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Q9ER60

- SCN4A_MOUSE

UniProt

Q9ER60 - SCN4A_MOUSE

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Protein

Sodium channel protein type 4 subunit alpha

Gene
Scn4a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: MGI

GO - Biological processi

  1. membrane depolarization during action potential Source: RefGenome
  2. neuronal action potential Source: RefGenome
  3. sodium ion transmembrane transport Source: GOC
  4. sodium ion transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 4 subunit alpha
Alternative name(s):
Sodium channel protein skeletal muscle subunit alpha
Sodium channel protein type IV subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.4
Gene namesi
Name:Scn4a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:98250. Scn4a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 128128Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei129 – 15022Helical; Name=S1 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini151 – 1588Extracellular Reviewed prediction
Transmembranei159 – 17820Helical; Name=S2 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini179 – 19012Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei191 – 21020Helical; Name=S3 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini211 – 2166Extracellular Reviewed prediction
Transmembranei217 – 23620Helical; Voltage-sensor; Name=S4 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini237 – 25216Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei253 – 26614Helical; Name=S5 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini267 – 417151Extracellular Reviewed predictionAdd
BLAST
Transmembranei418 – 44326Helical; Name=S6 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini444 – 567124Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei568 – 59124Helical; Name=S1 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini592 – 60211Extracellular Reviewed predictionAdd
BLAST
Transmembranei603 – 62624Helical; Name=S2 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini627 – 6348Cytoplasmic Reviewed prediction
Transmembranei635 – 65420Helical; Name=S3 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini655 – 6606Extracellular Reviewed prediction
Transmembranei661 – 68020Helical; Voltage-sensor; Name=S4 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini681 – 69515Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei696 – 71823Helical; Name=S5 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini719 – 77052Extracellular Reviewed predictionAdd
BLAST
Transmembranei771 – 79626Helical; Name=S6 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini797 – 1020224Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1021 – 104323Helical; Name=S1 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1044 – 105714Extracellular Reviewed predictionAdd
BLAST
Transmembranei1058 – 108326Helical; Name=S2 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1084 – 10896Cytoplasmic Reviewed prediction
Transmembranei1090 – 111021Helical; Name=S3 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1111 – 11155Extracellular Reviewed prediction
Transmembranei1116 – 113722Helical; Voltage-sensor; Name=S4 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1138 – 115619Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1157 – 117822Helical; Name=S5 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1179 – 126284Extracellular Reviewed predictionAdd
BLAST
Transmembranei1263 – 128927Helical; Name=S6 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1290 – 134253Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1343 – 136624Helical; Name=S1 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1367 – 137711Extracellular Reviewed predictionAdd
BLAST
Transmembranei1378 – 140124Helical; Name=S2 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1402 – 14076Cytoplasmic Reviewed prediction
Transmembranei1408 – 143124Helical; Name=S3 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1432 – 14409Extracellular Reviewed prediction
Transmembranei1441 – 146323Helical; Voltage-sensor; Name=S4 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1464 – 147815Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1479 – 150123Helical; Name=S5 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1502 – 156766Extracellular Reviewed predictionAdd
BLAST
Transmembranei1568 – 159225Helical; Name=S6 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1593 – 1841249Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. plasma membrane Source: RefGenome
  2. voltage-gated sodium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18411841Sodium channel protein type 4 subunit alphaPRO_0000371316Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi214 – 2141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi291 – 2911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi297 – 2971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi303 – 3031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi315 – 3151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi327 – 3271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi356 – 3561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1185 – 11851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1199 – 11991N-linked (GlcNAc...) Reviewed prediction
Modified residuei1322 – 13221Phosphoserine; by PKC By similarity

Post-translational modificationi

Phosphorylation at Ser-1322 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ER60.
PRIDEiQ9ER60.

PTM databases

PhosphoSiteiQ9ER60.

Expressioni

Tissue specificityi

Expressed in the myocardium.1 Publication

Gene expression databases

GenevestigatoriQ9ER60.

Interactioni

Subunit structurei

Muscle sodium channels contain an alpha subunit and a smaller beta subunit. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102431.

Structurei

3D structure databases

ProteinModelPortaliQ9ER60.
SMRiQ9ER60. Positions 131-272, 582-796, 1014-1290, 1349-1748.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati128 – 444317IAdd
BLAST
Repeati565 – 790226IIAdd
BLAST
Repeati1018 – 1275258IIIAdd
BLAST
Repeati1343 – 1589247IVAdd
BLAST
Domaini1721 – 175030IQAdd
BLAST

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 IQ domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231755.
InParanoidiB1ARK0.
KOiK04837.
PhylomeDBiQ9ER60.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028826. Na_channel_a4su.
IPR008052. Na_channel_a4su_mammal.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF193. PTHR10037:SF193. 1 hit.
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01665. NACHANNEL4.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ER60-1 [UniParc]FASTAAdd to Basket

« Hide

MASSSLPTLV PPGPHCLRPF TPESLAAIEQ RAMEEEARLQ RNKQMEIEEP     50
ERKPRSDLEA GKNLPLIYGD PPPEVIGVPL EDLDPYYSDK KTFIVLNKGK 100
AIFRFSATPA LYMLSPFSIV RRVAIKVLIH ALFSMFIMIT ILTNCVFMTM 150
SNPPSWSKDV EYTFTGIYTF ESLIKMLARG FCIDDFTFLR DPWNWLDFSV 200
ITMAYVTEFV DLGNISALRT FRVLRALKTI TVIPGLKTIV GALIQSVKKL 250
SDVMILTVFC LSVFALVGLQ LFMGNLRQKC VRWPPPMNDT NTTWYGNDTW 300
YGNDTWYGND TWYGNDTWNS QESWVSNSTF DWEAYINDEG NFYFLEGSND 350
ALLCGNSSDA GHCPEGYECM KAGRNPNYGY TSYDTFSWAF LALFRLMTQD 400
YWENLFQLTL RAAGKTYMIF FVVIIFLGSF YLINLILAVV AMAYAEQNEA 450
TLAEDQEKEE EFQQMLEKFK KHQEELEKAK AAQALEGGEE ADGDPTHSKD 500
CNGSLDTSGE KGPPRPSCSA ESAISDAMEE LEEAHQKCPP WWYKCAHKVL 550
IWNCCAPWVK FKHIILLIVM DPFVDLGITI CIVLNTLFMA MEHYPMTEHF 600
DNVLSVGNLV FTGIFTAEMV LKLIAMDPYE YFQQGWNIFD SFIVTLSLVE 650
LGLANVQGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV 700
LAIIVFIFAV VGMQLFGKSY KECVCKIASD CSLPRWHMHD FFHSFLIVFR 750
ILCGEWIETM WDCMEVAGQA MCLTVFLMVM VIGNLVVLNL FLALLLSSFS 800
ADSLAASDED GEMNNLQIAI GRIKWGIAFA KTFLLGLLHG KILSLKDIML 850
SLGEPGGAGE NGESPPEDEK KEPPPEDGNK ELKDNHILNH VGLTDGPRSS 900
IEMDHLNFIN NPYLTIHVPI ASEESDLEMP TEEETDTFSE PEDIKKPLQP 950
LYDGNSSVCS TADYKPPEED PEEQAEENPE GELPEECFTE ACVKRCPCLY 1000
VDISQGRGKM WWTLRRACFK IVEHNWFETF IVFMILLSSG ALAFEDIYIE 1050
QRRVIRTILE YADKVFTYIF ILEMLLKWVA YGFKVYFTNA WCWLDFLIVD 1100
VSIISLVANW LGYSELGPIK SLRTLRALRP LRALSRFEGM RVVVNALLGA 1150
IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF YYCINTTTSE RFDISVVNNK 1200
SECESLMYTG QVRWMNVKVN YDNVGLGYLS LLQVATFKGW MDIMYAAVDS 1250
REKEEQPDYE VNLYMYLYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKFG 1300
GKDIFMTEEQ KKYYNAMKKL GSKKPQKPIP RPQNKIQGMV YDFVTKQVFD 1350
ISIMILICLN MVTMMVETDD QSQLKVDILY NINMVFIIVF TGECVLKMFA 1400
LRHYYFTIGW NIFDFVVVIL SIVGLALSDL IQKYFVSPTL FRVIRLARIG 1450
RVLRLIRGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY SIFGMSNFAY 1500
VKKESGIDDM FNFETFGNSI ICLFEITTSA GWDGLLNPIL NSGPPDCDPT 1550
LENPGTNIKG DCGNPSIGIC FFCSYIIISF LIVVNMYIAI ILENFNVATE 1600
ESSEPLCEDD FEMFYETWEK FDPDATQFID YSRLSDFVDT LQEPLKIAKP 1650
NKIKLITLDL PMVPGDKIHC LDILFALTKE VLGDSGEMDA LKQTMEEKFM 1700
AANPSKVSYE PITTTLKRKQ EEVCAIKIQR AYRRHLLQRS VKQASYMYRH 1750
SQEGNGDGAP EKEGLLANTM NKMYGSEKED NGVQSQGEKE KDSTEDAGPT 1800
TEVTAPSSSD TALTPPPPSP PPPSSPPQGQ TVRPGVKESL V 1841
Length:1,841
Mass (Da):208,798
Last modified:March 1, 2001 - v1
Checksum:i0766DFD33A9E0E55
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1311A → T in CAM23795. 1 Publication
Sequence conflicti1056 – 10561R → Q in CAM23795. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ278787 mRNA. Translation: CAC17146.1.
AL604045 Genomic DNA. Translation: CAM23795.1.
BC129805 mRNA. Translation: AAI29806.1.
CCDSiCCDS48961.1.
RefSeqiNP_573462.2. NM_133199.2.
UniGeneiMm.432528.

