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Protein

Potassium voltage-gated channel subfamily H member 7

Gene

Kcnh7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel (By similarity). Channel properties may be modulated by cAMP and subunit assembly.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi745 – 862118cNMPAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 7
Alternative name(s):
Ether-a-go-go-related gene potassium channel 3
Short name:
ERG-3
Short name:
Eag-related protein 3
Short name:
Ether-a-go-go-related protein 3
Voltage-gated potassium channel subunit Kv11.3
Gene namesi
Name:Kcnh7
Synonyms:Erg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2159566. Kcnh7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 412412CytoplasmicSequence analysisAdd
BLAST
Transmembranei413 – 43321Helical; Name=Segment S1Sequence analysisAdd
BLAST
Topological domaini434 – 44916ExtracellularSequence analysisAdd
BLAST
Transmembranei450 – 47021Helical; Name=Segment S2Sequence analysisAdd
BLAST
Topological domaini471 – 49424CytoplasmicSequence analysisAdd
BLAST
Transmembranei495 – 51521Helical; Name=Segment S3Sequence analysisAdd
BLAST
Topological domaini516 – 5216ExtracellularSequence analysis
Transmembranei522 – 54221Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd
BLAST
Topological domaini543 – 5497CytoplasmicSequence analysis
Transmembranei550 – 57021Helical; Name=Segment S5Sequence analysisAdd
BLAST
Topological domaini571 – 61444ExtracellularSequence analysisAdd
BLAST
Intramembranei615 – 63521Pore-forming; Name=Segment H5Sequence analysisAdd
BLAST
Topological domaini636 – 6416ExtracellularSequence analysis
Transmembranei642 – 66221Helical; Name=Segment S6Sequence analysisAdd
BLAST
Topological domaini663 – 1195533CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11951195Potassium voltage-gated channel subfamily H member 7PRO_0000054016Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741PhosphoserineCombined sources
Modified residuei238 – 2381PhosphoserineCombined sources
Modified residuei319 – 3191PhosphoserineBy similarity
Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence analysis
Modified residuei891 – 8911PhosphoserineBy similarity
Modified residuei894 – 8941PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9ER47.
PaxDbiQ9ER47.
PRIDEiQ9ER47.

PTM databases

iPTMnetiQ9ER47.
PhosphoSiteiQ9ER47.

Expressioni

Gene expression databases

BgeeiQ9ER47.
ExpressionAtlasiQ9ER47. baseline and differential.
GenevisibleiQ9ER47. MM.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074563.

