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Protein

Fructosamine-3-kinase

Gene

Fn3k

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme (By similarity).By similarity

GO - Molecular functioni

  • fructosamine-3-kinase activity Source: MGI

GO - Biological processi

  • epithelial cell differentiation Source: Ensembl
  • fructosamine metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Enzyme and pathway databases

BRENDAi2.7.1.171. 3474.
ReactomeiR-MMU-163841. Gamma carboxylation, hypusine formation and arylsulfatase activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructosamine-3-kinase (EC:2.7.1.-)
Gene namesi
Name:Fn3k
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1926834. Fn3k.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Fructosamine-3-kinasePRO_0000216338Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9ER35.
PaxDbiQ9ER35.
PRIDEiQ9ER35.

PTM databases

iPTMnetiQ9ER35.
PhosphoSiteiQ9ER35.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025175.
CleanExiMM_FN3K.
ExpressionAtlasiQ9ER35. baseline and differential.
GenevisibleiQ9ER35. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9ER35. 1 interaction.
STRINGi10090.ENSMUSP00000026175.

Structurei

3D structure databases

ProteinModelPortaliQ9ER35.
SMRiQ9ER35. Positions 38-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fructosamine kinase family.Curated

Phylogenomic databases

eggNOGiKOG3021. Eukaryota.
COG3001. LUCA.
GeneTreeiENSGT00390000005730.
HOGENOMiHOG000023913.
HOVERGENiHBG005740.
InParanoidiQ9ER35.
KOiK15522.
OMAiTHEISAR.
OrthoDBiEOG091G0KFO.
PhylomeDBiQ9ER35.
TreeFamiTF313452.

Family and domain databases

InterProiIPR016477. Fructo-/Ketosamine-3-kinase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF03881. Fructosamin_kin. 1 hit.
[Graphical view]
PIRSFiPIRSF006221. Ketosamine-3-kinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ER35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLLRAQLH TTTLRAFGSS GGGCISEGYA YYTDSGPVFV KVNRRTQARQ
60 70 80 90 100
MFEGEMASLE ALRNTGLVRV PKPMKVIDLP GGGAVFVMEH LKMKSLSSQA
110 120 130 140 150
SKLGEQMADL HLYNQKLREK SKTRQNTVGC GAEGAEPQGV TKFGFHTVTC
160 170 180 190 200
CGFIPQVNEW QEDWPTFFTR HRLQAQLDLI EKDYADRETQ ELWSRLQVKI
210 220 230 240 250
PDLFAGIEIV PALLHGDLWS GNVAEDDQGP VIYDPASFYG HSEFELAIAS
260 270 280 290 300
MFGGFPRSFF TAYHRKIPKA PGFDKRLLLY QLFNYLNHWN HFGREYRSPS

LGVMRKLLR
Length:309
Mass (Da):35,032
Last modified:March 1, 2001 - v1
Checksum:i7FD29F83C4FE7874
GO

Sequence cautioni

The sequence AK010151 differs from that shown. Reason: Frameshift at position 255. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404616 mRNA. Translation: CAC16407.1.
AK010151 mRNA. No translation available.
CCDSiCCDS25776.1.
RefSeqiNP_071297.1. NM_022014.4.
UniGeneiMm.266448.

Genome annotation databases

EnsembliENSMUST00000026175; ENSMUSP00000026175; ENSMUSG00000025175.
GeneIDi63828.
KEGGimmu:63828.
UCSCiuc007mvx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404616 mRNA. Translation: CAC16407.1.
AK010151 mRNA. No translation available.
CCDSiCCDS25776.1.
RefSeqiNP_071297.1. NM_022014.4.
UniGeneiMm.266448.

3D structure databases

ProteinModelPortaliQ9ER35.
SMRiQ9ER35. Positions 38-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ER35. 1 interaction.
STRINGi10090.ENSMUSP00000026175.

PTM databases

iPTMnetiQ9ER35.
PhosphoSiteiQ9ER35.

Proteomic databases

MaxQBiQ9ER35.
PaxDbiQ9ER35.
PRIDEiQ9ER35.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026175; ENSMUSP00000026175; ENSMUSG00000025175.
GeneIDi63828.
KEGGimmu:63828.
UCSCiuc007mvx.2. mouse.

Organism-specific databases

CTDi64122.
MGIiMGI:1926834. Fn3k.

Phylogenomic databases

eggNOGiKOG3021. Eukaryota.
COG3001. LUCA.
GeneTreeiENSGT00390000005730.
HOGENOMiHOG000023913.
HOVERGENiHBG005740.
InParanoidiQ9ER35.
KOiK15522.
OMAiTHEISAR.
OrthoDBiEOG091G0KFO.
PhylomeDBiQ9ER35.
TreeFamiTF313452.

Enzyme and pathway databases

BRENDAi2.7.1.171. 3474.
ReactomeiR-MMU-163841. Gamma carboxylation, hypusine formation and arylsulfatase activation.

Miscellaneous databases

PROiQ9ER35.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025175.
CleanExiMM_FN3K.
ExpressionAtlasiQ9ER35. baseline and differential.
GenevisibleiQ9ER35. MM.

Family and domain databases

InterProiIPR016477. Fructo-/Ketosamine-3-kinase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF03881. Fructosamin_kin. 1 hit.
[Graphical view]
PIRSFiPIRSF006221. Ketosamine-3-kinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFN3K_MOUSE
AccessioniPrimary (citable) accession number: Q9ER35
Secondary accession number(s): Q9D6N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.