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Q9ER39 (TOR1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Torsin-1A
Alternative name(s):
Dystonia 1 protein
Torsin ATPase 1
EC=3.6.4.-
Torsin family 1 member A
Gene names
Name:Tor1a
Synonyms:Dyt1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins By similarity. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subunit structure

May form homohexamers. Interacts (ATP-bound) with TOR1AIP1 and TOR1AIP2; the interactions induce ATPase activity. Interacts with KLHL14, preferentially when ATP-free. Ref.3

Subcellular location

Endoplasmic reticulum lumen By similarity. Nucleus membrane By similarity. Note: Mainly located in the lumen of the endoplasmic reticulum. The association with nuclear envelope is mediated by the interaction with TOR1AIP2 By similarity.

Sequence similarities

Belongs to the ClpA/ClpB family. Torsin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 333313Torsin-1A
PRO_0000005508

Regions

Nucleotide binding103 – 1108ATP Potential

Amino acid modifications

Glycosylation1441N-linked (GlcNAc...) By similarity
Glycosylation1591N-linked (GlcNAc...) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ER39 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: CD2D7B97E3F03274

FASTA33337,830
        10         20         30         40         50         60 
MKLGRAALAL LLLAPCVVRA VEPISLSLAL AGVLTTYISY PRLYCLFAEC CGQMRSLSRE 

        70         80         90        100        110        120 
ALQKDLDNKL FGQHLAKKVI LNAVSGFLSN PKPKKPLTLS LHGWTGTGKN FASKIIAENI 

       130        140        150        160        170        180 
YEGGLNSDYV HLFVATLHFP HASNITQYKD QLQMWIRGNV SACARSIFIF DEMDKMHAGL 

       190        200        210        220        230        240 
IDAIKPFLDY YDVVDEVSYQ KAIFIFLSNA GAERITDVAL DFWKSGKQRE EIKLRDMEPA 

       250        260        270        280        290        300 
LAVSVFNNKN SGFWHSSLID RNLIDYFVPF LPLEYKHLKM CIRVEMQSRG YEVDEDIISK 

       310        320        330 
VAEEMTFFPK EEKVFSDKGC KTVFTKLDYY LDD 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the mouse torsinA gene."
Kuner R., Teismann P., Trutzel A., Naim J., Richter A., Bach A., Ferger B., Schneider A.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
[3]"Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis."
Giles L.M., Li L., Chin L.S.
J. Biol. Chem. 284:21765-21775(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KLHL14.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ298841 mRNA. Translation: CAC12785.1.
BC017683 mRNA. Translation: AAH17683.1.
RefSeqNP_659133.1. NM_144884.2.
UniGeneMm.154994.

3D structure databases

ProteinModelPortalQ9ER39.
SMRQ9ER39. Positions 92-122.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid206008. 1 interaction.
MINTMINT-1836416.

PTM databases

PhosphoSiteQ9ER39.

Proteomic databases

PaxDbQ9ER39.
PRIDEQ9ER39.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028200; ENSMUSP00000028200; ENSMUSG00000026849.
GeneID30931.
KEGGmmu:30931.
UCSCuc008jdc.2. mouse.

Organism-specific databases

CTD1861.
MGIMGI:1353568. Tor1a.

Phylogenomic databases

eggNOGNOG283963.
GeneTreeENSGT00390000001920.
HOGENOMHOG000115770.
HOVERGENHBG054188.
InParanoidQ9ER39.
OMACCRPEWI.
OrthoDBEOG7TF791.
PhylomeDBQ9ER39.
TreeFamTF314941.

Gene expression databases

ArrayExpressQ9ER39.
BgeeQ9ER39.
CleanExMM_TOR1A.
GenevestigatorQ9ER39.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR010448. Torsin.
IPR017378. Torsin_subgr.
[Graphical view]
PANTHERPTHR10760. PTHR10760. 1 hit.
PfamPF06309. Torsin. 1 hit.
[Graphical view]
PIRSFPIRSF038079. Torsin_2A. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

ChiTaRSTOR1A. mouse.
NextBio307342.
PROQ9ER39.
SOURCESearch...

Entry information

Entry nameTOR1A_MOUSE
AccessionPrimary (citable) accession number: Q9ER39
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot