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Protein

Homeobox protein BarH-like 1

Gene

Barx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi142 – 201HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anatomical structure development Source: MGI
  • animal organ development Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • cell-cell signaling Source: MGI
  • digestive system development Source: MGI
  • epithelial cell differentiation Source: MGI
  • negative regulation of Wnt signaling pathway Source: MGI
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • spleen development Source: MGI
  • tissue development Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein BarH-like 1
Gene namesi
Name:Barx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:103124 Barx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488351 – 254Homeobox protein BarH-like 1Add BLAST254

Proteomic databases

PaxDbiQ9ER42
PRIDEiQ9ER42

PTM databases

iPTMnetiQ9ER42
PhosphoSitePlusiQ9ER42

Expressioni

Tissue specificityi

Expressed predominantly in the facial primordia, developing stomach, and proximal limbs.

Developmental stagei

Expressed in areas of the first and second branchial arches, before any apparent cellular or morphologic differentiation. Later in development, all expressing tissue in this region, including the mesenchyme underlying the olfactory epithelium, the primary and secondary palate, the molar tooth papillae, and the stroma of the submandibular gland, appear to be derived from ectomesenchyme of neural crest origin. By day 16.5, all areas except the developing molars are BARX1-negative. In addition, BARX1 marks the area of the future stomach in the primitive gut at embryonic day 9.5, and is present in the mesenchymal wall of the stomach until embryonic day 16.5.2 Publications

Gene expression databases

BgeeiENSMUSG00000021381
CleanExiMM_BARX1
GenevisibleiQ9ER42 MM

Interactioni

Protein-protein interaction databases

BioGridi1983024 interactors.
STRINGi10090.ENSMUSP00000021813

Structurei

3D structure databases

ProteinModelPortaliQ9ER42
SMRiQ9ER42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 53Poly-Ala10

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143987
HOGENOMiHOG000231924
HOVERGENiHBG050665
InParanoidiQ9ER42
KOiK09361
OMAiFHSHLAV
OrthoDBiEOG091G10IN
PhylomeDBiQ9ER42
TreeFamiTF350735

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ER42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRPGEPGAA RFGPPEGCAD HRPHRYRSFM IEEILTEPPG PKGAAPAAAA
60 70 80 90 100
AAAGELLKFG VQALLAARPF HSHLAVLKAE QAAVFKFPLA PLGCSGLGSA
110 120 130 140 150
LLAAGPGMPG PAGASHLPLE LQLRGKLEAA GSGEPGAKAK KGRRSRTVFT
160 170 180 190 200
ELQLMGLEKR FEKQKYLSTP DRIDLAESLG LSQLQVKTWY QNRRMKWKKI
210 220 230 240 250
VLQGGGLESP TKPKGRPKKN SIPTSEQLTE QERAKETEKP AETPGEPSDR

NCED
Length:254
Mass (Da):27,282
Last modified:March 1, 2001 - v1
Checksum:i48586B28F4A23FCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297677 mRNA Translation: CAC10357.1
AF277160 Genomic DNA Translation: AAG18573.1
BC119047 mRNA Translation: AAI19048.2
BC119049 mRNA Translation: AAI19050.2
Y07960 mRNA Translation: CAA69257.1
CCDSiCCDS49258.1
RefSeqiNP_031552.2, NM_007526.4
UniGeneiMm.42241

Genome annotation databases

EnsembliENSMUST00000021813; ENSMUSP00000021813; ENSMUSG00000021381
GeneIDi12022
KEGGimmu:12022
UCSCiuc007qil.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBARX1_MOUSE
AccessioniPrimary (citable) accession number: Q9ER42
Secondary accession number(s): O09066
, P70159, Q0VF04, Q9ERV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome