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Protein

Homeobox protein BarH-like 1

Gene

Barx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi142 – 20160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anatomical structure development Source: MGI
  • animal organ development Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • cell-cell signaling Source: MGI
  • digestive system development Source: MGI
  • epithelial cell differentiation Source: MGI
  • negative regulation of Wnt signaling pathway Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • spleen development Source: MGI
  • tissue development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein BarH-like 1
Gene namesi
Name:Barx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:103124. Barx1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Homeobox protein BarH-like 1PRO_0000048835Add
BLAST

Proteomic databases

PaxDbiQ9ER42.
PRIDEiQ9ER42.

PTM databases

PhosphoSiteiQ9ER42.

Expressioni

Tissue specificityi

Expressed predominantly in the facial primordia, developing stomach, and proximal limbs.

Developmental stagei

Expressed in areas of the first and second branchial arches, before any apparent cellular or morphologic differentiation. Later in development, all expressing tissue in this region, including the mesenchyme underlying the olfactory epithelium, the primary and secondary palate, the molar tooth papillae, and the stroma of the submandibular gland, appear to be derived from ectomesenchyme of neural crest origin. By day 16.5, all areas except the developing molars are BARX1-negative. In addition, BARX1 marks the area of the future stomach in the primitive gut at embryonic day 9.5, and is present in the mesenchymal wall of the stomach until embryonic day 16.5.2 Publications

Gene expression databases

BgeeiQ9ER42.
CleanExiMM_BARX1.
GenevisibleiQ9ER42. MM.

Interactioni

Protein-protein interaction databases

BioGridi198302. 4 interactions.
STRINGi10090.ENSMUSP00000021813.

Structurei

3D structure databases

ProteinModelPortaliQ9ER42.
SMRiQ9ER42. Positions 134-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 5310Poly-Ala

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00840000129678.
HOGENOMiHOG000231924.
HOVERGENiHBG050665.
InParanoidiQ9ER42.
KOiK09361.
OMAiARPFHSH.
OrthoDBiEOG71G9VZ.
PhylomeDBiQ9ER42.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ER42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRPGEPGAA RFGPPEGCAD HRPHRYRSFM IEEILTEPPG PKGAAPAAAA
60 70 80 90 100
AAAGELLKFG VQALLAARPF HSHLAVLKAE QAAVFKFPLA PLGCSGLGSA
110 120 130 140 150
LLAAGPGMPG PAGASHLPLE LQLRGKLEAA GSGEPGAKAK KGRRSRTVFT
160 170 180 190 200
ELQLMGLEKR FEKQKYLSTP DRIDLAESLG LSQLQVKTWY QNRRMKWKKI
210 220 230 240 250
VLQGGGLESP TKPKGRPKKN SIPTSEQLTE QERAKETEKP AETPGEPSDR

NCED
Length:254
Mass (Da):27,282
Last modified:March 1, 2001 - v1
Checksum:i48586B28F4A23FCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297677 mRNA. Translation: CAC10357.1.
AF277160 Genomic DNA. Translation: AAG18573.1.
BC119047 mRNA. Translation: AAI19048.2.
BC119049 mRNA. Translation: AAI19050.2.
Y07960 mRNA. Translation: CAA69257.1.
CCDSiCCDS49258.1.
RefSeqiNP_031552.2. NM_007526.4.
UniGeneiMm.42241.

Genome annotation databases

EnsembliENSMUST00000021813; ENSMUSP00000021813; ENSMUSG00000021381.
GeneIDi12022.
KEGGimmu:12022.
UCSCiuc007qil.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297677 mRNA. Translation: CAC10357.1.
AF277160 Genomic DNA. Translation: AAG18573.1.
BC119047 mRNA. Translation: AAI19048.2.
BC119049 mRNA. Translation: AAI19050.2.
Y07960 mRNA. Translation: CAA69257.1.
CCDSiCCDS49258.1.
RefSeqiNP_031552.2. NM_007526.4.
UniGeneiMm.42241.

3D structure databases

ProteinModelPortaliQ9ER42.
SMRiQ9ER42. Positions 134-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198302. 4 interactions.
STRINGi10090.ENSMUSP00000021813.

PTM databases

PhosphoSiteiQ9ER42.

Proteomic databases

PaxDbiQ9ER42.
PRIDEiQ9ER42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021813; ENSMUSP00000021813; ENSMUSG00000021381.
GeneIDi12022.
KEGGimmu:12022.
UCSCiuc007qil.1. mouse.

Organism-specific databases

CTDi56033.
MGIiMGI:103124. Barx1.

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00840000129678.
HOGENOMiHOG000231924.
HOVERGENiHBG050665.
InParanoidiQ9ER42.
KOiK09361.
OMAiARPFHSH.
OrthoDBiEOG71G9VZ.
PhylomeDBiQ9ER42.
TreeFamiTF350735.

Miscellaneous databases

NextBioi280251.
PROiQ9ER42.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ER42.
CleanExiMM_BARX1.
GenevisibleiQ9ER42. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Buchner G.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Head.
  2. "Characterization of the mouse Barx1 gene."
    Meech R., Edelman D.B., Jones F.S.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-254.
    Strain: BALB/cJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-254.
    Tissue: Brain.
  4. "Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach."
    Tissier-Seta J.-P., Mucchielli M.L., Mark M., Mattei M.-G., Goridis C., Brunet J.-F.
    Mech. Dev. 51:3-15(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 108-254, DEVELOPMENTAL STAGE.
    Strain: NMRI.
  5. "The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling."
    Kim B.-M., Buchner G., Miletich I., Sharpe P.T., Shivdasani R.A.
    Dev. Cell 8:611-622(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen."
    Kim B.M., Miletich I., Mao J., McMahon A.P., Sharpe P.A., Shivdasani R.A.
    Development 134:3603-3613(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiBARX1_MOUSE
AccessioniPrimary (citable) accession number: Q9ER42
Secondary accession number(s): O09066
, P70159, Q0VF04, Q9ERV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.