Genome annotation databases

GeneIDi110880.
KEGGimmu:110880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ278787 mRNA. Translation: CAC17146.1 .
AL604045 Genomic DNA. Translation: CAM23795.1 .
BC129805 mRNA. Translation: AAI29806.1 .
CCDSi CCDS48961.1.
RefSeqi NP_573462.2. NM_133199.2.
UniGenei Mm.432528.

3D structure databases

ProteinModelPortali Q9ER60.
SMRi Q9ER60. Positions 131-272, 582-796, 1014-1290, 1349-1748.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000102431.

PTM databases

PhosphoSitei Q9ER60.

Proteomic databases

PaxDbi Q9ER60.
PRIDEi Q9ER60.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 110880.
KEGGi mmu:110880.

Organism-specific databases

CTDi 6329.
MGIi MGI:98250. Scn4a.

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231755.
InParanoidi B1ARK0.
KOi K04837.
PhylomeDBi Q9ER60.

Miscellaneous databases

NextBioi 364857.
PROi Q9ER60.
SOURCEi Search...

Gene expression databases

Genevestigatori Q9ER60.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028826. Na_channel_a4su.
IPR008052. Na_channel_a4su_mammal.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
PANTHERi PTHR10037:SF193. PTHR10037:SF193. 1 hit.
Pfami PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
PR01665. NACHANNEL4.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
PROSITEi PS50096. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants."
    Zimmer T., Bollensdorff C., Haufe V., Birch-Hirschfeld E., Benndorf K.
    Am. J. Physiol. 282:H1007-H1017(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Heart.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1841.

Entry informationi

Entry nameiSCN4A_MOUSE
AccessioniPrimary (citable) accession number: Q9ER60
Secondary accession number(s): A2VDE9, B1ARK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi