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ER62
PRIDEiQ9ER62

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000010751
ExpressionAtlasiQ9ER62 baseline and differential
GenevisibleiQ9ER62 MM

Interactioni

GO - Molecular functioni

  • nerve growth factor binding Source: GO_Central
  • TRAIL binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081432

Structurei

3D structure databases

ProteinModelPortaliQ9ER62
SMRiQ9ER62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 82TNFR-Cys 1Add BLAST36
Repeati84 – 124TNFR-Cys 2Add BLAST41
Repeati125 – 165TNFR-Cys 3Add BLAST41

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1NE Eukaryota
ENOG4111ZZM LUCA
GeneTreeiENSGT00730000110985
HOGENOMiHOG000132999
HOVERGENiHBG085073
InParanoidiQ9ER62
KOiK05158
OMAiHRGGQFC
OrthoDBiEOG091G0X13
PhylomeDBiQ9ER62
TreeFamiTF333916

Family and domain databases

CDDicd15837 TNFRSF26, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR034062 TNFRSF26_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
SMARTiView protein in SMART
SM00208 TNFR, 3 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 3 hits
PS50050 TNFR_NGFR_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ER62-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGFFCSLVS SLSRWFLWRR LLLLLLLLLL NLPLQVKFAM LELHSFKCPA
60 70 80 90 100
GEYWSKDVCC KNCSAGTFVK APCEIPHTQG QCEKCHPGTF TEKDNYLDAC
110 120 130 140 150
ILCSTCDKDQ EMVADCSATS DRKCQCRTGL YYYDPKFPES CRPCTKCPQG
160 170 180 190
IPVLQECNST ANTVCSSSVS NPRNRLFLLL SPLSVLIVSV VVFRIIRR
Length:198
Mass (Da):22,375
Last modified:June 27, 2003 - v3
Checksum:iEBF8F52961EA9983
GO
Isoform 2 (identifier: Q9ER62-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-198: NPRNRLFLLLSPLSVLIVSVVVFRIIRR → RRSASVAWPI

Show »
Length:180
Mass (Da):20,227
Checksum:iF8F56E165ADD53FA
GO

Sequence cautioni

The sequence BAB28502 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC16406 differs from that shown. Reason: Frameshift at position 38.Curated
The sequence CAC27353 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → V in AAL05073 (PubMed:12466268).Curated1
Sequence conflicti24L → C in CAC16406 (PubMed:11063728).Curated1
Sequence conflicti27 – 30LLLL → CVV in CAC16406 (PubMed:11063728).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007648171 – 198NPRNR…RIIRR → RRSASVAWPI in isoform 2. 3 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278265 mRNA Translation: CAC16406.1 Frameshift.
AJ276505 Genomic DNA Translation: CAC27353.1 Sequence problems.
AY165626 mRNA Translation: AAN87806.1
AY165627 mRNA Translation: AAN87807.1
AY046551 mRNA Translation: AAL05073.1
AK012838 mRNA Translation: BAB28502.2 Different initiation.
CCDSiCCDS22043.1 [Q9ER62-2]
CCDS80846.1 [Q9ER62-1]
RefSeqiNP_001298074.1, NM_001311145.1 [Q9ER62-1]
NP_076169.2, NM_023680.4 [Q9ER62-2]
UniGeneiMm.261384

Genome annotation databases

EnsembliENSMUST00000075588; ENSMUSP00000075018; ENSMUSG00000010751 [Q9ER62-1]
ENSMUST00000084396; ENSMUSP00000081432; ENSMUSG00000010751 [Q9ER62-2]
ENSMUST00000146692; ENSMUSP00000119297; ENSMUSG00000010751 [Q9ER62-2]
GeneIDi79202
KEGGimmu:79202
UCSCiuc009kps.1 mouse [Q9ER62-2]
uc009kpt.1 mouse [Q9ER62-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTNR22_MOUSE
AccessioniPrimary (citable) accession number: Q9ER62
Secondary accession number(s): Q8VHB9, Q9CZA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 27, 2003
Last modified: March 28, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health