Structurei

3D structure databases

ProteinModelPortaliQ9ER47.
SMRiQ9ER47. Positions 1-135, 572-614, 673-868.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 7030PASAdd
BLAST
Domaini92 – 14453PACAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi627 – 6326Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
GeneTreeiENSGT00760000118772.
HOGENOMiHOG000230793.
HOVERGENiHBG052232.
InParanoidiQ9ER47.
KOiK04910.
OMAiESQMTTD.
OrthoDBiEOG75B879.
TreeFamiTF313130.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR000014. PAS.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ER47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVRRGHVAP QNTFLGTIIR KFEGQNKKFI IANARVQNCA IIYCNDGFCE
60 70 80 90 100
MTGFSRPDVM QKPCTCDFLH GPETKRHDIA QIAQALLGSE ERKVEVTYYH
110 120 130 140 150
KNGSTFICNT HIIPVKNQEG VAMMFIINFE YVTDEENAAT PERVNPILPV
160 170 180 190 200
KTVNRKLFGF KFPGLRVLTY RKQSLPQEDP DVVVIDSSKH SDDSVAMKHF
210 220 230 240 250
KSPTKESCSP SEADDTKALI QPSQCSPLVN ISGPLDHSSP KRQWDRLYPD
260 270 280 290 300
MLQSSSQLTH SRSRESLCSI RRASSVHDIE GFSVHPKNIF RDRHASEDNG
310 320 330 340 350
RNVKGPFNHI KSSLLGSTSD SNLNKYSTIN KIPQLTLNFS DVKTEKKNTS
360 370 380 390 400
PPSSDKTIIA PKVKERTHNV TEKVTQVLSL GADVLPEYKL QTPRINKFTI
410 420 430 440 450
LHYSPFKAVW DWLILLLVIY TAIFTPYSAA FLLNDREEQK RRECGYSCSP
460 470 480 490 500
LNVVDLIVDI MFIIDILINF RTTYVNQNEE VVSDPAKIAI HYFKGWFLID
510 520 530 540 550
MVAAIPFDLL IFGSGSDETT TLIGLLKTAR LLRLVRVARK LDRYSEYGAA
560 570 580 590 600
VLMLLMCIFA LIAHWLACIW YAIGNVERPY LTDKIGWLDS LGTQIGKRYN
610 620 630 640 650
DSDSSSGPSI KDKYVTALYF TFSSLTSVGF GNVSPNTNSE KIFSICVMLI
660 670 680 690 700
GSLMYASIFG NVSAIIQRLY SGTARYHMQM LRVKEFIRFH QIPNPLRQRL
710 720 730 740 750
EEYFQHAWTY TNGIDMNMVL KGFPECLQAD ICLHLNQTLL QNCKAFRGAS
760 770 780 790 800
KGCLRALAMK FKTTHAPPGD TLVHCGDVLT ALYFLSRGSI EILKDDIVVA
810 820 830 840 850
ILGKNDIFGE MVHLYAKPGK SNADVRALTY CDLHKIQRED LLEVLDMYPE
860 870 880 890 900
FSDHFLTNLE LTFNLRHESA KSQSVNDSEG DTGKLRRRRL SFESEGEKDF
910 920 930 940 950
SKENSANDAD DSTDTIRRYQ SSKKHFEERK SRSSSFISSI DDEQKPLFLG
960 970 980 990 1000
TVDSTPRMVK ATRLHGEETM PHSGRIHTEK RSHSCRDITD THSWEREPAR
1010 1020 1030 1040 1050
AQPEECSPSG LQRAAWGVSE TESDLTYGEV EQRLDLLQEQ LNRLESQMTT
1060 1070 1080 1090 1100
DIQAILQLLQ KQTTVVPPAY SMVTAGAEYQ RPILRLLRTS HPRASIKTDR
1110 1120 1130 1140 1150
SFSPSSQCPE FLDLEKSKLQ SKESLSSGRR LNTASEDNLT SLLKQDSDAS
1160 1170 1180 1190
SELDPRQRKT YLHPIRHPSL PDSSLSTVGI LGLHRHVSDP GLPGK
Length:1,195
Mass (Da):135,062
Last modified:July 27, 2011 - v2
Checksum:iEC9A541243FED06D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481F → L in CAC14797 (Ref. 1) Curated
Sequence conflicti511 – 5111I → V in CAC14797 (Ref. 1) Curated
Sequence conflicti750 – 7501S → N in CAC14797 (Ref. 1) Curated
Sequence conflicti972 – 9743HSG → PSP in CAC14797 (Ref. 1) Curated
Sequence conflicti979 – 9791E → D in CAC14797 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291608 mRNA. Translation: CAC14797.1.
AL928663, AL928689, AL929246 Genomic DNA. Translation: CAM20556.1.
AL929246, AL928663, AL928689 Genomic DNA. Translation: CAM21791.1.
AL928689, AL928663, AL929246 Genomic DNA. Translation: CAM22230.1.
CCDSiCCDS38128.1.
RefSeqiNP_573470.2. NM_133207.2.
UniGeneiMm.242532.

Genome annotation databases

EnsembliENSMUST00000075052; ENSMUSP00000074563; ENSMUSG00000059742.
GeneIDi170738.
KEGGimmu:170738.
UCSCiuc008jvq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291608 mRNA. Translation: CAC14797.1.
AL928663, AL928689, AL929246 Genomic DNA. Translation: CAM20556.1.
AL929246, AL928663, AL928689 Genomic DNA. Translation: CAM21791.1.
AL928689, AL928663, AL929246 Genomic DNA. Translation: CAM22230.1.
CCDSiCCDS38128.1.
RefSeqiNP_573470.2. NM_133207.2.
UniGeneiMm.242532.

3D structure databases

ProteinModelPortaliQ9ER47.
SMRiQ9ER47. Positions 1-135, 572-614, 673-868.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074563.

PTM databases

iPTMnetiQ9ER47.
PhosphoSiteiQ9ER47.

Proteomic databases

MaxQBiQ9ER47.
PaxDbiQ9ER47.
PRIDEiQ9ER47.

Protocols and materials databases

DNASUi170738.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075052; ENSMUSP00000074563; ENSMUSG00000059742.
GeneIDi170738.
KEGGimmu:170738.
UCSCiuc008jvq.1. mouse.

Organism-specific databases

CTDi90134.
MGIiMGI:2159566. Kcnh7.

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
GeneTreeiENSGT00760000118772.
HOGENOMiHOG000230793.
HOVERGENiHBG052232.
InParanoidiQ9ER47.
KOiK04910.
OMAiESQMTTD.
OrthoDBiEOG75B879.
TreeFamiTF313130.

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Miscellaneous databases

ChiTaRSiKcnh7. mouse.
NextBioi370290.
PROiQ9ER47.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ER47.
ExpressionAtlasiQ9ER47. baseline and differential.
GenevisibleiQ9ER47. MM.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR000014. PAS.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Erg genes expression during development of mouse embryos."
    Arcangeli A.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174 AND SER-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiKCNH7_MOUSE
AccessioniPrimary (citable) accession number: Q9ER47
Secondary accession number(s): A2AUY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.